Geneset	Geneset_Size	Genes	null_AIC	null_AICc	null_BIC	null_df	NA.	linear_AIC	linear_AICc	linear_BIC	linear_df	linear_ICC	non_linear_fixed_AIC	non_linear_fixed_AICc	non_linear_fixed_BIC	non_linear_fixed_df	non_linear_fixed_ICC	non_linear_mixed_AIC	non_linear_mixed_AICc	non_linear_mixed_BIC	non_linear_mixed_df	non_linear_mixed_ICC	p_value_linear	p_value_non_linear_fixed	p_value_non_linear_mixed	adjusted_linear_p_value	adjusted_non_linear_fixed_p_value	adjusted_non_linear_mixed_p_value	best_model	best_model_pvalue	best_model_adj_pvalue	best_model_aicc	best_model_bic	OptimalClusters
Platelet activation - Homo sapiens (human)	123	23	16872.7267709876	16872.7454625764	16888.2093087076	1285	NA	16646.671722725	16646.7372964954	16677.6367981649	1282	0.950303304349732	16637.4015221168	16637.5141100761	16678.6882893701	1280	0.953956942194555	16558.7986684473	16559.1760269378	16636.2113570472	1273	0.955632253421286	4.97143376835108e-50	5.53389840892879e-51	4.92721058169439e-65	4.6234334045665e-48	5.14652552030378e-49	4.58230584097579e-63	non_linear_mixed	4.92721058169439e-65	4.58230584097579e-63	16559.1760269378	16636.2113570472	3
Focal adhesion - Homo sapiens (human)	200	29	20853.431150224	20853.4459650388	20869.6090927862	1621	NA	20668.1995517265	20668.2514997785	20700.5554368509	1618	0.93618734351637	20665.4578186754	20665.5469827621	20708.5989988412	1616	0.943732423215026	20603.9473220987	20604.2458295614	20684.8370349096	1609	0.94506468308891	3.30795338615181e-41	7.70780002611566e-41	1.69872398752411e-51	3.07639664912118e-39	7.16825402428756e-39	1.57981330839742e-49	non_linear_mixed	1.69872398752411e-51	1.57981330839742e-49	20604.2458295614	20684.8370349096	2
Relaxin signaling pathway - Homo sapiens (human)	128	21	13410.3893887462	13410.4098665619	13425.5990111316	1173	NA	13296.6037360006	13296.675592288	13327.0229807713	1170	0.946330778006942	13290.6541683264	13290.7775616426	13331.2131613541	1168	0.956130641126903	13263.7654030569	13264.1791961603	13339.8135149838	1161	NA	8.58222142316322e-26	2.70871830846061e-26	3.55830491793233e-30	7.9814659235418e-24	2.51910802686837e-24	3.30922357367707e-28	non_linear_mixed	3.55830491793233e-30	3.30922357367707e-28	13264.1791961603	13339.8135149838	2
Oxytocin signaling pathway - Homo sapiens (human)	153	25	16606.8930435222	16606.9102354993	16622.625726069	1397	NA	16560.4666470742	16560.5269485818	16591.9320121678	1394	0.936884853563881	16556.2684338215	16556.3719564671	16598.2222539463	1392	0.939998295109207	16545.344143743	16545.6909645523	16624.0075564771	1385	NA	2.42955449418773e-11	9.02888289113329e-12	3.56930481589786e-13	2.25948567959459e-09	8.39686108875396e-10	3.31945347878501e-11	non_linear_mixed	3.56930481589786e-13	3.31945347878501e-11	16545.6909645523	16624.0075564771	2
Yersinia infection - Homo sapiens (human)	135	22	14262.1367545666	14262.1562985406	14277.4859369989	1229	NA	14225.6137957898	14225.6823672183	14256.3121606543	1226	0.923320706382669	14223.9728220328	14224.0905652871	14264.9039751856	1224	0.927947442541986	14208.7050451354	14209.0997819775	14285.4509572968	1217	0.929874312459793	3.1073038108811e-09	3.28849115932599e-09	1.27188145116596e-11	2.88979254411942e-07	3.05829677817317e-07	1.18284974958434e-09	non_linear_mixed	1.27188145116596e-11	1.18284974958434e-09	14209.0997819775	14285.4509572968	4
Adherens junction - Homo sapiens (human)	70	24	16194.8707281042	16194.888638552	16210.4809446675	1341	NA	16153.9736607511	16154.0364879762	16185.1940938775	1338	0.867393654320563	16148.0038173938	16148.1116825624	16189.6310615625	1336	0.87425063939535	16133.5446257301	16133.9060715133	16211.5957085464	1329	NA	3.6553182205622e-10	5.38665108542801e-11	3.93951503510351e-13	3.39944594512285e-08	5.00958550944805e-09	3.66374898264626e-11	non_linear_mixed	3.93951503510351e-13	3.66374898264626e-11	16133.9060715133	16211.5957085464	2
Glutamatergic synapse - Homo sapiens (human)	113	22	16713.619805663	16713.639349637	16728.9689880953	1229	NA	16539.8958680791	16539.9644395077	16570.5942329437	1226	NA	16537.6165960625	16537.7343393168	16578.5477492152	1224	0.95987725715781	16508.1189073178	16508.5136441599	16584.8648194792	1217	NA	1.01177150981047e-38	2.79255217160987e-38	2.53090030027682e-42	9.40947504123736e-37	2.59707351959718e-36	2.35373727925744e-40	non_linear_mixed	2.53090030027682e-42	2.35373727925744e-40	16508.5136441599	16584.8648194792	3
Growth hormone synthesis, secretion and action - Homo sapiens (human)	118	24	15328.9274846387	15328.9453950865	15344.537701202	1341	NA	15215.9614946418	15216.0243218669	15247.1819277683	1338	0.948564305368342	15210.0524283911	15210.1602935596	15251.6796725598	1336	0.954508065948187	15180.1706550527	15180.5321008358	15258.2217378689	1329	0.961067335530788	1.28860734694596e-25	4.12362419985267e-26	1.30242418407033e-30	1.19840483265974e-23	3.83497050586298e-24	1.21125449118541e-28	non_linear_mixed	1.30242418407033e-30	1.21125449118541e-28	15180.5321008358	15258.2217378689	2
JAK-STAT signaling pathway - Homo sapiens (human)	161	21	13783.9551067345	13783.9755845502	13799.1647291199	1173	NA	13705.0144122878	13705.0862685752	13735.4336570585	1170	0.928823044220442	13700.4991575857	13700.6225509019	13741.0581506133	1168	0.926405910435762	13641.8316528143	13642.2454459177	13717.8797647412	1161	0.933910117109568	2.67230523440973e-18	1.2615161209451e-18	2.95930530575837e-29	2.48524386800105e-16	1.17320999247895e-16	2.75215393435529e-27	non_linear_mixed	2.95930530575837e-29	2.75215393435529e-27	13642.2454459177	13717.8797647412	3
Tight junction - Homo sapiens (human)	168	38	26732.5469624513	26732.5582618863	26749.5357760026	2125	NA	26456.8395221385	26456.8791260989	26490.8171492412	2122	0.93794735696454	26452.6580325627	26452.725989146	26497.9615353664	2120	0.947160324798815	26277.9027049947	26278.129977722	26362.8467727517	2113	NA	9.04439092513071e-61	1.49304041694715e-60	7.73719393203841e-95	8.41128356037157e-59	1.38852758776085e-58	7.19559035679573e-93	non_linear_mixed	7.73719393203841e-95	7.19559035679573e-93	26278.129977722	26362.8467727517	4
Chemokine signaling pathway - Homo sapiens (human)	191	22	13764.3563887936	13764.3759327676	13779.7055712259	1229	NA	13602.9474134472	13603.0159848758	13633.6457783118	1226	NA	13593.4269168257	13593.54466008	13634.3580699784	1224	NA	13554.701370416	13555.0961072581	13631.4472825774	1217	NA	4.61321486161916e-36	3.38788047973271e-37	3.46599376187869e-43	4.29028982130582e-34	3.15072884615142e-35	3.22337419854718e-41	non_linear_mixed	3.46599376187869e-43	3.22337419854718e-41	13555.0961072581	13631.4472825774	2
Gastric cancer - Homo sapiens (human)	148	25	15875.4804344896	15875.4976264667	15891.2131170364	1397	NA	15806.8695695543	15806.9298710618	15838.3349346479	1394	0.941327956687943	15805.5004317228	15805.6039543684	15847.4542518477	1392	0.943059837211873	15753.9304419316	15754.2772627409	15832.5938546657	1385	NA	4.3904160774643e-16	8.47305313159752e-16	4.52277402453302e-25	4.0830869520418e-14	7.87993941238569e-14	4.20617984281571e-23	non_linear_mixed	4.52277402453302e-25	4.20617984281571e-23	15754.2772627409	15832.5938546657	2
Ubiquitin mediated proteolysis - Homo sapiens (human)	139	24	15566.8786521393	15566.8965625871	15582.4888687026	1341	NA	15461.3183083027	15461.3811355278	15492.5387414292	1338	0.918013954320826	15463.6341697226	15463.7420348911	15505.2614138912	1336	0.865143939163419	15391.184916858	15391.5463626411	15469.2359996742	1329	NA	5.06425996242306e-24	8.44444051352869e-23	3.7724426074999e-36	4.70976176505345e-22	7.85332967758168e-21	3.50837162497491e-34	non_linear_mixed	3.7724426074999e-36	3.50837162497491e-34	15391.5463626411	15469.2359996742	2
Breast cancer - Homo sapiens (human)	146	21	14681.4200899063	14681.440567722	14696.6297122917	1173	NA	14548.6431911099	14548.7150473974	14579.0624358807	1170	0.930898819787069	14547.1667666568	14547.290159973	14587.7257596845	1168	0.935596244536085	14483.718983063	14484.1327761664	14559.7670949898	1161	0.938421431478367	6.93704113121862e-30	2.22995756318462e-29	1.05336553715799e-40	6.45144825203331e-28	2.0738605337617e-27	9.79629949556929e-39	non_linear_mixed	1.05336553715799e-40	9.79629949556929e-39	14484.1327761664	14559.7670949898	2
Gap junction - Homo sapiens (human)	87	22	14551.8138276649	14551.8333716389	14567.1630100972	1229	NA	14393.4682885842	14393.5368600128	14424.1666534488	1226	0.945369122602868	14367.9964991301	14368.1142423844	14408.9276522829	1224	0.937872684783978	14204.6115292306	14205.0062660727	14281.357441392	1217	NA	2.11474258336783e-35	5.96642630645232e-40	4.67693619282958e-72	1.96671060253208e-33	5.54877646500065e-38	4.34955065933151e-70	non_linear_mixed	4.67693619282958e-72	4.34955065933151e-70	14205.0062660727	14281.357441392	2
RNA transport - Homo sapiens (human)	185	33	24282.6785915735	24282.6916067579	24299.2441693301	1845	NA	24303.640305192	24303.6859325684	24336.7714607052	1842	0.820373122435455	24164.221364003	24164.2996674288	24208.3962380206	1840	NA	23458.7775700107	23459.0395787443	23541.6054587937	1833	0.97317055863706	1	5.05739135083353e-26	8.77338650230853e-174	1	4.70337395627518e-24	8.15924944714693e-172	non_linear_mixed	8.77338650230853e-174	8.15924944714693e-172	23459.0395787443	23541.6054587937	2
Spliceosome - Homo sapiens (human)	150	24	16528.7409165784	16528.7588270261	16544.3511331416	1341	NA	16511.834345015	16511.8971722402	16543.0547781415	1338	0.902801425456799	16498.2029916782	16498.3108568467	16539.8302358468	1336	0.851407906324131	16457.7766521165	16458.1380978997	16535.8277349328	1329	0.908810890641095	4.22348650411289e-05	1.16315969303669e-07	5.36318174948711e-15	0.00392784244882499	1.08173851452412e-05	4.98775902702301e-13	non_linear_mixed	5.36318174948711e-15	4.98775902702301e-13	16458.1380978997	16535.8277349328	2
Axon guidance - Homo sapiens (human)	181	36	25008.7245558536	25008.7364842831	25025.5511677412	2013	NA	24684.0395949934	24684.0814068401	24717.6928187685	2010	0.919554094757507	24675.1134920451	24675.185240924	24719.9844570786	2008	0.936867555033811	24557.6063609431	24557.8463609431	24641.739420381	2001	NA	2.26792046814523e-71	4.15442802092168e-72	4.34780912155625e-94	2.10916603537507e-69	3.86361805945716e-70	4.04346248304731e-92	non_linear_mixed	4.34780912155625e-94	4.04346248304731e-92	24557.8463609431	24641.739420381	2
NOD-like receptor signaling pathway - Homo sapiens (human)	180	24	14957.5980914938	14957.6160019416	14973.2083080571	1341	NA	14792.6418878252	14792.7047150503	14823.8623209517	1338	0.871940318737693	14769.7949887448	14769.9028539134	14811.4222329135	1336	0.93446865493366	14706.5872941691	14706.9487399522	14784.6383769853	1329	NA	7.91102952743275e-37	8.38185994160096e-41	8.13853133049545e-52	7.35725746051246e-35	7.79512974568889e-39	7.56883413736077e-50	non_linear_mixed	8.13853133049545e-52	7.56883413736077e-50	14706.9487399522	14784.6383769853	2
Apelin signaling pathway - Homo sapiens (human)	136	27	18111.5601238181	18111.5760389374	18127.5236894883	1509	NA	18078.6220854642	18078.6778994177	18110.5492168046	1506	0.956166709786945	18075.8621998176	18075.9580082008	18118.4317082715	1504	0.951094749820004	18020.6443214655	18020.9651770805	18100.4621498166	1497	NA	1.78892433897603e-08	1.04633899028201e-08	6.34891447209019e-19	1.66369963524771e-06	9.73095260962272e-07	5.90449045904388e-17	non_linear_mixed	6.34891447209019e-19	5.90449045904388e-17	18020.9651770805	18100.4621498166	2
C-type lectin receptor signaling pathway - Homo sapiens (human)	103	20	12511.1042594746	12511.1257648509	12526.1675113675	1117	NA	12435.6332498445	12435.7087215427	12465.7597536303	1114	0.917586478073218	12430.6781991731	12430.8078121344	12470.8468708874	1112	0.935459972307777	12384.8994172538	12385.3341998625	12460.2156767182	1105	0.950133789275362	1.48413179438067e-17	5.4678511708411e-18	5.15244712060358e-26	1.38024256877402e-15	5.08510158888223e-16	4.79177582216133e-24	non_linear_mixed	5.15244712060358e-26	4.79177582216133e-24	12385.3341998625	12460.2156767182	2
Tuberculosis - Homo sapiens (human)	178	24	17647.5089152625	17647.5268257102	17663.1191318257	1341	NA	17483.4751063566	17483.5379335818	17514.6955394831	1338	0.889988003031879	17481.4881426741	17481.5960078427	17523.1153868428	1336	0.888790982523402	17180.6096649525	17180.9711107356	17258.6607477687	1329	NA	1.25131668930585e-36	3.78547333211287e-36	1.91475784176497e-97	1.16372452105444e-34	3.52049019886497e-34	1.78072479284143e-95	non_linear_mixed	1.91475784176497e-97	1.78072479284143e-95	17180.9711107356	17258.6607477687	2
Pathogenic Escherichia coli infection - Homo sapiens (human)	195	46	30862.9708693742	30862.980200634	30880.5328486359	2573	NA	30597.3678818418	30597.4005793895	30632.4918403651	2570	0.941180250179193	30595.8612837692	30595.91738038	30642.693228467	2568	0.939009041142246	30434.4435249949	30434.6310249949	30522.2534213033	2561	NA	1.38885920710759e-58	8.31586292085101e-58	2.74466529712289e-89	1.29163906261006e-56	7.73375251639144e-56	2.55253872632429e-87	non_linear_mixed	2.74466529712289e-89	2.55253872632429e-87	30434.6310249949	30522.2534213033	2
Hepatitis C - Homo sapiens (human)	156	34	23333.8927526949	23333.9053842738	23350.547889341	1901	NA	23278.8813544174	23278.9256348602	23312.1916277095	1898	0.924597079636671	23288.7165697118	23288.7925591577	23333.1302674346	1896	0.86414276048011	23205.0990353206	23205.3532726087	23288.3747185508	1889	0.933943127580761	3.57387796560039e-13	1.20083316599253e-10	1.53618992078678e-26	3.32370650800836e-11	1.11677484437305e-08	1.42865662633171e-24	non_linear_mixed	1.53618992078678e-26	1.42865662633171e-24	23205.3532726087	23288.3747185508	2
Insulin signaling pathway - Homo sapiens (human)	136	29	20042.2543944816	20042.2692092964	20058.4323370437	1621	NA	19978.9654287971	19979.017376849	20011.3213139214	1618	0.944878861986133	19986.7368113405	19986.8259754272	20029.8779915063	1616	0.877524828262111	19907.3330201398	19907.6315276025	19988.2227329506	1609	NA	6.06040815675726e-15	8.7523214676312e-13	8.71137909120841e-28	5.63617958578426e-13	8.13965896489702e-11	8.10158255482382e-26	non_linear_mixed	8.71137909120841e-28	8.10158255482382e-26	19907.6315276025	19988.2227329506	2
cGMP-PKG signaling pathway - Homo sapiens (human)	166	29	18654.5522440745	18654.5670588894	18670.7301866367	1621	NA	18568.7400599875	18568.7920080394	18601.0959451118	1618	0.925275105028441	18563.8087747714	18563.897938858	18606.9499549371	1616	0.912463790005578	18500.1582757499	18500.4567832126	18581.0479885607	1609	0.929713418738694	8.93887876057275e-20	3.68421581593217e-20	9.11100809137748e-32	8.31315724733266e-18	3.42632070881692e-18	8.47323752498106e-30	non_linear_mixed	9.11100809137748e-32	8.47323752498106e-30	18500.4567832126	18581.0479885607	2
Apoptosis - Homo sapiens (human)	135	27	19455.57057194	19455.5864870594	19471.5341376102	1509	NA	19239.3106651081	19239.3664790616	19271.2377964485	1506	0.827823697765008	19216.0547824906	19216.1505908739	19258.6242909446	1504	0.815188902486491	18825.464749606	18825.785605221	18905.2825779571	1497	0.87022250792174	6.51907619827612e-48	6.98251224142095e-52	2.90605764537891e-132	6.0627408643968e-46	6.49373638452148e-50	2.70263361020239e-130	non_linear_mixed	2.90605764537891e-132	2.70263361020239e-130	18825.785605221	18905.2825779571	2
Cellular senescence - Homo sapiens (human)	155	42	28673.9273473323	28673.9375687973	28691.2164112593	2349	NA	28603.2850027791	28603.3208236746	28637.8631306332	2346	0.899072574661048	28599.1032207808	28599.1646804479	28645.2073912529	2344	0.902431262303868	28471.413791988	28471.61927144	28557.8591116232	2337	NA	1.61086946705437e-16	8.19483404555348e-17	1.05626651781841e-41	1.49810860436057e-14	7.62119566236474e-15	9.82327861571122e-40	non_linear_mixed	1.05626651781841e-41	9.82327861571122e-40	28471.61927144	28557.8591116232	2
Epstein-Barr virus infection - Homo sapiens (human)	200	37	24040.1522758295	24040.1638812453	24057.0610846396	2069	NA	23985.1205709124	23985.1612488785	24018.9381885327	2066	0.935242883014951	24007.9923986025	24008.0621998628	24053.0825554295	2064	0.805328150424584	23826.7371181392	23826.9705811742	23911.2811621899	2057	0.942641693547093	3.53834512030546e-13	5.46750024206861e-08	5.72385542071597e-44	3.29066096188408e-11	5.08477522512381e-06	5.32318554126585e-42	non_linear_mixed	5.72385542071597e-44	5.32318554126585e-42	23826.9705811742	23911.2811621899	2
Colorectal cancer - Homo sapiens (human)	85	20	13104.1147674672	13104.1362728436	13119.1780193601	1117	NA	13051.0634735337	13051.1389452318	13081.1899773194	1114	0.932002780369396	13051.9372169242	13052.0668298854	13092.1058886385	1112	0.913141923117054	13004.8663096938	13005.3010923025	13080.1825691581	1105	NA	9.37357875670752e-13	4.30890121008504e-12	1.38870721868544e-20	8.71742824373799e-11	4.00727812537909e-10	1.29149771337746e-18	non_linear_mixed	1.38870721868544e-20	1.29149771337746e-18	13005.3010923025	13080.1825691581	2
Thyroid hormone signaling pathway - Homo sapiens (human)	120	20	14032.3744209957	14032.3959263721	14047.4376728886	1117	NA	13901.6695869286	13901.7450586267	13931.7960907143	1114	0.909820007147402	13898.6225794317	13898.752192393	13938.791251146	1112	0.880116481673747	13859.7715277612	13860.2063103699	13935.0877872255	1105	NA	1.94042645557793e-29	2.85072045958743e-29	1.63783470261943e-35	1.80459660368748e-27	2.65117002741631e-27	1.52318627343607e-33	non_linear_mixed	1.63783470261943e-35	1.52318627343607e-33	13860.2063103699	13935.0877872255	2
Hepatitis B - Homo sapiens (human)	161	30	19442.0063996193	19442.0207194284	19458.2860468365	1677	NA	19415.2652445994	19415.3154538044	19447.8245390338	1674	0.907017032491604	19410.7042912598	19410.7904672023	19454.116683839	1672	0.917154530254833	19357.8071463215	19358.0956078599	19439.2053824074	1665	NA	3.65207516004014e-07	8.1524061749686e-08	1.35792178382864e-17	3.39642989883733e-05	7.5817377427208e-06	1.26286725896063e-15	non_linear_mixed	1.35792178382864e-17	1.26286725896063e-15	19358.0956078599	19439.2053824074	3
Neurotrophin signaling pathway - Homo sapiens (human)	118	20	12586.2138044583	12586.2353098347	12601.2770563512	1117	NA	12496.2670132335	12496.3424849316	12526.3935170192	1114	0.945760009038616	12492.6976329223	12492.8272458836	12532.8663046366	1112	0.947602234776533	12433.2847993469	12433.7195819555	12508.6010588112	1105	NA	1.15566504471247e-20	9.5852722010594e-21	1.8196249998189e-31	1.0747684915826e-18	8.91430314698524e-19	1.69225124983157e-29	non_linear_mixed	1.8196249998189e-31	1.69225124983157e-29	12433.7195819555	12508.6010588112	2
Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)	192	36	23343.0030282275	23343.0149566569	23359.8296401151	2013	NA	23291.360075691	23291.4018875377	23325.0132994662	2010	0.942309397366867	23286.5251421224	23286.5968910014	23331.396107156	2008	0.918645508127758	23197.398502895	23197.638502895	23281.5315623329	2001	NA	1.87349419267419e-12	5.53085641467835e-13	5.75123793644673e-30	1.742349599187e-10	5.14369646565087e-11	5.34865128089546e-28	non_linear_mixed	5.75123793644673e-30	5.34865128089546e-28	23197.638502895	23281.5315623329	2
Leptin signaling pathway	75	20	14203.3511917979	14203.3726971742	14218.4144436907	1117	NA	14111.9696167633	14112.0450884614	14142.096120549	1114	0.926485116880622	14109.5034300342	14109.6330429954	14149.6721017485	1112	0.947656400807957	14056.3597299314	14056.7945125401	14131.6759893958	1105	0.951861799076893	5.68108246602286e-21	8.15913586994615e-21	2.99269052163376e-30	5.28340669340126e-19	7.58799635904992e-19	2.7832021851194e-28	non_linear_mixed	2.99269052163376e-30	2.7832021851194e-28	14056.7945125401	14131.6759893958	2
Prolactin Signaling Pathway	75	23	17233.9367563919	17233.9554479807	17249.4192941119	1285	NA	17132.9758402329	17133.0414140034	17163.9409156729	1282	0.903340704314498	17114.7794352115	17114.8920231708	17156.0662024648	1280	0.901562473818545	16928.6147446535	16928.9921031441	17006.0274332535	1273	NA	4.94640451653215e-23	3.5924385718338e-26	3.20415965281047e-63	4.6001562003749e-21	3.34096787180543e-24	2.97986847711374e-61	non_linear_mixed	3.20415965281047e-63	2.97986847711374e-61	16928.9921031441	17006.0274332535	2
Glioblastoma signaling pathways	82	24	15732.8606374728	15732.8785479205	15748.470854036	1341	NA	15664.6750724927	15664.7378997179	15695.8955056192	1338	0.926612608448743	15659.7178576408	15659.8257228094	15701.3451018095	1336	0.942655008609544	15596.4623379682	15596.8237837514	15674.5134207845	1329	NA	5.4156321278869e-16	1.84460964746368e-16	4.35715306332594e-28	5.03653787893482e-14	1.71548697214122e-14	4.05215234889312e-26	non_linear_mixed	4.35715306332594e-28	4.05215234889312e-26	15596.8237837514	15674.5134207845	2
B Cell Receptor Signaling Pathway	97	20	11672.1324877578	11672.1539931341	11687.1957396506	1117	NA	11668.3265250453	11668.4019967434	11698.4530288311	1114	0.919697252908354	11664.6640459112	11664.7936588725	11704.8327176256	1112	0.917571968666844	11648.1556052431	11648.5903878518	11723.4718647074	1105	NA	0.0202896198108953	0.00369195699992607	3.15475545218301e-06	1	0.343352000993124	0.00029339225705302	non_linear_mixed	3.15475545218301e-06	0.00029339225705302	11648.5903878518	11723.4718647074	2
Adipogenesis	130	21	13553.3460095922	13553.3664874079	13568.5556319776	1173	NA	13515.5124754586	13515.5843317461	13545.9317202294	1170	0.904585092445349	13512.8643735332	13512.9877668494	13553.4233665608	1168	0.901958536044973	13419.7949542473	13420.2087473508	13495.8430661742	1161	NA	1.63719866948426e-09	1.10437226639199e-09	1.65611178154261e-27	1.52259476262037e-07	1.02706620774455e-07	1.54018395683462e-25	non_linear_mixed	1.65611178154261e-27	1.54018395683462e-25	13420.2087473508	13495.8430661742	5
Oncostatin M Signaling Pathway	64	20	14083.3033488755	14083.3248542518	14098.3666007683	1117	NA	14055.6735669017	14055.7490385998	14085.8000706874	1114	0.937958814238945	14051.7025992359	14051.8322121972	14091.8712709503	1112	0.948455931624557	14011.0555187731	14011.4903013818	14086.3717782374	1105	0.951196040426793	2.37175329200261e-07	7.09429771448438e-08	3.01443000006355e-15	2.20573056156243e-05	6.59769687447047e-06	2.8034199000591e-13	non_linear_mixed	3.01443000006355e-15	2.8034199000591e-13	14011.4903013818	14086.3717782374	2
Brain-derived neurotrophic factor (BDNF) signaling pathway	143	29	20655.9848041072	20655.999618922	20672.1627466694	1621	NA	20636.6162323089	20636.6681803609	20668.9721174333	1618	0.92889246954375	20679.1507352356	20679.2398993223	20722.2919154014	1616	0.772362600946092	20596.2400686002	20596.5385760629	20677.129781411	1609	NA	1.29294017141426e-05	1	7.92938944532716e-13	0.00120243435941526	1	7.37433218415426e-11	non_linear_mixed	7.92938944532716e-13	7.37433218415426e-11	20596.5385760629	20677.129781411	2
Spinal Cord Injury	116	20	13272.138171399	13272.1596767754	13287.2014232919	1117	NA	13213.1957870422	13213.2712587403	13243.3222908279	1114	0.949283494557351	13208.6717272151	13208.8013401764	13248.8403989294	1112	0.925251229937641	13119.0274945261	13119.4622771348	13194.3437539904	1105	NA	5.1604068624559e-14	1.94324421182762e-14	1.67007077478205e-31	4.79917838208399e-12	1.80721711699968e-12	1.55316582054731e-29	non_linear_mixed	1.67007077478205e-31	1.55316582054731e-29	13119.4622771348	13194.3437539904	2
NRF2 pathway	142	27	20674.215015041	20674.2309301603	20690.1785807112	1509	NA	20562.7081861154	20562.7640000689	20594.6353174558	1506	0.946362131775723	20555.3104334103	20555.4062417936	20597.8799418643	1504	0.948018167981561	20312.1461855943	20312.4670412093	20391.9640139454	1497	NA	2.65667095151837e-25	4.06457045237567e-26	3.36161510655453e-75	2.47070398491208e-23	3.78005052070938e-24	3.12630204909571e-73	non_linear_mixed	3.36161510655453e-75	3.12630204909571e-73	20312.4670412093	20391.9640139454	4
Focal Adhesion	197	26	18850.2207057848	18850.2372347104	18866.071050471	1453	NA	18683.7431902745	18683.801161289	18715.4438796471	1450	0.939718155232464	18682.2174328556	18682.3169490961	18724.4850186857	1448	0.933213156719299	18627.9892130655	18628.3225463988	18707.2409364969	1441	0.94292014020057	3.71352303835737e-37	1.4283671198652e-36	8.35122808485886e-46	3.45357642567236e-35	1.32838142147463e-34	7.76664211891874e-44	non_linear_mixed	8.35122808485886e-46	7.76664211891874e-44	18628.3225463988	18707.2409364969	2
TGF-beta Signaling Pathway	131	35	22120.5542107219	22120.5664806606	22137.2963099786	1957	NA	21916.2325416991	21916.2755524518	21949.7167402124	1954	0.938079394588193	21910.9271656532	21911.0009739566	21955.572763671	1952	0.94087607514108	21785.1931306944	21785.4400442747	21868.9036269778	1945	NA	2.48120305863831e-45	1.78590884838006e-45	1.4833482512256e-69	2.30751884453363e-43	1.66089522899346e-43	1.37951387363981e-67	non_linear_mixed	1.4833482512256e-69	1.37951387363981e-67	21785.4400442747	21868.9036269778	2
Angiopoietin Like Protein 8 Regulatory Pathway	130	25	15957.749325384	15957.766517361	15973.4820079308	1397	NA	15824.8733327094	15824.9336342169	15856.338697803	1394	0.886686260333643	15798.6216635964	15798.725186242	15840.5754837212	1392	0.929290907916223	15743.7521171851	15744.0989379944	15822.4155299192	1385	NA	6.60403125714677e-30	1.11999520965591e-34	4.33081092548016e-44	6.1417490691465e-28	1.04159554498e-32	4.02765416069655e-42	non_linear_mixed	4.33081092548016e-44	4.02765416069655e-42	15744.0989379944	15822.4155299192	2
Chemokine signaling pathway	164	21	13088.31004991	13088.3305277257	13103.5196722954	1173	NA	12930.5933013969	12930.6651576843	12961.0125461677	1170	NA	12920.1062985605	12920.2296918766	12960.6652915881	1168	NA	12876.0688444183	12876.4826375217	12952.1169563451	1161	NA	2.89051489140127e-35	1.29429002102885e-36	1.00447326363432e-43	2.68817884900318e-33	1.20368971955683e-34	9.34160135179915e-42	non_linear_mixed	1.00447326363432e-43	9.34160135179915e-42	12876.4826375217	12952.1169563451	2
mRNA Processing	126	20	13525.8522903386	13525.873795715	13540.9155422315	1117	NA	13516.9758616211	13517.0513333192	13547.1023654068	1114	0.895470448427487	13484.4132525878	13484.5428655491	13524.5819243021	1112	0.894478432171721	13434.8666787548	13435.3014613635	13510.1829382191	1105	0.904823317068895	0.00192535269738315	7.03051281611164e-10	6.14943447680217e-19	0.179057800856633	6.53837691898382e-08	5.71897406342602e-17	non_linear_mixed	6.14943447680217e-19	5.71897406342602e-17	13435.3014613635	13510.1829382191	2
Ras signaling	183	25	16244.4802099152	16244.4974018922	16260.212892462	1397	NA	16099.398211925	16099.4585134326	16130.8635770186	1394	0.946768526890448	16090.5540421062	16090.6575647518	16132.507862231	1392	0.94409142769127	16060.0396974531	16060.3865182623	16138.7031101871	1385	NA	1.53940875378109e-32	1.4407865298823e-33	5.88075449334032e-38	1.43165014101642e-30	1.33993147279054e-31	5.46910167880649e-36	non_linear_mixed	5.88075449334032e-38	5.46910167880649e-36	16060.3865182623	16138.7031101871	2
Breast cancer pathway	153	26	17883.6958861734	17883.7124150991	17899.5462308597	1453	NA	17719.5680972523	17719.6260682668	17751.2687866248	1450	0.934185335450547	17718.269627127	17718.3691433675	17760.537212957	1448	0.931973555568928	17633.012153892	17633.3454872253	17712.2638773234	1441	NA	1.19420349085646e-36	5.07035216873897e-36	9.52801646444053e-52	1.1106092464965e-34	4.71542751692724e-34	8.8610553119297e-50	non_linear_mixed	9.52801646444053e-52	8.8610553119297e-50	17633.3454872253	17712.2638773234	2
EGF-EGFR signaling pathway	161	35	22566.0454068048	22566.0576767435	22582.7875060615	1957	NA	22423.7339340521	22423.7769448048	22457.2181325655	1954	0.887905758733626	22415.7885674871	22415.8623757906	22460.4341655049	1952	0.906307413166809	22308.8375167853	22309.0844303655	22392.5480130687	1945	NA	6.0953623612699e-32	8.72604537169689e-33	4.10107494734182e-53	5.668686995981e-30	8.11522219567811e-31	3.81399970102789e-51	non_linear_mixed	4.10107494734182e-53	3.81399970102789e-51	22309.0844303655	22392.5480130687	2
Genes related to primary cilium development (based on CRISPR)	102	21	12617.3549761705	12617.3754539862	12632.5645985558	1173	NA	12510.5779037538	12510.6497600412	12540.9971485246	1170	0.909924837076866	12463.5972215119	12463.7206148281	12504.1562145396	1168	0.90396678732664	11786.4409969007	11786.8547900042	11862.4891088276	1161	NA	2.77090288926276e-24	1.56497929709845e-33	2.74262754166107e-175	2.57693968701437e-22	1.45543074630156e-31	2.55064361374479e-173	non_linear_mixed	2.74262754166107e-175	2.55064361374479e-173	11786.8547900042	11862.4891088276	2
Fragile X Syndrome	118	20	13064.5009777196	13064.5224830959	13079.5642296124	1117	NA	13055.9211272874	13055.9965989855	13086.0476310731	1114	0.875494535773835	13057.7308988089	13057.8605117702	13097.8995705232	1112	0.874906037423521	13028.7084036876	13029.1431862963	13104.0246631519	1105	0.883121105765794	0.00221328505750048	0.00495713539047817	2.4626170646951e-08	0.205835510347544	0.46101359131447	2.29023387016644e-06	non_linear_mixed	2.4626170646951e-08	2.29023387016644e-06	13029.1431862963	13104.0246631519	3
Joubert Syndrome	71	20	13083.635993028	13083.6574984044	13098.6992449209	1117	NA	12972.1976816853	12972.2731533834	13002.324185471	1114	0.935350375943106	12954.5780903413	12954.7077033026	12994.7467620556	1112	0.936485566789993	12747.4403491954	12747.8751318041	12822.7566086597	1105	0.949173429271276	2.7484739184605e-25	2.83731547660402e-28	9.88617990780628e-70	2.55608074416827e-23	2.63870339324174e-26	9.19414731425984e-68	non_linear_mixed	9.88617990780628e-70	9.19414731425984e-68	12747.8751318041	12822.7566086597	3
Gastrin signaling pathway	113	24	16485.133884875	16485.1517953228	16500.7441014383	1341	NA	16483.983742608	16484.0465698331	16515.2041757345	1338	0.890446452889143	16466.0158714146	16466.1237365832	16507.6431155833	1336	0.94547416963501	16430.094240824	16430.4556866071	16508.1453236402	1329	NA	0.0672631178768934	2.19836354271827e-05	6.29057025811477e-12	1	0.00204447809472799	5.85023034004674e-10	non_linear_mixed	6.29057025811477e-12	5.85023034004674e-10	16430.4556866071	16508.1453236402	2
Hepatitis B infection	151	24	15801.0041855303	15801.0220959781	15816.6144020936	1341	NA	15780.678905726	15780.7417329511	15811.8993388525	1338	0.929953769775646	15780.0775953269	15780.1854604955	15821.7048394956	1336	0.927695924482746	15744.7951518608	15745.1565976439	15822.8462346771	1329	NA	8.15287125331121e-06	9.68511114978585e-06	3.76521916851411e-12	0.000758217026557942	0.000900715336930084	3.50165382671812e-10	non_linear_mixed	3.76521916851411e-12	3.50165382671812e-10	15745.1565976439	15822.8462346771	2
Ciliopathies	182	28	16640.2089208515	16640.22426612	16656.2815894542	1565	NA	16513.0977117299	16513.151523389	16545.2430489353	1562	0.909875936673987	16434.1361793941	16434.2285462959	16476.9966290014	1560	0.903864464015828	15718.5093164675	15718.818594818	15798.8726594812	1553	0.943598623345415	1.15489426573541e-28	1.03070619499726e-44	8.76964139892215e-195	1.07405166713393e-26	9.58556761347449e-43	8.1557665009976e-193	non_linear_mixed	8.76964139892215e-195	8.1557665009976e-193	15718.818594818	15798.8726594812	3
EGFR Tyrosine Kinase Inhibitor Resistance	83	21	14384.1035666754	14384.1240444911	14399.3131890607	1173	NA	14366.5554779888	14366.6273342762	14396.9747227595	1170	0.953091940497607	14370.4072692284	14370.5306625446	14410.9662622561	1168	0.911143898293226	14323.1037414744	14323.5175345779	14399.1518534013	1161	0.957848902774931	3.10388370970229e-05	0.00024831433746731	4.5517955435701e-13	0.00288661185002313	0.0230932333844598	4.23316985552019e-11	non_linear_mixed	4.5517955435701e-13	4.23316985552019e-11	14323.5175345779	14399.1518534013	3
Insulin Signaling	159	34	21944.8652334963	21944.8778650752	21961.5203701423	1901	NA	21826.2432851487	21826.2875655915	21859.5535584408	1898	0.881035047939566	21804.4467078851	21804.522697331	21848.8604056079	1896	0.938791063635474	21769.432258845	21769.6864961331	21852.7079420753	1889	0.940681179127776	7.79594870113181e-27	1.08751570444494e-30	4.27009972537697e-36	7.25023229205258e-25	1.01138960513379e-28	3.97119274460059e-34	non_linear_mixed	4.27009972537697e-36	3.97119274460059e-34	21769.6864961331	21852.7079420753	2
Regulation of Actin Cytoskeleton	150	23	16320.2655813873	16320.2842729761	16335.7481191073	1285	NA	16230.2911617437	16230.3567355142	16261.2562371837	1282	0.918131950370463	16228.8046543239	16228.9172422832	16270.0914215772	1280	0.912858548872269	16195.8170618001	16196.1944202907	16273.2297504001	1273	0.929869339379942	1.13997098663975e-20	2.60065925482112e-20	1.17006424446257e-25	1.06017301757497e-18	2.41861310698364e-18	1.08815974735019e-23	non_linear_mixed	1.17006424446257e-25	1.08815974735019e-23	16196.1944202907	16273.2297504001	2
Calcium Regulation in the Cardiac Cell	150	24	16502.7002930199	16502.7182034677	16518.3105095832	1341	NA	16486.4680244763	16486.5308517014	16517.6884576028	1338	0.913753260695111	16483.7486907876	16483.8565559562	16525.3759349563	1336	0.916214685855027	16437.7056625884	16438.0671083715	16515.7567454046	1329	0.930370091247491	5.83601370429156e-05	2.37000464177488e-05	7.72677984469227e-14	0.00542749274499115	0.00220410431685064	7.18590525556381e-12	non_linear_mixed	7.72677984469227e-14	7.18590525556381e-12	16438.0671083715	16515.7567454046	2
Senescence and Autophagy in Cancer	105	24	17134.1837853761	17134.2016958239	17149.7940019394	1341	NA	17058.9337527327	17058.9965799579	17090.1541858592	1338	NA	17058.348332477	17058.4561976456	17099.9755766457	1336	NA	17033.1349200162	17033.4963657993	17111.1860028324	1329	0.915289797130085	1.65531718855427e-17	5.02893026400593e-17	6.06200848343859e-21	1.53944498535547e-15	4.67690514552551e-15	5.63766788959788e-19	non_linear_mixed	6.06200848343859e-21	5.63766788959788e-19	17033.4963657993	17111.1860028324	2
Transcriptional regulation by RUNX1	194	26	18794.0226903984	18794.039219324	18809.8730350847	1453	NA	18653.0850993613	18653.1430703758	18684.7857887339	1450	0.928042856024066	18653.9447870118	18654.0443032523	18696.2123728419	1448	0.930975713916396	18591.3719773028	18591.7053106361	18670.6237007341	1441	0.936781096783374	1.20597991722208e-31	1.28511910143499e-30	9.8921943601779e-42	1.12156132301653e-29	1.19516076433454e-28	9.19974075496545e-40	non_linear_mixed	9.8921943601779e-42	9.19974075496545e-40	18591.7053106361	18670.6237007341	2
Prolactin	69	23	17091.4754947128	17091.4941863016	17106.9580324328	1285	NA	16926.7305124893	16926.7960862598	16957.6955879293	1282	0.858969351774785	16914.8546704481	16914.9672584075	16956.1414377014	1280	0.856383998998319	16681.642872401	16682.0202308915	16759.0555610009	1273	NA	8.7868616933908e-37	2.0607457720686e-38	2.55154228532051e-85	8.17178137485344e-35	1.9164935680238e-36	2.37293432534807e-83	non_linear_mixed	2.55154228532051e-85	2.37293432534807e-83	16682.0202308915	16759.0555610009	2
Signaling by NTRK1 (TRKA)	113	20	13171.5692446766	13171.590750053	13186.6324965695	1117	NA	13110.2609285755	13110.3364002736	13140.3874323612	1114	0.920516597430758	13106.7340530475	13106.8636660088	13146.9027247618	1112	0.92133500291916	12983.1469817614	12983.5817643701	13058.4632412257	1105	NA	1.60869459139393e-14	1.00696204360788e-14	8.82053050627567e-39	1.49608596999636e-12	9.3647470055533e-13	8.20309337083637e-37	non_linear_mixed	8.82053050627567e-39	8.20309337083637e-37	12983.5817643701	13058.4632412257	2
Cellular Senescence	185	29	20670.2182212232	20670.2330360381	20686.3961637854	1621	NA	20582.300667177	20582.352615229	20614.6565523013	1618	0.941651336960572	20582.9686993198	20583.0578634065	20626.1098794856	1616	0.927171422713333	20528.1995576924	20528.4980651551	20609.0892705032	1609	NA	3.15448330456151e-20	2.00683550031509e-19	3.10879169067694e-29	2.93366947324221e-18	1.86635701529304e-17	2.89117627232955e-27	non_linear_mixed	3.10879169067694e-29	2.89117627232955e-27	20528.4980651551	20609.0892705032	2
Glycosaminoglycan metabolism	118	23	15252.1633261095	15252.1820176983	15267.6458638295	1285	NA	15163.7667812752	15163.8323550457	15194.7318567152	1282	0.923386114557086	15164.6008150869	15164.7134030462	15205.8875823402	1280	0.913985040935966	15083.8949335552	15084.2722920458	15161.3076221552	1273	NA	2.48884940079587e-20	1.7242402026162e-19	1.28114500555137e-34	2.31462994274016e-18	1.60354338843307e-17	1.19146485516278e-32	non_linear_mixed	1.28114500555137e-34	1.19146485516278e-32	15084.2722920458	15161.3076221552	4
Signaling by NTRKs	126	23	15078.9566121035	15078.9753036923	15094.4391498235	1285	NA	15017.3277252679	15017.3932990384	15048.2928007079	1282	0.923150138459453	15013.1411231051	15013.2537110644	15054.4278903584	1280	0.919879259052047	14886.1161594817	14886.4935179722	14963.5288480816	1273	NA	1.37361493012045e-14	6.28637539436966e-15	1.07243290084e-39	1.27746188501202e-12	5.84632911676379e-13	9.97362597781202e-38	non_linear_mixed	1.07243290084e-39	9.97362597781202e-38	14886.4935179722	14963.5288480816	2
BCR	128	27	18662.7711162673	18662.7870313867	18678.7346819376	1509	NA	18648.8274369773	18648.8832509308	18680.7545683177	1506	0.953768779827016	18644.2769109777	18644.3727193609	18686.8464194316	1504	0.944956169583871	18593.0242419262	18593.3450975412	18672.8420702773	1497	NA	0.000174365928746659	2.91335153822735e-05	9.25529147383317e-15	0.0162160313734393	0.00270941693055144	8.60742107066485e-13	non_linear_mixed	9.25529147383317e-15	8.60742107066485e-13	18593.3450975412	18672.8420702773	2
TGF_beta_Receptor	172	40	27253.3683270883	27253.3790605409	27270.5110205229	2237	NA	27048.1237693292	27048.1613868841	27082.4091561983	2234	0.938807704114344	27027.1056177228	27027.1701627699	27072.8194668816	2232	0.939407496582341	26837.1786637499	26837.3944910881	26922.8921309227	2225	NA	1.56747789333408e-45	4.85980547242469e-49	1.14243227524557e-86	1.45775444080069e-43	4.51961908935496e-47	1.06246201597838e-84	non_linear_mixed	1.14243227524557e-86	1.06246201597838e-84	26837.3944910881	26922.8921309227	2
Signaling by NOTCH	188	31	20677.3088345456	20677.3226913585	20693.6868512312	1733	NA	20650.2802076058	20650.3287906017	20683.0362409771	1730	0.881471687305422	20645.3913834202	20645.4747650068	20689.066094582	1728	0.884494252777515	20590.2245129859	20590.5035827533	20672.1145964142	1721	NA	3.17620215579871e-07	6.12136805924102e-08	3.6511777314143e-18	2.9538680048928e-05	5.69287229509415e-06	3.3955952902153e-16	non_linear_mixed	3.6511777314143e-18	3.3955952902153e-16	20590.5035827533	20672.1145964142	2
SUMO E3 ligases SUMOylate target proteins	176	40	28489.4456091978	28489.4563426504	28506.5883026323	2237	NA	28267.7667334644	28267.8043510192	28302.0521203335	2234	0.927596109308894	28286.2404027746	28286.3049478217	28331.9542519334	2232	0.847466996270324	28142.7557842203	28142.9716115584	28228.4692513931	2225	NA	4.39194424776468e-49	4.23828014079529e-44	6.00150430528271e-72	4.08450815042116e-47	3.94160053093962e-42	5.58139900391292e-70	non_linear_mixed	6.00150430528271e-72	5.58139900391292e-70	28142.9716115584	28228.4692513931	2
mRNA Splicing	184	28	19203.2310735042	19203.2464187727	19219.3037421069	1565	NA	19189.4747714536	19189.5285831128	19221.620108659	1562	0.875457698248635	19161.6287737445	19161.7211406464	19204.4892233518	1560	0.912930909420893	19098.7142612306	19099.0235395811	19179.0776042442	1553	NA	0.000190669350655296	6.50909990292201e-10	1.22456186813464e-21	0.0177322496109426	6.05346290971747e-08	1.13884253736521e-19	non_linear_mixed	1.22456186813464e-21	1.13884253736521e-19	19099.0235395811	19179.0776042442	2
Interferon gamma signaling	95	20	11525.5959462804	11525.6174516568	11540.6591981733	1117	NA	11522.7080594299	11522.783531128	11552.8345632156	1114	0.932434671898009	11520.6731960706	11520.8028090319	11560.841867785	1112	0.926923026624297	11497.0282041748	11497.4629867835	11572.3444636391	1105	NA	0.0308192334255571	0.0106975646096658	4.9165625616916e-07	1	0.994873508698921	4.57240318237318e-05	non_linear_mixed	4.9165625616916e-07	4.57240318237318e-05	11497.4629867835	11572.3444636391	2
Cell-Cell communication	123	20	13648.2055366617	13648.227042038	13663.2687885546	1117	NA	13594.3989556918	13594.4744273899	13624.5254594776	1114	0.917572084454013	13593.7408606188	13593.8704735801	13633.9095323331	1112	0.898315489251099	13564.8960074329	13565.3307900416	13640.2122668973	1105	NA	6.46499530409613e-13	1.44718694684691e-12	2.03468596464155e-17	6.0124456328094e-11	1.34588386056763e-10	1.89225794711664e-15	non_linear_mixed	2.03468596464155e-17	1.89225794711664e-15	13565.3307900416	13640.2122668973	2
Transport to the Golgi and subsequent modification	166	27	17443.234385402	17443.2503005213	17459.1979510722	1509	NA	17321.3080054767	17321.3638194302	17353.2351368171	1506	0.909462778741161	17315.5212147553	17315.6170231385	17358.0907232092	1504	0.914974531318776	17256.970143841	17257.290999456	17336.7879721921	1497	NA	1.51326717255797e-27	5.47864294838523e-28	2.46686761355686e-38	1.40733847047891e-25	5.09513794199826e-26	2.29418688060788e-36	non_linear_mixed	2.46686761355686e-38	2.29418688060788e-36	17257.290999456	17336.7879721921	2
HIV Infection	191	29	19462.6378159487	19462.6526307635	19478.8157585109	1621	NA	19444.6501080394	19444.7020560913	19477.0059931637	1618	0.929408149321728	19421.5761835237	19421.6653476104	19464.7173636895	1616	0.933814312766939	19347.3065087594	19347.6050162221	19428.1962215702	1609	NA	2.51280205162887e-05	8.40089765578528e-10	8.17233017190453e-24	0.00233690590801485	7.81283481988031e-08	7.60026705987121e-22	non_linear_mixed	8.17233017190453e-24	7.60026705987121e-22	19347.6050162221	19428.1962215702	2
Interferon Signaling	161	35	22629.371849808	22629.3841197466	22646.1139490646	1957	NA	22605.5860761927	22605.6290869454	22639.0702747061	1954	0.909658530544203	22606.6994975509	22606.7733058544	22651.3450955687	1952	0.919346058603281	22570.357664905	22570.6045784853	22654.0681611884	1945	NA	1.53092690742302e-06	4.37134068098237e-06	1.09481327013768e-12	0.000142376202390341	0.000406534683331361	1.01817634122804e-10	non_linear_mixed	1.09481327013768e-12	1.01817634122804e-10	22570.6045784853	22654.0681611884	2
AndrogenReceptor	141	25	18070.6185410348	18070.6357330119	18086.3512235816	1397	NA	17910.9438839864	17911.004185494	17942.4092490801	1394	0.87337408429392	17902.1673839676	17902.2709066132	17944.1212040924	1392	0.876352665585813	17829.5326020785	17829.8794228877	17908.1960148125	1385	NA	1.09237428146148e-35	1.14604545847981e-36	9.69372739959088e-50	1.01590808175917e-33	1.06582227638622e-34	9.01516648161952e-48	non_linear_mixed	9.69372739959088e-50	9.01516648161952e-48	17829.8794228877	17908.1960148125	2
ErbB1 downstream signaling	105	21	14721.1704467632	14721.1909245789	14736.3800691486	1173	NA	14720.9130953915	14720.984951679	14751.3323401623	1170	0.936202038439764	14717.4596675179	14717.5830608341	14758.0186605455	1168	0.943650648374472	14690.284971019	14690.6987641224	14766.3330829459	1161	NA	0.0997391873368303	0.0175548083377547	1.89751305249734e-07	1	1	1.76468713882252e-05	non_linear_mixed	1.89751305249734e-07	1.76468713882252e-05	14690.6987641224	14766.3330829459	2
PDGFR-beta signaling pathway	126	31	20280.2304284992	20280.2442853121	20296.6084451848	1733	NA	20245.5067198771	20245.5553028731	20278.2627532484	1730	0.922474126104237	20246.5482541509	20246.6316357375	20290.2229653127	1728	0.88856318111477	20196.965748022	20197.2448177894	20278.8558314503	1721	NA	7.48375427571223e-09	2.68709563027577e-08	2.07656873751233e-17	6.95989147641238e-07	2.49899893615646e-06	1.93120892588647e-15	non_linear_mixed	2.07656873751233e-17	1.93120892588647e-15	20197.2448177894	20278.8558314503	2
Signaling events mediated by VEGFR1 and VEGFR2	67	20	13529.8316935845	13529.8531989608	13544.8949454774	1117	NA	13468.1302978911	13468.2057695892	13498.2568016768	1114	0.938277592612673	13466.4676552186	13466.5972681799	13506.6363269329	1112	0.939981544986406	13415.9852743806	13416.4200569893	13491.3015338449	1105	NA	1.32539706604297e-14	2.04117500934047e-14	1.6288063773327e-23	1.23261927141996e-12	1.89829275868664e-12	1.51478993091941e-21	non_linear_mixed	1.6288063773327e-23	1.51478993091941e-21	13416.4200569893	13491.3015338449	2
Direct p53 effectors	141	30	22277.7221892437	22277.7365090528	22294.0018364609	1677	NA	22089.6771174452	22089.7273266502	22122.2364118796	1674	0.899723859428343	22090.5224266206	22090.6086025631	22133.9348191998	1672	0.896719604666514	21705.9875462827	21706.2760078211	21787.3857823686	1665	NA	8.16132120985691e-42	1.12819462028507e-40	8.63228556540343e-120	7.59002872516692e-40	1.04922099686511e-38	8.02802557582519e-118	non_linear_mixed	8.63228556540343e-120	8.02802557582519e-118	21706.2760078211	21787.3857823686	2
Programmed Cell Death	141	28	19264.148658799	19264.1640040675	19280.2213274017	1565	NA	19211.3204153147	19211.3742269739	19243.4657525202	1562	0.927942702955859	19211.6011256988	19211.6934926006	19254.4615753061	1560	0.909499507374035	19172.5820753338	19172.8913536843	19252.9454183475	1553	NA	1.0460321055795e-12	3.61217541041743e-12	4.71436091742856e-19	9.72809858188939e-11	3.35932313168821e-10	4.38435565320856e-17	non_linear_mixed	4.71436091742856e-19	4.38435565320856e-17	19172.8913536843	19252.9454183475	2
RHOA GTPase cycle	148	28	16960.7293098147	16960.7446550833	16976.8019784175	1565	NA	16780.6363072131	16780.6901188723	16812.7816444186	1562	0.909459758578228	16774.6792267135	16774.7715936154	16817.5396763208	1560	0.857935241543089	16641.8646967469	16642.1739750974	16722.2280397605	1553	0.918515486920137	4.26126194252449e-40	1.98729925382248e-40	4.48698844053651e-66	3.96297360654778e-38	1.84818830605491e-38	4.17289924969896e-64	non_linear_mixed	4.48698844053651e-66	4.17289924969896e-64	16642.1739750974	16722.2280397605	2
Metabolism of vitamins and cofactors	179	27	17476.5655216493	17476.5814367687	17492.5290873195	1509	NA	17389.8235877946	17389.8794017481	17421.750719135	1506	0.87781372908786	17387.9078718845	17388.0036802677	17430.4773803384	1504	0.867244200691178	17357.5162439248	17357.8370995397	17437.3340722758	1497	NA	5.64329062753945e-20	1.01371627545468e-19	1.44990313753916e-24	5.24826028361169e-18	9.42756136172851e-18	1.34840991791142e-22	non_linear_mixed	1.44990313753916e-24	1.34840991791142e-22	17357.8370995397	17437.3340722758	2
Toll-like Receptor Cascades	129	22	14445.6669846591	14445.6865286331	14461.0161670914	1229	NA	14385.0325979244	14385.101169353	14415.730962789	1226	0.935088515364508	14379.9765003989	14380.0942436532	14420.9076535517	1224	0.935798351700668	14274.7189466014	14275.1136834435	14351.4648587628	1217	NA	2.24229553465175e-14	6.67571448728795e-15	3.59298497239404e-35	2.08533484722613e-12	6.20841447317779e-13	3.34147602432646e-33	non_linear_mixed	3.59298497239404e-35	3.34147602432646e-33	14275.1136834435	14351.4648587628	2
RAC1 GTPase cycle	184	36	23397.8508222005	23397.8627506299	23414.6774340881	2013	NA	23236.514186273	23236.5559981197	23270.1674100481	2010	0.941979344285023	23227.7850940181	23227.8568428971	23272.6560590517	2008	0.946598302476908	23139.1040046963	23139.3440046963	23223.2370641342	2001	NA	4.78210642852688e-36	5.18089304995094e-37	1.95204181757615e-53	4.44735897853e-34	4.81823053645437e-35	1.81539889034582e-51	non_linear_mixed	1.95204181757615e-53	1.81539889034582e-51	23139.3440046963	23223.2370641342	2
SUMOylation	181	43	30470.3047255619	30470.3147089229	30487.6643809811	2405	NA	30240.1795146789	30240.2145001016	30274.8988255175	2402	0.886973761393689	30228.5695359742	30228.6295609847	30274.8619504257	2400	0.927856595816313	30098.5240684182	30098.7247373145	30185.3223455146	2393	NA	6.55240736557529e-51	2.33237341513498e-52	2.96019451960984e-77	6.09373884998502e-49	2.16910727607553e-50	2.75298090323715e-75	non_linear_mixed	2.96019451960984e-77	2.75298090323715e-75	30098.7247373145	30185.3223455146	2
CDC42 GTPase cycle	159	29	19073.5396619675	19073.5544767823	19089.7176045296	1621	NA	18879.3363156511	18879.388263703	18911.6922007754	1618	0.94518215447815	18869.7057232656	18869.7948873523	18912.8469034314	1616	NA	18820.9221120964	18821.2206195591	18901.8118249072	1609	NA	3.81263024684795e-43	3.10858352829484e-44	3.75146030136007e-52	3.54574612956859e-41	2.8909826813142e-42	3.48885808026487e-50	non_linear_mixed	3.75146030136007e-52	3.48885808026487e-50	18821.2206195591	18901.8118249072	4
mRNA Splicing - Major Pathway	176	27	18564.3932409932	18564.4091561126	18580.3568066635	1509	NA	18549.117577104	18549.1733910575	18581.0447084445	1506	0.914107754732276	18528.4406292744	18528.5364376577	18571.0101377283	1504	0.867802869122535	18464.3154207126	18464.6362763276	18544.1332490637	1497	NA	9.22712310649814e-05	9.2861112638271e-09	9.48054335557252e-21	0.00858122448904327	8.6360834753592e-07	8.81690532068244e-19	non_linear_mixed	9.48054335557252e-21	8.81690532068244e-19	18464.6362763276	18544.1332490637	2
Apoptosis	126	27	18630.651973078	18630.6678881974	18646.6155387482	1509	NA	18579.9082021838	18579.9640161373	18611.8353335242	1506	0.926501257564013	18579.1922415128	18579.288049896	18621.7617499667	1504	0.922621651199261	18543.1982238281	18543.519079443	18623.0160521792	1497	0.929738217359034	2.91478622888769e-12	6.06617775260408e-12	3.08521726101132e-18	2.71075119286555e-10	5.64154530992179e-10	2.86925205274053e-16	non_linear_mixed	3.08521726101132e-18	2.86925205274053e-16	18543.519079443	18623.0160521792	2
Death Receptor Signalling	133	20	14064.017723293	14064.0392286693	14079.0809751858	1117	NA	14043.1958333377	14043.2713050358	14073.3223371234	1114	0.785778749939048	14045.9671780264	14046.0967909877	14086.1358497407	1112	0.811516183998013	14016.9321051722	14017.3668877809	14092.2483646365	1105	NA	6.41587158404139e-06	3.55799391225255e-05	2.005443630227e-10	0.000596676057315849	0.00330893433839488	1.86506257611111e-08	non_linear_mixed	2.005443630227e-10	1.86506257611111e-08	14017.3668877809	14092.2483646365	2