DoseRider: Dose-Response Analysis Tool

Configure your dose-response analysis

Adjust the settings below to custom your analysis of dose-response analysis. Set parameters like feature sets, size filters, and transformation options to refine your results. Once configured, click "Submit" to begin.

Dataset summary

Name:	PRJNA869442 - BTUM - homo_sapiens - RNA-seq
Doses/Concentrations:	0, 5.00e-04, 1.00e-03, 1.00e-02, 1.00e-01, 5.00e-01, 1.00e+00, 5.00e+00, 1.00e+01
Dose/Concentration units:	µM
Omics type:	RNA-seq
Feature annotation:	symbols
Number of samples:	52
Species:	Homo sapiens

Feature sets field

Custom gmt file
Upload custom GMT file:
Feature set database:
Minimum set size:
Maximum set size:
Avoid feature sets (proteins, genes, metabolites) with antagonistic effects by applying the First Principal Component (PC1).

Data preprocessing

Log-transform dose/concentration values. This is recommended for doses/concentrations selected in logarithmic increments

Models fitting:

Linear

Non-linear (Fixed)

Non-linear (Mixed)

Benchmark dose modeling

Number of SD for BMD calculation:
Number of bootstrap iterations for BMD calculation:
Use main cluster for BMD calculation If checked, the BMD will be calculated using the main cluster. If unchecked, the BMD will be calculated using all data points.

Viability analysis

Calculate IC50 values for viability data
Viability Column: