Geneset	Geneset_Size	Genes	null_AIC	null_AICc	null_BIC	null_df	NA.	linear_AIC	linear_AICc	linear_BIC	linear_df	linear_ICC	non_linear_fixed_AIC	non_linear_fixed_AICc	non_linear_fixed_BIC	non_linear_fixed_df	non_linear_fixed_ICC	non_linear_mixed_AIC	non_linear_mixed_AICc	non_linear_mixed_BIC	non_linear_mixed_df	non_linear_mixed_ICC	p_value_linear	p_value_non_linear_fixed	p_value_non_linear_mixed	adjusted_linear_p_value	adjusted_non_linear_fixed_p_value	adjusted_non_linear_mixed_p_value	best_model	best_model_pvalue	best_model_adj_pvalue	best_model_aicc	best_model_bic	OptimalClusters
Focal adhesion - Homo sapiens (human)	200	42	29765.2891413635	29765.2986803142	29782.785183905	2517	NA	29149.2663619758	29149.2997881597	29184.2584470589	2514	0.931960176660323	29136.0863418667	29136.143689537	29182.7424553107	2512	0.919379570294703	29092.1934754006	29092.7566522959	29243.8258440938	2494	NA	1.69437437327234e-134	6.82635995640799e-136	4.19869052173701e-137	2.84654894709753e-132	1.14682847267654e-133	7.05380007651818e-135	non_linear_mixed	4.19869052173701e-137	7.05380007651818e-135	29092.7566522959	29243.8258440938	2
Bacterial invasion of epithelial cells - Homo sapiens (human)	76	20	13114.2092928902	13114.2293597799	13129.4795233976	1197	NA	12995.1745287065	12995.2449394358	13025.7149897212	1194	0.946196712329785	12993.3853645761	12993.5062713771	13034.1059792623	1192	0.941210063910971	13013.6978819363	13014.8948128826	13146.0398796664	1174	NA	6.35234439876138e-27	1.59116400796921e-26	5.71259118389236e-20	1.06719385899191e-24	2.67315553338828e-24	9.59715318893916e-18	non_linear_fixed	1.59116400796921e-26	2.67315553338828e-24	12993.5062713771	13034.1059792623	2
Relaxin signaling pathway - Homo sapiens (human)	128	28	18836.4685231993	18836.4828430083	18852.7481704164	1677	NA	18406.8667070404	18406.9169162455	18439.4260014748	1674	0.946060437932437	18400.3815118447	18400.4676877873	18443.7939044239	1672	0.935830199444264	18394.7401232252	18395.5894880165	18535.8303991076	1654	NA	4.29285241597509e-94	3.43006096679534e-94	1.25800698500525e-88	7.21199205883815e-92	5.76250242421617e-92	2.11345173480883e-86	non_linear_mixed	1.25800698500525e-88	2.11345173480883e-86	18395.5894880165	18535.8303991076	2
Oxytocin signaling pathway - Homo sapiens (human)	153	25	17014.9641462413	17014.9801890221	17030.9038074026	1497	NA	16702.6782839259	16702.7345464845	16734.5576062484	1494	0.956210820641416	16700.7027792002	16700.7993586771	16743.2085422969	1492	0.950289458021521	16707.9849153144	16708.9380721372	16846.1286453787	1474	NA	1.09599861782173e-68	6.06334376320229e-68	7.81688953107384e-61	1.84127767794051e-66	1.01864175221798e-65	1.31323744122041e-58	non_linear_fixed	6.06334376320229e-68	1.01864175221798e-65	16700.7993586771	16743.2085422969	5
Fc gamma R-mediated phagocytosis - Homo sapiens (human)	95	30	20745.1769606912	20745.1903237202	20761.6635865229	1797	NA	20298.2102760948	20298.2571249514	20331.1835277581	1794	0.939746667675375	20296.2889264876	20296.3693284977	20340.2532620387	1792	0.929241072078788	20299.7855378364	20300.5774160089	20442.6696283773	1774	0.938004355876066	7.42100991679994e-98	5.94216196943151e-97	2.1789306795202e-89	1.24672966602239e-95	9.98283210864494e-95	3.66060354159394e-87	non_linear_fixed	5.94216196943151e-97	9.98283210864494e-95	20296.3693284977	20340.2532620387	2
Yersinia infection - Homo sapiens (human)	135	36	24579.8263877862	24579.8375195116	24596.8599782882	2157	NA	24150.6485171679	24150.6875324953	24184.7156981719	2154	0.942177980072198	24147.689719412	24147.7566650187	24193.1126274174	2152	0.933557776907989	24150.1099250365	24150.7681528846	24297.7343760541	2134	0.942622339273501	5.30388486156183e-94	2.43971664396145e-93	3.93384979767427e-86	8.91052656742387e-92	4.09872396185524e-91	6.60886766009278e-84	non_linear_fixed	2.43971664396145e-93	4.09872396185524e-91	24147.7566650187	24193.1126274174	2
Choline metabolism in cancer - Homo sapiens (human)	97	25	16778.2777025019	16778.2937452826	16794.2173636631	1497	NA	16376.9973410976	16377.0536036563	16408.8766634202	1494	0.930505133847802	16375.3268170794	16375.4233965563	16417.8325801761	1492	0.914299615407656	16383.4212877717	16384.3744445946	16521.5650178361	1474	NA	5.86330453762303e-88	4.79371499017857e-87	6.59354812271607e-79	9.8503516232067e-86	8.0534411835e-85	1.1077160846163e-76	non_linear_fixed	4.79371499017857e-87	8.0534411835e-85	16375.4233965563	16417.8325801761	2
Glutamatergic synapse - Homo sapiens (human)	113	20	16387.6987740179	16387.7188409076	16402.9690045253	1197	NA	15816.2138866146	15816.2842973438	15846.7543476292	1194	NA	15808.2449358038	15808.3658426048	15848.96555049	1192	NA	15720.3208567388	15721.5177876851	15852.662854469	1174	NA	7.65967747610421e-125	3.8408496944829e-125	6.73608754916273e-136	1.28682581598551e-122	6.45262748673128e-123	1.13166270825934e-133	non_linear_mixed	6.73608754916273e-136	1.13166270825934e-133	15721.5177876851	15852.662854469	2
Insulin resistance - Homo sapiens (human)	107	26	17783.2974578322	17783.3128819968	17799.354781133	1557	NA	17563.9938519492	17564.0479408095	17596.1084985507	1554	0.936821180169031	17560.0395116329	17560.1323549598	17602.8590404348	1552	0.929741027922819	17550.966785429	17551.882636701	17690.1302540353	1534	NA	1.43279040148086e-48	2.14203986310888e-48	1.06319134710892e-45	2.40708787448785e-46	3.59862697002291e-46	1.78616146314299e-43	non_linear_mixed	1.06319134710892e-45	1.78616146314299e-43	17551.882636701	17690.1302540353	2
Growth hormone synthesis, secretion and action - Homo sapiens (human)	118	29	19387.5335570461	19387.5473819309	19403.9184782227	1737	NA	18946.5634382449	18946.6119091046	18979.3332805981	1734	0.93074013110894	18944.8261590513	18944.9093479595	18988.519282189	1732	0.916494042342445	18944.8559215863	18945.6755362973	19086.8585717837	1714	NA	1.47815379326624e-96	1.28014024217181e-95	7.98707870671654e-89	2.48329837268729e-94	2.15063560684864e-93	1.34182922272838e-86	non_linear_fixed	1.28014024217181e-95	2.15063560684864e-93	18944.9093479595	18988.519282189	3
JAK-STAT signaling pathway - Homo sapiens (human)	161	21	13704.8385316488	13704.8576399291	13720.2551326487	1257	NA	13546.993446119	13547.0604852251	13577.8266481187	1254	0.898049571209027	13545.7844045489	13545.8995124625	13586.8953405484	1252	0.883865688191346	13502.7369285755	13503.8756147069	13636.3474705741	1234	0.902418298125419	2.71191014414497e-35	1.1611920390571e-34	1.17693775530515e-39	4.55600904216355e-33	1.95080262561594e-32	1.97725542891265e-37	non_linear_mixed	1.17693775530515e-39	1.97725542891265e-37	13503.8756147069	13636.3474705741	4
Tight junction - Homo sapiens (human)	168	38	26864.4586021113	26864.4691469268	26881.6543942772	2277	NA	26347.7068635536	26347.7438191189	26382.0984478853	2274	0.928466998291526	26338.2264239339	26338.2898321241	26384.0818697095	2272	0.916763120915494	26293.568631922	26294.1918010298	26442.5988306926	2254	NA	5.59523702066369e-113	1.20209153723492e-113	1.31787952291349e-115	9.39999819471501e-111	2.01951378255467e-111	2.21403759849466e-113	non_linear_mixed	1.31787952291349e-115	2.21403759849466e-113	26294.1918010298	26442.5988306926	5
Chemokine signaling pathway - Homo sapiens (human)	191	29	19568.9334062272	19568.947231112	19585.3183274039	1737	NA	19114.5626109798	19114.6110818396	19147.3324533331	1734	0.941296542469394	19107.7847582441	19107.8679471522	19151.4778813818	1732	0.929724086626006	19099.299964167	19100.119578878	19241.3026143644	1714	0.943723216508597	1.84580681392761e-99	1.34489732609915e-99	1.96265890511049e-94	3.10095544739838e-97	2.25942750784656e-97	3.29726696058562e-92	non_linear_mixed	1.96265890511049e-94	3.29726696058562e-92	19100.119578878	19241.3026143644	2
Th17 cell differentiation - Homo sapiens (human)	106	20	14182.9646502067	14182.9847170964	14198.2348807141	1197	NA	13932.6097073314	13932.6801180606	13963.150168346	1194	0.944809671080172	13932.6894078699	13932.8103146709	13973.4100225561	1192	0.935595324329466	13942.9437618088	13944.1406927551	14075.285759539	1174	NA	2.76233706373946e-55	3.42699473451881e-54	3.02030570548451e-47	4.64072626708229e-53	5.75735115399161e-52	5.07411358521398e-45	linear	2.76233706373946e-55	4.64072626708229e-53	13932.6801180606	13963.150168346	2
GnRH signaling pathway - Homo sapiens (human)	92	27	17909.3863498149	17909.4012013001	17925.5568940996	1617	NA	17444.3624534403	17444.4145303157	17476.7035420096	1614	0.938381108990281	17437.7363096663	17437.8256951411	17480.8577610921	1612	0.925302303047095	17440.6756204889	17441.5569764212	17580.8203376228	1594	0.939112825497659	9.07488469406582e-102	7.28854949937605e-102	3.05544630814767e-94	1.52458062860306e-99	1.22447631589518e-99	5.13314979768808e-92	non_linear_fixed	7.28854949937605e-102	1.22447631589518e-99	17437.8256951411	17480.8577610921	2
Gastric cancer - Homo sapiens (human)	148	28	18708.2647290691	18708.2790488781	18724.5443762863	1677	NA	18220.613122984	18220.663332189	18253.1724174184	1674	0.92554741007773	18217.7816875828	18217.8678635254	18261.194080162	1672	0.906083329009997	18206.1042745843	18206.9536393756	18347.1945504666	1654	0.932904649724213	1.13355654096579e-106	6.28046638308889e-106	3.21780313798872e-101	1.90437498882253e-104	1.05511835235893e-103	5.40590927182105e-99	non_linear_mixed	3.21780313798872e-101	5.40590927182105e-99	18206.9536393756	18347.1945504666	2
Ubiquitin mediated proteolysis - Homo sapiens (human)	139	32	23209.5661477857	23209.5786738817	23226.2463891807	1917	NA	23169.3441372582	23169.3880473471	23202.7046200483	1914	0.959591513500354	23162.3559417098	23162.431294928	23206.83658543	1912	0.958478716186602	23088.1529586003	23088.8946384735	23232.7150506909	1894	NA	5.08733978269743e-10	4.57676967403943e-11	6.56936242735585e-24	8.54673083493168e-08	7.68897305238624e-09	1.10365288779578e-21	non_linear_mixed	6.56936242735585e-24	1.10365288779578e-21	23088.8946384735	23232.7150506909	3
Renal cell carcinoma - Homo sapiens (human)	68	22	15501.5775141035	15501.5957511856	15517.1336751503	1317	NA	15084.1445817566	15084.2085573849	15115.2569038501	1314	0.945104723751139	15078.8367797382	15078.9466195551	15120.3198758628	1312	0.933774405301849	15069.9245506764	15071.0103975442	15204.7446130815	1294	0.947405492286157	1.85806726756129e-91	2.59245505275778e-91	1.55867843566608e-86	3.12155300950296e-89	4.35532448863307e-89	2.61857977191902e-84	non_linear_mixed	1.55867843566608e-86	2.61857977191902e-84	15071.0103975442	15204.7446130815	3
Breast cancer - Homo sapiens (human)	146	25	18876.4420153218	18876.4580581026	18892.3816764831	1497	NA	18376.4859461392	18376.5422086978	18408.3652684617	1494	0.920519331901754	18369.0698147395	18369.1663942163	18411.5755778362	1492	0.897882962241115	18315.9254348959	18316.8785917188	18454.0691649603	1474	NA	2.44279956678002e-109	1.41936263311773e-109	1.97403966577308e-113	4.10390327219043e-107	2.38452922363779e-107	3.31638663849878e-111	non_linear_mixed	1.97403966577308e-113	3.31638663849878e-111	18316.8785917188	18454.0691649603	2
Phagosome - Homo sapiens (human)	150	29	23273.3432444201	23273.3570693049	23289.7281655968	1737	NA	22558.4203063741	22558.4687772339	22591.1901487274	1734	0.951046551638621	22550.5924810633	22550.6756699714	22594.2856042009	1732	0.938795681935759	22552.970142448	22553.789757159	22694.9727926454	1714	NA	6.09619308761759e-156	4.06652562320952e-156	4.43109494382595e-147	1.02416043871975e-153	6.831763046992e-154	7.44423950562759e-145	non_linear_fixed	4.06652562320952e-156	6.831763046992e-154	22550.6756699714	22594.2856042009	3
Autophagy - animal - Homo sapiens (human)	136	37	28587.2222056685	28587.2330359934	28604.3379930931	2217	NA	27792.0330688744	27792.0710263981	27826.2646437236	2214	0.926169867492691	27785.5496421171	27785.614771018	27831.191741916	2212	0.908592510910754	27702.2895502343	27702.9297691125	27850.6263745808	2194	NA	2.3896709462556e-173	3.45172801043389e-173	6.27668542840755e-182	4.01464718970941e-171	5.79890305752894e-171	1.05448315197247e-179	non_linear_mixed	6.27668542840755e-182	1.05448315197247e-179	27702.9297691125	27850.6263745808	5
Gap junction - Homo sapiens (human)	87	23	15637.7544969099	15637.7719387703	15653.4440132443	1377	NA	15187.4496416431	15187.5108215412	15218.828674312	1374	0.931261978243052	15184.2639546696	15184.3689874924	15226.1026648948	1372	0.914217282072816	15084.2184442241	15085.2561382374	15220.194252456	1354	NA	1.40338201712201e-98	6.03942575249905e-98	5.73523094465635e-112	2.35768178876498e-96	1.01462352641984e-95	9.63518798702267e-110	non_linear_mixed	5.73523094465635e-112	9.63518798702267e-110	15085.2561382374	15220.194252456	2
TNF signaling pathway - Homo sapiens (human)	111	27	18387.3645136876	18387.3793651727	18403.5350579723	1617	NA	18009.6920846645	18009.7441615399	18042.0331732339	1614	0.941452544800605	18008.6855949463	18008.7749804212	18051.8070463721	1612	0.930943222557171	18007.1891580492	18008.0705139814	18147.333875183	1594	0.941329768421027	7.61444955818947e-83	8.16579010456166e-82	7.13459525436697e-76	1.27922752577583e-80	1.37185273756636e-79	1.19861200273365e-73	non_linear_mixed	7.13459525436697e-76	1.19861200273365e-73	18008.0705139814	18147.333875183	3
Prostate cancer - Homo sapiens (human)	96	25	19144.4235014783	19144.4395442591	19160.3631626396	1497	NA	19005.6773258433	19005.7335884019	19037.5566481658	1494	0.952802390298212	19000.843642607	19000.9402220839	19043.3494057037	1492	0.950295256703555	18970.6948159439	18971.6479727668	19108.8385460083	1474	0.950391658502875	3.58080629670641e-31	2.30851683815837e-31	4.82132906852159e-34	6.01575457846676e-29	3.87830828810606e-29	8.09983283511627e-32	non_linear_mixed	4.82132906852159e-34	8.09983283511627e-32	18971.6479727668	19108.8385460083	2
RNA transport - Homo sapiens (human)	185	44	32394.699991164	32394.7090958681	32412.3355937524	2637	NA	32298.6231415075	32298.65504428	32333.8943466843	2634	0.933280269705512	32273.3096826988	32273.3644147398	32320.3379562679	2632	0.929479388353173	32263.8163976835	32264.3537111163	32416.6582867831	2614	0.929226179529687	5.5576498441641e-22	1.20642043057405e-26	1.0203570052952e-25	9.33685173819569e-20	2.0267863233644e-24	1.71419976889593e-23	non_linear_mixed	1.0203570052952e-25	1.71419976889593e-23	32264.3537111163	32416.6582867831	3
Ribosome - Homo sapiens (human)	157	34	27098.0114576324	27098.0232454516	27114.8735728929	2037	NA	27075.0639381763	27075.1052564252	27108.7881686973	2034	0.929235466603828	27037.3995660559	27037.4704670899	27082.3652067506	2032	0.926815613140786	27020.7109588401	27021.4084253081	27166.8492910979	2014	0.923780895059012	2.29701944541007e-06	7.64320399719202e-14	1.05645358469565e-15	0.000385899266828892	1.28405827152826e-11	1.77484202228869e-13	non_linear_mixed	1.05645358469565e-15	1.77484202228869e-13	27021.4084253081	27166.8492910979	4
Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)	69	25	19930.7231948522	19930.7392376329	19946.6628560135	1497	NA	19247.7748894107	19247.8311519693	19279.6542117333	1494	NA	19245.991997411	19246.0885768879	19288.4977605077	1492	NA	19257.2865185166	19258.2396753395	19395.430248581	1474	NA	5.22924152308491e-149	6.76792139578698e-148	3.55811701430784e-137	8.78512575878266e-147	1.13701079449221e-145	5.97763658403718e-135	non_linear_fixed	6.76792139578698e-148	1.13701079449221e-145	19246.0885768879	19288.4977605077	2
Neutrophil extracellular trap formation - Homo sapiens (human)	187	20	13941.9453499866	13941.9654168762	13957.2155804939	1197	NA	13656.1529091936	13656.2233199228	13686.6933702082	1194	0.935744581940677	13652.5294492103	13652.6503560113	13693.2500638965	1192	0.923941456521344	13656.0107697645	13657.2077007108	13788.3527674947	1174	NA	5.94339264387476e-63	1.33732957638365e-62	1.52837345984734e-56	9.9848996417096e-61	2.24671368832453e-60	2.56766741254353e-54	non_linear_fixed	1.33732957638365e-62	2.24671368832453e-60	13652.6503560113	13693.2500638965	4
Spliceosome - Homo sapiens (human)	150	35	26170.5499791227	26170.5614295044	26187.4990569938	2097	NA	25953.1468388914	25953.1869726707	25987.0449946337	2094	0.889784288461973	25938.8280460543	25938.8969126253	25984.025587044	2092	0.876448938306912	25935.9544744397	25936.631753745	26082.8464826562	2074	0.884699871120863	3.69011825889773e-48	3.28035482010828e-50	3.72807178933337e-46	6.19939867494818e-46	5.51099609778191e-48	6.26316060608006e-44	non_linear_mixed	3.72807178933337e-46	6.26316060608006e-44	25936.631753745	26082.8464826562	5
Axon guidance - Homo sapiens (human)	181	38	25701.2525573948	25701.2631022102	25718.4483495606	2277	NA	25006.3323622897	25006.369317855	25040.7239466214	2274	0.951768284383302	24996.6544319584	24996.7178401486	25042.5098777339	2272	0.941762553996443	24946.791574793	24947.4147439009	25095.8217735637	2254	0.953559108993969	1.32588586085065e-151	3.42548640387046e-152	2.76919131697589e-154	2.2274882462291e-149	5.75481715850238e-150	4.6522414125195e-152	non_linear_mixed	2.76919131697589e-154	4.6522414125195e-152	24947.4147439009	25095.8217735637	2
NOD-like receptor signaling pathway - Homo sapiens (human)	180	30	20961.2253730491	20961.238736078	20977.7119988807	1797	NA	20568.6622597839	20568.7091086405	20601.6355114472	1794	0.939878756763364	20569.450218996	20569.5306210061	20613.4145545471	1792	0.929897346305962	20566.009205089	20566.8010832616	20708.89329563	1774	0.941875139879328	4.53308435788738e-86	1.2293229731975e-84	5.55522800728845e-79	7.61558172125081e-84	2.0652625949718e-82	9.33278305224459e-77	non_linear_mixed	5.55522800728845e-79	9.33278305224459e-77	20566.8010832616	20708.89329563	2
Apelin signaling pathway - Homo sapiens (human)	136	24	16991.9261411036	16991.9428541955	17007.7433362813	1437	NA	16767.6003388181	16767.6589571014	16799.2347291735	1434	0.96663086174768	16765.2711699081	16765.3717988389	16807.4503570486	1432	0.963836762553296	16750.9158384853	16751.9094690585	16887.9981966921	1414	0.96643767322772	1.17590519417178e-49	4.00416428712598e-49	1.90911821019942e-47	1.97552072620859e-47	6.72699600237165e-47	3.20731859313503e-45	non_linear_mixed	1.90911821019942e-47	3.20731859313503e-45	16751.9094690585	16887.9981966921	2
Estrogen signaling pathway - Homo sapiens (human)	136	35	27983.4544698676	27983.4659202493	28000.4035477388	2097	NA	27232.4433769489	27232.4835107282	27266.3415326912	2094	0.884713439691986	27226.7007860404	27226.7696526114	27271.89832703	2092	0.87931072108574	26716.4248286374	26717.1021079428	26863.3168368539	2074	NA	9.10318879912147e-164	1.79909373156997e-163	2.46472793306301e-263	1.52933571825241e-161	3.02247746903755e-161	4.14074292754586e-261	non_linear_mixed	2.46472793306301e-263	4.14074292754586e-261	26717.1021079428	26863.3168368539	2
C-type lectin receptor signaling pathway - Homo sapiens (human)	103	27	20110.7418097181	20110.7566612033	20126.9123540028	1617	NA	20019.0158277734	20019.0679046487	20051.3569163427	1614	0.959095994269876	20014.9509073807	20015.0402928556	20058.0723588065	1612	0.957260946965013	19961.0559318745	19961.9372878067	20101.2006490083	1594	0.958460368111885	4.79066114785213e-21	3.17354846635464e-21	2.40494046089683e-29	8.04831072839157e-19	5.33156142347579e-19	4.04029997430668e-27	non_linear_mixed	2.40494046089683e-29	4.04029997430668e-27	19961.9372878067	20101.2006490083	3
Tuberculosis - Homo sapiens (human)	178	29	22251.2048087101	22251.2186335949	22267.5897298867	1737	NA	21735.5279013266	21735.5763721864	21768.2977436798	1734	0.91435484974678	21730.4427631045	21730.5259520127	21774.1358862422	1732	0.898317383778082	21682.7623129575	21683.5819276685	21824.7649631549	1714	NA	9.56687011444122e-113	1.8243460076908e-112	4.29804244279697e-115	1.60723417922613e-110	3.06490129292054e-110	7.22071130389891e-113	non_linear_mixed	4.29804244279697e-115	7.22071130389891e-113	21683.5819276685	21824.7649631549	2
Toxoplasmosis - Homo sapiens (human)	111	21	14739.6538262471	14739.6729345273	14755.0704272469	1257	NA	14425.2527958635	14425.3198349696	14456.0859978631	1254	0.942977864837028	14422.9503016592	14423.0654095729	14464.0612376588	1252	0.932218663240916	14423.3580401001	14424.4967262315	14556.9685820987	1234	NA	3.81888385134248e-69	1.80826631362955e-68	9.72906133331666e-63	6.41572487025536e-67	3.03788740689764e-66	1.6344823039972e-60	non_linear_fixed	1.80826631362955e-68	3.03788740689764e-66	14423.0654095729	14464.0612376588	2
Phospholipase D signaling pathway - Homo sapiens (human)	146	34	22938.4148880138	22938.4266758331	22955.2770032743	2037	NA	22064.3677085678	22064.4090268167	22098.0919390889	2034	0.932493889849785	22035.5989782615	22035.6698792955	22080.5646189562	2032	0.911978558264534	21933.5798608152	21934.2773272832	22079.718193073	2014	NA	1.88307998277234e-190	4.48088552030333e-195	2.05397292555023e-207	3.16357437105752e-188	7.52788767410959e-193	3.45067451492438e-205	non_linear_mixed	2.05397292555023e-207	3.45067451492438e-205	21934.2773272832	22079.718193073	3
Pathogenic Escherichia coli infection - Homo sapiens (human)	195	45	31874.3708445553	31874.3797466325	31892.0738657113	2697	NA	31029.1621698514	31029.1933618306	31064.5682121634	2694	0.950618666273096	31019.0657757889	31019.1192874946	31066.2738322048	2692	0.941015406188455	30946.6600349316	30947.1852874569	31100.0862182834	2674	NA	3.38728866645577e-184	8.57964334901964e-185	5.16424862422522e-191	5.6906449596457e-182	1.4413800826353e-182	8.67593768869836e-189	non_linear_mixed	5.16424862422522e-191	8.67593768869836e-189	30947.1852874569	31100.0862182834	2
Homologous recombination - Homo sapiens (human)	40	20	13559.9429557748	13559.9630226644	13575.2131862821	1197	NA	13390.2702950539	13390.3407057832	13420.8107560686	1194	NA	13385.6403464364	13385.7612532374	13426.3609611226	1192	NA	13359.7599040886	13360.9568350349	13492.1019018188	1174	NA	7.58420344901161e-38	6.44707611626589e-38	2.83314587400158e-39	1.27414617943395e-35	1.08310878753267e-35	4.75968506832265e-37	non_linear_mixed	2.83314587400158e-39	4.75968506832265e-37	13360.9568350349	13492.1019018188	2
Transcriptional misregulation in cancer - Homo sapiens (human)	190	32	23840.825390262	23840.8379163581	23857.5056316571	1917	NA	23687.0488734869	23687.0927835758	23720.409356277	1914	0.953954867577953	23682.2714168451	23682.3467700633	23726.7520605653	1912	0.951630657747282	23630.1347409922	23630.8764208654	23774.6968330828	1894	NA	2.04814083811854e-34	1.48457997765343e-34	2.28846216305707e-41	3.44087660803914e-32	2.49409436245776e-32	3.84461643393587e-39	non_linear_mixed	2.28846216305707e-41	3.84461643393587e-39	23630.8764208654	23774.6968330828	3
Hepatitis C - Homo sapiens (human)	156	30	20939.8998480689	20939.9132110979	20956.3864739006	1797	NA	20481.1364843958	20481.1833332525	20514.1097360591	1794	0.926767526749009	20470.7311591682	20470.8115611782	20514.6954947193	1792	0.913049157872266	20458.4891676129	20459.2810457855	20601.3732581539	1774	0.931040816370046	2.06255402253356e-100	2.50097246040821e-101	6.88690694302885e-97	3.46509075785638e-98	4.2016337334858e-99	1.15700036642885e-94	non_linear_mixed	6.88690694302885e-97	1.15700036642885e-94	20459.2810457855	20601.3732581539	2
ErbB signaling pathway - Homo sapiens (human)	84	26	18225.0373293766	18225.0527535411	18241.0946526773	1557	NA	17682.4833454658	17682.5374343261	17714.5979920672	1554	0.944418024407878	17675.8742237718	17675.9670670987	17718.6937525738	1552	0.93238053752898	17648.745249184	17649.661100456	17787.9087177903	1534	NA	1.43006304254554e-118	1.34192707087217e-118	9.69280378641485e-117	2.40250591147651e-116	2.25443747906525e-116	1.62839103611769e-114	non_linear_mixed	9.69280378641485e-117	1.62839103611769e-114	17649.661100456	17787.9087177903	4
Insulin signaling pathway - Homo sapiens (human)	136	40	28684.6965856037	28684.7066022982	28702.0462576527	2397	NA	28325.640351081	28325.6754534629	28360.339695179	2394	0.951884661922382	28314.5842320494	28314.6444578964	28360.8500241801	2392	0.947286029083398	28261.2788476455	28261.870503777	28411.6426720702	2374	NA	8.19125869819136e-79	5.72480966995178e-80	7.98093996402923e-85	1.37613146129615e-76	9.61768024551899e-78	1.34079791395691e-82	non_linear_mixed	7.98093996402923e-85	1.34079791395691e-82	28261.870503777	28411.6426720702	2
cGMP-PKG signaling pathway - Homo sapiens (human)	166	27	18348.8889451061	18348.9037965913	18365.0594893908	1617	NA	17925.6069609344	17925.6590378098	17957.9480495038	1614	0.928154507866152	17916.7906275925	17916.8800130674	17959.9120790183	1612	0.914762413683982	17910.9579633452	17911.8393192774	18051.1026804791	1594	0.927043668534704	1.00443330518343e-92	2.48662857033505e-93	7.74088213294841e-88	1.68744795270816e-90	4.17753599816289e-91	1.30046819833533e-85	non_linear_mixed	7.74088213294841e-88	1.30046819833533e-85	17911.8393192774	18051.1026804791	5
Apoptosis - Homo sapiens (human)	135	47	33730.9138452867	33730.922368014	33748.7473217785	2817	NA	33283.8081519144	33283.8380132724	33319.475104898	2814	0.896539200989898	33261.7244002568	33261.775627578	33309.2803375682	2812	0.892441802768229	33071.7204614594	33072.223146744	33226.2772577216	2794	0.892156308232388	6.92379142646442e-98	2.47531158050491e-101	3.57427972196297e-134	1.16319695964602e-95	4.15852345524824e-99	6.00478993289778e-132	non_linear_mixed	3.57427972196297e-134	6.00478993289778e-132	33072.223146744	33226.2772577216	2
Cellular senescence - Homo sapiens (human)	155	47	34192.3709331536	34192.3794558809	34210.2044096454	2817	NA	33965.5979289384	33965.6277902964	34001.264881922	2814	0.9586016661417	33952.8157957511	33952.8670230724	34000.3717330626	2812	0.955945700569582	33823.7048560782	33824.2075413628	33978.2616523404	2794	NA	3.47731953150718e-50	6.84808762601163e-52	1.69181547033366e-73	5.84189681293206e-48	1.15047872116995e-49	2.84224999016055e-71	non_linear_mixed	1.69181547033366e-73	2.84224999016055e-71	33824.2075413628	33978.2616523404	5
Epstein-Barr virus infection - Homo sapiens (human)	200	57	41268.9518052073	41268.9588309684	41287.3639926974	3417	NA	41180.6904250807	41180.7150368592	41217.5148000611	3414	0.960626036183979	41160.8937958088	41160.9360121677	41209.9929624493	3412	0.959221873461769	41054.6521131177	41055.0659062212	41214.2244046992	3394	0.957800370220462	2.66099774299241e-20	8.09057615094093e-24	4.35503131302838e-42	4.47047620822726e-18	1.35921679335808e-21	7.31645260588768e-40	non_linear_mixed	4.35503131302838e-42	7.31645260588768e-40	41055.0659062212	41214.2244046992	2
Pancreatic cancer - Homo sapiens (human)	75	23	16088.6866692395	16088.7041111	16104.376185574	1377	NA	15741.2205933322	15741.2817732302	15772.5996260011	1374	0.919583978301357	15735.7405928079	15735.8456256306	15777.5793030331	1372	0.904136206386703	15740.3611137032	15741.3988077165	15876.3369219351	1354	0.922315212748964	2.64944116124547e-76	2.85382689208286e-76	2.61256570502326e-69	4.4510611508924e-74	4.7944291786992e-74	4.38911038443908e-67	non_linear_fixed	2.85382689208286e-76	4.7944291786992e-74	15735.8456256306	15777.5793030331	4
Colorectal cancer - Homo sapiens (human)	85	24	16063.2158077359	16063.2325208278	16079.0330029136	1437	NA	15659.812573602	15659.8711918853	15691.4469639574	1434	0.936415528964552	15658.3105074068	15658.4111363376	15700.4896945474	1432	0.92122534321287	15653.8272219873	15654.8208525605	15790.9095801941	1414	0.939313791836945	2.03371413219822e-88	1.81692688411937e-87	6.46702681672638e-82	3.41663974209301e-86	3.05243716532055e-85	1.08646050521003e-79	non_linear_mixed	6.46702681672638e-82	1.08646050521003e-79	15654.8208525605	15790.9095801941	5
Thyroid hormone signaling pathway - Homo sapiens (human)	120	28	21793.046290886	21793.0606106951	21809.3259381032	1677	NA	21521.0427435013	21521.0929527063	21553.6020379357	1674	0.941992767775476	21513.21449615	21513.3006720925	21556.6268887291	1672	0.936573397106133	21444.5442329175	21445.3935977088	21585.6345087998	1654	NA	5.72553123956649e-60	1.53585699685931e-60	2.40309015637792e-69	9.61889248247171e-58	2.58023975472365e-58	4.03719146271491e-67	non_linear_mixed	2.40309015637792e-69	4.03719146271491e-67	21445.3935977088	21585.6345087998	3
Hepatitis B - Homo sapiens (human)	161	36	23936.5038126166	23936.514944342	23953.5374031186	2157	NA	23438.7841777835	23438.823193111	23472.8513587876	2154	0.944188964299185	23433.0629163206	23433.1298619273	23478.485824326	2152	0.933765379497705	23415.4006181941	23416.0588460422	23563.0250692117	2134	0.945877413878173	7.45701825787771e-109	1.00187962253749e-108	3.53625681261792e-105	1.25277906732346e-106	1.68315776586298e-106	5.94091144519811e-103	non_linear_mixed	3.53625681261792e-105	5.94091144519811e-103	23416.0588460422	23563.0250692117	2
Neurotrophin signaling pathway - Homo sapiens (human)	118	31	20981.0891098072	20981.1020408417	20997.6741051073	1857	NA	20574.994545283	20575.0398771772	20608.1645358832	1854	0.938866947025419	20572.4529364643	20572.5307322504	20616.679590598	1852	0.927379914128393	20569.1738807878	20569.9398382346	20712.9105067222	1834	NA	5.31240122945991e-89	2.85096841313879e-88	1.93716784007476e-82	8.92483406549264e-87	4.78962693407318e-86	3.2544419713256e-80	non_linear_mixed	1.93716784007476e-82	3.2544419713256e-80	20569.9398382346	20712.9105067222	2
Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)	192	40	26843.8114673308	26843.8214840253	26861.1611393798	2397	NA	26359.6139713431	26359.649073725	26394.3133154411	2394	0.931155661224786	26353.753839199	26353.814065046	26400.0196313297	2392	0.919081933623552	26330.9060373578	26331.4976934893	26481.2698617826	2374	NA	6.35294497199476e-106	7.75920948479364e-106	1.83024558431229e-103	1.06729475529512e-103	1.30354719344533e-103	3.07481258164465e-101	non_linear_mixed	1.83024558431229e-103	3.07481258164465e-101	26331.4976934893	26481.2698617826	2
Androgen receptor signaling pathway	88	25	19585.2211441453	19585.237186926	19601.1608053065	1497	NA	19464.6913574412	19464.7476199998	19496.5706797638	1494	0.934044045533744	19451.9949898259	19452.0915693028	19494.5007529226	1492	0.930921086640788	19426.0902033276	19427.0433601504	19564.2339333919	1474	NA	3.02576312048216e-27	3.68767439570708e-29	3.48937682672428e-31	5.08328204241003e-25	6.19529298478789e-27	5.86215306889679e-29	non_linear_mixed	3.48937682672428e-31	5.86215306889679e-29	19427.0433601504	19564.2339333919	2
Regulation of toll-like receptor signaling pathway	144	31	21683.8926570112	21683.9055880457	21700.4776523114	1857	NA	21159.106944377	21159.1522762712	21192.2769349772	1854	0.943276265450039	21153.1155144259	21153.1933102119	21197.3421685595	1852	0.932048350040059	21125.4937773353	21126.2597347821	21269.2304032697	1834	0.945690219384097	1.01522557407609e-114	1.25455255351339e-114	5.48672461174829e-113	1.70557896444783e-112	2.10764828990249e-112	9.21769734773712e-111	non_linear_mixed	5.48672461174829e-113	9.21769734773712e-111	21126.2597347821	21269.2304032697	2
Integrated breast cancer pathway	66	25	18713.5247132055	18713.5407559862	18729.4643743668	1497	NA	18300.5409160858	18300.5971786444	18332.4202384083	1494	0.925201688828487	18301.8065200944	18301.9030995712	18344.3122831911	1492	0.906262429015786	18238.9985956868	18239.9517525096	18377.1423257512	1474	NA	1.7096058076594e-90	6.17299611708389e-89	1.87632137144436e-95	2.8721377568678e-88	1.03706334767009e-86	3.15221990402652e-93	non_linear_mixed	1.87632137144436e-95	3.15221990402652e-93	18239.9517525096	18377.1423257512	2
Leptin signaling pathway	75	25	18702.7259437876	18702.7419865683	18718.6656049488	1497	NA	18326.7542145071	18326.8104770657	18358.6335368297	1494	0.947907777271602	18324.4079601631	18324.5045396399	18366.9137232598	1492	0.941051874156621	18268.148474523	18269.1016313458	18406.2922045874	1474	NA	1.77820196689649e-82	9.76724680487519e-82	3.8496610108362e-87	2.98737930438611e-80	1.64089746321903e-79	6.46743049820482e-85	non_linear_mixed	3.8496610108362e-87	6.46743049820482e-85	18269.1016313458	18406.2922045874	2
Prolactin Signaling Pathway	75	23	17586.6163427576	17586.633784618	17602.305859092	1377	NA	17394.8654085573	17394.9265884553	17426.2444412262	1374	0.928418803753316	17381.6492916514	17381.7543244742	17423.4880018766	1372	0.924747117569822	17330.6023210575	17331.6400150708	17466.5781292894	1354	0.925850661350601	1.29154435208792e-42	1.77795694318571e-44	1.79268449689422e-50	2.16979451150771e-40	2.98696766455199e-42	3.0117099547823e-48	non_linear_mixed	1.79268449689422e-50	3.0117099547823e-48	17331.6400150708	17466.5781292894	2
Alzheimer,s disease	143	20	13894.8348780313	13894.8549449209	13910.1051085386	1197	NA	13639.5294682894	13639.5998790187	13670.0699293041	1194	0.914453288863703	13638.7758150784	13638.8967218794	13679.4964297646	1192	0.897512891275305	13656.304963627	13657.5018945733	13788.6469613572	1174	0.916549810956798	2.34648656785886e-56	1.96418388079993e-55	6.02776337612913e-47	3.94209743400289e-54	3.29982891974388e-53	1.01266424718969e-44	non_linear_fixed	1.96418388079993e-55	3.29982891974388e-53	13638.8967218794	13679.4964297646	4
Glioblastoma signaling pathways	82	26	19367.6316800219	19367.6471041865	19383.6890033227	1557	NA	19247.2539560326	19247.3080448928	19279.368602634	1554	0.957967598702706	19241.0708867305	19241.1637300574	19283.8904155324	1552	0.956333613207515	19185.7694326684	19186.6852839404	19324.9329012747	1534	NA	3.26285546428195e-27	9.62750234700135e-28	1.20540955137762e-35	5.48159717999368e-25	1.61742039429623e-25	2.0250880463144e-33	non_linear_mixed	1.20540955137762e-35	2.0250880463144e-33	19186.6852839404	19324.9329012747	2
B Cell Receptor Signaling Pathway	97	27	17758.481452919	17758.4963044041	17774.6519972037	1617	NA	17567.6152745598	17567.6673514352	17599.9563631292	1614	0.92731581915148	17566.7447120266	17566.8340975015	17609.8661634525	1612	0.918407402787421	17565.8922480323	17566.7736039645	17706.0369651662	1594	0.928411586037857	2.0057076039271e-42	1.20742954530827e-41	9.11256718123206e-38	3.36958877459752e-40	2.0284816361179e-39	1.53091128644699e-35	non_linear_mixed	9.11256718123206e-38	1.53091128644699e-35	17566.7736039645	17706.0369651662	2
AGE-RAGE pathway	65	20	14053.6048155709	14053.6248824605	14068.8750460782	1197	NA	13792.5119903702	13792.5824010994	13823.0524513848	1194	0.921578166294464	13790.6115248845	13790.7324316855	13831.3321395707	1192	0.90734846019533	13802.4750708453	13803.6720017916	13934.8170685755	1174	0.925167294349085	1.31346369577535e-57	6.36899160907e-57	1.73894821205371e-49	2.20661900890259e-55	1.06999059032376e-54	2.92143299625023e-47	non_linear_fixed	6.36899160907e-57	1.06999059032376e-54	13790.7324316855	13831.3321395707	3
Adipogenesis	130	27	18432.4022917502	18432.4171432354	18448.5728360349	1617	NA	18330.9395448493	18330.9916217247	18363.2806334187	1614	0.87508868635586	18313.6118351951	18313.7012206699	18356.7332866209	1612	0.869628220755164	18240.4761255584	18241.3574814906	18380.6208426923	1594	0.866998107855866	3.85759322330591e-23	4.29762463019068e-26	1.23322459560671e-37	6.48075661515392e-21	7.22000937872034e-24	2.07181732061928e-35	non_linear_mixed	1.23322459560671e-37	2.07181732061928e-35	18241.3574814906	18380.6208426923	3
Oncostatin M Signaling Pathway	64	27	19320.5216090517	19320.5364605368	19336.6921533364	1617	NA	19112.9600196615	19113.0120965369	19145.3011082309	1614	0.959994138157659	19107.1532591277	19107.2426446026	19150.2747105535	1612	0.95639785384671	19094.9861592435	19095.8675151757	19235.1308763774	1594	0.960682376418734	4.94778944492555e-46	2.82065571882282e-46	2.45660744350126e-44	8.31228626747492e-44	4.73870160762234e-44	4.12710050508212e-42	non_linear_mixed	2.45660744350126e-44	4.12710050508212e-42	19095.8675151757	19235.1308763774	2
Brain-derived neurotrophic factor (BDNF) signaling pathway	143	37	26443.2203344707	26443.2311647956	26460.3361218953	2217	NA	26172.6709266749	26172.7088841986	26206.9025015241	2214	0.957209360506229	26165.7497449858	26165.8148738867	26211.3918447847	2212	0.953683980852071	26149.2939734218	26149.9341923001	26297.6307977684	2194	0.955683854872296	1.18153750715461e-59	4.94069301527907e-60	3.6028490516783e-58	1.98498301201975e-57	8.30036426566883e-58	6.05278640681954e-56	non_linear_mixed	3.6028490516783e-58	6.05278640681954e-56	26149.9341923001	26297.6307977684	2
Apoptosis	86	28	20623.7799940011	20623.7943138102	20640.0596412183	1677	NA	20579.93066623	20579.9808754351	20612.4899606644	1674	0.962161629359385	20574.6888312215	20574.775007164	20618.1012238007	1672	0.961200435727165	20549.271917141	20550.1212819323	20690.3621930234	1654	0.922075018103958	8.60180658934429e-11	1.87273419133743e-11	3.37081356132451e-15	1.44510350700984e-08	3.14619344144689e-09	5.66296678302518e-13	non_linear_mixed	3.37081356132451e-15	5.66296678302518e-13	20550.1212819323	20690.3621930234	2
Mesodermal commitment pathway	152	26	19235.1112757174	19235.1266998819	19251.1685990181	1557	NA	18827.2229245073	18827.2770133676	18859.3375711088	1554	0.896378773223869	18799.7380154666	18799.8308587935	18842.5575442686	1552	0.870762594907887	18716.3814577213	18717.2973089933	18855.5449263276	1534	0.90427503069685	2.17126915483873e-89	4.88936470913594e-94	1.10882031165075e-104	3.64773218012906e-87	8.21413271134838e-92	1.86281812357325e-102	non_linear_mixed	1.10882031165075e-104	1.86281812357325e-102	18717.2973089933	18855.5449263276	3
NRF2 pathway	142	34	27742.0986189552	27742.1104067745	27758.9607342157	2037	NA	27022.3461598364	27022.3874780853	27056.0703903574	2034	0.951251104663219	27023.999344461	27024.0702454949	27068.9649851557	2032	0.940064294856346	26958.6947796395	26959.3922461074	27104.8331118973	2014	NA	5.4674822514623e-157	4.12234474002971e-155	2.08476513873267e-160	9.18537018245666e-155	6.92553916324992e-153	3.50240543307089e-158	non_linear_mixed	2.08476513873267e-160	3.50240543307089e-158	26959.3922461074	27104.8331118973	5
Focal Adhesion	197	39	27795.9617247857	27795.9719987584	27813.2354434108	2337	NA	27225.0477757884	27225.083780932	27259.5952130385	2334	0.930633548069609	27212.1880886277	27212.2498646895	27258.2513382945	2332	0.917673568881136	27174.6214076646	27175.2284115556	27324.3269690817	2314	0.934664543202577	1.01853071810234e-124	4.47853239752171e-126	3.32690613888538e-126	1.71113160641193e-122	7.52393442783647e-124	5.58920231332743e-124	non_linear_mixed	3.32690613888538e-126	5.58920231332743e-124	27175.2284115556	27324.3269690817	2
TGF-beta Signaling Pathway	131	39	26624.2157468103	26624.2260207829	26641.4894654354	2337	NA	26039.9241438182	26039.9601489618	26074.4715810683	2334	0.92966678308143	26031.8579524365	26031.9197284983	26077.9212021033	2332	0.914756189623593	25931.029245442	25931.636249333	26080.7348068591	2314	0.931563231761884	1.28237276446242e-127	6.25790067418516e-128	2.43079723939456e-141	2.15438624429687e-125	1.05132731326311e-125	4.08373936218287e-139	non_linear_mixed	2.43079723939456e-141	4.08373936218287e-139	25931.636249333	26080.7348068591	2
Angiopoietin Like Protein 8 Regulatory Pathway	130	34	22777.1248647518	22777.136652571	22793.9869800123	2037	NA	22340.9764415273	22341.0177597762	22374.7006720483	2034	0.929156308820519	22339.8738691569	22339.9447701909	22384.8395098516	2032	0.916761561447573	22333.3722402534	22334.0697067214	22479.5105725112	2014	0.928918512569896	1.63829774556483e-95	1.92413657862007e-94	4.77457666445128e-89	2.75234021254891e-93	3.23254945208171e-92	8.02128879627816e-87	non_linear_mixed	4.77457666445128e-89	8.02128879627816e-87	22334.0697067214	22479.5105725112	4
Chemokine signaling pathway	164	24	16454.3921254013	16454.4088384933	16470.2093205791	1437	NA	16074.8691950987	16074.9278133821	16106.5035854542	1434	0.936915998196935	16067.5465586027	16067.6471875335	16109.7257457433	1432	0.924476284427836	16068.5565086674	16069.5501392407	16205.6388668742	1414	NA	3.02584506570942e-83	1.41941743239067e-83	4.83207477747627e-77	5.08341971039183e-81	2.38462128641633e-81	8.11788562616013e-75	non_linear_fixed	1.41941743239067e-83	2.38462128641633e-81	16067.6471875335	16109.7257457433	2
ESC Pluripotency Pathways	115	22	16295.0616799185	16295.0799170005	16310.6178409652	1317	NA	16280.2126170384	16280.2765926667	16311.3249391319	1314	NA	16275.2288443143	16275.3386841312	16316.7119404389	1312	0.961526870282779	16228.9982485047	16230.0840953724	16363.8183109098	1294	0.958327648589531	0.000113154303701729	1.5909042906878e-05	1.088428458488e-13	0.0190099230218905	0.0026727192083555	1.82855981025985e-11	non_linear_mixed	1.088428458488e-13	1.82855981025985e-11	16230.0840953724	16363.8183109098	2
mRNA Processing	126	29	21656.2292716527	21656.2430965375	21672.6141928293	1737	NA	21476.4825296532	21476.531000513	21509.2523720064	1734	0.911687344521985	21466.1213236561	21466.2045125642	21509.8144467938	1732	0.903280212757296	21473.1700513673	21473.9896660783	21615.1727015647	1714	0.909966612937495	5.06206396294708e-40	2.69352488279438e-41	6.99650875558267e-36	8.5042674577511e-38	4.52512180309457e-39	1.17541347093789e-33	non_linear_fixed	2.69352488279438e-41	4.52512180309457e-39	21466.2045125642	21509.8144467938	2
Chromosomal and microsatellite instability in colorectal cancer	72	21	14135.929864746	14135.9489730262	14151.3464657458	1257	NA	13776.3697625466	13776.4368016527	13807.2029645462	1254	0.940073067205458	13774.9247923448	13775.0399002585	13816.0357283444	1252	0.925871949657684	13783.173964696	13784.3126508274	13916.7845066946	1234	0.943400061745336	6.37140262335531e-79	5.24406101628069e-78	3.20412814228602e-70	1.07039564072369e-76	8.81002250735156e-76	5.38293527904052e-68	non_linear_fixed	5.24406101628069e-78	8.81002250735156e-76	13775.0399002585	13816.0357283444	3
Ebola Virus Pathway on Host	129	25	18245.0151574871	18245.0312002678	18260.9548186483	1497	NA	17842.4969895062	17842.5532520648	17874.3763118288	1494	0.936825224876593	17840.1362944307	17840.2328739075	17882.6420575274	1492	0.924162395479726	17854.6038977068	17855.5570545296	17992.7476277711	1474	NA	3.16236441624068e-88	1.84092849916207e-87	5.47493102241084e-78	5.31277221928433e-86	3.09275987859228e-85	9.1978841176502e-76	non_linear_fixed	1.84092849916207e-87	3.09275987859228e-85	17840.2328739075	17882.6420575274	2
Ras signaling	183	30	21295.6907542081	21295.7041172371	21312.1773800398	1797	NA	20762.2572087181	20762.3040575748	20795.2304603814	1794	0.940596474618275	20743.4312241622	20743.5116261722	20787.3955597132	1792	0.929117636158478	20723.598365826	20724.3902439986	20866.482456367	1774	NA	1.35583182402296e-116	2.87695822940104e-119	7.37265739999541e-116	2.27779746435858e-114	4.83328982539374e-117	1.23860644319923e-113	non_linear_mixed	7.37265739999541e-116	1.23860644319923e-113	20724.3902439986	20866.482456367	2
Non-small cell lung cancer	71	20	13634.3218700584	13634.341936948	13649.5921005657	1197	NA	13208.2592843347	13208.329695064	13238.7997453494	1194	0.927158996101031	13206.387862484	13206.508769285	13247.1084771702	1192	0.907786705796902	13213.4660185326	13214.6629494788	13345.8080162627	1174	NA	2.50909255892695e-93	1.96671760909711e-92	2.71341339366055e-84	4.21527549899727e-91	3.30408558328315e-90	4.55853450134972e-82	non_linear_fixed	1.96671760909711e-92	3.30408558328315e-90	13206.508769285	13247.1084771702	2
Breast cancer pathway	153	31	23380.873335306	23380.8862663405	23397.4583306061	1857	NA	22837.3719652684	22837.4172971626	22870.5419558686	1854	0.923627012374094	22829.8913773238	22829.9691731099	22874.1180314575	1852	0.905925060184429	22761.7236205156	22762.4895779624	22905.46024645	1834	NA	8.9126375435426e-119	5.43097965553402e-119	9.61117446874086e-126	1.49732310731516e-116	9.12404582129715e-117	1.61467731074847e-123	non_linear_mixed	9.61117446874086e-126	1.61467731074847e-123	22762.4895779624	22905.46024645	4
Acute viral myocarditis	77	21	17086.5308055719	17086.5499138522	17101.9474065718	1257	NA	16729.7357816166	16729.8028207227	16760.5689836162	1254	0.970643096465828	16730.9181430885	16731.0332510022	16772.0290790881	1252	0.965923695465361	16721.0672957812	16722.2059819126	16854.6778377798	1234	0.971637753981729	2.52944015347091e-78	7.60551096554097e-77	7.73757162781705e-73	4.24945945783113e-76	1.27772584221088e-74	1.29991203347326e-70	non_linear_mixed	7.73757162781705e-73	1.29991203347326e-70	16722.2059819126	16854.6778377798	2
EGF-EGFR signaling pathway	161	51	35916.7020691427	35916.7099225458	35934.7805797275	3057	NA	35272.8414188296	35272.8689327503	35308.9984399992	3054	0.916343690359634	35256.5744624429	35256.621660083	35304.7838240025	3052	0.899617261034597	35189.3739674237	35189.8368754356	35346.0543924923	3034	NA	1.56159969778739e-140	1.41135727981982e-142	1.50431842600249e-148	2.62348749228282e-138	2.3710802300973e-140	2.52725495568418e-146	non_linear_mixed	1.50431842600249e-148	2.52725495568418e-146	35189.8368754356	35346.0543924923	3
Genes related to primary cilium development (based on CRISPR)	102	25	15215.6383530801	15215.6543958608	15231.5780142413	1497	NA	14995.8113187425	14995.8675813011	15027.690641065	1494	0.924251188521224	14990.0162582911	14990.1128377679	15032.5220213878	1492	0.928327412153276	14824.0720965396	14825.0252533624	14962.215826604	1474	0.915664414069118	1.10413227135438e-48	6.66764933710612e-49	3.15914545026405e-78	1.85494221587535e-46	1.12016508863383e-46	5.3073643564436e-76	non_linear_mixed	3.15914545026405e-78	5.3073643564436e-76	14825.0252533624	14962.215826604	4
Fragile X Syndrome	118	28	18939.35361985	18939.3679396591	18955.6332670672	1677	NA	18815.5507383513	18815.6009475563	18848.1100327857	1674	0.891048425599746	18817.1530488658	18817.2392248083	18860.565441445	1672	0.885251973443899	18823.8593034906	18824.7086682819	18964.9495793729	1654	0.885260729752334	5.96420566510145e-28	8.1188983775182e-27	8.72708107710138e-23	1.00198655173704e-25	1.36397492742306e-24	1.46614962095303e-20	linear	5.96420566510145e-28	1.00198655173704e-25	18815.6009475563	18848.1100327857	4
Gastrin signaling pathway	113	34	23928.3202182045	23928.3320060238	23945.182333465	2037	NA	23620.0938045381	23620.135122787	23653.8180350591	2034	0.961783957408668	23616.909350362	23616.980251396	23661.8749910567	2032	0.958322428725126	23590.2740505618	23590.9715170297	23736.4123828196	2014	0.959366293387424	8.28968853059795e-68	2.4887070213156e-67	3.38379703725539e-67	1.39266767314046e-65	4.1810277958102e-65	5.68477902258905e-65	non_linear_mixed	3.38379703725539e-67	5.68477902258905e-65	23590.9715170297	23736.4123828196	5
Hepatitis B infection	151	31	20841.0266675655	20841.0395986	20857.6116628656	1857	NA	20402.9220454101	20402.9673773043	20436.0920360103	1854	0.942624509508751	20397.371823967	20397.449619753	20441.5984781006	1852	0.932219398300523	20390.1751788284	20390.9411362752	20533.9118047628	1834	0.942673214518607	6.17396185296026e-96	7.99610143648071e-96	1.59508475042338e-90	1.03722559129732e-93	1.34334504132876e-93	2.67974238071128e-88	non_linear_mixed	1.59508475042338e-90	2.67974238071128e-88	20390.9411362752	20533.9118047628	2
Male infertility	144	26	19873.2325571131	19873.2479812776	19889.2898804138	1557	NA	19730.057386778	19730.1114756383	19762.1720333795	1554	0.953863624491414	19731.8678614258	19731.9607047527	19774.6873902277	1552	0.950777386169582	19662.4285604581	19663.3444117301	19801.5920290644	1534	0.955511651813162	3.96912025891655e-32	6.83924929584277e-31	2.17233628443289e-41	6.6681220349798e-30	1.14899388170159e-28	3.64952495784726e-39	non_linear_mixed	2.17233628443289e-41	3.64952495784726e-39	19663.3444117301	19801.5920290644	4
Head and Neck Squamous Cell Carcinoma	73	20	14309.298165272	14309.3182321617	14324.5683957794	1197	NA	14183.6012669674	14183.6716776967	14214.1417279821	1194	0.96436269898083	14183.3256195538	14183.4465263548	14224.04623424	1192	0.962130497050871	14176.0461145461	14177.2430454924	14308.3881122763	1174	NA	2.33007899493047e-28	1.28374490554905e-27	3.58386177780852e-26	3.91453271148319e-26	2.1566914413224e-25	6.02088778671832e-24	non_linear_mixed	3.58386177780852e-26	6.02088778671832e-24	14177.2430454924	14308.3881122763	3
Ciliopathies	182	31	20020.378899633	20020.3918306674	20036.9638949331	1857	NA	19849.1847523543	19849.2300842485	19882.3547429546	1854	0.912332250562485	19837.475253201	19837.5530489871	19881.7019073347	1852	0.908509688971935	19748.3353332661	19749.1012907129	19892.0719592005	1834	0.894990614449914	3.55938600283205e-38	9.35559152893008e-40	1.01612785673648e-53	5.97976848475784e-36	1.57173937686025e-37	1.70709479931729e-51	non_linear_mixed	1.01612785673648e-53	1.70709479931729e-51	19749.1012907129	19892.0719592005	3
EGFR Tyrosine Kinase Inhibitor Resistance	83	26	18391.5285726298	18391.5439967943	18407.5858959305	1557	NA	18122.1000709978	18122.1541598581	18154.2147175993	1554	0.964707783118597	18119.3985477331	18119.49139106	18162.2180765351	1552	0.961751249981237	18097.602149072	18098.518000344	18236.7656176783	1534	0.962517358935888	2.06525455841161e-59	6.93978563354187e-59	3.60274336145363e-58	3.4696276581315e-57	1.16588398643503e-56	6.05260884724209e-56	non_linear_mixed	3.60274336145363e-58	6.05260884724209e-56	18098.518000344	18236.7656176783	4
Insulin Signaling	159	46	32033.6079891427	32033.6166974156	32051.3769470189	2757	NA	31576.6453675377	31576.6758797063	31612.18328329	2754	0.94305496858923	31570.218500878	31570.27084548	31617.6023885477	2752	0.936111237900432	31525.2084042303	31525.7221254158	31679.2060391568	2734	NA	5.06514796585548e-100	4.41748185990334e-100	1.60016922887421e-102	8.5094485826372e-98	7.42136952463761e-98	2.68828430450867e-100	non_linear_mixed	1.60016922887421e-102	2.68828430450867e-100	31525.7221254158	31679.2060391568	4
DNA Repair Pathways Full Network	118	38	26683.5908477483	26683.6013925638	26700.7866399142	2277	NA	26526.9150185135	26526.9519740788	26561.3066028452	2274	0.934913492158033	26509.756733139	26509.8201413293	26555.6121789146	2272	NA	26463.7598701176	26464.3830392255	26612.7900688883	2254	NA	4.84885938213483e-35	8.11811104452773e-38	3.41188782365509e-43	8.14608376198651e-33	1.36384265548066e-35	5.73197154374056e-41	non_linear_mixed	3.41188782365509e-43	5.73197154374056e-41	26464.3830392255	26612.7900688883	4
Regulation of Actin Cytoskeleton	150	36	26430.8673859378	26430.8785176632	26447.9009764398	2157	NA	25483.8869882478	25483.9260035753	25517.9541692519	2154	0.94413867707966	25476.80153598	25476.8684815867	25522.2244439854	2152	0.928480787177175	25481.5461843152	25482.2044121633	25629.1706353328	2134	0.946471477316619	2.85018475693241e-206	3.61484920851275e-206	1.31905375352465e-195	4.78831039164646e-204	6.07294667030142e-204	2.21601030592141e-193	non_linear_fixed	3.61484920851275e-206	6.07294667030142e-204	25476.8684815867	25522.2244439854	2
Calcium Regulation in the Cardiac Cell	150	25	16627.1198479231	16627.1358907038	16643.0595090843	1497	NA	16584.0743102767	16584.1305728353	16615.9536325992	1494	0.925543395295189	16583.5721901146	16583.6687695914	16626.0779532113	1492	0.926423342528245	16564.8503547639	16565.8035115867	16702.9940848283	1474	NA	1.27566128044144e-10	2.59597177594052e-10	5.09249552627582e-13	2.14311095114162e-08	4.36123258358008e-08	8.55539248414338e-11	non_linear_mixed	5.09249552627582e-13	8.55539248414338e-11	16565.8035115867	16702.9940848283	2
Senescence and Autophagy in Cancer	105	27	20107.6679657261	20107.6828172113	20123.8385100108	1617	NA	19976.6680643927	19976.7201412681	20009.0091529621	1614	0.960675815095209	19972.6959896203	19972.7853750952	20015.8174410461	1612	0.958589644213562	19921.3567830982	19922.2381390304	20061.5015002321	1594	NA	1.67604486059004e-29	1.56832477755787e-29	1.59371462736572e-36	2.81575536579127e-27	2.63478562629722e-27	2.67744057397441e-34	non_linear_mixed	1.59371462736572e-36	2.67744057397441e-34	19922.2381390304	20061.5015002321	4
ErbB signaling pathway	91	29	21636.6672771893	21636.6811020741	21653.0521983659	1737	NA	21453.0980328355	21453.1465036953	21485.8678751887	1734	0.960192572878703	21447.0507703624	21447.1339592705	21490.7438935001	1732	0.957554358592859	21376.2791893352	21377.0988040463	21518.2818395327	1714	NA	7.56238383953591e-41	3.4312329468151e-41	2.33776757059373e-51	1.27048048504203e-38	5.76447135064937e-39	3.92744951859747e-49	non_linear_mixed	2.33776757059373e-51	3.92744951859747e-49	21377.0988040463	21518.2818395327	2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	158	29	19205.5928999012	19205.6067247859	19221.9778210778	1737	NA	18995.5415640752	18995.590034935	19028.3114064284	1734	0.907667967614938	18978.36312213	18978.4463110382	19022.0562452677	1732	0.904913058216273	18931.7815056916	18932.6011204027	19073.784155889	1714	0.897195910267011	1.43305689330942e-46	3.01481938252075e-49	4.44814522069551e-54	2.40753558075983e-44	5.06489656263486e-47	7.47288397076845e-52	non_linear_mixed	4.44814522069551e-54	7.47288397076845e-52	18932.6011204027	19073.784155889	3
IL6	73	22	15592.9207471172	15592.9389841993	15608.4769081639	1317	NA	15292.322977461	15292.3869530894	15323.4352995545	1314	0.920916045608185	15292.9964493056	15293.1062891225	15334.4795454302	1312	0.90716606289354	15270.7775990904	15271.8634459581	15405.5976614955	1294	NA	3.71342301313187e-66	7.35687070406711e-65	6.17908900930545e-64	6.23855066206155e-64	1.23595427828327e-62	1.03808695356332e-61	non_linear_mixed	6.17908900930545e-64	1.03808695356332e-61	15271.8634459581	15405.5976614955	3
Transcriptional regulation by RUNX1	194	30	21471.0276356149	21471.0409986439	21487.5142614466	1797	NA	20864.427021509	20864.4738703656	20897.4002731723	1794	0.927503958310789	20862.9060679179	20862.986469928	20906.870403469	1792	0.908298868959904	20738.8682480963	20739.6601262689	20881.7523386373	1774	NA	1.86940252531206e-132	2.45551592643955e-131	1.43405106155051e-149	3.14059624252427e-130	4.12526675641845e-129	2.40920578340486e-147	non_linear_mixed	1.43405106155051e-149	2.40920578340486e-147	20739.6601262689	20881.7523386373	3
Prolactin	69	20	15583.8442881681	15583.8643550577	15599.1145186754	1197	NA	15276.7500125768	15276.8204233061	15307.2904735915	1194	0.865290133166215	15279.1201194545	15279.2410262555	15319.8407341407	1192	0.843379152379453	15200.6404248974	15201.8373558437	15332.9824226276	1174	NA	1.45747140304909e-67	6.82907995830179e-66	1.68993744553282e-76	2.44855195712248e-65	1.1472854329947e-63	2.83909490849514e-74	non_linear_mixed	1.68993744553282e-76	2.83909490849514e-74	15201.8373558437	15332.9824226276	2
RHO GTPases Activate Formins	122	49	32586.5220312192	32586.5302056061	32604.4805258002	2937	NA	32519.8780038532	32519.9066434713	32555.7949930152	2934	0.938819667496922	32466.3285044317	32466.3776344214	32514.2178233143	2932	0.936986093455697	32410.3229818942	32410.8049592371	32565.9632682628	2914	NA	1.15864255765103e-15	2.16524005357687e-26	1.57477012699206e-34	1.94651949685373e-13	3.63760329000914e-24	2.64561381334666e-32	non_linear_mixed	1.57477012699206e-34	2.64561381334666e-32	32410.8049592371	32565.9632682628	2
Cellular response to heat stress	96	27	19647.4428560902	19647.4577075754	19663.6134003749	1617	NA	19343.9257265733	19343.9778034486	19376.2668151426	1614	0.927759769981214	19340.2809072984	19340.3702927732	19383.4023587242	1612	0.918546165356906	19366.2723191406	19367.1536750728	19506.4170362745	1594	0.923131023974218	8.66738528285139e-67	2.04173670347232e-66	1.42307434541157e-55	1.45612072751903e-64	3.43011766183349e-64	2.39076490029144e-53	non_linear_fixed	2.04173670347232e-66	3.43011766183349e-64	19340.3702927732	19383.4023587242	2
Mitochondrial translation initiation	87	21	13153.0117179487	13153.0308262289	13168.4283189485	1257	NA	13037.6123277246	13037.6793668307	13068.4455297242	1254	0.924616338626624	13022.5341561478	13022.6492640615	13063.6450921474	1252	0.919233046330475	13002.6186707596	13003.757356891	13136.2292127582	1234	NA	3.85513764237981e-26	1.41630080142402e-28	1.75311609221035e-29	6.47663123919808e-24	2.37938534639236e-26	2.94523503491339e-27	non_linear_mixed	1.75311609221035e-29	2.94523503491339e-27	13003.757356891	13136.2292127582	5
Signaling by NTRK1 (TRKA)	113	23	15893.167572472	15893.1850143324	15908.8570888064	1377	NA	15504.5913112652	15504.6524911632	15535.9703439341	1374	0.932736486093206	15497.4501122427	15497.5551450655	15539.2888224679	1372	0.920054816951692	15506.9265055828	15507.9641995961	15642.9023138147	1354	0.936267864505837	3.31097253795055e-85	1.73753911413143e-85	3.98428236756217e-77	5.56243386375692e-83	2.9190657117408e-83	6.69359437750445e-75	non_linear_fixed	1.73753911413143e-85	2.9190657117408e-83	15497.5551450655	15539.2888224679	2
Cellular Senescence	185	38	28270.4706359981	28270.4811808136	28287.666428164	2277	NA	28057.1481585223	28057.1851140876	28091.5397428539	2274	0.954331589083724	28046.6529826559	28046.7163908461	28092.5084284315	2272	0.95127500180364	27963.8236974955	27964.4468666033	28112.8538962661	2254	NA	2.81305074441085e-47	1.62493745510459e-48	9.13947092743893e-61	4.72592525061023e-45	2.72989492457572e-46	1.53543111580974e-58	non_linear_mixed	9.13947092743893e-61	1.53543111580974e-58	27964.4468666033	28112.8538962661	2
Glycosaminoglycan metabolism	118	28	18883.5790802677	18883.5934000767	18899.8587274849	1677	NA	18423.0222210992	18423.0724303042	18455.5815155335	1674	0.926444731793211	18418.1257001273	18418.2118760699	18461.5380927065	1672	0.912898847969278	18322.2425989521	18323.0919637434	18463.3328748344	1654	0.93205323223518	8.42918355155476e-101	1.58426716150804e-100	1.32878903829385e-113	1.4161028366612e-98	2.6615688313335e-98	2.23236558433367e-111	non_linear_mixed	1.32878903829385e-113	2.23236558433367e-111	18323.0919637434	18463.3328748344	2
Signaling by NTRKs	126	25	17298.0417279852	17298.057770766	17313.9813891465	1497	NA	16905.1158134012	16905.1720759598	16936.9951357237	1494	0.934705490023431	16899.5838525718	16899.6804320487	16942.0896156686	1492	0.923682924406255	16913.7301747443	16914.6833315671	17051.8739048086	1474	NA	3.78276259086004e-86	4.45887056445219e-86	9.97781423846352e-77	6.35504115264486e-84	7.49090254827967e-84	1.67627279206187e-74	non_linear_fixed	4.45887056445219e-86	7.49090254827967e-84	16899.6804320487	16942.0896156686	2
BCR	128	33	23434.1678715292	23434.1800172782	23450.9404279003	1977	NA	23133.3631216699	23133.4056964292	23166.9082344121	1974	0.960672394055219	23129.5165411492	23129.5896005099	23174.2433581387	1972	0.957463281600196	23112.7829567145	23113.5018507237	23258.1451119304	1954	NA	3.34946035651091e-66	7.07993078463379e-66	8.83536622375111e-64	5.62709339893833e-64	1.18942837181848e-63	1.48434152559019e-61	non_linear_mixed	8.83536622375111e-64	1.48434152559019e-61	23113.5018507237	23258.1451119304	4
Signaling by NOTCH1	73	24	16067.4401163612	16067.4568294531	16083.2573115389	1437	NA	16002.7331495568	16002.7917678401	16034.3675399122	1434	0.864413891454963	15995.0240042582	15995.1246331891	16037.2031913988	1432	0.860402105963118	16009.0571288829	16010.0507594561	16146.1394870897	1414	0.836122014275515	3.01207157777138e-15	2.61888353653623e-16	2.44271475916501e-12	5.06028025065592e-13	4.39972434138086e-14	4.10376079539722e-10	non_linear_fixed	2.61888353653623e-16	4.39972434138086e-14	15995.1246331891	16037.2031913988	3
Nucleotide Excision Repair	96	24	15915.0212857242	15915.0379988161	15930.8384809019	1437	NA	15906.1513926324	15906.2100109157	15937.7857829878	1434	0.940271668021605	15890.5400077564	15890.6406366872	15932.719194897	1432	0.938451599420542	15905.0877629062	15906.0813934794	16042.170121113	1414	NA	0.00193127830913588	1.90937178266408e-06	0.000144600376692747	0.324454755934829	0.000320774459487566	0.0242928632843815	non_linear_fixed	1.90937178266408e-06	0.000320774459487566	15890.6406366872	15932.719194897	2
TGF_beta_Receptor	172	46	32785.915927035	32785.9246353079	32803.6848849112	2757	NA	32147.2790652217	32147.3095773902	32182.8169809739	2754	0.924871878176399	32141.799353728	32141.85169833	32189.1832413977	2752	0.912245294283117	31914.8523300675	31915.366051253	32068.849964994	2734	NA	2.11911152934145e-139	4.08021150600256e-139	5.50885775072292e-179	3.56010736929364e-137	6.8547553300843e-137	9.25488102121451e-177	non_linear_mixed	5.50885775072292e-179	9.25488102121451e-177	31915.366051253	32068.849964994	2
Fibroblast growth factor-1	73	30	21979.8132345303	21979.8265975593	21996.299860362	1797	NA	21731.8730894492	21731.9199383058	21764.8463411125	1794	0.913703425644959	21730.7514058089	21730.8318078189	21774.71574136	1792	0.905967955398181	21725.3902660639	21726.1821442365	21868.2743566049	1774	0.906421779036379	9.19610892136712e-55	6.24283795524491e-54	3.75906035881944e-50	1.54494629878968e-52	1.04879677648114e-51	6.31522140281667e-48	non_linear_mixed	3.75906035881944e-50	6.31522140281667e-48	21726.1821442365	21868.2743566049	2
Anchoring of the basal body to the plasma membrane	96	35	23120.6410279221	23120.6524783038	23137.5901057933	2097	NA	22805.2623703463	22805.3025041255	22839.1605260885	2094	0.937735060135927	22783.0176345278	22783.0865010988	22828.2151755175	2092	0.928071544894721	22742.0423653591	22742.7196446645	22888.9343735756	2074	0.936144733293555	2.34587507664264e-69	5.68544006644563e-73	1.50981824731423e-75	3.94107012875963e-67	9.55153931162865e-71	2.5364946554879e-73	non_linear_mixed	1.50981824731423e-75	2.5364946554879e-73	22742.7196446645	22888.9343735756	2
O-linked glycosylation	114	24	13713.873731924	13713.890445016	13729.6909271017	1437	NA	13465.4453873818	13465.5040056651	13497.0797777372	1434	0.878683236368483	13460.1647963033	13460.2654252342	13502.3439834439	1432	0.858801284784747	13461.7748317591	13462.7684623323	13598.8571899659	1414	NA	7.21118706002828e-55	6.2772505886434e-55	1.10810532918445e-49	1.21147942608475e-52	1.05457809889209e-52	1.86161695302987e-47	non_linear_fixed	6.2772505886434e-55	1.05457809889209e-52	13460.2654252342	13502.3439834439	3
G2/M DNA damage checkpoint	94	23	15568.901228027	15568.9186698875	15584.5907443615	1377	NA	15361.0830581296	15361.1442380277	15392.4620907985	1374	0.947598191278395	15349.461263702	15349.5662965248	15391.2999739272	1372	0.939760316642895	15279.0760343263	15280.1137283396	15415.0518425582	1354	NA	4.35465532297536e-46	1.41004589064525e-47	2.46715539327318e-57	7.3158209425986e-44	2.36887709628402e-45	4.14482106069894e-55	non_linear_mixed	2.46715539327318e-57	4.14482106069894e-55	15280.1137283396	15415.0518425582	2
Signaling by NOTCH	188	37	24930.4319614608	24930.4427917857	24947.5477488854	2217	NA	24600.2736593325	24600.3116168562	24634.5052341817	2214	0.879983338682832	24594.5171425102	24594.5822714112	24640.1592423092	2212	0.862850468995171	24579.3145082136	24579.9547270919	24727.6513325601	2194	0.876619217040318	1.48132506199629e-72	1.32612673291015e-72	6.96333127677158e-70	2.48862610415376e-70	2.22789291128905e-70	1.16983965449762e-67	non_linear_mixed	6.96333127677158e-70	1.16983965449762e-67	24579.9547270919	24727.6513325601	2
Ion channel transport	164	31	24451.9940478862	24452.0069789207	24468.5790431863	1857	NA	23592.1906338811	23592.2359657753	23625.3606244813	1854	0.955922703273797	23585.8835824672	23585.9613782532	23630.1102366008	1852	0.944489135983386	23581.1577654031	23581.9237228499	23724.8943913375	1834	NA	2.31381106316514e-187	3.93706918063828e-187	6.15593922588783e-179	3.88720258611743e-185	6.61427622347231e-185	1.03419778994916e-176	non_linear_mixed	6.15593922588783e-179	1.03419778994916e-176	23581.9237228499	23724.8943913375	2
SUMO E3 ligases SUMOylate target proteins	176	50	37384.6001754458	37384.6081861267	37402.6192781488	2997	NA	37035.9907861952	37036.0188516814	37072.0289916011	2994	0.946476639518684	37026.6983464981	37026.7464909314	37074.7492870393	2992	0.942547060400725	36900.1862216703	36900.6584719226	37056.3517784292	2974	0.946728054296702	1.49824990519578e-76	2.44391546848057e-77	1.62803515681753e-97	2.51705984072891e-74	4.10577798704736e-75	2.73509906345345e-95	non_linear_mixed	1.62803515681753e-97	2.73509906345345e-95	36900.6584719226	37056.3517784292	4
Neurotransmitter receptors and postsynaptic signal transmission	184	24	18014.2011483545	18014.2178614464	18030.0183435322	1437	NA	17884.6540232527	17884.712641536	17916.2884136081	1434	0.963638810180924	17882.5111220842	17882.611751015	17924.6903092248	1432	0.961688167548102	17832.2495188457	17833.243149419	17969.3318770526	1414	0.963834948024287	3.447230059483e-29	7.82333406599042e-29	1.15743608549111e-35	5.79134649993144e-27	1.31432012308639e-26	1.94449262362507e-33	non_linear_mixed	1.15743608549111e-35	1.94449262362507e-33	17833.243149419	17969.3318770526	2
mRNA Splicing	184	46	33685.3408453963	33685.3495536692	33703.1098032725	2757	NA	33396.9766917118	33397.0072038803	33432.5146074641	2754	0.910027991240024	33382.7264943904	33382.7788389923	33430.11038206	2752	0.900483267071293	33365.4732485884	33365.9869697739	33519.4708835148	2734	NA	1.65001022069118e-63	1.94155351208365e-65	1.80693054638313e-63	2.77201717076118e-61	3.26180990030054e-63	3.03564331792365e-61	non_linear_mixed	1.80693054638313e-63	3.03564331792365e-61	33365.9869697739	33519.4708835148	4
Intra-Golgi and retrograde Golgi-to-ER traffic	185	43	30208.2846162494	30208.2939330196	30225.8512502831	2577	NA	29665.7074489481	29665.740095664	29700.8407170156	2574	0.961241088610566	29663.0165503762	29663.0725597111	29709.8609077995	2572	0.955286101865141	29636.1729153916	29636.7228566372	29788.4170770174	2554	NA	1.41361165664408e-118	9.31083529056241e-118	7.3041958160182e-116	2.37486758316205e-116	1.56422032881449e-115	1.22710489709106e-113	non_linear_mixed	7.3041958160182e-116	1.22710489709106e-113	29636.7228566372	29788.4170770174	2
Cilium Assembly	177	53	34815.3246631635	34815.3322198385	34833.5185725908	3177	NA	34303.1313829406	34303.1578563097	34339.5192017953	3174	0.933561223792019	34278.7070544457	34278.7524659878	34327.2241462519	3172	0.92543749534622	34141.8986031398	34142.3438933396	34299.5791515099	3154	0.932310703300421	5.44227585007168e-112	6.87416566302107e-116	3.57650164966895e-137	9.14302342812043e-110	1.15485983138754e-113	6.00852277144383e-135	non_linear_mixed	3.57650164966895e-137	6.00852277144383e-135	34142.3438933396	34299.5791515099	2
C-type lectin receptors (CLRs)	83	22	15109.5869212342	15109.6051583163	15125.143082281	1317	NA	14771.8800794706	14771.944055099	14802.9924015641	1314	0.955280457232762	14770.1054906149	14770.2153304319	14811.5885867396	1312	0.94718043643489	14734.3853543657	14735.4712012335	14869.2054167708	1294	NA	3.43795238132169e-74	2.26333701134421e-73	7.58829627192908e-75	5.77576000062044e-72	3.80240617905827e-71	1.27483377368408e-72	non_linear_mixed	7.58829627192908e-75	1.27483377368408e-72	14735.4712012335	14869.2054167708	2
IL2	75	27	19745.1400861091	19745.1549375943	19761.3106303938	1617	NA	19535.452267451	19535.5043443264	19567.7933560204	1614	0.953543440329916	19530.9904991688	19531.0798846437	19574.1119505946	1612	0.9493029810931	19534.5141470087	19535.3955029409	19674.6588641426	1594	0.951828417187116	1.71726712309198e-46	1.91849574717656e-46	2.35751918985514e-41	2.88500876679453e-44	3.22307285525662e-44	3.96063223895663e-39	non_linear_fixed	1.91849574717656e-46	3.22307285525662e-44	19531.0798846437	19574.1119505946	2
Notch	77	23	16872.5497917911	16872.5672336516	16888.2393081256	1377	NA	16772.3272190549	16772.3883989529	16803.7062517238	1374	0.950900600170119	16765.216102914	16765.3211357368	16807.0548131392	1372	0.947383972887441	16764.7525370267	16765.79023104	16900.7283452586	1354	NA	7.13086438576081e-23	1.15165418425904e-23	2.47018917392287e-21	1.19798521680782e-20	1.93477902955518e-21	4.14991781219042e-19	non_linear_fixed	1.15165418425904e-23	1.93477902955518e-21	16765.3211357368	16807.0548131392	2
Selenoamino acid metabolism	127	27	21868.6129374107	21868.6277888959	21884.7834816954	1617	NA	21850.6354912615	21850.6875681369	21882.9765798309	1614	0.919861281818591	21818.8580797334	21818.9474652083	21861.9795311592	1612	0.917126886227188	21817.1087864319	21817.9901423641	21957.2535035657	1594	NA	2.52522800876403e-05	1.36581554383133e-11	3.78497469707028e-11	0.00424238305472358	2.29457011363663e-09	6.35875749107808e-09	non_linear_mixed	3.78497469707028e-11	6.35875749107808e-09	21817.9901423641	21957.2535035657	2
Toll Like Receptor 4 (TLR4) Cascade	111	31	22923.2349329544	22923.2478639889	22939.8199282545	1857	NA	22419.5688173445	22419.6141492387	22452.7388079447	1854	0.952537190906466	22415.6042507611	22415.6820465472	22459.8309048948	1852	0.942114364130046	22409.1767909732	22409.94274842	22552.9134169075	1834	NA	3.83567456546911e-110	1.2482136454853e-109	1.05090089660669e-103	6.4439332699881e-108	2.0969989244153e-107	1.76551350629925e-101	non_linear_mixed	1.05090089660669e-103	1.76551350629925e-101	22409.94274842	22552.9134169075	2
Transport to the Golgi and subsequent modification	166	44	31467.6228658532	31467.6319705573	31485.2584684416	2637	NA	30792.8614441967	30792.8933469692	30828.1326493736	2634	0.940789049676909	30785.464483246	30785.5192152871	30832.4927568151	2632	0.929033535911876	30765.4059797783	30765.9432932111	30918.247868878	2614	NA	3.11608736248337e-147	2.43626727456399e-147	3.02026294987102e-143	5.23502676897206e-145	4.09292902126751e-145	5.07404175578332e-141	non_linear_mixed	3.02026294987102e-143	5.07404175578332e-141	30765.9432932111	30918.247868878	2
Phase II - Conjugation of compounds	110	24	14930.9576278616	14930.9743409535	14946.7748230393	1437	NA	14758.8245226063	14758.8831408896	14790.4589129617	1434	0.91466857028913	14752.8495122034	14752.9501411342	14795.028699344	1432	0.908602264934879	14743.6323678123	14744.6259983855	14880.7147260191	1414	NA	2.23160785223733e-38	9.91241415481093e-39	1.00434962787027e-36	3.74910119175871e-36	1.66528557800824e-36	1.68730737482205e-34	non_linear_mixed	1.00434962787027e-36	1.68730737482205e-34	14744.6259983855	14880.7147260191	2
Clathrin-mediated endocytosis	141	34	24953.0393389847	24953.0511268039	24969.9014542452	2037	NA	24038.6777404695	24038.7190587184	24072.4019709905	2034	0.955464179680435	24034.7389284806	24034.8098295145	24079.7045691753	2032	0.944037812461324	23991.3074783713	23992.0049448393	24137.4458106291	2014	NA	3.39163117111486e-199	1.99471779749828e-198	3.03190479125801e-198	5.69794036747296e-197	3.35112589979711e-196	5.09360004931346e-196	non_linear_mixed	3.03190479125801e-198	5.09360004931346e-196	23992.0049448393	24137.4458106291	2
Host Interactions of HIV factors	88	21	15352.9420231971	15352.9611314773	15368.3586241969	1257	NA	15268.2894265735	15268.3564656796	15299.1226285731	1254	0.943006951924816	15261.6783280464	15261.7934359601	15302.789264046	1252	0.938928046979849	15251.1784861393	15252.3171722707	15384.7890281379	1234	0.945046880425791	1.58629091247303e-19	2.86199581105343e-20	3.33541426306624e-20	2.66496873295469e-17	4.80815296256977e-18	5.60349596195128e-18	non_linear_mixed	3.33541426306624e-20	5.60349596195128e-18	15252.3171722707	15384.7890281379	2
HIV Infection	191	42	30606.2456653727	30606.2552043234	30623.7417079142	2517	NA	30447.051197649	30447.0846238328	30482.043282732	2514	0.934810287443301	30433.082133436	30433.1394811062	30479.73824688	2512	0.930128061812006	30399.8287232277	30400.391900123	30551.4610919208	2494	NA	1.38682112386183e-35	1.1290555787226e-37	1.6279833686882e-40	2.32985948808787e-33	1.89681337225397e-35	2.73501205939618e-38	non_linear_mixed	1.6279833686882e-40	2.73501205939618e-38	30400.391900123	30551.4610919208	3
Interferon Signaling	161	35	24145.3472146624	24145.3586650441	24162.2962925336	2097	NA	23909.7440437532	23909.7841775324	23943.6421994954	2094	0.927160061114599	23904.6878322132	23904.7566987842	23949.8853732029	2092	0.918698317250163	23903.8304027397	23904.5076820451	24050.7224109562	2074	0.925953562772222	4.28366926249212e-52	3.96861356814937e-52	1.50947782374644e-47	7.19656436098676e-50	6.66727079449095e-50	2.53592274389403e-45	non_linear_mixed	1.50947782374644e-47	2.53592274389403e-45	23904.5076820451	24050.7224109562	2
G2/M Transition	137	57	37854.6734772125	37854.6805029736	37873.0856647027	3417	NA	37503.0208915949	37503.0455033734	37539.8452665752	3414	0.934182728305956	37444.3651853109	37444.4074016698	37493.4643519514	3412	0.927500555937455	37380.3702802038	37380.7840733072	37539.9425717853	3394	0.930347306449591	3.28554787073504e-77	1.24302805683108e-88	2.08818145090282e-95	5.51972042283488e-75	2.08828713547621e-86	3.50814483751673e-93	non_linear_mixed	2.08818145090282e-95	3.50814483751673e-93	37380.7840733072	37539.9425717853	2
Mitotic G2-G2/M phases	139	57	37854.6734772125	37854.6805029736	37873.0856647027	3417	NA	37503.0208915949	37503.0455033734	37539.8452665752	3414	0.934182728305956	37444.3651853109	37444.4074016698	37493.4643519514	3412	0.927500555937455	37380.3702802038	37380.7840733072	37539.9425717853	3394	0.930347306449591	3.28554787073504e-77	1.24302805683108e-88	2.08818145090282e-95	5.51972042283488e-75	2.08828713547621e-86	3.50814483751673e-93	non_linear_mixed	2.08818145090282e-95	3.50814483751673e-93	37380.7840733072	37539.9425717853	2
AndrogenReceptor	141	41	32384.8822668186	32384.8920388055	32402.3060167053	2457	NA	31985.0785775845	31985.1128213676	32019.9260773581	2454	0.917568163319437	31975.6782290854	31975.7369806154	32022.1415621168	2452	0.910105276546813	31939.6249539235	31940.2020192749	32090.6307862756	2434	0.91763697774606	1.22465243989613e-87	2.15060708383224e-88	2.32340844421344e-89	2.05741609902551e-85	3.61301990083817e-86	3.90332618627858e-87	non_linear_mixed	2.32340844421344e-89	3.90332618627858e-87	31940.2020192749	32090.6307862756	3
mTOR signaling pathway	63	22	15570.0778373816	15570.0960744636	15585.6339984283	1317	NA	15368.6328523032	15368.6968279316	15399.7451743967	1314	0.922127314341331	15366.7572050385	15366.8670448554	15408.2403011631	1312	0.912666085261079	15380.5564184831	15381.6422653509	15515.3764808882	1294	NA	1.03839833107141e-44	4.00381989351041e-44	3.69252595629751e-37	1.74450919619996e-42	6.72641742109749e-42	6.20344360657981e-35	non_linear_fixed	4.00381989351041e-44	6.72641742109749e-42	15366.8670448554	15408.2403011631	2
ErbB1 downstream signaling	105	31	21921.5038992317	21921.5168302662	21938.0888945318	1857	NA	21650.5502482477	21650.595580142	21683.720238848	1854	0.962686394360707	21644.6345107426	21644.7123065286	21688.8611648762	1852	0.959528077421336	21629.4885981463	21630.2545555931	21773.2252240807	1834	NA	9.66011135835111e-60	6.65246586647643e-60	8.83238428792341e-58	1.62289870820299e-57	1.11761426556804e-57	1.48384056037113e-55	non_linear_mixed	8.83238428792341e-58	1.48384056037113e-55	21630.2545555931	21773.2252240807	2
CDC42 signaling events	70	23	16282.6885568211	16282.7059986815	16298.3780731555	1377	NA	15873.2515187639	15873.3126986619	15904.6305514328	1374	0.955387952402328	15868.6947545367	15868.7997873595	15910.5334647619	1372	0.944603218835892	15863.6434387689	15864.6811327822	15999.6192470008	1354	0.954184395448834	1.00283090180878e-89	1.9945409871153e-89	6.44272551274715e-84	1.68475591503875e-87	3.35082885835371e-87	1.08237788614152e-81	non_linear_mixed	6.44272551274715e-84	1.08237788614152e-81	15864.6811327822	15999.6192470008	2
Regulation of Telomerase	67	20	15477.239826748	15477.2598936376	15492.5100572553	1197	NA	15217.0647726253	15217.1351833546	15247.60523364	1194	0.914542521818921	15218.5221704023	15218.6430772033	15259.2427850885	1192	0.89733653722758	15186.4778516708	15187.6747826171	15318.819849401	1174	NA	2.07475891673223e-57	5.27600108012538e-56	1.59001101027283e-57	3.48559498011014e-55	8.86368181461064e-54	2.67121849725836e-55	non_linear_mixed	1.59001101027283e-57	2.67121849725836e-55	15187.6747826171	15318.819849401	5
PDGFR-beta signaling pathway	126	34	23258.9648454661	23258.9766332854	23275.8269607266	2037	NA	22796.81444268	22796.8557609289	22830.538673201	2034	0.937874469811634	22793.1945944866	22793.2654955206	22838.1602351813	2032	0.927272808142575	22791.4214764242	22792.1189428922	22937.559808682	2014	NA	3.80617869600708e-101	1.35348356340021e-100	5.34873845095997e-94	6.3943802092919e-99	2.27385238651234e-98	8.98588059761275e-92	non_linear_mixed	5.34873845095997e-94	8.98588059761275e-92	22792.1189428922	22937.559808682	3
Signaling events mediated by VEGFR1 and VEGFR2	67	23	16602.3308640161	16602.3483058766	16618.0203803506	1377	NA	16243.4073097943	16243.4684896923	16274.7863424632	1374	0.934902298582263	16243.3368594997	16243.4418923224	16285.1755697249	1372	0.923065955764225	16227.7380868315	16228.7757808448	16363.7138950634	1354	NA	8.75151608941326e-79	1.42181751456765e-77	1.0133936129535e-74	1.47025470302143e-76	2.38865342447366e-75	1.70250126976188e-72	non_linear_mixed	1.0133936129535e-74	1.70250126976188e-72	16228.7757808448	16363.7138950634	5
Direct p53 effectors	141	33	26048.082827825	26048.0949735739	26064.855384196	1977	NA	25589.4746730009	25589.5172477602	25623.019785743	1974	0.948429673512026	25576.3972586056	25576.4703179663	25621.1240755951	1972	0.942535796885478	25505.5450223976	25506.2639164068	25650.9071776135	1954	0.946963973734666	2.22862135145851e-100	7.16100407457881e-102	1.15518804336527e-109	3.7440838704503e-98	1.20304868452924e-99	1.94071591285365e-107	non_linear_mixed	1.15518804336527e-109	1.94071591285365e-107	25506.2639164068	25650.9071776135	4
Autophagy	112	27	20082.3710074507	20082.3858589358	20098.5415517354	1617	NA	19678.4272960553	19678.4793729307	19710.7683846247	1614	0.949859938287889	19676.8262157726	19676.9156012474	19719.9476671984	1612	0.940301168595728	19684.0947044011	19684.9760603333	19824.239421535	1594	NA	1.55314445941864e-88	1.32273284844792e-87	1.29292154137562e-79	2.60928269182331e-86	2.22219118539251e-85	2.17210818951104e-77	non_linear_fixed	1.32273284844792e-87	2.22219118539251e-85	19676.9156012474	19719.9476671984	2
Programmed Cell Death	141	36	25539.6889581711	25539.7000898965	25556.7225486731	2157	NA	25075.825898556	25075.8649138834	25109.8930795601	2154	0.94262868294915	25067.5561673611	25067.6231129678	25112.9790753665	2152	0.932447218652538	25017.0686719658	25017.7268998139	25164.6931229834	2134	0.9457681679069	1.61949667054287e-101	5.73407057454819e-102	1.70313851247566e-105	2.72075440651202e-99	9.63323856524097e-100	2.8612727009591e-103	non_linear_mixed	1.70313851247566e-105	2.8612727009591e-103	25017.7268998139	25164.6931229834	3
Estrogen-dependent gene expression	141	26	21624.8757021394	21624.891126304	21640.9330254402	1557	NA	21000.4441327539	21000.4982216141	21032.5587793553	1554	0.831074432425648	20974.5750854235	20974.6679287504	21017.3946142255	1552	0.829659292422531	20476.2315068337	20477.1473581057	20615.39497544	1534	0.852797160447076	2.54665661521386e-136	1.87908277301906e-140	4.66296543894599e-238	4.27838311355929e-134	3.15685905867203e-138	7.83378193742927e-236	non_linear_mixed	4.66296543894599e-238	7.83378193742927e-236	20477.1473581057	20615.39497544	2
Muscle contraction	173	21	14581.3989000566	14581.4180083369	14596.8155010565	1257	NA	14423.1859845484	14423.2530236545	14454.0191865481	1254	0.944556662295794	14422.1431361083	14422.2582440219	14463.2540721078	1252	0.939161988388725	14434.8092068252	14435.9478929566	14568.4197488238	1234	0.943650468661114	2.25882791072006e-35	1.05168716294662e-34	9.5834937952882e-29	3.79483089000971e-33	1.76683443375032e-32	1.61002695760842e-26	non_linear_fixed	1.05168716294662e-34	1.76683443375032e-32	14422.2582440219	14463.2540721078	2
Metabolism of water-soluble vitamins and cofactors	110	21	14988.4365839277	14988.4556922079	15003.8531849275	1257	NA	14968.4684653276	14968.5355044338	14999.3016673273	1254	0.941022238763199	14964.2496752508	14964.3647831645	15005.3606112504	1252	0.940451701367573	14971.1655847193	14972.3042708507	15104.7761267179	1234	NA	9.68512663699892e-06	2.18545531631811e-06	1.26881961202318e-05	0.00162710127501582	0.000367156493141442	0.00213161694819894	non_linear_fixed	2.18545531631811e-06	0.000367156493141442	14964.3647831645	15005.3606112504	2
RHOA GTPase cycle	148	40	27846.5868756107	27846.5968923052	27863.9365476597	2397	NA	27125.308384164	27125.3434865459	27160.007728262	2394	0.939776725448279	27117.4298736036	27117.4900994506	27163.6956657343	2392	0.925651330920276	27086.7816926309	27087.3733487624	27237.1455170556	2374	0.9415353031913	2.55192869751571e-157	1.6741011687277e-157	2.05182934858723e-155	4.28724021182639e-155	2.81248996346254e-155	3.44707330562655e-153	non_linear_mixed	2.05182934858723e-155	3.44707330562655e-153	27087.3733487624	27237.1455170556	5
RHOC GTPase cycle	73	20	13310.8390793417	13310.8591462313	13326.109309849	1197	NA	13155.216422735	13155.2868334643	13185.7568837497	1194	0.891151195264028	13154.935268288	13155.056175089	13195.6558829742	1192	0.870740052004327	13154.1895500617	13155.386481008	13286.5315477919	1174	NA	8.18351360642452e-35	5.45604345726667e-34	1.0633437980091e-30	1.37483028587932e-32	9.166153008208e-32	1.78641758065529e-28	non_linear_fixed	5.45604345726667e-34	9.166153008208e-32	13155.056175089	13195.6558829742	2
Metabolism of vitamins and cofactors	179	37	26111.8942527908	26111.9050831157	26129.0100402154	2217	NA	25961.8337911165	25961.8717486402	25996.0653659657	2214	0.938011996418746	25958.1219483451	25958.1870772461	26003.764048144	2212	0.935259884247508	25948.2332671313	25948.8734860095	26096.5700914778	2194	NA	1.29790954026394e-33	1.55384010241118e-33	4.5459493744115e-32	2.18048802764341e-31	2.61045137205077e-31	7.63719494901133e-30	non_linear_mixed	4.5459493744115e-32	7.63719494901133e-30	25948.8734860095	26096.5700914778	5
Toll-like Receptor Cascades	129	35	25755.6301085912	25755.6415589729	25772.5791864624	2097	NA	25253.4715626325	25253.5116964118	25287.3697183748	2094	0.952651104371423	25244.7267148305	25244.7955814016	25289.9242558202	2092	0.944446382667583	25224.6598098464	25225.3370891518	25371.5518180629	2074	NA	8.13889775229946e-110	2.45311901879246e-110	3.05003800383533e-107	1.36733482238631e-107	4.12123995157133e-108	5.12406384644336e-105	non_linear_mixed	3.05003800383533e-107	5.12406384644336e-105	25225.3370891518	25371.5518180629	3
RAC1 GTPase cycle	184	48	33444.7510713131	33444.7594162366	33462.6477080325	2877	NA	32699.5540133009	32699.5832510315	32735.3472867397	2874	0.943420098646111	32693.4619471418	32693.5121038816	32741.1863117268	2872	0.93287758817135	32614.2756345794	32614.7677481441	32769.3798194808	2854	0.946803110765104	1.65968408272923e-162	2.73539881937421e-162	2.23208670571914e-170	2.78826925898511e-160	4.59547001654867e-160	3.74990566560815e-168	non_linear_mixed	2.23208670571914e-170	3.74990566560815e-168	32614.7677481441	32769.3798194808	4
RAC3 GTPase cycle	93	30	21827.1614176994	21827.1747807283	21843.648043531	1797	NA	21349.6626687377	21349.7095175943	21382.635920401	1794	0.935278938218674	21345.6873165457	21345.7677185558	21389.6516520968	1792	0.921578451730334	21310.588035249	21311.3799134216	21453.47212579	1774	0.937482886483549	1.79727221744904e-104	5.52678996796415e-104	3.13143105374709e-104	3.01941732531438e-102	9.28500714617977e-102	5.26080417029511e-102	non_linear_mixed	3.13143105374709e-104	5.26080417029511e-102	21311.3799134216	21453.47212579	5
Extension of Telomeres	50	22	12504.6959873506	12504.7142244327	12520.2521483974	1317	NA	12433.4992678866	12433.5632435149	12464.6115899801	1314	0.914476944497829	12388.485994176	12388.595833993	12429.9690903007	1312	0.908871670797068	12355.0381373234	12356.1239841911	12489.8581997285	1294	NA	1.22519498425828e-16	1.5156162466525e-25	2.43525589992354e-29	2.05832757355391e-14	2.5462352943762e-23	4.09122991187155e-27	non_linear_mixed	2.43525589992354e-29	4.09122991187155e-27	12356.1239841911	12489.8581997285	2
SUMOylation	181	52	38776.1916409261	38776.1993431084	38794.3284057685	3117	NA	38413.0902172216	38413.1172008387	38449.3637469064	3114	0.946418014039764	38403.815241258	38403.8615286254	38452.1799475044	3112	0.942596400646372	38271.3838833807	38271.8378116057	38428.5691786816	3094	0.944065141463457	1.08975536197336e-79	1.86199318573215e-80	9.00724677022154e-102	1.83078900811525e-77	3.12814855203002e-78	1.51321745739722e-99	non_linear_mixed	9.00724677022154e-102	1.51321745739722e-99	38271.8378116057	38428.5691786816	4
RHOG GTPase cycle	73	24	17513.5743378129	17513.5910509048	17529.3915329906	1437	NA	17050.613354218	17050.6719725014	17082.2477445735	1434	0.942477273304304	17043.6960749548	17043.7967038856	17085.8752620953	1432	0.928567429214131	17050.3768611369	17051.3704917102	17187.4592193438	1414	NA	2.54008266090998e-101	1.75787034674666e-101	4.2988507006796e-93	4.26733887032876e-99	2.95322218253439e-99	7.22206917714173e-91	non_linear_fixed	1.75787034674666e-101	2.95322218253439e-99	17043.7967038856	17085.8752620953	2
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	80	26	18448.1857961416	18448.2012203061	18464.2431194423	1557	NA	17972.9372661251	17972.9913549854	18005.0519127266	1554	0.938085402458036	17961.3691397851	17961.461983112	18004.188668587	1552	0.925019299883242	17956.8715261536	17957.7873774256	18096.0349947599	1534	0.941395136437628	5.52374855755931e-104	3.88478202125923e-105	5.91551003094066e-99	9.27989757669965e-102	6.52643379571551e-103	9.93805685198031e-97	non_linear_mixed	5.91551003094066e-99	9.93805685198031e-97	17957.7873774256	18096.0349947599	2
Telomere Maintenance	103	25	15029.673554023	15029.6895968038	15045.6132151843	1497	NA	14946.03018165	14946.0864442086	14977.9095039725	1494	0.933311406189745	14900.5066983264	14900.6032778032	14943.0124614231	1492	0.930494961990957	14818.5313835243	14819.4845403471	14956.6751135886	1474	NA	2.61308951924007e-19	2.68999647045266e-28	1.85970741682171e-41	4.38999039232331e-17	4.51919407036047e-26	3.12430846026047e-39	non_linear_mixed	1.85970741682171e-41	3.12430846026047e-39	14819.4845403471	14956.6751135886	3
CDC42 GTPase cycle	159	40	27898.4859482445	27898.495964939	27915.8356202935	2397	NA	27127.9264570932	27127.9615594752	27162.6258011912	2394	0.949688343498728	27115.1481504408	27115.2083762877	27161.4139425715	2392	0.938798405023202	27097.0454925564	27097.6371486878	27247.4093169811	2374	0.951048492307891	5.2460770827403e-168	3.1954596187274e-169	3.16460777641874e-164	8.81340949900371e-166	5.36837215946203e-167	5.31654106438349e-162	non_linear_mixed	3.16460777641874e-164	5.31654106438349e-162	27097.6371486878	27247.4093169811	2
RHOJ GTPase cycle	55	22	16064.2604269707	16064.2786640528	16079.8165880174	1317	NA	15623.3388868113	15623.4028624396	15654.4512089048	1314	0.946812056493041	15618.9440972989	15619.0539371158	15660.4271934235	1312	0.935073916643972	15626.1212784785	15627.2071253462	15760.9413408836	1294	NA	1.51441479357319e-96	3.50317822401619e-96	7.00713308142285e-88	2.54421685320296e-94	5.8853394163472e-94	1.17719835767904e-85	non_linear_fixed	3.50317822401619e-96	5.8853394163472e-94	15619.0539371158	15660.4271934235	2
mRNA Splicing - Major Pathway	176	43	31628.4509450638	31628.460261834	31646.0175790976	2577	NA	31366.5032617305	31366.5359084464	31401.636529798	2574	0.909178477963902	31351.8061585855	31351.8621679204	31398.6505160088	2572	0.89943202005982	31339.1380398987	31339.6879811443	31491.3822015245	2554	NA	8.57979182295652e-58	7.43442984049903e-60	3.13704437096218e-57	1.4414050262567e-55	1.24898421320384e-57	5.27023454321647e-55	non_linear_mixed	3.13704437096218e-57	5.27023454321647e-55	31339.6879811443	31491.3822015245	4
Apoptosis	126	32	22501.1664448968	22501.1789709929	22517.8466862919	1917	NA	22033.3531599474	22033.3970700363	22066.7136427376	1914	0.943985423178471	22026.8566414761	22026.9319946943	22071.3372851963	1912	0.93316438513761	21967.7929050555	21968.5345849287	22112.354997146	1894	NA	2.25636749728052e-102	1.94380867356462e-102	9.57933007135043e-108	3.79069739543127e-100	3.26559857158857e-100	1.60932745198687e-105	non_linear_mixed	9.57933007135043e-108	1.60932745198687e-105	21968.5345849287	22112.354997146	3
Mitochondrial translation elongation	87	20	12576.6311608277	12576.6512277173	12591.901391335	1197	NA	12469.3722857955	12469.4426965248	12499.9127468102	1194	0.924593137380813	12454.105334382	12454.226241183	12494.8259490682	1192	0.919113851130144	12437.640575159	12438.8375061052	12569.9825728891	1174	NA	2.18227233783106e-24	6.92541117968521e-27	2.81971867326243e-27	3.66621752755617e-22	1.16346907818712e-24	4.73712737108087e-25	non_linear_mixed	2.81971867326243e-27	4.73712737108087e-25	12438.8375061052	12569.9825728891	5
Macroautophagy	105	26	19315.1296602157	19315.1450843803	19331.1869835165	1557	NA	18945.419707646	18945.4737965063	18977.5343542475	1554	0.950715161106466	18944.1024798129	18944.1953231398	18986.9220086148	1552	0.941448245848938	18955.1945752918	18956.1104265638	19094.3580438981	1534	0.951608933777487	4.0377382596307e-81	3.63635837345914e-80	1.06590122795301e-71	6.78340027617957e-79	6.10908206741135e-78	1.79071406296106e-69	non_linear_fixed	3.63635837345914e-80	6.10908206741135e-78	18944.1953231398	18986.9220086148	2
Mitochondrial translation termination	87	21	13152.6969076684	13152.7160159487	13168.1135086683	1257	NA	13038.7308974689	13038.7979365751	13069.5640994686	1254	0.924744912050409	13023.5072313995	13023.6223393131	13064.618167399	1252	0.919349364805572	13003.7840123379	13004.9226984693	13137.3945543365	1234	NA	7.84796357257127e-26	2.66012213383772e-28	3.39710330820244e-29	1.31845788019197e-23	4.46900518484736e-26	5.7071335577801e-27	non_linear_mixed	3.39710330820244e-29	5.7071335577801e-27	13004.9226984693	13137.3945543365	5
Mitochondrial translation	93	22	13727.0048274689	13727.0230645509	13742.5609885156	1317	NA	13604.7357920402	13604.7997676685	13635.8481141337	1314	0.924705892890507	13589.6718930327	13589.7817328496	13631.1549891573	1312	0.919413306676812	13566.5386593517	13567.6245062195	13701.3587217568	1294	0.918121458230117	1.27667663315405e-27	4.93334031295478e-30	1.91460991104156e-31	2.1448167436988e-25	8.28801172576403e-28	3.21654465054981e-29	non_linear_mixed	1.91460991104156e-31	3.21654465054981e-29	13567.6245062195	13701.3587217568	5
p75 NTR receptor-mediated signalling	95	26	17668.1057944981	17668.1212186626	17684.1631177988	1557	NA	17578.9965142202	17579.0506030805	17611.1111608217	1554	0.9032538889378	17575.1978809196	17575.2907242465	17618.0174097215	1552	0.896164478275121	17587.437613891	17588.353465163	17726.6010824973	1534	0.897893278685485	1.74916206153836e-20	1.28801374834443e-20	2.58930889588542e-16	2.93859226338444e-18	2.16386309721865e-18	4.35003894508751e-14	non_linear_fixed	1.28801374834443e-20	2.16386309721865e-18	17575.2907242465	17618.0174097215	3
Death Receptor Signalling	133	37	24413.2745064442	24413.2853367691	24430.3902938688	2217	NA	24287.8151105777	24287.8530681014	24322.0466854269	2214	0.916471784612006	24281.9546500268	24282.0197789277	24327.5967498257	2212	0.910185364638324	24281.8315606811	24282.4717795593	24430.1683850276	2194	0.914461613951548	2.62154618293668e-28	9.37762820364402e-29	7.97092147651393e-26	4.40419758733363e-26	1.57544153821219e-26	1.33911480805434e-23	non_linear_fixed	9.37762820364402e-29	1.57544153821219e-26	24282.0197789277	24327.5967498257	3