Geneset	Geneset_Size	Genes	null_AIC	null_AICc	null_BIC	null_df	NA.	linear_AIC	linear_AICc	linear_BIC	linear_df	linear_ICC	non_linear_fixed_AIC	non_linear_fixed_AICc	non_linear_fixed_BIC	non_linear_fixed_df	non_linear_fixed_ICC	non_linear_mixed_AIC	non_linear_mixed_AICc	non_linear_mixed_BIC	non_linear_mixed_df	non_linear_mixed_ICC	p_value_linear	p_value_non_linear_fixed	p_value_non_linear_mixed	adjusted_linear_p_value	adjusted_non_linear_fixed_p_value	adjusted_non_linear_mixed_p_value	best_model	best_model_pvalue	best_model_adj_pvalue	best_model_aicc	best_model_bic	OptimalClusters
Platelet activation - Homo sapiens (human)	123	26	17012.25982739	17012.2783459085	17027.7701860203	1297	NA	16670.8327822011	16670.8977473983	16701.8534994618	1294	0.960115027511516	16658.5007658785	16658.6123073192	16699.8617222261	1292	0.949825196430507	16618.3948452516	16618.7686770273	16695.9466384034	1285	NA	5.38012363911297e-75	1.90695186433718e-76	6.20995664951217e-82	6.72515454889121e-73	2.38368983042147e-74	7.76244581189021e-80	non_linear_mixed	6.20995664951217e-82	7.76244581189021e-80	16618.7686770273	16695.9466384034	3
Focal adhesion - Homo sapiens (human)	200	37	23391.0405994553	23391.0536005387	23407.6094222095	1847	NA	22960.9169312489	22960.9625091111	22994.0545767573	1844	0.956953879472719	22947.6071351588	22947.6853535184	22991.7906625033	1842	0.95007736602985	22911.7732895659	22912.0350125757	22994.617403337	1835	0.958228141344476	3.30891817800425e-94	8.92552197353324e-96	4.4692593809702e-100	4.13614772250531e-92	1.11569024669165e-93	5.58657422621274e-98	non_linear_mixed	4.4692593809702e-100	5.58657422621274e-98	22912.0350125757	22994.617403337	2
Relaxin signaling pathway - Homo sapiens (human)	128	25	15233.3613429266	15233.3806045639	15248.7540394175	1247	NA	15054.7856031614	15054.8531816006	15085.5709961431	1244	0.936344359162271	15054.7550621688	15054.8710976241	15095.8022528112	1242	0.921988971883498	15062.5391071167	15062.928086047	15139.5025895712	1235	NA	9.06251707559659e-40	7.75727153437839e-39	3.81404762847868e-35	1.13281463444957e-37	9.69658941797299e-37	4.76755953559835e-33	linear	9.06251707559659e-40	1.13281463444957e-37	15054.8531816006	15085.5709961431	2
Oxytocin signaling pathway - Homo sapiens (human)	153	22	13193.6609578718	13193.682855682	13208.6701542482	1097	NA	13097.7313477022	13097.8082004012	13127.7497404549	1094	0.933586663129354	13098.2740980962	13098.4060870972	13138.2986217665	1092	0.931071432601355	13099.0242160424	13099.4670204705	13174.0701979242	1085	0.934858010760922	5.97800610314751e-22	3.86220956142892e-21	1.15520379683125e-19	7.47250762893439e-20	4.82776195178615e-19	1.44400474603906e-17	linear	5.97800610314751e-22	7.47250762893439e-20	13097.8082004012	13127.7497404549	2
Fc gamma R-mediated phagocytosis - Homo sapiens (human)	95	23	13197.2955539338	13197.3164963422	13212.4381055979	1147	NA	13123.9999315093	13124.0734223229	13154.2850348374	1144	0.93649520386009	13101.9446131116	13102.0708181949	13142.3247508825	1142	0.928715151280625	13054.9697447706	13055.3930251938	13130.6825030909	1135	0.939875433270751	4.34626208988383e-17	3.93022706365659e-21	2.69066356224785e-29	5.43282761235478e-15	4.91278382957073e-19	3.36332945280982e-27	non_linear_mixed	2.69066356224785e-29	3.36332945280982e-27	13055.3930251938	13130.6825030909	3
TGF-beta signaling pathway - Homo sapiens (human)	93	21	12239.7515405085	12239.7744850592	12254.621176838	1047	NA	12123.1782056053	12123.2587425181	12152.9174782642	1044	0.94546516550235	12115.028304876	12115.1666334062	12154.6806684212	1042	0.935058252039549	12086.0651052664	12086.5293219009	12160.4132869137	1035	NA	2.15366098458301e-26	2.36503771274141e-27	1.27255348275077e-31	2.69207623072876e-24	2.95629714092676e-25	1.59069185343846e-29	non_linear_mixed	1.27255348275077e-31	1.59069185343846e-29	12086.5293219009	12160.4132869137	3
Yersinia infection - Homo sapiens (human)	135	29	16567.7249549565	16567.7415524668	16583.5629114627	1447	NA	16482.1047245442	16482.1629366024	16513.7806375567	1444	0.943412281660506	16470.0766020389	16470.1765326427	16512.3111527223	1442	0.937161842411958	16455.1887404346	16455.5234684681	16534.3785229659	1435	NA	9.82925017209506e-20	1.28627256658019e-21	2.99194926554811e-23	1.22865627151188e-17	1.60784070822524e-19	3.73993658193514e-21	non_linear_mixed	2.99194926554811e-23	3.73993658193514e-21	16455.5234684681	16534.3785229659	2
Choline metabolism in cancer - Homo sapiens (human)	97	25	14436.483306723	14436.5025683602	14451.8760032139	1247	NA	14288.0820053975	14288.1495838368	14318.8673983793	1244	0.920912871143001	14284.1655871921	14284.2816226474	14325.2127778345	1242	0.903706078574416	14275.5444204829	14275.9333994132	14352.5079029373	1235	NA	2.95961277195206e-33	3.173397550229e-33	4.12767826272804e-33	3.69951596494008e-31	3.96674693778625e-31	5.15959782841005e-31	non_linear_mixed	4.12767826272804e-33	5.15959782841005e-31	14275.9333994132	14352.5079029373	4
Glutamatergic synapse - Homo sapiens (human)	113	21	14534.3715871335	14534.3945316841	14549.2412234629	1047	NA	14535.9710970633	14536.051633976	14565.7103697222	1044	NA	14534.6978652415	14534.8361937718	14574.3502287868	1042	NA	14495.9835366821	14496.4477533166	14570.3317183294	1035	NA	0.221339950600209	0.0850260209227971	8.25559795329982e-09	1	1	1.03194974416248e-06	non_linear_mixed	8.25559795329982e-09	1.03194974416248e-06	14496.4477533166	14570.3317183294	2
Insulin resistance - Homo sapiens (human)	107	24	14956.7604228496	14956.7804897392	14972.0306533569	1197	NA	14832.818152311	14832.8885630402	14863.3586133256	1194	0.953441095651351	14828.7947717849	14828.9156785859	14869.5153864711	1192	0.947928621835864	14817.9097211544	14818.3151265598	14894.260873691	1185	0.954478522425743	5.56562851620594e-28	4.84198714551492e-28	1.37783400671637e-28	6.95703564525743e-26	6.05248393189365e-26	1.72229250839547e-26	non_linear_mixed	1.37783400671637e-28	1.72229250839547e-26	14818.3151265598	14894.260873691	3
Growth hormone synthesis, secretion and action - Homo sapiens (human)	118	26	15316.018291872	15316.0368103905	15331.5286505023	1297	NA	15208.9740601027	15209.0390253	15239.9947773634	1294	0.924135501423938	15207.352063121	15207.4636045617	15248.7130194686	1292	0.915328926363438	15205.9379583864	15206.3117901621	15283.4897515381	1285	NA	2.42724333037382e-24	6.01447531705908e-24	9.34193096343169e-23	3.03405416296727e-22	7.51809414632386e-22	1.16774137042896e-20	non_linear_mixed	9.34193096343169e-23	1.16774137042896e-20	15206.3117901621	15283.4897515381	2
JAK-STAT signaling pathway - Homo sapiens (human)	161	20	11794.5509938425	11794.575090228	11809.2742596794	997	NA	11766.9381903107	11767.0227824557	11796.3847219846	994	0.935662200225219	11766.7976961731	11766.943003943	11806.0597384049	992	0.931097142518797	11765.4622495957	11765.9500544737	11839.0785787804	985	NA	2.39140251462049e-07	4.22921501036677e-07	3.97228460501443e-07	2.98925314327561e-05	5.28651876295846e-05	4.96535575626803e-05	non_linear_mixed	3.97228460501443e-07	4.96535575626803e-05	11765.9500544737	11839.0785787804	2
Tight junction - Homo sapiens (human)	168	20	13000.7412632045	13000.76535959	13015.4645290414	997	NA	12605.3456670279	12605.4302591729	12634.7921987018	994	0.957072487659741	12595.4271712162	12595.5724789862	12634.6892134481	992	0.9427700575936	12572.3737789256	12572.8615838036	12645.9901081103	985	NA	1.10371785966808e-86	1.48322799336019e-87	2.96782833041285e-89	1.3796473245851e-84	1.85403499170024e-85	3.70978541301606e-87	non_linear_mixed	2.96782833041285e-89	3.70978541301606e-87	12572.8615838036	12645.9901081103	2
Chemokine signaling pathway - Homo sapiens (human)	191	27	16513.2711394826	16513.2889700918	16528.8947190969	1347	NA	16352.9419706839	16353.0045172215	16384.1891299125	1344	0.92043365615612	16352.4947315001	16352.6021140504	16394.1576104715	1342	0.905831122160287	16359.5099426851	16359.869762775	16437.6278407566	1335	0.921480565428884	7.89027392788911e-36	4.98243216279437e-35	1.22841357100539e-31	9.86284240986139e-34	6.22804020349297e-33	1.53551696375674e-29	non_linear_fixed	4.98243216279437e-35	6.22804020349297e-33	16352.6021140504	16394.1576104715	3
Ribosome biogenesis in eukaryotes - Homo sapiens (human)	107	20	14754.4344859423	14754.4585823279	14769.1577517793	997	NA	14390.4489293451	14390.5335214901	14419.895461019	994	NA	14387.1640673258	14387.3093750957	14426.4261095576	992	NA	14261.9803479049	14262.468152783	14335.5966770896	985	NA	7.01227165365503e-80	2.34431674077724e-79	6.96136611570201e-103	8.76533956706879e-78	2.93039592597155e-77	8.70170764462751e-101	non_linear_mixed	6.96136611570201e-103	8.70170764462751e-101	14262.468152783	14335.5966770896	2
GnRH signaling pathway - Homo sapiens (human)	92	24	13815.4988598233	13815.518926713	13830.7690903307	1197	NA	13667.0402818602	13667.1106925894	13697.5807428748	1194	0.926134693666948	13661.8051903798	13661.9260971808	13702.525805066	1192	0.909790207087153	13653.923698128	13654.3291035334	13730.2748506647	1185	NA	2.87658322533692e-33	1.61500039783097e-33	3.05432535711108e-33	3.59572903167115e-31	2.01875049728871e-31	3.81790669638884e-31	non_linear_mixed	3.05432535711108e-33	3.81790669638884e-31	13654.3291035334	13730.2748506647	2
Gastric cancer - Homo sapiens (human)	148	32	19051.1171118202	19051.1321494141	19067.2503885448	1597	NA	18920.1524451674	18920.2051758642	18952.4189986168	1594	0.947744375388527	18915.0077846363	18915.0982937501	18958.0298559022	1592	0.940377791737456	18882.4650399211	18882.7680702241	18963.1314235445	1585	0.949954206118855	1.70561770598742e-29	8.98430961921723e-30	1.06798690738881e-34	2.13202213248427e-27	1.12303870240215e-27	1.33498363423602e-32	non_linear_mixed	1.06798690738881e-34	1.33498363423602e-32	18882.7680702241	18963.1314235445	2
Breast cancer - Homo sapiens (human)	146	29	17934.6783279807	17934.6949254911	17950.5162844869	1447	NA	17844.5269180283	17844.5851300865	17876.2028310407	1444	0.923251467946828	17823.9368357785	17824.0367663823	17866.1713864618	1442	0.911833417350348	17761.5086394218	17761.8433674552	17840.698421953	1435	NA	1.04436628160142e-20	2.18608485165199e-24	1.25134717061457e-35	1.30545785200178e-18	2.73260606456498e-22	1.56418396326821e-33	non_linear_mixed	1.25134717061457e-35	1.56418396326821e-33	17761.8433674552	17840.698421953	2
Phagosome - Homo sapiens (human)	150	24	16002.1037762521	16002.1238431418	16017.3740067595	1197	NA	15860.2046371354	15860.2750478647	15890.7450981501	1194	0.941598902965151	15856.2617454708	15856.3826522718	15896.982360157	1192	0.928962604440509	15842.2921610924	15842.6975664978	15918.643313629	1185	NA	7.48066303932647e-32	7.61222868312233e-32	7.03658477893656e-33	9.35082879915809e-30	9.51528585390291e-30	8.79573097367069e-31	non_linear_mixed	7.03658477893656e-33	8.79573097367069e-31	15842.6975664978	15918.643313629	2
Autophagy - animal - Homo sapiens (human)	136	36	24018.3451114322	24018.3584744612	24034.8317372639	1797	NA	23365.0109008101	23365.0577496668	23397.9841524734	1794	0.921070638886339	23353.5560228272	23353.6364248372	23397.5203583783	1792	0.918588966373551	23119.5040705535	23119.7731288494	23201.9371997117	1785	0.93328811007502	1.37893996756001e-142	1.38647305921136e-143	7.13902296117509e-190	1.72367495945001e-140	1.7330913240142e-141	8.92377870146886e-188	non_linear_mixed	7.13902296117509e-190	8.92377870146886e-188	23119.7731288494	23201.9371997117	2
Gap junction - Homo sapiens (human)	87	21	12421.0393341499	12421.0622787005	12435.9089704793	1047	NA	12245.1305726535	12245.2111095663	12274.8698453125	1044	0.920010158827369	12247.7190347597	12247.8573632899	12287.3713983049	1042	0.901953756291997	12209.5094515846	12209.973668219	12283.8576332318	1035	0.926179173062126	3.41388788955901e-39	1.04526154818337e-37	1.41224145261816e-43	4.26735986194877e-37	1.30657693522921e-35	1.7653018157727e-41	non_linear_mixed	1.41224145261816e-43	1.7653018157727e-41	12209.973668219	12283.8576332318	2
TNF signaling pathway - Homo sapiens (human)	111	20	11425.9473489583	11425.9714453438	11440.6706147952	997	NA	11315.8940233209	11315.9786154659	11345.3405549948	994	NA	11309.6579655739	11309.8032733439	11348.9200078058	992	NA	11301.3053697766	11301.7931746546	11374.9216989613	985	NA	5.46140495152917e-25	1.45798514592969e-25	1.0690275915394e-25	6.82675618941146e-23	1.82248143241212e-23	1.33628448942425e-23	non_linear_mixed	1.0690275915394e-25	1.33628448942425e-23	11301.7931746546	11374.9216989613	2
Prostate cancer - Homo sapiens (human)	96	25	16178.0420292611	16178.0612908984	16193.434725752	1247	NA	16063.7015253046	16063.7691037439	16094.4869182864	1244	0.956398021447201	16062.476795766	16062.5928312213	16103.5239864084	1242	0.959972010465205	16049.5288167105	16049.9177956408	16126.4922991649	1235	0.957459013556001	6.51782211634371e-26	2.07641000567578e-25	1.75153958730612e-26	8.14727764542964e-24	2.59551250709473e-23	2.18942448413265e-24	non_linear_mixed	1.75153958730612e-26	2.18942448413265e-24	16049.9177956408	16126.4922991649	3
RNA transport - Homo sapiens (human)	185	23	16836.6257809829	16836.6467233912	16851.7683326469	1147	NA	16433.567935242	16433.6414260556	16463.8530385701	1144	0.928318862799811	16432.9492572543	16433.0754623376	16473.3293950252	1142	0.94717575554041	16293.8847945523	16294.3080749756	16369.5975528726	1135	NA	2.41605969920631e-88	3.34379807177221e-87	1.33061971832349e-113	3.02007462400789e-86	4.17974758971527e-85	1.66327464790437e-111	non_linear_mixed	1.33061971832349e-113	1.66327464790437e-111	16294.3080749756	16369.5975528726	2
Spliceosome - Homo sapiens (human)	150	25	15062.0772623927	15062.09652403	15077.4699588836	1247	NA	14981.8917480506	14981.9593264898	15012.6771410323	1244	0.931660501087372	14978.0897838394	14978.2058192947	15019.1369744818	1242	0.929972618276696	14980.1873995281	14980.5763784584	15057.1508819825	1235	NA	1.44432427389342e-18	9.75190034011228e-19	3.87639234928453e-17	1.80540534236678e-16	1.21898754251403e-16	4.84549043660566e-15	non_linear_fixed	9.75190034011228e-19	1.21898754251403e-16	14978.2058192947	15019.1369744818	2
NOD-like receptor signaling pathway - Homo sapiens (human)	180	31	18136.6448591067	18136.6603830395	18152.6828897365	1547	NA	18041.5704262191	18041.6248656229	18073.6464874786	1544	0.940207653749812	18028.7828614185	18028.8763072329	18071.5509430978	1542	0.933348274693631	18017.7811638943	18018.0940713259	18097.971317043	1535	NA	9.12979956844356e-22	8.90181488253976e-24	1.58073790166655e-24	1.14122494605544e-19	1.11272686031747e-21	1.97592237708319e-22	non_linear_mixed	1.58073790166655e-24	1.97592237708319e-22	18018.0940713259	18097.971317043	2
Apelin signaling pathway - Homo sapiens (human)	136	33	20321.4092396312	20321.4238204331	20337.6348313318	1647	NA	20166.7084346823	20166.7595606713	20199.1596180837	1644	0.944769891575384	20163.0746760865	20163.1624274576	20206.3429206216	1642	0.936104866331314	20157.5353034027	20157.8290610527	20238.6632619061	1635	NA	1.29386925511078e-34	1.6535194786262e-34	1.02844391468518e-33	1.61733656888848e-32	2.06689934828274e-32	1.28555489335647e-31	non_linear_mixed	1.02844391468518e-33	1.28555489335647e-31	20157.8290610527	20238.6632619061	2
Estrogen signaling pathway - Homo sapiens (human)	136	37	26134.2092759346	26134.222277018	26150.7780986888	1847	NA	24455.5471823189	24455.5927601811	24488.6848278273	1844	0.88059518351806	24451.3698340217	24451.4480523813	24495.5533613663	1842	0.92252748689693	24046.513505507	24046.7752285169	24129.3576192781	1835	NA	0	0	0	0	0	0	non_linear_mixed	0	0	24046.7752285169	24129.3576192781	2
C-type lectin receptor signaling pathway - Homo sapiens (human)	103	23	14772.3593797665	14772.3803221748	14787.5019314305	1147	NA	14664.2865099386	14664.3600007523	14694.5716132668	1144	0.959773835271048	14665.2080367251	14665.3342418083	14705.5881744959	1142	0.963515528374079	14658.7339248163	14659.1572052396	14734.4466831367	1135	0.96053382740986	1.45774184127948e-24	1.25869914757437e-23	1.80476402526296e-23	1.82217730159935e-22	1.57337393446796e-21	2.2559550315787e-21	non_linear_mixed	1.80476402526296e-23	2.2559550315787e-21	14659.1572052396	14734.4466831367	2
Tuberculosis - Homo sapiens (human)	178	28	18489.379113705	18489.3963056821	18505.1117962518	1397	NA	17755.399518518	17755.4598200256	17786.8648836117	1394	0.935727466225014	17757.9222801925	17758.0258028381	17799.8761003173	1392	0.939626079128329	17593.4788827941	17593.8257036033	17672.1422955281	1385	NA	4.49374261301316e-160	5.32596047096479e-158	3.05711537866817e-189	5.61717826626645e-158	6.65745058870598e-156	3.82139422333521e-187	non_linear_mixed	3.05711537866817e-189	3.82139422333521e-187	17593.8257036033	17672.1422955281	2
Phospholipase D signaling pathway - Homo sapiens (human)	146	36	21476.7781176727	21476.7914807016	21493.2647435043	1797	NA	21287.1921007008	21287.2389495574	21320.1653523641	1794	0.951367729501629	21278.1265611534	21278.2069631635	21322.0908967045	1792	0.944153527208592	21251.1309442087	21251.4000025046	21333.5640733669	1785	0.952840079520877	3.79182864600851e-42	4.00009800362575e-43	1.62073795002487e-46	4.73978580751064e-40	5.00012250453219e-41	2.02592243753109e-44	non_linear_mixed	1.62073795002487e-46	2.02592243753109e-44	21251.4000025046	21333.5640733669	2
Pathogenic Escherichia coli infection - Homo sapiens (human)	195	47	29447.7437281601	29447.7539583391	29465.0302399815	2347	NA	29225.683663705	29225.7195151774	29260.2566873478	2344	0.946786779412515	29195.0960136412	29195.1575258155	29241.1933784983	2342	0.942190486788309	29121.8187055166	29122.0243610436	29208.2512646237	2335	NA	3.632811339076e-49	1.06072732431528e-54	1.45481630449929e-67	4.541014173845e-47	1.3259091553941e-52	1.81852038062411e-65	non_linear_mixed	1.45481630449929e-67	1.81852038062411e-65	29122.0243610436	29208.2512646237	3
Transcriptional misregulation in cancer - Homo sapiens (human)	190	32	20331.4755294674	20331.4905670614	20347.6088061921	1597	NA	20204.3079141634	20204.3606448602	20236.5744676127	1594	0.957244056707355	20193.1992757016	20193.2897848153	20236.2213469674	1592	0.960583204420356	20157.1663147463	20157.4693450493	20237.8326983697	1585	NA	1.12301206855156e-28	3.10744652220899e-30	7.28309806278012e-36	1.40376508568945e-26	3.88430815276124e-28	9.10387257847515e-34	non_linear_mixed	7.28309806278012e-36	9.10387257847515e-34	20157.4693450493	20237.8326983697	2
Hepatitis C - Homo sapiens (human)	156	31	18979.7988113297	18979.8143352624	18995.8368419594	1547	NA	18762.5749143621	18762.6293537659	18794.6509756216	1544	0.937122099282954	18748.045707166	18748.1391529804	18790.8137888453	1542	0.926076695045261	18699.5573131782	18699.8702206098	18779.7474663269	1535	0.940512931793119	4.03449991907764e-48	3.23024463014154e-50	6.03913473941684e-58	5.04312489884705e-46	4.03780578767692e-48	7.54891842427105e-56	non_linear_mixed	6.03913473941684e-58	7.54891842427105e-56	18699.8702206098	18779.7474663269	2
ErbB signaling pathway - Homo sapiens (human)	84	24	14425.9816856285	14426.0017525181	14441.2519161358	1197	NA	14356.3850685141	14356.4554792433	14386.9255295287	1194	0.940961686122813	14344.9568670899	14345.0777738909	14385.6774817761	1192	0.935365008115359	14312.3579987712	14312.7634041766	14388.7091513078	1185	0.943879829148831	2.6991649541701e-16	4.0926405475047e-18	1.80624595596199e-23	3.37395619271263e-14	5.11580068438088e-16	2.25780744495248e-21	non_linear_mixed	1.80624595596199e-23	2.25780744495248e-21	14312.7634041766	14388.7091513078	3
Leukocyte transendothelial migration - Homo sapiens (human)	113	20	12903.9766479911	12904.0007443766	12918.699913828	997	NA	12508.2850743966	12508.3696665416	12537.7316060704	994	0.96132540011877	12497.6969143757	12497.8422221456	12536.9589566076	992	0.949110670627119	12479.848033452	12480.3358383301	12553.4643626367	985	0.962742012854021	9.52240520816119e-87	9.18389986375231e-88	2.35801272482241e-88	1.19030065102015e-84	1.14798748296904e-85	2.94751590602802e-86	non_linear_mixed	2.35801272482241e-88	2.94751590602802e-86	12480.3358383301	12553.4643626367	2
Insulin signaling pathway - Homo sapiens (human)	136	30	17967.5283167747	17967.5443595555	17983.467977936	1497	NA	17857.0827406661	17857.1390032247	17888.9620629886	1494	0.919247204079072	17842.2076784209	17842.3042578978	17884.7134415176	1492	0.911395811329359	17822.8853285136	17823.2087786484	17902.58363432	1485	NA	4.49623168809707e-25	1.76584933551327e-27	9.04402832715906e-30	5.62028961012133e-23	2.20731166939159e-25	1.13050354089488e-27	non_linear_mixed	9.04402832715906e-30	1.13050354089488e-27	17823.2087786484	17902.58363432	2
cGMP-PKG signaling pathway - Homo sapiens (human)	166	30	18020.0764561255	18020.0924989062	18036.0161172867	1497	NA	17941.8417999848	17941.8980625434	17973.7211223073	1494	0.945384760342344	17930.0639534123	17930.1605328891	17972.569716509	1492	0.939715958320877	17914.0299087389	17914.3533588737	17993.7282145453	1485	0.94655636041672	3.78816808426637e-18	5.25317760475515e-20	6.04061806347797e-22	4.73521010533296e-16	6.56647200594394e-18	7.55077257934746e-20	non_linear_mixed	6.04061806347797e-22	7.55077257934746e-20	17914.3533588737	17993.7282145453	2
Apoptosis - Homo sapiens (human)	135	36	23204.5626320579	23204.5759950869	23221.0492578896	1797	NA	22141.7193495786	22141.7661984352	22174.6926012419	1794	0.922138943095146	22145.3087287318	22145.3891307419	22189.2730642829	1792	0.931770935086223	21895.7023287737	21895.9713870697	21978.135457932	1785	0.934381262284149	2.09138038623025e-231	6.08307282999827e-229	4.1297162440479e-278	2.61422548278781e-229	7.60384103749784e-227	5.16214530505988e-276	non_linear_mixed	4.1297162440479e-278	5.16214530505988e-276	21895.9713870697	21978.135457932	2
Cellular senescence - Homo sapiens (human)	155	47	29614.5051007234	29614.5153309024	29631.7916125448	2347	NA	29445.6833245515	29445.7191760239	29480.2563481943	2344	0.951009527004547	29438.5876614191	29438.6491735934	29484.6850262762	2342	0.952868439942279	29269.1828030661	29269.3884585931	29355.6153621732	2335	0.956170217515087	1.15780311261057e-37	2.91292181988084e-38	1.16743661396385e-71	1.44725389076321e-35	3.64115227485106e-36	1.45929576745481e-69	non_linear_mixed	1.16743661396385e-71	1.45929576745481e-69	29269.3884585931	29355.6153621732	2
Epstein-Barr virus infection - Homo sapiens (human)	200	41	25231.1053918349	25231.1171220402	25247.9821770513	2047	NA	25062.7981596704	25062.8392756763	25096.5517301032	2044	0.965815876392428	25058.2029253401	25058.2734789903	25103.2076859171	2042	0.968600434289304	25011.1671075784	25011.4030957789	25095.5510336603	2035	0.967029297913449	1.49531838769717e-37	1.28376605235031e-37	2.50937718872966e-45	1.86914798462146e-35	1.60470756543789e-35	3.13672148591207e-43	non_linear_mixed	2.50937718872966e-45	3.13672148591207e-43	25011.4030957789	25095.5510336603	2
Pancreatic cancer - Homo sapiens (human)	75	25	15014.7531487197	15014.7724103569	15030.1458452106	1247	NA	14905.7785243997	14905.8461028389	14936.5639173814	1244	0.946784763327106	14891.4559431379	14891.5719785932	14932.5031337803	1242	0.939724083186975	14874.838197156	14875.2271760863	14951.8016796105	1235	0.948856854114417	9.32283138242211e-25	4.74970944555877e-27	8.35724492676473e-29	1.16535392280276e-22	5.93713680694846e-25	1.04465561584559e-26	non_linear_mixed	8.35724492676473e-29	1.04465561584559e-26	14875.2271760863	14951.8016796105	2
Colorectal cancer - Homo sapiens (human)	85	33	19713.9234183793	19713.9379991812	19730.14901008	1647	NA	19581.9184673788	19581.9695933679	19614.3696507802	1644	0.944338661169123	19574.1945340131	19574.2822853842	19617.4627785483	1642	0.936421823198764	19515.759977589	19516.0537352389	19596.8879360924	1635	0.947960961289417	1.01766885844754e-29	1.52487852077994e-30	8.44629706821293e-41	1.27208607305943e-27	1.90609815097493e-28	1.05578713352662e-38	non_linear_mixed	8.44629706821293e-41	1.05578713352662e-38	19516.0537352389	19596.8879360924	2
Thyroid hormone signaling pathway - Homo sapiens (human)	120	29	18867.0913752898	18867.1079728002	18882.929331796	1447	NA	18767.7615145628	18767.819726621	18799.4374275753	1444	0.945113669885228	18767.8149059472	18767.9148365509	18810.0494566305	1442	0.949405005891509	18735.1601325377	18735.4948605712	18814.349915069	1435	0.947617196602125	1.10966830379597e-22	5.82629265384693e-22	3.53739810523966e-27	1.38708537974496e-20	7.28286581730866e-20	4.42174763154958e-25	non_linear_mixed	3.53739810523966e-27	4.42174763154958e-25	18735.4948605712	18814.349915069	2
Hepatitis B - Homo sapiens (human)	161	32	18860.3936627398	18860.4087003337	18876.5269394644	1597	NA	18708.9952334828	18709.0479641796	18741.2617869322	1594	0.944325671307624	18706.4087449566	18706.4992540704	18749.4308162225	1592	0.936199786348377	18679.6237865173	18679.9268168203	18760.2901701407	1585	NA	6.67634843231015e-34	1.39982209823818e-33	3.37524746491091e-37	8.34543554038769e-32	1.74977762279773e-31	4.21905933113864e-35	non_linear_mixed	3.37524746491091e-37	4.21905933113864e-35	18679.9268168203	18760.2901701407	2
Neurotrophin signaling pathway - Homo sapiens (human)	118	24	14625.8960848555	14625.9161517452	14641.1663153629	1197	NA	14540.5138515831	14540.5842623124	14571.0543125978	1194	0.935144455896531	14537.0885957586	14537.2095025596	14577.8092104448	1192	0.926660356549369	14526.4149752464	14526.8203806518	14602.7661277831	1185	0.937025744037983	1.10572712497628e-19	9.42644743142476e-20	1.24771819712137e-20	1.38215890622035e-17	1.1783059289281e-17	1.55964774640171e-18	non_linear_mixed	1.24771819712137e-20	1.55964774640171e-18	14526.8203806518	14602.7661277831	2
Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)	192	38	23060.6257001619	23060.6383583897	23077.2745276574	1897	NA	22853.5197639007	22853.5641379102	22886.8174188917	1894	0.932678713649183	22849.930107253	22850.0062574381	22894.3269805743	1892	0.92267700195807	22843.3242524989	22843.579029569	22926.5683899762	1885	0.934000632943409	6.20719686258257e-46	1.05429038776969e-45	8.88683096011061e-45	7.75899607822821e-44	1.31786298471211e-43	1.11085387001383e-42	non_linear_mixed	8.88683096011061e-45	1.11085387001383e-42	22843.579029569	22926.5683899762	2
Androgen receptor signaling pathway	88	26	17128.6090923319	17128.6276108504	17144.1194509622	1297	NA	17022.3915664847	17022.456531682	17053.4122837454	1294	0.95725431721359	17020.0628240914	17020.1743655321	17061.423780439	1292	0.962099359835894	17021.3221592632	17021.6959910389	17098.8739524149	1285	NA	3.65648624424681e-24	6.37674389812969e-24	3.40422602075469e-22	4.57060780530851e-22	7.97092987266211e-22	4.25528252594336e-20	non_linear_fixed	6.37674389812969e-24	7.97092987266211e-22	17020.1743655321	17061.423780439	2
Regulation of toll-like receptor signaling pathway	144	23	14304.8698476133	14304.8907900217	14320.0123992774	1147	NA	14237.8913497197	14237.9648405333	14268.1764530478	1144	NA	14208.4197614897	14208.545966573	14248.7998992606	1142	NA	14005.3014158674	14005.7246962907	14081.0141741878	1135	NA	9.82406652038941e-16	2.30343632852017e-21	5.21259404285833e-62	1.22800831504868e-13	2.87929541065021e-19	6.51574255357292e-60	non_linear_mixed	5.21259404285833e-62	6.51574255357292e-60	14005.7246962907	14081.0141741878	2
Integrated breast cancer pathway	66	20	12401.043500669	12401.0675970545	12415.766766506	997	NA	12361.7487283578	12361.8333205028	12391.1952600317	994	0.928299265872973	12355.6127164469	12355.7580242168	12394.8747586787	992	0.922266841771523	12272.8477716492	12273.3355765273	12346.464100834	985	NA	8.00973930271996e-10	1.0643620114773e-10	2.0318767336289e-26	1.00121741284e-07	1.33045251434662e-08	2.53984591703613e-24	non_linear_mixed	2.0318767336289e-26	2.53984591703613e-24	12273.3355765273	12346.464100834	2
Leptin signaling pathway	75	22	13913.6991606868	13913.7210584971	13928.7083570632	1097	NA	13860.9352715836	13861.0121242826	13890.9536643363	1094	0.917432721505951	13846.7723896228	13846.9043786237	13886.7969132931	1092	0.90800301618888	13801.713968539	13802.1567729671	13876.7599504208	1085	NA	1.07966597523607e-12	3.68402809480592e-15	3.8633192655877e-23	1.34958246904509e-10	4.6050351185074e-13	4.82914908198462e-21	non_linear_mixed	3.8633192655877e-23	4.82914908198462e-21	13802.1567729671	13876.7599504208	2
Prolactin Signaling Pathway	75	21	14025.0825559254	14025.1055004761	14039.9521922549	1047	NA	13374.6957066515	13374.7762435643	13404.4349793104	1044	0.910760877672858	13377.6183243045	13377.7566528348	13417.2706878497	1042	0.925538561769095	13249.8555855353	13250.3198021697	13324.2037671825	1035	NA	6.00602062289228e-142	7.71015750242532e-140	2.42405380697094e-163	7.50752577861534e-140	9.63769687803166e-138	3.03006725871367e-161	non_linear_mixed	2.42405380697094e-163	3.03006725871367e-161	13250.3198021697	13324.2037671825	2
Alzheimer,s disease	143	23	13248.3953210205	13248.4162634289	13263.5378726846	1147	NA	13167.0844730146	13167.1579638283	13197.3695763428	1144	0.935048697478646	13157.7681016591	13157.8943067424	13198.14823943	1142	0.927714694940273	13132.1831647334	13132.6064451567	13207.8959230538	1135	NA	8.28048486753224e-19	3.89808279159689e-20	5.42690838102094e-24	1.03506060844153e-16	4.87260348949611e-18	6.78363547627618e-22	non_linear_mixed	5.42690838102094e-24	6.78363547627618e-22	13132.6064451567	13207.8959230538	3
Glioblastoma signaling pathways	82	26	16607.0349049202	16607.0534234387	16622.5452635505	1297	NA	16468.7807359534	16468.8457011506	16499.8014532141	1294	0.956704458095793	16468.2291177934	16468.3406592341	16509.590074141	1292	0.961037279172407	16459.9130345762	16460.2868663519	16537.464827728	1285	NA	4.5718227429513e-31	2.39722184040977e-30	2.81435835812937e-30	5.71477842868912e-29	2.99652730051221e-28	3.51794794766172e-28	non_linear_mixed	2.81435835812937e-30	3.51794794766172e-28	16460.2868663519	16537.464827728	2
AGE-RAGE pathway	65	22	13233.3867679897	13233.4086657999	13248.395964366	1097	NA	13121.2911488913	13121.3680015903	13151.309541644	1094	0.927826129475892	13116.5542562897	13116.6862452906	13156.57877996	1092	0.916581694040697	13115.6658952181	13116.1086996461	13190.7118770999	1085	NA	1.98404250566886e-25	1.11831998948697e-25	2.690517389058e-24	2.48005313208608e-23	1.39789998685872e-23	3.3631467363225e-22	non_linear_mixed	2.690517389058e-24	3.3631467363225e-22	13116.1086996461	13190.7118770999	2
Adipogenesis	130	27	16510.0798677041	16510.0976983133	16525.7034473184	1347	NA	16260.4516618443	16260.5142083819	16291.6988210729	1344	0.949437441787076	16251.7190015145	16251.8263840649	16293.381880486	1342	0.939939874983634	16226.3067403581	16226.6665604481	16304.4246384296	1335	NA	3.96710693610367e-55	6.29392797242212e-56	1.09391959130429e-58	4.95888367012959e-53	7.86740996552765e-54	1.36739948913037e-56	non_linear_mixed	1.09391959130429e-58	1.36739948913037e-56	16226.6665604481	16304.4246384296	2
Brain-derived neurotrophic factor (BDNF) signaling pathway	143	27	17503.0992505275	17503.1170811367	17518.7228301418	1347	NA	17434.975353553	17435.0379000906	17466.2225127816	1344	0.9399066542601	17412.1187045156	17412.226087066	17453.7815834871	1342	0.943808328387858	17297.8471770999	17298.2069971898	17375.9650751714	1335	0.946612568629244	5.58295715429239e-16	3.28371664268638e-20	2.85083558501673e-42	6.97869644286549e-14	4.10464580335797e-18	3.56354448127091e-40	non_linear_mixed	2.85083558501673e-42	3.56354448127091e-40	17298.2069971898	17375.9650751714	4
Apoptosis	86	24	15336.4427886476	15336.4628555372	15351.7130191549	1197	NA	15244.7882680488	15244.8586787781	15275.3287290635	1194	0.962009648209537	15242.098315865	15242.219222666	15282.8189305512	1192	0.965439370932922	15217.0859882267	15217.4913936321	15293.4371407633	1185	NA	4.96314997397589e-21	6.40964632463982e-21	1.2564828708464e-24	6.20393746746987e-19	8.01205790579977e-19	1.570603588558e-22	non_linear_mixed	1.2564828708464e-24	1.570603588558e-22	15217.4913936321	15293.4371407633	2
Mesodermal commitment pathway	152	31	18902.4437785006	18902.4593024333	18918.4818091303	1547	NA	18793.7787305141	18793.8331699179	18825.8547917736	1544	0.93393639387014	18760.7456780448	18760.8391238592	18803.5137597241	1542	0.925590741949543	18620.0116131803	18620.3245206118	18700.201766329	1535	0.942034861962233	1.0869159109787e-24	5.80797908682031e-31	2.09292095020022e-58	1.35864488872338e-22	7.25997385852539e-29	2.61615118775028e-56	non_linear_mixed	2.09292095020022e-58	2.61615118775028e-56	18620.3245206118	18700.201766329	2
Focal Adhesion	197	35	22220.3914108864	22220.4051565909	22236.7935240872	1747	NA	21813.4687553999	21813.516948171	21846.2729818014	1744	0.956346993657742	21801.3664267315	21801.4491378171	21845.1053952668	1742	0.949262078142915	21768.9772374705	21769.2540540795	21850.9878034743	1735	NA	3.51485177595623e-89	1.64053071577025e-90	3.76137042063073e-94	4.39356471994529e-87	2.05066339471281e-88	4.70171302578841e-92	non_linear_mixed	3.76137042063073e-94	4.70171302578841e-92	21769.2540540795	21850.9878034743	2
TGF-beta Signaling Pathway	131	33	18733.5708368783	18733.5854176802	18749.7964285789	1647	NA	18584.9798260874	18585.0309520764	18617.4310094887	1644	0.957138828656817	18578.4772592707	18578.5650106418	18621.7455038059	1642	0.952651532287972	18512.4481601112	18512.7419177612	18593.5761186146	1635	0.960181916196142	2.69341490751231e-33	8.12207148160618e-34	1.4216996930232e-45	3.36676863439039e-31	1.01525893520077e-31	1.77712461627899e-43	non_linear_mixed	1.4216996930232e-45	1.77712461627899e-43	18512.7419177612	18593.5761186146	2
Angiopoietin Like Protein 8 Regulatory Pathway	130	22	12873.1346730717	12873.1565708819	12888.143869448	1097	NA	12808.6588828074	12808.7357355064	12838.6772755602	1094	0.924739822802987	12799.6114563404	12799.7434453413	12839.6359800106	1092	0.919532695142378	12786.5877789914	12787.0305834195	12861.6337608732	1085	NA	3.37577000135328e-15	1.53531384740986e-16	4.66447903231174e-18	4.21971250169159e-13	1.91914230926232e-14	5.83059879038967e-16	non_linear_mixed	4.66447903231174e-18	5.83059879038967e-16	12787.0305834195	12861.6337608732	2
Chemokine signaling pathway	164	26	15952.1510386319	15952.1695571504	15967.6613972622	1297	NA	15797.7564182181	15797.8213834153	15828.7771354787	1294	0.91665398842047	15797.2690891423	15797.380630583	15838.6300454899	1292	0.9010060783947	15804.7249328634	15805.0987646391	15882.2767260151	1285	0.917756975254235	1.50649764916615e-34	9.01147201361796e-34	2.43851872963546e-30	1.88312206145768e-32	1.12643400170225e-31	3.04814841204432e-28	non_linear_fixed	9.01147201361796e-34	1.12643400170225e-31	15797.380630583	15838.6300454899	2
mRNA Processing	126	27	15895.3166484411	15895.3344790503	15910.9402280554	1347	NA	15831.4865331575	15831.5490796951	15862.7336923861	1344	0.937862690391749	15827.9908928618	15828.0982754121	15869.6537718333	1342	0.939455756780863	15833.1787445853	15833.5385646753	15911.2966426568	1335	NA	4.64125546512783e-15	3.04066330188313e-15	2.74922908562341e-13	5.80156933140979e-13	3.80082912735391e-13	3.43653635702926e-11	non_linear_fixed	3.04066330188313e-15	3.80082912735391e-13	15828.0982754121	15869.6537718333	2
Chromosomal and microsatellite instability in colorectal cancer	72	27	16132.8279646865	16132.8457952957	16148.4515443008	1347	NA	16047.3790167002	16047.4415632378	16078.6261759288	1344	0.948776357378323	16031.9726649654	16032.0800475157	16073.6355439368	1342	0.942376751948508	15982.1762907223	15982.5361108122	16060.2941887938	1335	0.95220502779801	1.06983342438291e-19	2.70227856974238e-22	5.3296375285348e-31	1.33729178047863e-17	3.37784821217798e-20	6.6620469106685e-29	non_linear_mixed	5.3296375285348e-31	6.6620469106685e-29	15982.5361108122	16060.2941887938	2
Ras signaling	183	34	20462.5919318432	20462.6060827866	20478.9070824333	1697	NA	20292.5994140258	20292.649030092	20325.2297152061	1694	0.94012128616796	20287.1397001653	20287.2248568773	20330.6467684057	1692	0.930908966027618	20261.3814474947	20261.6664831241	20342.9572004453	1685	NA	6.46910921296153e-38	3.66212164801496e-38	1.96932644441754e-41	8.08638651620192e-36	4.57765206001869e-36	2.46165805552193e-39	non_linear_mixed	1.96932644441754e-41	2.46165805552193e-39	20261.6664831241	20342.9572004453	3
Non-small cell lung cancer	71	21	12631.0736274522	12631.0965720029	12645.9432637817	1047	NA	12526.8070292842	12526.8875661969	12556.5463019431	1044	0.935950453491263	12521.763608901	12521.9019374313	12561.4159724462	1042	0.925784662876478	12490.5855704044	12491.0497870388	12564.9337520517	1035	NA	9.61525585744769e-24	4.3940651559536e-24	6.38407771188308e-29	1.20190698218096e-21	5.492581444942e-22	7.98009713985385e-27	non_linear_mixed	6.38407771188308e-29	7.98009713985385e-27	12491.0497870388	12564.9337520517	4
Breast cancer pathway	153	30	18544.0385635289	18544.0546063097	18559.9782246902	1497	NA	18447.8425965363	18447.8988590949	18479.7219188588	1494	0.92050363722744	18430.581373777	18430.6779532539	18473.0871368738	1492	0.908205426199754	18365.3478293255	18365.6712794603	18445.0461351319	1485	NA	5.23930414620733e-22	5.81052242863068e-25	9.07504296674767e-37	6.54913018275916e-20	7.26315303578835e-23	1.13438037084346e-34	non_linear_mixed	9.07504296674767e-37	1.13438037084346e-34	18365.6712794603	18445.0461351319	2
Acute viral myocarditis	77	23	13919.6228007444	13919.6437431527	13934.7653524084	1147	NA	13853.4909364334	13853.5644272471	13883.7760397616	1144	0.941964106697317	13839.6999359455	13839.8261410287	13880.0800737163	1142	0.937082613408277	13804.6177088156	13805.0409892389	13880.3304671359	1135	NA	1.49165600030955e-15	6.97475075289081e-18	9.50974666953098e-24	1.86457000038694e-13	8.71843844111351e-16	1.18871833369137e-21	non_linear_mixed	9.50974666953098e-24	1.18871833369137e-21	13805.0409892389	13880.3304671359	2
EGF-EGFR signaling pathway	161	42	24644.0358134503	24644.047263832	24660.9848913215	2097	NA	24585.5759451116	24585.6160788909	24619.4741008539	2094	0.918641138149913	24551.803680386	24551.872546957	24597.0012213756	2092	0.914347135389405	24521.4798862985	24521.710212594	24606.2252756541	2085	NA	6.54469539440221e-14	1.78836103661727e-20	2.82951320876145e-25	8.18086924300276e-12	2.23545129577158e-18	3.53689151095181e-23	non_linear_mixed	2.82951320876145e-25	3.53689151095181e-23	24521.710212594	24606.2252756541	2
Fragile X Syndrome	118	23	13111.379306094	13111.4002485023	13126.521857758	1147	NA	12978.8493229559	12978.9228137695	13009.134426284	1144	0.924643798128733	12973.8298166895	12973.9560217728	13014.2099544604	1142	0.930103529178075	12974.9319325046	12975.3552129279	13050.6446908249	1135	NA	7.84169751571684e-30	4.43670630000666e-30	4.25796596770212e-28	9.80212189464606e-28	5.54588287500833e-28	5.32245745962766e-26	non_linear_fixed	4.43670630000666e-30	5.54588287500833e-28	12973.9560217728	13014.2099544604	2
Gastrin signaling pathway	113	30	17421.3484490014	17421.3644917822	17437.2881101627	1497	NA	17299.9924739681	17300.0487365267	17331.8717962906	1494	0.933305506235994	17286.1324951597	17286.2290746366	17328.6382582565	1492	0.926252387361365	17262.1597740688	17262.4832242036	17341.8580798752	1485	NA	2.00826919280502e-27	1.39167340506372e-29	9.44806788227069e-33	2.51033649100627e-25	1.73959175632965e-27	1.18100848528384e-30	non_linear_mixed	9.44806788227069e-33	1.18100848528384e-30	17262.4832242036	17341.8580798752	2
Hepatitis B infection	151	30	17980.2097264955	17980.2257692762	17996.1493876567	1497	NA	17829.6120494485	17829.6683120071	17861.491371771	1494	0.946302344535712	17826.6942615915	17826.7908410683	17869.2000246882	1492	0.938328885680544	17814.2197533031	17814.5432034379	17893.9180591095	1485	0.948019794479096	9.93862797724701e-34	1.76265899680573e-33	3.7734978089883e-34	1.24232849715588e-31	2.20332374600717e-31	4.71687226123537e-32	non_linear_mixed	3.7734978089883e-34	4.71687226123537e-32	17814.5432034379	17893.9180591095	2
Male infertility	144	22	14228.7807411314	14228.8026389416	14243.7899375077	1097	NA	14147.8367124053	14147.9135651043	14177.855105158	1094	0.959875710513082	14148.3924456798	14148.5244346807	14188.4169693501	1092	0.96316595145155	14112.9819850121	14113.4247894402	14188.0279668939	1085	0.961985750329946	9.9269454716974e-19	5.56866444769081e-18	6.57665288192879e-24	1.24086818396217e-16	6.96083055961352e-16	8.22081610241099e-22	non_linear_mixed	6.57665288192879e-24	8.22081610241099e-22	14113.4247894402	14188.0279668939	2
Ciliopathies	182	22	12327.1485779225	12327.1704757327	12342.1577742989	1097	NA	11759.8820844305	11759.9589371294	11789.9004771832	1094	0.905498387269198	11754.5567634389	11754.6887524398	11794.5812871092	1092	0.933239173114581	11627.6519780639	11628.094782492	11702.6979599457	1085	NA	6.28979593296357e-124	1.16652671653298e-123	4.10760214338253e-147	7.86224491620446e-122	1.45815839566623e-121	5.13450267922816e-145	non_linear_mixed	4.10760214338253e-147	5.13450267922816e-145	11628.094782492	11702.6979599457	2
EGFR Tyrosine Kinase Inhibitor Resistance	83	28	16757.6302633815	16757.6474553585	16773.3629459283	1397	NA	16647.1922093127	16647.2525108202	16678.6575744063	1394	0.936471358790191	16642.5211444439	16642.6246670895	16684.4749645687	1392	0.928781216864886	16617.0405147136	16617.3873355229	16695.7039274477	1385	0.938961223141543	4.51303061551601e-25	2.5943226446181e-25	6.08613046254831e-29	5.64128826939501e-23	3.24290330577262e-23	7.60766307818539e-27	non_linear_mixed	6.08613046254831e-29	7.60766307818539e-27	16617.3873355229	16695.7039274477	2
Insulin Signaling	159	36	22114.7575125614	22114.7708755904	22131.2441383931	1797	NA	21930.4501397112	21930.4969885678	21963.4233913745	1794	0.945839075107428	21908.1222046109	21908.202606621	21952.086540162	1792	0.937518075831175	21872.8129923255	21873.0820506214	21955.2461214837	1785	0.947420593948726	5.23855212221291e-41	7.81004304317041e-45	6.41239000444473e-50	6.54819015276614e-39	9.76255380396301e-43	8.01548750555591e-48	non_linear_mixed	6.41239000444473e-50	8.01548750555591e-48	21873.0820506214	21955.2461214837	2
Regulation of Actin Cytoskeleton	150	25	15981.5440572363	15981.5633188735	15996.9367537272	1247	NA	15784.0828219229	15784.1504003621	15814.8682149046	1244	0.948634310093782	15779.334585408	15779.4506208633	15820.3817760504	1242	0.939616599490223	15760.5824005124	15760.9713794427	15837.5458829668	1235	NA	7.53796340671103e-44	6.92451968704115e-44	1.53588238657752e-45	9.42245425838879e-42	8.65564960880144e-42	1.9198529832219e-43	non_linear_mixed	1.53588238657752e-45	1.9198529832219e-43	15760.9713794427	15837.5458829668	2
Calcium Regulation in the Cardiac Cell	150	20	11618.6725375153	11618.6966339009	11633.3958033523	997	NA	11495.2513124058	11495.3359045509	11524.6978440797	994	0.92030175296246	11495.1157440604	11495.2610518303	11534.3777862922	992	0.899580633945771	11507.3018051637	11507.7896100417	11580.9181343484	985	NA	7.20772942218303e-28	4.18356776729945e-27	5.13695827188968e-23	9.00966177772879e-26	5.22945970912431e-25	6.4211978398621e-21	non_linear_fixed	4.18356776729945e-27	5.22945970912431e-25	11495.2610518303	11534.3777862922	4
Senescence and Autophagy in Cancer	105	22	14535.4343296588	14535.456227469	14550.4435260352	1097	NA	14469.7567376323	14469.8335903313	14499.775130385	1094	0.953492925979543	14453.1047999283	14453.2367889292	14493.1293235986	1092	0.95594666365723	14371.0895972734	14371.5324017015	14446.1355791552	1085	0.958406755206432	1.86628270991476e-15	2.17650854810195e-18	8.22855573731612e-34	2.33285338739345e-13	2.72063568512743e-16	1.02856946716451e-31	non_linear_mixed	8.22855573731612e-34	1.02856946716451e-31	14371.5324017015	14446.1355791552	2
ErbB signaling pathway	91	29	18442.4521985238	18442.4687960342	18458.29015503	1447	NA	18330.5569949596	18330.6152070179	18362.2329079721	1444	0.960672603339432	18327.4465475718	18327.5464781756	18369.6810982552	1442	0.963822436581584	18310.0484013417	18310.3831293752	18389.2381838729	1435	NA	2.19133071088695e-25	2.72873488934894e-25	2.83500232083547e-27	2.73916338860869e-23	3.41091861168617e-23	3.54375290104434e-25	non_linear_mixed	2.83500232083547e-27	3.54375290104434e-25	18310.3831293752	18389.2381838729	2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	158	22	13641.1925360047	13641.2144338149	13656.2017323811	1097	NA	13395.38914932	13395.466002019	13425.4075420728	1094	0.959871739987534	13395.6043618722	13395.7363508731	13435.6288855425	1092	0.95887426476462	13308.9553507855	13309.3981552136	13384.0013326673	1085	NA	2.66547578871387e-54	3.47496670562936e-53	6.77231379802938e-69	3.33184473589234e-52	4.3437083820367e-51	8.46539224753672e-67	non_linear_mixed	6.77231379802938e-69	8.46539224753672e-67	13309.3981552136	13384.0013326673	3
IL6	73	22	13401.741268294	13401.7631661043	13416.7504646704	1097	NA	13355.0812134237	13355.1580661227	13385.0996061764	1094	0.916897636988383	13345.9667820582	13346.0987710591	13385.9913057285	1092	0.91100385690377	13341.4480632559	13341.8908676839	13416.4940451377	1085	NA	2.16630299089425e-11	7.74123792845798e-13	6.22235490805565e-13	2.70787873861781e-09	9.67654741057248e-11	7.77794363506956e-11	non_linear_mixed	6.22235490805565e-13	7.77794363506956e-11	13341.8908676839	13416.4940451377	2
Transcriptional regulation by RUNX1	194	21	13705.5517425017	13705.5746870524	13720.4213788311	1047	NA	13653.704388403	13653.7849253158	13683.4436610619	1044	0.942650707098613	13632.9034197472	13633.0417482775	13672.5557832925	1042	0.934877381790896	13500.1146899825	13500.578906617	13574.4628716298	1035	NA	1.69437846790061e-12	2.34143067981449e-16	2.60939731407802e-42	2.11797308487577e-10	2.92678834976811e-14	3.26174664259752e-40	non_linear_mixed	2.60939731407802e-42	3.26174664259752e-40	13500.578906617	13574.4628716298	2
Prolactin	69	20	13466.1037522049	13466.1278485904	13480.8270180418	997	NA	12897.9686820726	12898.0532742176	12927.4152137465	994	0.904567474973502	12900.2433467491	12900.388654519	12939.5053889809	992	0.917526378918753	12753.7448213574	12754.2326262355	12827.3611505421	985	NA	4.0771355725025e-124	3.31937978132689e-122	7.22317755531613e-150	5.09641946562813e-122	4.14922472665861e-120	9.02897194414516e-148	non_linear_mixed	7.22317755531613e-150	9.02897194414516e-148	12754.2326262355	12827.3611505421	2
Cellular response to heat stress	96	20	11926.6418649689	11926.6659613544	11941.3651308058	997	NA	11879.5076744807	11879.5922666257	11908.9542061545	994	0.938915984006205	11875.5641213415	11875.7094291114	11914.8261635734	992	0.932628716993695	11876.4676155924	11876.9554204704	11950.0839447771	985	0.939788946705622	1.71647946655409e-11	7.2766514461533e-12	5.26168950599905e-11	2.14559933319261e-09	9.09581430769162e-10	6.57711188249882e-09	non_linear_fixed	7.2766514461533e-12	9.09581430769162e-10	11875.7094291114	11914.8261635734	5
Signaling by NTRK1 (TRKA)	113	26	15849.0452597666	15849.0637782852	15864.555618397	1297	NA	15490.526472015	15490.5914372122	15521.5471892757	1294	0.905347798884399	15486.7735279359	15486.8850693767	15528.1344842835	1292	0.89756482740614	15406.9761037073	15407.349935483	15484.5278968591	1285	NA	1.07087194060193e-78	2.79785071337866e-78	3.64474820960243e-92	1.33858992575241e-76	3.49731339172333e-76	4.55593526200304e-90	non_linear_mixed	3.64474820960243e-92	4.55593526200304e-90	15407.349935483	15484.5278968591	2
Signaling by NTRKs	126	28	16968.5939813996	16968.6111733767	16984.3266639464	1397	NA	16581.7613210411	16581.8216225486	16613.2266861347	1394	0.909025242156819	16577.6875462746	16577.7910689202	16619.6413663994	1392	0.90228669667275	16490.8204354535	16491.1672562628	16569.4838481876	1385	0.917533278130391	7.89981385465698e-85	1.89192036397926e-84	9.29337527526252e-100	9.87476731832122e-83	2.36490045497408e-82	1.16167190940781e-97	non_linear_mixed	9.29337527526252e-100	1.16167190940781e-97	16491.1672562628	16569.4838481876	2
PI3K/AKT Signaling in Cancer	105	22	14405.637228916	14405.6591267262	14420.6464252924	1097	NA	14317.7226070224	14317.7994597214	14347.7409997751	1094	0.952316994776163	14310.8942360625	14311.0262250634	14350.9187597328	1092	0.956375043354922	14274.5958610032	14275.0386654313	14349.641842885	1085	NA	3.15906311266198e-20	5.28120208933976e-21	5.36606715909696e-27	3.94882889082748e-18	6.6015026116747e-19	6.7075839488712e-25	non_linear_mixed	5.36606715909696e-27	6.7075839488712e-25	14275.0386654313	14349.641842885	2
Nucleotide Excision Repair	96	22	12958.9937795884	12959.0156773986	12974.0029759647	1097	NA	12936.2797699617	12936.3566226606	12966.2981627144	1094	0.934066845828265	12939.3584340516	12939.4904230525	12979.3829577219	1092	0.933495355759977	12945.5598478941	12946.0026523221	13020.6058297759	1085	NA	2.57171496628678e-06	1.73973130077649e-05	0.000189936989550362	0.000321464370785848	0.00217466412597061	0.0237421236937953	linear	2.57171496628678e-06	0.000321464370785848	12936.3566226606	12966.2981627144	2
TGF_beta_Receptor	172	40	24146.4071409591	24146.4191650072	24163.2098483378	1997	NA	24012.1896361219	24012.2317836382	24045.7950508792	1994	0.93183987576017	24005.6725700057	24005.7448954703	24050.479789682	1992	0.926086653636023	23923.8535260141	23924.0954614979	24007.8670629072	1985	NA	3.39282679544298e-30	9.3144333069211e-31	7.15513232022805e-46	4.24103349430372e-28	1.16430416336514e-28	8.94391540028506e-44	non_linear_mixed	7.15513232022805e-46	8.94391540028506e-44	23924.0954614979	24007.8670629072	2
Signaling by NOTCH	188	31	17324.37400116	17324.3895250927	17340.4120317897	1547	NA	17184.0076639517	17184.0621033554	17216.0837252112	1544	0.921813540258972	17172.788655959	17172.8821017734	17215.5567376383	1542	0.914783791896771	17143.6347934302	17143.9477008618	17223.8249465789	1535	NA	1.60159136800755e-31	4.54619181949172e-33	3.4248631415603e-37	2.00198921000944e-29	5.68273977436465e-31	4.28107892695037e-35	non_linear_mixed	3.4248631415603e-37	4.28107892695037e-35	17143.9477008618	17223.8249465789	2
Ion channel transport	164	29	19086.8448264958	19086.8614240062	19102.682783002	1447	NA	18919.425353677	18919.4835657352	18951.1012666895	1444	NA	18904.4867805387	18904.5867111424	18946.721331222	1442	NA	18884.6252773458	18884.9600053792	18963.815059877	1435	NA	2.32494098576892e-37	1.22382924007255e-39	1.21568597413814e-41	2.90617623221115e-35	1.52978655009069e-37	1.51960746767267e-39	non_linear_mixed	1.21568597413814e-41	1.51960746767267e-39	18884.9600053792	18963.815059877	2
SUMO E3 ligases SUMOylate target proteins	176	37	24293.3760064654	24293.3890075488	24309.9448292196	1847	NA	24195.5824533105	24195.6280311726	24228.7200988189	1844	0.951550566432803	24182.6825700074	24182.7607883669	24226.8660973519	1842	0.952251419448837	24057.8713178001	24058.1330408099	24140.7154315712	1835	NA	2.3750180444281e-22	2.2379331957822e-24	1.4210093139789e-48	2.96877255553513e-20	2.79741649472775e-22	1.77626164247362e-46	non_linear_mixed	1.4210093139789e-48	1.77626164247362e-46	24058.1330408099	24140.7154315712	3
Neurotransmitter receptors and postsynaptic signal transmission	184	24	15754.0052079032	15754.0252747929	15769.2754384105	1197	NA	15615.1912656232	15615.2616763524	15645.7317266378	1194	0.954960921058914	15615.705462072	15615.826368873	15656.4260767582	1192	0.957918959907453	15598.1246328481	15598.5300382535	15674.4757853847	1185	0.956440734948554	3.46230842091704e-31	3.07188000031418e-30	4.51405074455302e-32	4.32788552614631e-29	3.83985000039272e-28	5.64256343069127e-30	non_linear_mixed	4.51405074455302e-32	5.64256343069127e-30	15598.5300382535	15674.4757853847	2
mRNA Splicing	184	26	15804.4221306064	15804.4406491249	15819.9324892368	1297	NA	15715.1609381275	15715.2259033247	15746.1816553882	1294	0.926685862849993	15712.3258966203	15712.437438061	15753.6868529679	1292	0.926538503546743	15717.5071727747	15717.8810045504	15795.0589659264	1285	0.927211001270336	1.62249075528873e-20	1.91036148102848e-20	3.94420547683406e-18	2.02811344411091e-18	2.3879518512856e-18	4.93025684604258e-16	non_linear_fixed	1.91036148102848e-20	2.3879518512856e-18	15712.437438061	15753.6868529679	2
Intra-Golgi and retrograde Golgi-to-ER traffic	185	34	20288.5674108285	20288.5815617719	20304.8825614187	1697	NA	20275.4921363979	20275.5417524641	20308.1224375782	1694	0.955435784591743	20274.71462269	20274.799779402	20318.2216909303	1692	0.954375879846642	20226.9699068841	20227.2549425136	20308.5456598348	1685	0.957209852833526	0.000263773537231022	0.000231720278779295	3.49326784605562e-13	0.0329716921538777	0.0289650348474119	4.36658480756952e-11	non_linear_mixed	3.49326784605562e-13	4.36658480756952e-11	20227.2549425136	20308.5456598348	2
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	99	25	15341.936931706	15341.9561933433	15357.3296281969	1247	NA	15227.6178631828	15227.685441622	15258.4032561646	1244	0.914295023584777	15209.7067099067	15209.822745362	15250.7539005491	1242	0.897284370579259	15123.4685472892	15123.8575262196	15200.4320297437	1235	NA	6.58747672590981e-26	6.00529219440031e-29	5.07851812428502e-45	8.23434590738726e-24	7.50661524300038e-27	6.34814765535628e-43	non_linear_mixed	5.07851812428502e-45	6.34814765535628e-43	15123.8575262196	15200.4320297437	3
Negative regulation of the PI3K/AKT network	106	26	16557.8846440448	16557.9031625634	16573.3950026752	1297	NA	16392.6213815063	16392.6863467035	16423.642098767	1294	0.938649899508952	16376.2896058831	16376.4011473238	16417.6505622307	1292	0.925136898210217	16328.7138815196	16329.0877132953	16406.2656746714	1285	NA	6.79111705526571e-37	1.78173678134355e-39	2.98374518210949e-47	8.48889631908213e-35	2.22717097667944e-37	3.72968147763686e-45	non_linear_mixed	2.98374518210949e-47	3.72968147763686e-45	16329.0877132953	16406.2656746714	4
Toll Like Receptor 4 (TLR4) Cascade	111	22	12695.3590214032	12695.3809192134	12710.3682177796	1097	NA	12607.7198432374	12607.7966959364	12637.7382359901	1094	0.949503543904796	12600.6726356393	12600.8046246402	12640.6971593095	1092	0.94310372833593	12592.5408577189	12592.9836621469	12667.5868396007	1085	NA	3.62030803345401e-20	5.4284939841506e-21	2.6817551909585e-21	4.52538504181752e-18	6.78561748018826e-19	3.35219398869813e-19	non_linear_mixed	2.6817551909585e-21	3.35219398869813e-19	12592.9836621469	12667.5868396007	2
Transport to the Golgi and subsequent modification	166	33	20156.9719684062	20156.9865492081	20173.1975601068	1647	NA	20145.9731840069	20146.0243099959	20178.4243674082	1644	0.945641076499848	20129.1367984794	20129.2245498505	20172.4050430145	1642	0.943888965910654	20091.5390006496	20091.8327582995	20172.666959153	1635	0.947484993413104	0.000707149347539712	4.07211512286059e-07	6.35665560445666e-14	0.088393668442464	5.09014390357574e-05	7.94581950557082e-12	non_linear_mixed	6.35665560445666e-14	7.94581950557082e-12	20091.8327582995	20172.666959153	3
Extra-nuclear estrogen signaling	72	21	13275.6462574502	13275.6692020009	13290.5158937797	1047	NA	13164.31996127	13164.4004981827	13194.0592339289	1044	0.910162843218052	13163.5518939635	13163.6902224938	13203.2042575087	1042	0.889519804981421	13136.8902763627	13137.3544929972	13211.23845801	1035	NA	2.905438109316e-25	1.12988645718067e-24	1.44051547335176e-28	3.631797636645e-23	1.41235807147583e-22	1.80064434168969e-26	non_linear_mixed	1.44051547335176e-28	1.80064434168969e-26	13137.3544929972	13211.23845801	2
Phase II - Conjugation of compounds	110	22	11361.0607843066	11361.0826821169	11376.069980683	1097	NA	11292.7533525939	11292.8302052929	11322.7717453466	1094	0.905111656059357	11281.2016557582	11281.3336447591	11321.2261794285	1092	0.91537542538366	11257.0880474764	11257.5308519044	11332.1340293582	1085	NA	5.09956719208936e-16	7.19311667232657e-18	1.57421189265955e-21	6.3744589901117e-14	8.99139584040822e-16	1.96776486582444e-19	non_linear_mixed	1.57421189265955e-21	1.96776486582444e-19	11257.5308519044	11332.1340293582	5
HIV Infection	191	24	13688.4516026894	13688.471669579	13703.7218331967	1197	NA	13677.7393457641	13677.8097564934	13708.2798067788	1194	0.960555600982486	13666.2908748679	13666.4117816689	13707.0114895541	1192	0.960727236993227	13607.1252989855	13607.5307043909	13683.4764515221	1185	NA	0.000809866646662043	5.5213351994019e-06	5.00549789220264e-17	0.101233330832755	0.000690166899925238	6.2568723652533e-15	non_linear_mixed	5.00549789220264e-17	6.2568723652533e-15	13607.5307043909	13683.4764515221	2
Interferon Signaling	161	22	13379.4760662158	13379.497964026	13394.4852625921	1097	NA	13261.883978	13261.960830699	13291.9023707527	1094	0.940479906756203	13259.3296848908	13259.4616738917	13299.3542085611	1092	0.945553911789036	13244.9163219891	13245.3591264171	13319.9623038709	1085	NA	1.29935160057826e-26	2.21570130947924e-26	1.03212359346096e-27	1.62418950072283e-24	2.76962663684905e-24	1.29015449182619e-25	non_linear_mixed	1.03212359346096e-27	1.29015449182619e-25	13245.3591264171	13319.9623038709	2
AndrogenReceptor	141	35	23245.0242192706	23245.037964975	23261.4263324713	1747	NA	23156.9916064174	23157.0397991884	23189.7958328189	1744	0.942744561296097	23145.9400728243	23146.0227839099	23189.6790413596	1742	0.947771063351114	23120.4411412499	23120.7179578589	23202.4517072536	1735	0.944338483450254	2.97991523474722e-20	6.39776051849379e-22	1.09883010112059e-25	3.72489404343402e-18	7.99720064811724e-20	1.37353762640074e-23	non_linear_mixed	1.09883010112059e-25	1.37353762640074e-23	23120.7179578589	23202.4517072536	3
mTOR signaling pathway	63	21	12978.7644465586	12978.7873911093	12993.6340828881	1047	NA	12862.8878218928	12862.9683588056	12892.6270945517	1044	0.905827144935904	12864.1446018015	12864.2829303317	12903.7969653467	1042	0.907596156618882	12870.5242033827	12870.9884200171	12944.8723850299	1035	0.907019020206452	3.04262219001101e-26	3.2942491081983e-25	2.19013582318435e-22	3.80327773751377e-24	4.11781138524788e-23	2.73766977898044e-20	linear	3.04262219001101e-26	3.80327773751377e-24	12862.9683588056	12892.6270945517	2
ErbB1 downstream signaling	105	27	15950.2595314164	15950.2773620256	15965.8831110307	1347	NA	15827.9933199104	15828.055866448	15859.240479139	1344	0.924548762749675	15816.8554903937	15816.962872944	15858.5183693652	1342	0.911666634120815	15811.3586809488	15811.7185010387	15889.4765790203	1335	NA	1.27846666548836e-27	3.38004393227407e-29	1.34575904124808e-28	1.59808333186045e-25	4.22505491534259e-27	1.6821988015601e-26	non_linear_mixed	1.34575904124808e-28	1.6821988015601e-26	15811.7185010387	15889.4765790203	2
PDGFR-beta signaling pathway	126	30	17779.4801696497	17779.4962124305	17795.419830811	1497	NA	17626.3678038967	17626.4240664553	17658.2471262192	1494	0.925025396124798	17609.4834501392	17609.5800296161	17651.9892132359	1492	0.918829477363129	17604.6912436183	17605.014693753	17684.3895494246	1485	0.927048497577359	2.84895119216811e-34	5.35972763638743e-37	5.79882742646113e-36	3.56118899021014e-32	6.69965954548428e-35	7.24853428307641e-34	non_linear_mixed	5.79882742646113e-36	7.24853428307641e-34	17605.014693753	17684.3895494246	2
Direct p53 effectors	141	33	22228.5303884887	22228.5449692907	22244.7559801894	1647	NA	21521.3877090493	21521.4388350384	21553.8388924507	1644	0.955183998940728	21518.4010376112	21518.4887889824	21561.6692821464	1642	0.957014660133416	21334.7666417523	21335.0603994023	21415.8946002557	1635	0.960537025109875	2.96599723366759e-154	2.18092574571463e-153	8.79438325364455e-189	3.70749654208448e-152	2.72615718214328e-151	1.09929790670557e-186	non_linear_mixed	8.79438325364455e-189	1.09929790670557e-186	21335.0603994023	21415.8946002557	2
Programmed Cell Death	141	33	19953.9072364088	19953.9218172107	19970.1328281094	1647	NA	19864.0618365275	19864.1129625165	19896.5130199289	1644	0.951525042855485	19855.2346433748	19855.322394746	19898.50288791	1642	0.948369608679426	19773.6583805836	19773.9521382335	19854.786339087	1635	0.955456449102132	1.21513318673319e-20	7.81588322626272e-22	4.3248124379303e-37	1.51891648341649e-18	9.7698540328284e-20	5.40601554741288e-35	non_linear_mixed	4.3248124379303e-37	5.40601554741288e-35	19773.9521382335	19854.786339087	2
Estrogen-dependent gene expression	141	26	19159.3566267931	19159.3751453117	19174.8669854235	1297	NA	17938.4901732005	17938.5551383977	17969.5108904612	1294	0.825935025404247	17915.5102780413	17915.6218194821	17956.8712343889	1292	0.895492997175006	17555.3349397028	17555.7087714785	17632.8867328546	1285	NA	1.08649278963253e-265	6.36720410602249e-269	0	1.35811598704066e-263	7.95900513252811e-267	0	non_linear_mixed	0	0	17555.7087714785	17632.8867328546	2
RHOA GTPase cycle	148	35	19589.356018396	19589.3697641005	19605.7581315968	1747	NA	19310.9264544358	19310.9746472069	19343.7306808373	1744	0.923161528291396	19308.016696758	19308.0994078436	19351.7556652933	1742	0.913002356913096	19285.0590839101	19285.3359005191	19367.0696499138	1735	NA	2.32997517987277e-61	7.28369767045713e-61	5.26719155322868e-63	2.91246897484097e-59	9.10462208807141e-59	6.58398944153586e-61	non_linear_mixed	5.26719155322868e-63	6.58398944153586e-61	19285.3359005191	19367.0696499138	2
RHOB GTPase cycle	69	22	12110.4806695876	12110.5025673979	12125.489865964	1097	NA	11898.7931329331	11898.8699856321	11928.8115256858	1094	0.887071767891578	11899.0252995106	11899.1572885115	11939.0498231809	1092	0.88685959301602	11874.3829558212	11874.8257602492	11949.428937703	1085	NA	6.34731917867863e-47	7.24761979845942e-46	1.06841690006966e-48	7.93414897334828e-45	9.05952474807428e-44	1.33552112508708e-46	non_linear_mixed	1.06841690006966e-48	1.33552112508708e-46	11874.8257602492	11949.428937703	2
RHOC GTPase cycle	73	21	11673.8817264316	11673.9046709822	11688.751362761	1047	NA	11504.5401874536	11504.6207243664	11534.2794601125	1044	0.924982130146123	11505.2210963542	11505.3594248845	11544.8734598994	1042	0.92082928082384	11480.9978053957	11481.4620220301	11555.345987043	1035	0.928024793523466	8.94143153772445e-38	1.03388226670532e-36	1.050418139738e-39	1.11767894221556e-35	1.29235283338165e-34	1.3130226746725e-37	non_linear_mixed	1.050418139738e-39	1.3130226746725e-37	11481.4620220301	11555.345987043	2
Metabolism of vitamins and cofactors	179	27	15144.3962582046	15144.4140888138	15160.0198378189	1347	NA	15068.1739297691	15068.2364763067	15099.4210889977	1344	0.922920006170367	15053.8574925101	15053.9648750604	15095.5203714816	1342	0.917754770954621	15037.8618125374	15038.2216326274	15115.9797106089	1335	NA	1.02393405494054e-17	4.06908647359783e-20	4.82099342298786e-22	1.27991756867568e-15	5.08635809199729e-18	6.02624177873482e-20	non_linear_mixed	4.82099342298786e-22	6.02624177873482e-20	15038.2216326274	15115.9797106089	2
Toll-like Receptor Cascades	129	23	13437.7653054789	13437.7862478873	13452.907857143	1147	NA	13341.5985993808	13341.6720901944	13371.8837027089	1144	0.95083997076034	13336.8389404836	13336.9651455668	13377.2190782544	1142	0.948403908802385	13320.5104074056	13320.9336878289	13396.2231657259	1135	0.952336784630645	5.3157742964496e-22	2.61040871391242e-22	3.34175650099754e-24	6.64471787056199e-20	3.26301089239053e-20	4.17719562624693e-22	non_linear_mixed	3.34175650099754e-24	4.17719562624693e-22	13320.9336878289	13396.2231657259	2
RAC1 GTPase cycle	184	48	28679.4331405683	28679.4431572628	28696.7828126173	2397	NA	28565.9190880714	28565.9541904533	28600.6184321694	2394	0.958556531110091	28551.2622489812	28551.3224748281	28597.5280411119	2392	0.955215668179784	28504.0278524224	28504.2291947043	28590.7762126675	2385	NA	9.81956126788308e-26	4.3793602590448e-28	4.32664938226875e-36	1.22744515848538e-23	5.474200323806e-26	5.40831172783594e-34	non_linear_mixed	4.32664938226875e-36	5.40831172783594e-34	28504.2291947043	28590.7762126675	2
RAC3 GTPase cycle	93	29	17567.9810795743	17567.9976770847	17583.8190360805	1447	NA	17467.0397606957	17467.0979727539	17498.7156737081	1444	0.947961260152964	17460.3479564025	17460.4478870062	17502.5825070858	1442	0.94305876326037	17441.1997011021	17441.5344291356	17520.3894836334	1435	0.94971933025683	4.99466149824744e-23	9.95252080871308e-24	3.93571998456128e-26	6.2433268728093e-21	1.24406510108914e-21	4.9196499807016e-24	non_linear_mixed	3.93571998456128e-26	4.9196499807016e-24	17441.5344291356	17520.3894836334	2
SUMOylation	181	37	24293.3760064654	24293.3890075488	24309.9448292196	1847	NA	24195.5824533105	24195.6280311726	24228.7200988189	1844	0.951550566432803	24182.6825700074	24182.7607883669	24226.8660973519	1842	0.952251419448837	24057.8713178001	24058.1330408099	24140.7154315712	1835	NA	2.3750180444281e-22	2.2379331957822e-24	1.4210093139789e-48	2.96877255553513e-20	2.79741649472775e-22	1.77626164247362e-46	non_linear_mixed	1.4210093139789e-48	1.77626164247362e-46	24058.1330408099	24140.7154315712	3
RHOG GTPase cycle	73	20	12232.5458771404	12232.569973526	12247.2691429774	997	NA	12156.2654632083	12156.3500553534	12185.7119948822	994	0.954116317423888	12151.9145482974	12152.0598560674	12191.1765905293	992	0.949198250152601	12131.6222908528	12132.1100957308	12205.2386200375	985	NA	9.94966894906603e-18	4.9509442129635e-18	6.42215066109906e-21	1.24370861863325e-15	6.18868026620437e-16	8.02768832637383e-19	non_linear_mixed	6.42215066109906e-21	8.02768832637383e-19	12132.1100957308	12205.2386200375	2
CDC42 GTPase cycle	159	36	21753.4296558429	21753.4430188719	21769.9162816746	1797	NA	21667.3137811887	21667.3606300453	21700.287032852	1794	0.960458493489629	21652.3480246133	21652.4284266233	21696.3123601643	1792	0.956794428840519	21604.2471721625	21604.5162304584	21686.6803013207	1785	NA	7.69200309306166e-20	2.42040371562765e-22	1.06562057019071e-30	9.61500386632708e-18	3.02550464453456e-20	1.33202571273839e-28	non_linear_mixed	1.06562057019071e-30	1.33202571273839e-28	21604.5162304584	21686.6803013207	2
mRNA Splicing - Major Pathway	176	26	15804.4221306064	15804.4406491249	15819.9324892368	1297	NA	15715.1609381275	15715.2259033247	15746.1816553882	1294	0.926685862849993	15712.3258966945	15712.4374381353	15753.6868530421	1292	0.926536851865732	15717.5071731663	15717.881004942	15795.0589663181	1285	0.927212628312395	1.62249075528727e-20	1.91036154990984e-20	3.94420618085656e-18	2.02811344410909e-18	2.3879519373873e-18	4.9302577260707e-16	non_linear_fixed	1.91036154990984e-20	2.3879519373873e-18	15712.4374381353	15753.6868530421	2
Apoptosis	126	32	19398.0342992039	19398.0493367978	19414.1675759285	1597	NA	19311.080178341	19311.1329090378	19343.3467317904	1594	0.950860871041216	19302.0847298132	19302.175238927	19345.106801079	1592	0.947631982748211	19223.954306686	19224.257336989	19304.6206903094	1585	0.95477397706112	5.08092149028977e-20	2.93798158506744e-21	8.120930976834e-36	6.35115186286221e-18	3.6724769813343e-19	1.01511637210425e-33	non_linear_mixed	8.120930976834e-36	1.01511637210425e-33	19224.257336989	19304.6206903094	2
Death Receptor Signalling	133	21	13835.3707753285	13835.3937198791	13850.2404116579	1047	NA	13783.6198670635	13783.7004039762	13813.3591397224	1044	0.947752193550136	13766.6887006728	13766.8270292031	13806.341064218	1042	0.949393626325527	13680.5029250214	13680.9671416558	13754.8511066686	1035	0.953795015495829	1.77665442398628e-12	1.583026689606e-15	7.28380321323173e-32	2.22081802998285e-10	1.9787833620075e-13	9.10475401653966e-30	non_linear_mixed	7.28380321323173e-32	9.10475401653966e-30	13680.9671416558	13754.8511066686	2