Geneset	Geneset_Size	Genes	null_AIC	null_AICc	null_BIC	null_df	NA.	linear_AIC	linear_AICc	linear_BIC	linear_df	linear_ICC	non_linear_fixed_AIC	non_linear_fixed_AICc	non_linear_fixed_BIC	non_linear_fixed_df	non_linear_fixed_ICC	non_linear_mixed_AIC	non_linear_mixed_AICc	non_linear_mixed_BIC	non_linear_mixed_df	non_linear_mixed_ICC	p_value_linear	p_value_non_linear_fixed	p_value_non_linear_mixed	adjusted_linear_p_value	adjusted_non_linear_fixed_p_value	adjusted_non_linear_mixed_p_value	best_model	best_model_pvalue	best_model_adj_pvalue	best_model_aicc	best_model_bic	OptimalClusters
Complement and coagulation cascades - Homo sapiens (human)	85	25	746.125193102318	746.165461558694	759.315982067967	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	429.138514057908	431.781870701265	547.855614748744	573	0.98347304830149	NA	NA	1.10547895762218e-62	NA	NA	9.84981751241366e-60	non_linear_mixed	1.10547895762218e-62	9.84981751241366e-60	431.781870701265	547.855614748744	4
Inflammatory mediator regulation of TRP channels - Homo sapiens (human)	98	37	235.498471219349	235.525620540616	249.865386448325	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-101.308031349482	-99.549891814598	27.9942057113069	861	0.991077503491789	NA	NA	9.79341772635628e-67	NA	NA	8.72593519418345e-64	non_linear_mixed	9.79341772635628e-67	8.72593519418345e-64	-99.549891814598	27.9942057113069	2
Non-small cell lung cancer - Homo sapiens (human)	72	31	448.889543664875	448.921976097308	462.725666769374	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	165.902199138854	168.01393098243	290.427307079348	717	0.981074974942252	NA	NA	9.1648267414278e-56	NA	NA	8.16586062661217e-53	non_linear_mixed	9.1648267414278e-56	8.16586062661217e-53	168.01393098243	290.427307079348	4
Platelet activation - Homo sapiens (human)	124	54	235.160202004118	235.178777855511	250.661315634854	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-225.532551194599	-224.340122172517	-86.022528517969	1269	NA	NA	NA	2.60866450075154e-92	NA	NA	2.32432007016963e-89	non_linear_mixed	2.60866450075154e-92	2.32432007016963e-89	-224.340122172517	-86.022528517969	4
Cell adhesion molecules - Homo sapiens (human)	148	46	530.511944058502	530.53376224032	545.532029739013	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-22.0288258929167	-20.6236214319502	113.151945231683	1077	NA	NA	NA	1.82752093889775e-111	NA	NA	1.6283211565579e-108	non_linear_mixed	1.82752093889775e-111	1.6283211565579e-108	-20.6236214319502	113.151945231683	2
Chronic myeloid leukemia - Homo sapiens (human)	76	32	442.863770814868	442.895184427434	456.795140014311	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	176.367986042404	178.411229285647	301.750308837391	741	NA	NA	NA	1.9982996903034e-52	NA	NA	1.78048502406033e-49	non_linear_mixed	1.9982996903034e-52	1.78048502406033e-49	178.411229285647	301.750308837391	2
ECM-receptor interaction - Homo sapiens (human)	88	39	261.28502752364	261.310778596602	275.809873953073	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-116.848239430566	-115.183041192681	13.8753784343287	909	0.992705259945908	NA	NA	3.17508987492322e-75	NA	NA	2.82900507855659e-72	non_linear_mixed	3.17508987492322e-75	2.82900507855659e-72	-115.183041192681	13.8753784343287	3
T cell receptor signaling pathway - Homo sapiens (human)	104	33	169.973633160264	170.004090013055	183.997317335707	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-155.077503527098	-153.098445935475	-28.8643459481089	765	NA	NA	NA	2.48992406850009e-64	NA	NA	2.21852234503358e-61	non_linear_mixed	2.48992406850009e-64	2.21852234503358e-61	-153.098445935475	-28.8643459481089	2
Bacterial invasion of epithelial cells - Homo sapiens (human)	77	35	514.167499296339	514.19620743031	528.367704971851	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	21.3346045213617	23.1966734868789	149.13645560097	813	0.994668846270897	NA	NA	5.3555326948024e-99	NA	NA	4.77177963106894e-96	non_linear_mixed	5.3555326948024e-99	4.77177963106894e-96	23.1966734868789	149.13645560097	2
GnRH secretion - Homo sapiens (human)	64	24	323.022367842213	323.064325884171	336.090690824301	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	89.236301190724	91.9954252783152	206.851208029513	549	0.974252353799503	NA	NA	7.63110268781234e-46	NA	NA	6.7993124948408e-43	non_linear_mixed	7.63110268781234e-46	6.7993124948408e-43	91.9954252783152	206.851208029513	2
Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)	106	43	357.298390341714	357.321736645216	372.116152179838	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-134.360920391327	-132.85494429571	-1.00106384820651	1005	0.975509802151345	NA	NA	9.40384096521135e-99	NA	NA	8.37882230000331e-96	non_linear_mixed	9.40384096521135e-99	8.37882230000331e-96	-132.85494429571	-1.00106384820651	2
Cortisol synthesis and secretion - Homo sapiens (human)	65	23	293.414141444142	293.45793706458	306.354785582974	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	58.7314708232698	61.6169670064759	175.197268072751	525	NA	NA	NA	5.04607679348181e-46	NA	NA	4.4960544229923e-43	non_linear_mixed	5.04607679348181e-46	4.4960544229923e-43	61.6169670064759	175.197268072751	2
Relaxin signaling pathway - Homo sapiens (human)	129	51	496.023013349789	496.042685480937	511.352651739006	1221	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-4.22867086149688	-2.96445681467414	133.738074641454	1197	0.987748169978213	NA	NA	1.52290038443833e-100	NA	NA	1.35690424253455e-97	non_linear_mixed	1.52290038443833e-100	1.35690424253455e-97	-2.96445681467414	133.738074641454	2
Aldosterone synthesis and secretion - Homo sapiens (human)	98	36	296.223225477861	296.251132454605	310.507943784273	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-17.3958214304768	-15.5872089902854	111.166643327233	837	NA	NA	NA	5.38016928922694e-62	NA	NA	4.79373083670121e-59	non_linear_mixed	5.38016928922694e-62	4.79373083670121e-59	-15.5872089902854	111.166643327233	2
Oxytocin signaling pathway - Homo sapiens (human)	154	59	702.462610235574	702.479607402713	718.229384058335	1413	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	113.298379376496	114.387716552289	255.199343781345	1389	0.991089545882711	NA	NA	3.89973398001653e-119	NA	NA	3.47466297619473e-116	non_linear_mixed	3.89973398001653e-119	3.47466297619473e-116	114.387716552289	255.199343781345	3
Adipocytokine signaling pathway - Homo sapiens (human)	69	22	394.967799225543	395.013600752261	407.775088076662	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	155.061491060113	158.085491060113	270.327090720183	501	0.980976086249559	NA	NA	4.52348860821317e-47	NA	NA	4.03042834991793e-44	non_linear_mixed	4.52348860821317e-47	4.03042834991793e-44	158.085491060113	270.327090720183	2
B cell receptor signaling pathway - Homo sapiens (human)	80	24	165.333952309071	165.375910351029	178.402275291158	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	130.824669610621	133.583793698212	248.43957644941	549	0.819494562561243	NA	NA	2.41145534590045e-08	NA	NA	2.1486067131973e-05	non_linear_mixed	2.41145534590045e-08	2.1486067131973e-05	133.583793698212	248.43957644941	2
Fc epsilon RI signaling pathway - Homo sapiens (human)	67	23	234.739453569938	234.783249190376	247.68009770877	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	11.6587203669173	14.5442165501234	128.124517616399	525	0.985037418219031	NA	NA	1.05589823637757e-43	NA	NA	9.40805328612416e-41	non_linear_mixed	1.05589823637757e-43	9.40805328612416e-41	14.5442165501234	128.124517616399	2
Fc gamma R-mediated phagocytosis - Homo sapiens (human)	96	27	231.08335100932	231.120618090065	244.505023098377	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-49.0396859702616	-46.6009762928423	71.7553628312498	621	NA	NA	NA	3.49016326372489e-55	NA	NA	3.10973546797888e-52	non_linear_mixed	3.49016326372489e-55	3.10973546797888e-52	-46.6009762928423	71.7553628312498	2
TGF-beta signaling pathway - Homo sapiens (human)	94	28	432.396940203143	432.432868346856	445.927715224713	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	157.928093747508	160.275919834465	279.705068941633	645	NA	NA	NA	4.87684661487302e-54	NA	NA	4.34527033385186e-51	non_linear_mixed	4.87684661487302e-54	4.34527033385186e-51	160.275919834465	279.705068941633	2
Arginine and proline metabolism - Homo sapiens (human)	50	21	485.980111533002	486.028111533002	498.647840337216	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	205.181355221426	208.357825809661	319.190914459353	477	0.989383058170382	NA	NA	2.54612530952431e-55	NA	NA	2.26859765078616e-52	non_linear_mixed	2.54612530952431e-55	2.26859765078616e-52	208.357825809661	319.190914459353	2
Yersinia infection - Homo sapiens (human)	136	54	492.021890916061	492.040466767454	507.523004546798	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-148.480067727894	-147.287638705812	-8.97004505126421	1269	NA	NA	NA	6.48980430321227e-130	NA	NA	5.78241563416213e-127	non_linear_mixed	6.48980430321227e-130	5.78241563416213e-127	-147.287638705812	-8.97004505126421	2
Inositol phosphate metabolism - Homo sapiens (human)	73	31	259.761477429591	259.793909862023	273.59760053409	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	19.2053381212575	21.3170699648329	143.730446061751	717	NA	NA	NA	3.3500813542178e-47	NA	NA	2.98492248660806e-44	non_linear_mixed	3.3500813542178e-47	2.98492248660806e-44	21.3170699648329	143.730446061751	2
Glycerophospholipid metabolism - Homo sapiens (human)	98	22	46.5551051274732	46.6009066541908	59.362393978592	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-100.596122244715	-97.5721222447153	14.6694774153538	501	NA	NA	NA	9.04425140287502e-29	NA	NA	8.05842799996165e-26	non_linear_mixed	9.04425140287502e-29	8.05842799996165e-26	-97.5721222447153	14.6694774153538	2
Morphine addiction - Homo sapiens (human)	91	32	566.144127581131	566.175541193696	580.075496780574	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	196.531838957243	198.575082200486	321.91416175223	741	0.97941642239936	NA	NA	1.80321177414562e-73	NA	NA	1.60666169076375e-70	non_linear_mixed	1.80321177414562e-73	1.60666169076375e-70	198.575082200486	321.91416175223	4
PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)	89	29	330.146137522342	330.180819603267	343.782186503345	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	46.6152266170956	48.8786996709878	169.339667446125	669	NA	NA	NA	7.11015932665536e-56	NA	NA	6.33515196004993e-53	non_linear_mixed	7.11015932665536e-56	6.33515196004993e-53	48.8786996709878	169.339667446125	4
Amphetamine addiction - Homo sapiens (human)	69	25	8.31005925664101	8.35032771301685	21.5008482222894	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-156.009488405752	-153.366131762396	-37.2923877149162	573	0.993098792953645	NA	NA	4.23439527302426e-32	NA	NA	3.77284618826462e-29	non_linear_mixed	4.23439527302426e-32	3.77284618826462e-29	-153.366131762396	-37.2923877149162	2
Central carbon metabolism in cancer - Homo sapiens (human)	70	21	401.806355229862	401.854355229862	414.474084034076	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	409.736468253746	412.912938841981	523.746027491673	477	0.832457725742059	NA	NA	0.0210201828412583	NA	NA	1	null	NA	NA	401.854355229862	414.474084034076	NA
Choline metabolism in cancer - Homo sapiens (human)	98	28	329.688117771773	329.724045915485	343.218892793342	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	57.9493918077158	60.2972178946723	179.726367001841	645	NA	NA	NA	1.74031254826323e-53	NA	NA	1.55061848050254e-50	non_linear_mixed	1.74031254826323e-53	1.55061848050254e-50	60.2972178946723	179.726367001841	3
Alcoholism - Homo sapiens (human)	186	47	185.990587470774	186.011939783941	201.075191766948	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-234.678985285619	-233.304439831074	-98.9175466200533	1101	NA	NA	NA	5.21830603300577e-84	NA	NA	4.64951067540814e-81	non_linear_mixed	5.21830603300577e-84	4.64951067540814e-81	-233.304439831074	-98.9175466200533	3
Serotonergic synapse - Homo sapiens (human)	113	32	365.635316043912	365.666729656478	379.566685243355	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	42.2626217537045	44.3058649969477	167.644944548692	741	0.987766627647106	NA	NA	5.48572973573013e-64	NA	NA	4.88778519453554e-61	non_linear_mixed	5.48572973573013e-64	4.88778519453554e-61	44.3058649969477	167.644944548692	2
Dopaminergic synapse - Homo sapiens (human)	132	53	238.474359869511	238.493287314306	253.919397101211	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-232.419283122646	-231.203849039045	-93.4139480373441	1245	0.991943851219097	NA	NA	1.97602039324657e-94	NA	NA	1.7606341703827e-91	non_linear_mixed	1.97602039324657e-94	1.7606341703827e-91	-231.203849039045	-93.4139480373441	2
Adherens junction - Homo sapiens (human)	71	41	539.582239190467	539.606728986385	554.257116881624	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	14.6497789345034	16.2313688926624	146.723678154914	957	0.993554707609592	NA	NA	1.07867752989072e-105	NA	NA	9.61101679132627e-103	non_linear_mixed	1.07867752989072e-105	9.61101679132627e-103	16.2313688926624	146.723678154914	2
Melanoma - Homo sapiens (human)	72	25	424.154048294874	424.19431675125	437.344837260522	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	209.081595905398	211.724952548754	327.798696596234	573	0.978856796391937	NA	NA	4.17341064134187e-42	NA	NA	3.71850888143561e-39	non_linear_mixed	4.17341064134187e-42	3.71850888143561e-39	211.724952548754	327.798696596234	2
Glutamatergic synapse - Homo sapiens (human)	114	38	134.53194539088	134.558377108941	148.978865361103	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-219.33088074451	-217.620473504691	-89.3086010125033	885	NA	NA	NA	3.11377085167609e-70	NA	NA	2.7743698288434e-67	non_linear_mixed	3.11377085167609e-70	2.7743698288434e-67	-217.620473504691	-89.3086010125033	4
Insulin resistance - Homo sapiens (human)	108	39	502.190769697269	502.21652077023	516.715616126702	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	89.423003678189	91.0882019160745	220.146621543084	909	NA	NA	NA	2.25173494348934e-82	NA	NA	2.00629583464901e-79	non_linear_mixed	2.25173494348934e-82	2.00629583464901e-79	91.0882019160745	220.146621543084	2
Non-alcoholic fatty liver disease - Homo sapiens (human)	150	53	310.148716494571	310.167643939366	325.593753726271	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-172.266975982933	-171.051541899332	-33.2616408976316	1245	NA	NA	NA	7.91250968469178e-97	NA	NA	7.05004612906037e-94	non_linear_mixed	7.91250968469178e-97	7.05004612906037e-94	-171.051541899332	-33.2616408976316	3
AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)	100	44	674.489968314996	674.512782003209	689.376698707794	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	190.186286266999	191.657103387622	324.166859802187	1029	NA	NA	NA	3.20074137824289e-97	NA	NA	2.85186056801442e-94	non_linear_mixed	3.20074137824289e-97	2.85186056801442e-94	191.657103387622	324.166859802187	2
Cushing syndrome - Homo sapiens (human)	155	61	650.601873601351	650.618311957515	666.468656684915	1461	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	109.085048119486	110.137972910573	251.88609587156	1437	NA	NA	NA	3.69384783575743e-109	NA	NA	3.29121842165987e-106	non_linear_mixed	3.69384783575743e-109	3.29121842165987e-106	110.137972910573	251.88609587156	3
Growth hormone synthesis, secretion and action - Homo sapiens (human)	119	46	406.865432110221	406.887250292039	421.885517790732	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-39.6581339300812	-38.2529294691147	95.5226371945188	1077	0.98744068289951	NA	NA	2.28466214644757e-89	NA	NA	2.03563397248478e-86	non_linear_mixed	2.28466214644757e-89	2.03563397248478e-86	-38.2529294691147	95.5226371945188	4
Insulin secretion - Homo sapiens (human)	86	29	97.5340335068274	97.5687155877523	111.170082487831	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-145.088148368106	-142.824675314213	-22.3637075390763	669	0.992197699818267	NA	NA	1.28899736546468e-47	NA	NA	1.14849665262903e-44	non_linear_mixed	1.28899736546468e-47	1.14849665262903e-44	-142.824675314213	-22.3637075390763	2
Bladder cancer - Homo sapiens (human)	41	20	346.510025154494	346.560445322561	359.031383466199	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	184.099650425458	187.444783168821	296.79187523081	453	0.981366601531286	NA	NA	9.96913070171715e-32	NA	NA	8.88249545522998e-29	non_linear_mixed	9.96913070171715e-32	8.88249545522998e-29	187.444783168821	296.79187523081	2
Cell cycle - Homo sapiens (human)	124	63	2004.23758938865	2004.25350450801	2020.20115505887	1509	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1365.47911532184	1366.49798324637	1509.15120635381	1485	NA	NA	NA	1.50920402060941e-129	NA	NA	1.34470078236299e-126	non_linear_mixed	1.50920402060941e-129	1.34470078236299e-126	1366.49798324637	1509.15120635381	2
Oocyte meiosis - Homo sapiens (human)	129	63	1267.09736343979	1267.11327855915	1283.06092911001	1509	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	666.110658787588	667.129526712116	809.782749819553	1485	NA	NA	NA	1.29230485862487e-121	NA	NA	1.15144362903476e-118	non_linear_mixed	1.29230485862487e-121	1.15144362903476e-118	667.129526712116	809.782749819553	2
Dilated cardiomyopathy - Homo sapiens (human)	95	35	-54.9538643420232	-54.9251562080519	-40.7536586665111	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-322.623539622182	-320.761470656664	-194.821688542573	813	0.99588428766977	NA	NA	1.15726335781867e-52	NA	NA	1.03112165181643e-49	non_linear_mixed	1.15726335781867e-52	1.03112165181643e-49	-320.761470656664	-194.821688542573	2
HIF-1 signaling pathway - Homo sapiens (human)	109	35	599.017777294764	599.046485428736	613.217982970276	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	257.219245318453	259.08131428397	385.021096398062	813	0.991263451955286	NA	NA	9.29332971388035e-68	NA	NA	8.28035677506739e-65	non_linear_mixed	9.29332971388035e-68	8.28035677506739e-65	259.08131428397	385.021096398062	2
Viral myocarditis - Homo sapiens (human)	59	33	601.193683159314	601.224140012106	615.217367334758	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	143.83510550916	145.814163100783	270.048263088149	765	0.99296996168168	NA	NA	1.28569716617368e-91	NA	NA	1.14555617506075e-88	non_linear_mixed	1.28569716617368e-91	1.14555617506075e-88	145.814163100783	270.048263088149	2
JAK-STAT signaling pathway - Homo sapiens (human)	162	56	396.115319993158	396.133230440919	411.725536556407	1341	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-137.853977362043	-136.705041191831	2.63797170720011	1317	0.981351546469459	NA	NA	1.39657179356118e-107	NA	NA	1.24434546806301e-104	non_linear_mixed	1.39657179356118e-107	1.24434546806301e-104	-136.705041191831	2.63797170720011	2
Hypertrophic cardiomyopathy - Homo sapiens (human)	90	36	265.875714375082	265.903621351826	280.160432681494	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-39.7869301499081	-37.9783177097167	88.7755346078013	837	NA	NA	NA	2.25345594186854e-60	NA	NA	2.00782924420487e-57	non_linear_mixed	2.25345594186854e-60	2.00782924420487e-57	-37.9783177097167	88.7755346078013	2
Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)	77	34	165.344098717049	165.373655367295	179.457341781941	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-121.116952016295	-119.198170290406	5.90223556773628	789	0.995617837016771	NA	NA	1.80874611093979e-56	NA	NA	1.61159278484735e-53	non_linear_mixed	1.80874611093979e-56	1.61159278484735e-53	-119.198170290406	5.90223556773628	2
Longevity regulating pathway - multiple species - Homo sapiens (human)	62	26	582.877629777342	582.916339454761	596.18608088245	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	275.624011928862	278.16092468054	395.400071874836	597	0.98725349290296	NA	NA	1.06828897134348e-60	NA	NA	9.51845473467041e-58	non_linear_mixed	1.06828897134348e-60	9.51845473467041e-58	278.16092468054	395.400071874836	4
Long-term depression - Homo sapiens (human)	60	27	315.50923037968	315.546497460425	328.930902468737	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	73.6351510402276	76.0738607176469	194.430199841739	621	NA	NA	NA	1.82170330992415e-47	NA	NA	1.62313764914241e-44	non_linear_mixed	1.82170330992415e-47	1.62313764914241e-44	76.0738607176469	194.430199841739	2
Tight junction - Homo sapiens (human)	169	66	961.22789996201	961.243089835428	977.331025679133	1581	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	269.295542082482	270.26726444752	414.22367353659	1557	NA	NA	NA	9.71467271109313e-141	NA	NA	8.65577338558398e-138	non_linear_mixed	9.71467271109313e-141	8.65577338558398e-138	270.26726444752	414.22367353659	2
Thyroid hormone synthesis - Homo sapiens (human)	75	28	305.773291648944	305.809219792656	319.304066670513	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	30.8089948952039	33.1568209821604	152.585970089329	645	0.993915067334733	NA	NA	3.87114632295432e-54	NA	NA	3.4491913737523e-51	non_linear_mixed	3.87114632295432e-54	3.4491913737523e-51	33.1568209821604	152.585970089329	2
Small cell lung cancer - Homo sapiens (human)	92	43	855.146706295413	855.170052598915	869.964468133538	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	415.637200881574	417.143176977192	548.997057424695	1005	0.988131747156446	NA	NA	6.5155548149425e-88	NA	NA	5.80535934011377e-85	non_linear_mixed	6.5155548149425e-88	5.80535934011377e-85	417.143176977192	548.997057424695	3
Chemokine signaling pathway - Homo sapiens (human)	192	64	330.095479696488	330.111145492832	346.106290437611	1533	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-351.090143795099	-350.087491275205	-206.992847124993	1509	0.991014624544272	NA	NA	1.78383141421055e-138	NA	NA	1.5893937900616e-135	non_linear_mixed	1.78383141421055e-138	1.5893937900616e-135	-350.087491275205	-206.992847124993	4
Systemic lupus erythematosus - Homo sapiens (human)	134	31	-74.3795665035072	-74.3471340710748	-60.5434433990079	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-269.948344079061	-267.836612235486	-145.423236138568	717	0.996466947982441	NA	NA	3.09596148995109e-38	NA	NA	2.75850168754643e-35	non_linear_mixed	3.09596148995109e-38	2.75850168754643e-35	-267.836612235486	-145.423236138568	2
Acute myeloid leukemia - Homo sapiens (human)	67	25	572.612665502279	572.652933958655	585.803454467927	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	344.378889339522	347.022245982879	463.095990030358	573	0.976190194876704	NA	NA	9.8607391169706e-45	NA	NA	8.78591855322081e-42	non_linear_mixed	9.8607391169706e-45	8.78591855322081e-42	347.022245982879	463.095990030358	2
Autoimmune thyroid disease - Homo sapiens (human)	52	20	314.108633220203	314.15905338827	326.629991531909	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-21.0329348861762	-17.6878021428134	91.659289919176	453	0.989074246065736	NA	NA	2.14718226079796e-66	NA	NA	1.91313939437099e-63	non_linear_mixed	2.14718226079796e-66	1.91313939437099e-63	-17.6878021428134	91.659289919176	2
Inflammatory bowel disease - Homo sapiens (human)	65	20	-258.18030174556	-258.129881577492	-245.658943433854	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-345.299117042179	-341.953984298816	-232.606892236826	453	NA	NA	NA	1.82162724834325e-17	NA	NA	1.62306987827383e-14	non_linear_mixed	1.82162724834325e-17	1.62306987827383e-14	-341.953984298816	-232.606892236826	2
Th17 cell differentiation - Homo sapiens (human)	107	44	-216.708234768274	-216.685421080062	-201.821504375476	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-532.311930458723	-530.8411133381	-398.331356923535	1029	NA	NA	NA	2.11753303221687e-62	NA	NA	1.88672193170524e-59	non_linear_mixed	2.11753303221687e-62	1.88672193170524e-59	-530.8411133381	-398.331356923535	2
Ribosome biogenesis in eukaryotes - Homo sapiens (human)	108	41	896.384804872708	896.409294668627	911.059682563865	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	272.540002294314	274.121592252473	404.613901514724	957	NA	NA	NA	2.05419671962918e-126	NA	NA	1.8302892771896e-123	non_linear_mixed	2.05419671962918e-126	1.8302892771896e-123	274.121592252473	404.613901514724	2
Th1 and Th2 cell differentiation - Homo sapiens (human)	92	33	-280.281436208489	-280.250979355697	-266.257752033046	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-478.135354348657	-476.156296757034	-351.922196769668	765	NA	NA	NA	1.09345602198858e-38	NA	NA	9.74269315591825e-36	non_linear_mixed	1.09345602198858e-38	9.74269315591825e-36	-476.156296757034	-351.922196769668	2
GnRH signaling pathway - Homo sapiens (human)	93	37	322.188038158894	322.215187480161	336.55495338787	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-42.6407505539979	-40.8826110191142	86.6614865067907	861	NA	NA	NA	1.73784595840418e-72	NA	NA	1.54842074893813e-69	non_linear_mixed	1.73784595840418e-72	1.54842074893813e-69	-40.8826110191142	86.6614865067907	2
Bile secretion - Homo sapiens (human)	90	31	551.504048890872	551.536481323304	565.340171995371	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	114.015557181821	116.127289025396	238.540665122314	717	NA	NA	NA	1.71020436555728e-87	NA	NA	1.52379208971154e-84	non_linear_mixed	1.71020436555728e-87	1.52379208971154e-84	116.127289025396	238.540665122314	3
Gastric cancer - Homo sapiens (human)	149	57	719.736718383484	719.754313691402	735.400033678031	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	166.132970619275	167.261328828231	307.102808270203	1341	0.98810957980787	NA	NA	1.09511340038e-111	NA	NA	9.75746039738583e-109	non_linear_mixed	1.09511340038e-111	9.75746039738583e-109	167.261328828231	307.102808270203	3
Lysine degradation - Homo sapiens (human)	63	21	286.025490416391	286.073490416391	298.693219220605	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	39.8500504927698	43.0265210810051	153.859609730697	477	0.992687600714781	NA	NA	2.49059619576647e-48	NA	NA	2.21912121042793e-45	non_linear_mixed	2.49059619576647e-48	2.21912121042793e-45	43.0265210810051	153.859609730697	2
Ubiquitin mediated proteolysis - Homo sapiens (human)	140	66	910.449610799178	910.464800672595	926.552736516301	1581	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	198.507578013023	199.479300378062	343.435709467132	1557	NA	NA	NA	5.88175700455312e-145	NA	NA	5.24064549105683e-142	non_linear_mixed	5.88175700455312e-145	5.24064549105683e-142	199.479300378062	343.435709467132	2
Renal cell carcinoma - Homo sapiens (human)	69	28	384.137125340128	384.17305348384	397.667900361697	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	89.41498799086	91.7628140778165	211.191963184985	645	NA	NA	NA	3.79613315609891e-58	NA	NA	3.38235464208413e-55	non_linear_mixed	3.79613315609891e-58	3.38235464208413e-55	91.7628140778165	211.191963184985	2
Breast cancer - Homo sapiens (human)	147	53	521.121220455657	521.140147900452	536.566257687357	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	60.8479236744832	62.0633577580845	199.853258759785	1245	NA	NA	NA	3.18843280319458e-92	NA	NA	2.84089362764637e-89	non_linear_mixed	3.18843280319458e-92	2.84089362764637e-89	62.0633577580845	199.853258759785	3
Gastric acid secretion - Homo sapiens (human)	76	27	204.721527208508	204.758794289254	218.143199297565	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-27.4639465054419	-25.0252368280226	93.3311022960695	621	NA	NA	NA	1.59641376093447e-45	NA	NA	1.42240466099261e-42	non_linear_mixed	1.59641376093447e-45	1.42240466099261e-42	-25.0252368280226	93.3311022960695	2
Phagosome - Homo sapiens (human)	151	69	931.397355796853	931.41188364189	947.633836801689	1653	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	78.6653648112588	79.5941117400057	224.793693854779	1629	NA	NA	NA	1.01698285990026e-174	NA	NA	9.06131728171135e-172	non_linear_mixed	1.01698285990026e-174	9.06131728171135e-172	79.5941117400057	224.793693854779	2
Peroxisome - Homo sapiens (human)	82	30	312.548960120935	312.582479674008	326.286713756965	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	36.3414870876728	38.5264581859387	159.981269811945	693	0.98843932757358	NA	NA	2.16830735949986e-54	NA	NA	1.93196185731437e-51	non_linear_mixed	2.16830735949986e-54	1.93196185731437e-51	38.5264581859387	159.981269811945	2
Wnt signaling pathway - Homo sapiens (human)	166	65	630.007045573506	630.022469738031	646.064368874237	1557	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	23.1833870939056	24.1703322636184	167.699296800482	1533	NA	NA	NA	7.70062209714237e-123	NA	NA	6.86125428855385e-120	non_linear_mixed	7.70062209714237e-123	6.86125428855385e-120	24.1703322636184	167.699296800482	3
Autophagy - animal - Homo sapiens (human)	137	51	823.595394709129	823.615066840277	838.925033098346	1221	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	248.63056446676	249.894778513582	386.597309969711	1197	0.98998985521561	NA	NA	3.69046404739435e-116	NA	NA	3.28820346622836e-113	non_linear_mixed	3.69046404739435e-116	3.28820346622836e-113	249.894778513582	386.597309969711	2
Lysosome - Homo sapiens (human)	128	55	453.40686642516	453.425103507227	468.963027471901	1317	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-81.8983246046197	-80.7280459668488	58.1071248160516	1293	0.992204219217849	NA	NA	7.34331739570458e-108	NA	NA	6.54289579957278e-105	non_linear_mixed	7.34331739570458e-108	6.54289579957278e-105	-80.7280459668488	58.1071248160516	2
Amoebiasis - Homo sapiens (human)	101	42	517.028233796409	517.052138178879	531.775404142303	1005	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	81.3124104993633	82.8552676422204	214.036943612409	981	0.991483160409905	NA	NA	3.98637217787962e-87	NA	NA	3.55185761049074e-84	non_linear_mixed	3.98637217787962e-87	3.55185761049074e-84	82.8552676422204	214.036943612409	2
Gap junction - Homo sapiens (human)	88	43	871.907788115804	871.931134419306	886.725549953929	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	403.514895506546	405.020871602164	536.874752049667	1005	0.99212581040284	NA	NA	6.54388695029656e-94	NA	NA	5.83060327271424e-91	non_linear_mixed	6.54388695029656e-94	5.83060327271424e-91	405.020871602164	536.874752049667	2
FoxO signaling pathway - Homo sapiens (human)	131	51	1186.98184561296	1187.00151774411	1202.31148400218	1221	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	607.784833543119	609.049047589942	745.75157904607	1197	NA	NA	NA	4.78974952653944e-117	NA	NA	4.26766682814664e-114	non_linear_mixed	4.78974952653944e-117	4.26766682814664e-114	609.049047589942	745.75157904607	2
TNF signaling pathway - Homo sapiens (human)	112	38	500.190095922022	500.216527640084	514.637015892245	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	144.772068188062	146.482475427881	274.794347920069	885	NA	NA	NA	1.4925715644567e-70	NA	NA	1.32988126393092e-67	non_linear_mixed	1.4925715644567e-70	1.32988126393092e-67	146.482475427881	274.794347920069	3
Spinocerebellar ataxia - Homo sapiens (human)	143	67	813.294939479231	813.309902072747	829.443178828448	1605	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-94.6929580471653	-93.7359960218489	50.6411960957853	1581	0.994083689928095	NA	NA	1.96085586633696e-186	NA	NA	1.74712257690624e-183	non_linear_mixed	1.96085586633696e-186	1.74712257690624e-183	-93.7359960218489	50.6411960957853	2
Prostate cancer - Homo sapiens (human)	97	34	509.873285064869	509.902841715116	523.986528129762	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	196.681318145846	198.600099871735	323.700505729877	789	NA	NA	NA	6.57540762496483e-62	NA	NA	5.85868819384366e-59	non_linear_mixed	6.57540762496483e-62	5.85868819384366e-59	198.600099871735	323.700505729877	2
Long-term potentiation - Homo sapiens (human)	67	29	283.498873839985	283.53355592091	297.134922820988	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	9.52876354238742	11.7922365962796	132.253204371417	669	NA	NA	NA	6.15308001851058e-54	NA	NA	5.48239429649293e-51	non_linear_mixed	6.15308001851058e-54	5.48239429649293e-51	11.7922365962796	132.253204371417	2
Circadian entrainment - Homo sapiens (human)	97	36	233.664538571605	233.692445548349	247.949256878017	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-78.9402699395479	-77.1316574993565	49.6221948181615	837	NA	NA	NA	8.66354328322617e-62	NA	NA	7.71921706535452e-59	non_linear_mixed	8.66354328322617e-62	7.71921706535452e-59	-77.1316574993565	49.6221948181615	3
mRNA surveillance pathway - Homo sapiens (human)	98	44	580.968387033647	580.99120072186	595.855117426446	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	53.5242095175755	54.995026638198	187.504783052763	1029	0.988902113160653	NA	NA	3.22330588133154e-106	NA	NA	2.8719655402664e-103	non_linear_mixed	3.22330588133154e-106	2.8719655402664e-103	54.995026638198	187.504783052763	2
RNA transport - Homo sapiens (human)	186	94	2025.22133918166	2025.23199637527	2042.38538501952	2253	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	707.957399694041	708.636035241617	862.433812234726	2229	NA	NA	NA	1.31414781637106e-273	NA	NA	1.17090570438662e-270	non_linear_mixed	1.31414781637106e-273	1.17090570438662e-270	708.636035241617	862.433812234726	2
Ribosome - Homo sapiens (human)	158	68	215.632305959619	215.647047974361	231.824990566191	1629	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-535.388350681038	-534.445707289517	-389.654189221888	1605	NA	NA	NA	3.33131203866311e-153	NA	NA	2.96819902644883e-150	non_linear_mixed	3.33131203866311e-153	2.96819902644883e-150	-534.445707289517	-389.654189221888	2
Mitophagy - animal - Homo sapiens (human)	68	32	346.111909199243	346.143322811809	360.043278398686	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	19.4729537401354	21.5161969833787	144.855276535123	741	0.991695193233743	NA	NA	1.17915771830781e-64	NA	NA	1.05062952701226e-61	non_linear_mixed	1.17915771830781e-64	1.05062952701226e-61	21.5161969833787	144.855276535123	2
GABAergic synapse - Homo sapiens (human)	89	28	416.665436895424	416.701365039137	430.196211916994	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	125.54507819714	127.892904284096	247.322053391265	645	0.990293212695307	NA	NA	2.04785335714475e-57	NA	NA	1.82463734121597e-54	non_linear_mixed	2.04785335714475e-57	1.82463734121597e-54	127.892904284096	247.322053391265	2
Cytosolic DNA-sensing pathway - Homo sapiens (human)	63	21	294.589241568256	294.637241568256	307.25697037247	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	68.2357267113075	71.4121972995428	182.245285949234	477	0.984730069505617	NA	NA	2.34329834200883e-44	NA	NA	2.08787882272987e-41	non_linear_mixed	2.34329834200883e-44	2.08787882272987e-41	71.4121972995428	182.245285949234	2
p53 signaling pathway - Homo sapiens (human)	73	33	813.953025081405	813.983481934197	827.976709256848	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	514.888098402254	516.867155993877	641.101255981244	765	NA	NA	NA	4.9671035067453e-59	NA	NA	4.42568922451006e-56	non_linear_mixed	4.9671035067453e-59	4.42568922451006e-56	516.867155993877	641.101255981244	4
Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)	70	26	379.545520388905	379.584230066324	392.853971494013	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	90.721462296998	93.2583750486759	210.497522242973	597	NA	NA	NA	5.99347329708144e-57	NA	NA	5.34018470769956e-54	non_linear_mixed	5.99347329708144e-57	5.34018470769956e-54	93.2583750486759	210.497522242973	2
AMPK signaling pathway - Homo sapiens (human)	120	47	828.419428679346	828.440780992514	843.50403297552	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	379.793361958866	381.167907413411	515.554800624432	1101	NA	NA	NA	8.36474335258293e-90	NA	NA	7.45298632715139e-87	non_linear_mixed	8.36474335258293e-90	7.45298632715139e-87	381.167907413411	515.554800624432	3
Glucagon signaling pathway - Homo sapiens (human)	107	34	378.019062842947	378.048619493193	392.132305907839	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	46.1914850172072	48.1102667430955	173.210672601238	789	0.984631788717133	NA	NA	1.02381245699362e-65	NA	NA	9.12216899181316e-63	non_linear_mixed	1.02381245699362e-65	9.12216899181316e-63	48.1102667430955	173.210672601238	2
Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)	143	53	582.279871365262	582.298798810057	597.724908596962	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	62.0852952140463	63.3007292976475	201.090630299348	1245	NA	NA	NA	1.05240729541188e-104	NA	NA	9.37694900211987e-102	non_linear_mixed	1.05240729541188e-104	9.37694900211987e-102	63.3007292976475	201.090630299348	2
Basal cell carcinoma - Homo sapiens (human)	63	21	236.57785241559	236.62585241559	249.245581219804	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	94.2602335039575	97.4367040921928	208.269792741884	477	NA	NA	NA	7.71845240899015e-28	NA	NA	6.87714109641023e-25	non_linear_mixed	7.71845240899015e-28	6.87714109641023e-25	97.4367040921928	208.269792741884	2
Sphingolipid signaling pathway - Homo sapiens (human)	119	47	457.320220298756	457.341572611923	472.40482459493	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	24.6158437336137	25.9903891881592	160.37728239918	1101	0.988010366199048	NA	NA	1.67802831697405e-86	NA	NA	1.49512323042388e-83	non_linear_mixed	1.67802831697405e-86	1.49512323042388e-83	25.9903891881592	160.37728239918	2
Neutrophil extracellular trap formation - Homo sapiens (human)	188	52	176.04941770925	176.068710313752	191.437310356038	1245	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-224.705227233689	-223.465882971394	-86.2141934125962	1221	0.996162149416095	NA	NA	6.84709963593705e-80	NA	NA	6.10076577561991e-77	non_linear_mixed	6.84709963593705e-80	6.10076577561991e-77	-223.465882971394	-86.2141934125962	2
Hepatocellular carcinoma - Homo sapiens (human)	168	69	682.25469156272	682.269219407757	698.491172567556	1653	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	27.4052867314456	28.3340336601925	173.533615774966	1629	NA	NA	NA	6.23678263056828e-133	NA	NA	5.55697332383634e-130	non_linear_mixed	6.23678263056828e-133	5.55697332383634e-130	28.3340336601925	173.533615774966	3
Glioma - Homo sapiens (human)	75	30	383.076534333677	383.110053886749	396.814287969707	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	139.627207377587	141.812178475853	263.266990101859	693	0.986655081009093	NA	NA	8.7926074369557e-48	NA	NA	7.83421322632753e-45	non_linear_mixed	8.7926074369557e-48	7.83421322632753e-45	141.812178475853	263.266990101859	3
Adrenergic signaling in cardiomyocytes - Homo sapiens (human)	150	54	324.636132213161	324.654708064554	340.137245843897	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-164.043878856033	-162.851449833951	-24.5338561794034	1269	0.993515337453598	NA	NA	3.92560715738859e-98	NA	NA	3.49771597723324e-95	non_linear_mixed	3.92560715738859e-98	3.49771597723324e-95	-162.851449833951	-24.5338561794034	2
Proteasome - Homo sapiens (human)	46	31	534.034707120096	534.067139552529	547.870830224596	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	35.668192775861	37.7799246194364	160.193300716355	717	NA	NA	NA	3.76390097703124e-100	NA	NA	3.35363577053483e-97	non_linear_mixed	3.76390097703124e-100	3.35363577053483e-97	37.7799246194364	160.193300716355	2
Hippo signaling pathway - Homo sapiens (human)	157	60	1023.18444123097	1023.2011543229	1039.00163640868	1437	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	319.097240175086	320.168061704832	461.451996774478	1413	0.992463462238898	NA	NA	2.66478182777737e-143	NA	NA	2.37432060854964e-140	non_linear_mixed	2.66478182777737e-143	2.37432060854964e-140	320.168061704832	461.451996774478	2
Longevity regulating pathway - Homo sapiens (human)	89	40	787.436923838049	787.46202844056	802.037723691435	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	354.915204796086	356.537522392653	486.322403476557	933	NA	NA	NA	1.83085990446887e-86	NA	NA	1.63129617488176e-83	non_linear_mixed	1.83085990446887e-86	1.63129617488176e-83	356.537522392653	486.322403476557	2
Chagas disease - Homo sapiens (human)	102	34	93.7756875839923	93.8052442342386	107.888930648885	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-156.902675888206	-154.983894162318	-29.8834883041756	789	0.991620790136504	NA	NA	3.09425411314577e-49	NA	NA	2.75698041481288e-46	non_linear_mixed	3.09425411314577e-49	2.75698041481288e-46	-154.983894162318	-29.8834883041756	2
Protein processing in endoplasmic reticulum - Homo sapiens (human)	170	56	720.794582349835	720.812492797596	736.404798913084	1341	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	73.7602873891331	74.9092235593458	214.252236458377	1317	NA	NA	NA	2.74618951049434e-131	NA	NA	2.44685485385045e-128	non_linear_mixed	2.74618951049434e-131	2.44685485385045e-128	74.9092235593458	214.252236458377	2
Spliceosome - Homo sapiens (human)	151	77	1454.45197127822	1454.46498646261	1471.01754903483	1845	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	382.88355060814	383.714319838909	531.973750417584	1821	NA	NA	NA	3.34565378575429e-221	NA	NA	2.98097752310707e-218	non_linear_mixed	3.34565378575429e-221	2.98097752310707e-218	383.714319838909	531.973750417584	2
Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)	53	22	115.486264438379	115.532065965097	128.293553289498	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-60.3497066599903	-57.3257066599903	54.9158930000787	501	NA	NA	NA	2.3760299339396e-34	NA	NA	2.11704267114018e-31	non_linear_mixed	2.3760299339396e-34	2.11704267114018e-31	-57.3257066599903	54.9158930000787	2
Axon guidance - Homo sapiens (human)	182	67	745.295625859416	745.310588452932	761.443865208632	1605	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	44.7228720269071	45.6798340522236	190.057026169858	1581	0.988145380433254	NA	NA	1.46723363072008e-142	NA	NA	1.30730516497159e-139	non_linear_mixed	1.46723363072008e-142	1.30730516497159e-139	45.6798340522236	190.057026169858	4
NOD-like receptor signaling pathway - Homo sapiens (human)	181	60	642.955632228418	642.97234532034	658.772827406128	1437	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	6.41811890331905	7.4889404330641	148.77287550271	1413	NA	NA	NA	4.42176118329729e-129	NA	NA	3.93978921431788e-126	non_linear_mixed	4.42176118329729e-129	3.93978921431788e-126	7.4889404330641	148.77287550271	4
RIG-I-like receptor signaling pathway - Homo sapiens (human)	70	24	140.209703821773	140.251661863731	153.278026803861	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-110.265588147077	-107.506464059486	7.34931869171186	549	0.989567860956668	NA	NA	3.39958872283817e-49	NA	NA	3.02903355204881e-46	non_linear_mixed	3.39958872283817e-49	3.02903355204881e-46	-107.506464059486	7.34931869171186	2
VEGF signaling pathway - Homo sapiens (human)	59	26	328.288110993896	328.326820671315	341.596562099004	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	93.7943289953426	96.3312417470204	213.570388941317	597	0.986774783536243	NA	NA	5.5055586003133e-46	NA	NA	4.90545271287915e-43	non_linear_mixed	5.5055586003133e-46	4.90545271287915e-43	96.3312417470204	213.570388941317	2
Mineral absorption - Homo sapiens (human)	59	23	590.532526869297	590.576322489736	603.473171008129	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	462.18470079817	465.070196981376	578.650498047652	525	0.986403115791888	NA	NA	3.64109927011311e-25	NA	NA	3.24421944967078e-22	non_linear_mixed	3.64109927011311e-25	3.24421944967078e-22	465.070196981376	578.650498047652	2
Apelin signaling pathway - Homo sapiens (human)	137	44	705.402874752901	705.425688441114	720.2896051457	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	244.094173504737	245.564990625359	378.074747039924	1029	NA	NA	NA	1.94278286985871e-92	NA	NA	1.73101953704411e-89	non_linear_mixed	1.94278286985871e-92	1.73101953704411e-89	245.564990625359	378.074747039924	3
Estrogen signaling pathway - Homo sapiens (human)	137	49	719.13717317736	719.157650993059	734.346795562735	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	211.027234233321	212.344307404053	347.913835701702	1149	0.986405580984247	NA	NA	3.49950149029657e-102	NA	NA	3.11805582785425e-99	non_linear_mixed	3.49950149029657e-102	3.11805582785425e-99	212.344307404053	347.913835701702	4
Fluid shear stress and atherosclerosis - Homo sapiens (human)	139	53	612.941640423129	612.960567867924	628.386677654829	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	29.3872296128717	30.602663696473	168.392564698174	1245	NA	NA	NA	5.84900811928022e-118	NA	NA	5.21146623427868e-115	non_linear_mixed	5.84900811928022e-118	5.21146623427868e-115	30.602663696473	168.392564698174	2
Vascular smooth muscle contraction - Homo sapiens (human)	133	43	528.035803361076	528.059149664577	542.8535651992	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	92.8463639126944	94.3523400083119	226.206220455815	1005	0.987755026288494	NA	NA	5.12509028746727e-87	NA	NA	4.56645544613333e-84	non_linear_mixed	5.12509028746727e-87	4.56645544613333e-84	94.3523400083119	226.206220455815	2
Necroptosis - Homo sapiens (human)	159	43	28.1286102135289	28.1519565170308	42.9463720516534	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-336.947472128594	-335.441496032977	-203.587615585474	1005	0.996063649363394	NA	NA	1.54581844563222e-72	NA	NA	1.37732423505831e-69	non_linear_mixed	1.54581844563222e-72	1.37732423505831e-69	-335.441496032977	-203.587615585474	2
C-type lectin receptor signaling pathway - Homo sapiens (human)	104	32	317.981169832848	318.012583445414	331.912539032291	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-28.5787900516763	-26.5355468084331	96.8035327433108	741	NA	NA	NA	9.81593083750386e-69	NA	NA	8.74599437621594e-66	non_linear_mixed	9.81593083750386e-69	8.74599437621594e-66	-26.5355468084331	96.8035327433108	2
Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)	76	26	663.237506929119	663.276216606538	676.545958034227	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	274.301492114943	276.838404866621	394.077552060917	597	0.991364957918827	NA	NA	1.883594282865e-77	NA	NA	1.67828250603271e-74	non_linear_mixed	1.883594282865e-77	1.67828250603271e-74	276.838404866621	394.077552060917	3
Drug metabolism - other enzymes - Homo sapiens (human)	80	28	450.130632089244	450.166560232957	463.661407110814	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	118.32978359671	120.677609683666	240.106758790835	645	0.99493577567494	NA	NA	1.03678873684767e-65	NA	NA	9.23778764531276e-63	non_linear_mixed	1.03678873684767e-65	9.23778764531276e-63	120.677609683666	240.106758790835	2
Drug metabolism - cytochrome P450 - Homo sapiens (human)	70	24	534.536345425948	534.578303467906	547.604668408035	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	210.681991036804	213.441115124396	328.296897875593	549	0.992747205164646	NA	NA	4.37320846120155e-64	NA	NA	3.89652873893058e-61	non_linear_mixed	4.37320846120155e-64	3.89652873893058e-61	213.441115124396	328.296897875593	2
Oxidative phosphorylation - Homo sapiens (human)	133	43	-185.606385529583	-185.583039226081	-170.788623691459	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-631.917008044661	-630.411031949044	-498.55715150154	1005	NA	NA	NA	2.5293747637001e-89	NA	NA	2.25367291445679e-86	non_linear_mixed	2.5293747637001e-89	2.25367291445679e-86	-630.411031949044	-498.55715150154	2
Hematopoietic cell lineage - Homo sapiens (human)	98	35	-1.87846038483366	-1.84975225086237	12.3217452906784	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-305.012456212044	-303.150387246526	-177.210605132435	813	NA	NA	NA	7.37672533530392e-60	NA	NA	6.57266227375579e-57	non_linear_mixed	7.37672533530392e-60	6.57266227375579e-57	-303.150387246526	-177.210605132435	2
IL-17 signaling pathway - Homo sapiens (human)	94	28	867.330540889674	867.366469033387	880.861315911243	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	482.994078466535	485.341904553491	604.77105366066	645	NA	NA	NA	1.6728395569594e-76	NA	NA	1.49050004525082e-73	non_linear_mixed	1.6728395569594e-76	1.49050004525082e-73	485.341904553491	604.77105366066	3
Tuberculosis - Homo sapiens (human)	179	63	134.174503343006	134.190418462369	150.138069013224	1509	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-459.794400494204	-458.775532569676	-316.122309462238	1485	NA	NA	NA	3.83253999873494e-120	NA	NA	3.41479313887283e-117	non_linear_mixed	3.83253999873494e-120	3.41479313887283e-117	-458.775532569676	-316.122309462238	2
DNA replication - Homo sapiens (human)	36	22	886.809741574754	886.855543101472	899.617030425873	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	672.104341580952	675.128341580952	787.369941241021	501	NA	NA	NA	4.93832683722304e-42	NA	NA	4.40004921196573e-39	non_linear_mixed	4.93832683722304e-42	4.40004921196573e-39	675.128341580952	787.369941241021	2
RNA degradation - Homo sapiens (human)	79	32	660.696407359745	660.72782097231	674.627776559188	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	307.585227971171	309.628471214414	432.967550766158	741	NA	NA	NA	4.44229648122296e-70	NA	NA	3.95808616476966e-67	non_linear_mixed	4.44229648122296e-70	3.95808616476966e-67	309.628471214414	432.967550766158	2
Renin secretion - Homo sapiens (human)	69	25	340.440017419883	340.480285876259	353.630806385532	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	306.803865225995	309.447221869352	425.520965916831	573	0.811460974854282	NA	NA	3.3312900594224e-08	NA	NA	2.96817944294536e-05	non_linear_mixed	3.3312900594224e-08	2.96817944294536e-05	309.447221869352	425.520965916831	2
Protein digestion and absorption - Homo sapiens (human)	103	30	-194.393010485544	-194.359490932472	-180.655256849514	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-437.378714892567	-435.193743794301	-313.738932168294	693	0.996682847440218	NA	NA	1.08953759157949e-47	NA	NA	9.70777994097324e-45	non_linear_mixed	1.08953759157949e-47	9.70777994097324e-45	-435.193743794301	-313.738932168294	2
Salivary secretion - Homo sapiens (human)	93	33	537.213665505857	537.244122358649	551.2373496813	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	160.949775711314	162.928833302937	287.162933290303	765	0.990123308297155	NA	NA	7.70523969661811e-75	NA	NA	6.86536856968673e-72	non_linear_mixed	7.70523969661811e-75	6.86536856968673e-72	162.928833302937	287.162933290303	2
Pancreatic secretion - Homo sapiens (human)	102	30	410.543494067461	410.577013620533	424.281247703491	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	90.7480989604803	92.9330700587462	214.387881684753	693	0.99226574731409	NA	NA	2.95159959092932e-63	NA	NA	2.62987523551802e-60	non_linear_mixed	2.95159959092932e-63	2.62987523551802e-60	92.9330700587462	214.387881684753	2
Natural killer cell mediated cytotoxicity - Homo sapiens (human)	130	47	724.849847252943	724.87119956611	739.934451549117	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	151.166053199305	152.54059865385	286.927491864871	1101	0.987259323553011	NA	NA	6.84625673546488e-116	NA	NA	6.10001475129921e-113	non_linear_mixed	6.84625673546488e-116	6.10001475129921e-113	152.54059865385	286.927491864871	2
Leishmaniasis - Homo sapiens (human)	76	25	-346.973069164311	-346.932800707935	-333.782280198663	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-460.50727499047	-457.863918347113	-341.790174299634	573	NA	NA	NA	2.3139343731655e-22	NA	NA	2.06171552649046e-19	non_linear_mixed	2.3139343731655e-22	2.06171552649046e-19	-457.863918347113	-341.790174299634	2
Toxoplasmosis - Homo sapiens (human)	112	49	412.864350393026	412.884828208726	428.073972778402	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-66.6335551032985	-65.3164819325668	70.253046365083	1149	NA	NA	NA	3.20372250040743e-96	NA	NA	2.85451674786302e-93	non_linear_mixed	3.20372250040743e-96	2.85451674786302e-93	-65.3164819325668	70.253046365083	2
Cardiac muscle contraction - Homo sapiens (human)	87	25	1.16102508263134	1.20129353900718	14.3518140482798	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-248.952715593522	-246.309358950165	-130.235614902686	573	NA	NA	NA	4.0196404847029e-49	NA	NA	3.58149967187029e-46	non_linear_mixed	4.0196404847029e-49	3.58149967187029e-46	-246.309358950165	-130.235614902686	4
Phosphatidylinositol signaling system - Homo sapiens (human)	97	39	251.836709723383	251.862460796345	266.361556152816	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-57.8833455808655	-56.2181473429801	72.8402722840295	909	NA	NA	NA	3.35711386065578e-61	NA	NA	2.9911884498443e-58	non_linear_mixed	3.35711386065578e-61	2.9911884498443e-58	-56.2181473429801	72.8402722840295	3
Phospholipase D signaling pathway - Homo sapiens (human)	147	41	532.433803354963	532.458293150881	547.10868104612	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	76.327842668264	77.909432626423	208.401741888675	957	NA	NA	NA	2.34063560331484e-91	NA	NA	2.08550632255353e-88	non_linear_mixed	2.34063560331484e-91	2.08550632255353e-88	77.909432626423	208.401741888675	2
Purine metabolism - Homo sapiens (human)	129	44	943.012749952544	943.035563640757	957.899480345343	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	422.745034372005	424.215851492627	556.725607907192	1029	NA	NA	NA	1.01604861664602e-104	NA	NA	9.05299317431607e-102	non_linear_mixed	1.01604861664602e-104	9.05299317431607e-102	424.215851492627	556.725607907192	2
PPAR signaling pathway - Homo sapiens (human)	74	23	436.516197491225	436.559993111663	449.456841630056	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	233.441911203401	236.327407386607	349.907708452882	525	NA	NA	NA	1.01092525857181e-39	NA	NA	9.0073440538748e-37	non_linear_mixed	1.01092525857181e-39	9.0073440538748e-37	236.327407386607	349.907708452882	2
Pathogenic Escherichia coli infection - Homo sapiens (human)	196	73	1082.81364720795	1082.82737718506	1099.21918702244	1749	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	211.827150703357	212.70418086577	359.477009033758	1725	0.99426234376101	NA	NA	1.37731143931014e-178	NA	NA	1.22718449242533e-175	non_linear_mixed	1.37731143931014e-178	1.22718449242533e-175	212.70418086577	359.477009033758	2
Homologous recombination - Homo sapiens (human)	41	21	411.110417140812	411.158417140812	423.778145945026	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	231.554769222515	234.73123981075	345.564328460442	477	NA	NA	NA	4.42703173482718e-35	NA	NA	3.94448527573102e-32	non_linear_mixed	4.42703173482718e-35	3.94448527573102e-32	234.73123981075	345.564328460442	2
Chemical carcinogenesis - Homo sapiens (human)	83	29	579.942648733995	579.97733081492	593.578697714998	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	146.54543743698	148.808910490872	269.269878266009	669	NA	NA	NA	1.20559895058545e-86	NA	NA	1.07418866497163e-83	non_linear_mixed	1.20559895058545e-86	1.07418866497163e-83	148.808910490872	269.269878266009	3
Prolactin signaling pathway - Homo sapiens (human)	70	27	168.720658103995	168.75792518474	182.142330193052	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-84.9429767145116	-82.5042670370922	35.8520720869998	621	NA	NA	NA	7.75331226539164e-50	NA	NA	6.90820122846395e-47	non_linear_mixed	7.75331226539164e-50	6.90820122846395e-47	-82.5042670370922	35.8520720869998	2
Rheumatoid arthritis - Homo sapiens (human)	92	32	-12.5384281247623	-12.5070145121968	1.39294107468074	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-319.075059206922	-317.031815963679	-193.692736411935	741	0.995320250563979	NA	NA	1.4954997507293e-60	NA	NA	1.3324902778998e-57	non_linear_mixed	1.4954997507293e-60	1.3324902778998e-57	-317.031815963679	-193.692736411935	2
Antigen processing and presentation - Homo sapiens (human)	78	37	696.685377764739	696.712527086006	711.052292993715	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	177.604668974972	179.362808509856	306.90690603576	861	0.992951036881501	NA	NA	1.79769853200878e-104	NA	NA	1.60174939201982e-101	non_linear_mixed	1.79769853200878e-104	1.60174939201982e-101	179.362808509856	306.90690603576	2
Transcriptional misregulation in cancer - Homo sapiens (human)	191	78	1307.14816486093	1307.16101282667	1323.75245283204	1869	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	513.380642730459	514.200599346511	662.819234470472	1845	NA	NA	NA	3.08039464499815e-162	NA	NA	2.74463162869336e-159	non_linear_mixed	3.08039464499815e-162	2.74463162869336e-159	514.200599346511	662.819234470472	2
Hepatitis C - Homo sapiens (human)	157	57	835.845544107223	835.863139415141	851.508859401771	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	259.402623694598	260.530981903553	400.372461345525	1341	NA	NA	NA	1.80884681784485e-116	NA	NA	1.61168251469977e-113	non_linear_mixed	1.80884681784485e-116	1.61168251469977e-113	260.530981903553	400.372461345525	2
ErbB signaling pathway - Homo sapiens (human)	85	35	901.645260786044	901.673968920015	915.845466461556	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	456.784088390483	458.646157356	584.585939470092	813	NA	NA	NA	5.05577266075025e-89	NA	NA	4.50469344072847e-86	non_linear_mixed	5.05577266075025e-89	4.50469344072847e-86	458.646157356	584.585939470092	2
Leukocyte transendothelial migration - Homo sapiens (human)	114	42	99.5782167086913	99.6021210911614	114.325387054585	1005	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-238.822626965689	-237.279769822832	-106.098093852643	981	NA	NA	NA	4.61713321757369e-67	NA	NA	4.11386569685816e-64	non_linear_mixed	4.61713321757369e-67	4.11386569685816e-64	-237.279769822832	-106.098093852643	2
Toll-like receptor signaling pathway - Homo sapiens (human)	104	31	-68.3356632763817	-68.3032308439493	-54.4995401718824	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-263.884281709609	-261.772549866033	-139.359173769115	717	NA	NA	NA	3.1245044299863e-38	NA	NA	2.78393344711779e-35	non_linear_mixed	3.1245044299863e-38	2.78393344711779e-35	-261.772549866033	-139.359173769115	2
Insulin signaling pathway - Homo sapiens (human)	137	53	747.613764829718	747.632692274513	763.058802061419	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	169.921530345226	171.136964428827	308.926865430528	1245	0.988021513606484	NA	NA	9.89996006671577e-117	NA	NA	8.82086441944375e-114	non_linear_mixed	9.89996006671577e-117	8.82086441944375e-114	171.136964428827	308.926865430528	2
Osteoclast differentiation - Homo sapiens (human)	127	36	26.9113012002729	26.9392081770171	41.196019506685	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-218.729620485471	-216.921008045279	-90.1671557277613	837	NA	NA	NA	3.18968085299654e-48	NA	NA	2.84200564001992e-45	non_linear_mixed	3.18968085299654e-48	2.84200564001992e-45	-216.921008045279	-90.1671557277613	2
Melanogenesis - Homo sapiens (human)	101	40	330.017888855111	330.042993457621	344.618688708496	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1.73192783186266	3.35424542842918	133.139126512333	933	0.981720532602463	NA	NA	5.42960085078952e-65	NA	NA	4.83777435805346e-62	non_linear_mixed	5.42960085078952e-65	4.83777435805346e-62	3.35424542842918	133.139126512333	2
cGMP-PKG signaling pathway - Homo sapiens (human)	167	57	643.696500107448	643.714095415366	659.359815401996	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	63.4865879719314	64.6149461808866	204.456425622859	1341	NA	NA	NA	2.93797373624457e-117	NA	NA	2.61773459899391e-114	non_linear_mixed	2.93797373624457e-117	2.61773459899391e-114	64.6149461808866	204.456425622859	2
Apoptosis - Homo sapiens (human)	136	59	970.119312946104	970.136310113243	985.886086768865	1413	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	397.511591852749	398.600929028542	539.412556257598	1389	NA	NA	NA	1.15045808600678e-115	NA	NA	1.02505815463204e-112	non_linear_mixed	1.15045808600678e-115	1.02505815463204e-112	398.600929028542	539.412556257598	3
NF-kappa B signaling pathway - Homo sapiens (human)	103	32	305.940089260803	305.971502873369	319.871458460246	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-12.5146998740978	-10.4714566308546	112.867622920889	741	0.987129883224021	NA	NA	5.54397746988449e-63	NA	NA	4.93968392566708e-60	non_linear_mixed	5.54397746988449e-63	4.93968392566708e-60	-10.4714566308546	112.867622920889	2
Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)	100	24	-67.419714474485	-67.377756432527	-54.3513914923973	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-332.531836665572	-329.772712577981	-214.916929826783	549	0.930503718113586	NA	NA	3.80361899669936e-52	NA	NA	3.38902452605913e-49	non_linear_mixed	3.80361899669936e-52	3.38902452605913e-49	-329.772712577981	-214.916929826783	4
Cellular senescence - Homo sapiens (human)	156	78	1709.11575178548	1709.12859975121	1725.72003975659	1869	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	797.997848035458	798.81780465151	947.436439775471	1845	NA	NA	NA	4.24967638204731e-187	NA	NA	3.78646165640415e-184	non_linear_mixed	4.24967638204731e-187	3.78646165640415e-184	798.81780465151	947.436439775471	2
Cholinergic synapse - Homo sapiens (human)	113	36	255.139504677448	255.167411654192	269.42422298386	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-93.7507526166045	-91.9421401764131	34.811712141105	837	0.988329901941977	NA	NA	3.26510134796343e-69	NA	NA	2.90920530103542e-66	non_linear_mixed	3.26510134796343e-69	2.90920530103542e-66	-91.9421401764131	34.811712141105	2
Nucleotide excision repair - Homo sapiens (human)	47	23	746.965124530834	747.008920151272	759.905768669665	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	517.800123449491	520.685619632697	634.265920698973	525	0.927174872037676	NA	NA	6.42170116653061e-45	NA	NA	5.72173573937877e-42	non_linear_mixed	6.42170116653061e-45	5.72173573937877e-42	520.685619632697	634.265920698973	2
Notch signaling pathway - Homo sapiens (human)	59	20	190.334965485944	190.385385654011	202.85632379765	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	16.9600385699154	20.3051713132782	129.652263375268	453	NA	NA	NA	7.21041461032042e-34	NA	NA	6.42447941779549e-31	non_linear_mixed	7.21041461032042e-34	6.42447941779549e-31	20.3051713132782	129.652263375268	3
Vibrio cholerae infection - Homo sapiens (human)	50	21	173.248812407014	173.296812407014	185.916541211228	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-22.3232503903791	-19.1467798021438	91.6863088475478	477	NA	NA	NA	3.0913347578529e-38	NA	NA	2.75437926924694e-35	non_linear_mixed	3.0913347578529e-38	2.75437926924694e-35	-19.1467798021438	91.6863088475478	2
Influenza A - Homo sapiens (human)	172	61	348.187095448704	348.203533804869	364.053878532268	1461	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-256.19071291461	-255.137788123524	-113.389665162536	1437	NA	NA	NA	2.51081462723518e-122	NA	NA	2.23713583286655e-119	non_linear_mixed	2.51081462723518e-122	2.23713583286655e-119	-255.137788123524	-113.389665162536	2
Pancreatic cancer - Homo sapiens (human)	76	30	390.065619588498	390.099139141571	403.803373224529	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	150.538787493665	152.723758591931	274.178570217938	693	NA	NA	NA	5.39040679478647e-47	NA	NA	4.80285245415474e-44	non_linear_mixed	5.39040679478647e-47	4.80285245415474e-44	152.723758591931	274.178570217938	3
Endometrial cancer - Homo sapiens (human)	58	23	341.207565992261	341.251361612699	354.148210131092	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	156.827921502031	159.713417685237	273.293718751513	525	0.9851456911024	NA	NA	4.98730799736822e-36	NA	NA	4.44369142565508e-33	non_linear_mixed	4.98730799736822e-36	4.44369142565508e-33	159.713417685237	273.293718751513	3
Colorectal cancer - Homo sapiens (human)	86	37	837.261035107614	837.288184428881	851.62795033659	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	445.957754961251	447.715894496135	575.25999202204	861	NA	NA	NA	6.11831778725219e-78	NA	NA	5.4514211484417e-75	non_linear_mixed	6.11831778725219e-78	5.4514211484417e-75	447.715894496135	575.25999202204	3
Synaptic vesicle cycle - Homo sapiens (human)	78	25	39.9732800015231	40.0135484578989	53.1640689671715	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-103.190700450125	-100.547343806769	15.5264002407108	573	0.99453412784321	NA	NA	5.30515564713461e-28	NA	NA	4.72689368159694e-25	non_linear_mixed	5.30515564713461e-28	4.72689368159694e-25	-100.547343806769	15.5264002407108	2
mTOR signaling pathway - Homo sapiens (human)	154	58	1064.64512629085	1064.66241735713	1080.36061681353	1389	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	371.116011205019	372.224515603846	512.555425909167	1365	NA	NA	NA	4.47678589899012e-141	NA	NA	3.9888162360002e-138	non_linear_mixed	4.47678589899012e-141	3.9888162360002e-138	372.224515603846	512.555425909167	2
Thyroid hormone signaling pathway - Homo sapiens (human)	121	51	476.920586384586	476.940258515734	492.250224773803	1221	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-20.5451272705486	-19.2809132237259	117.421618232403	1197	NA	NA	NA	5.79951451889423e-100	NA	NA	5.16736743633476e-97	non_linear_mixed	5.79951451889423e-100	5.16736743633476e-97	-19.2809132237259	117.421618232403	2
Retrograde endocannabinoid signaling - Homo sapiens (human)	148	50	364.906869035606	364.926935925238	380.177099542934	1197	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-151.883619470618	-150.593517081539	-14.4515449046633	1173	0.995266303104247	NA	NA	5.4046793629747e-104	NA	NA	4.81556931241046e-101	non_linear_mixed	5.4046793629747e-104	4.81556931241046e-101	-150.593517081539	-14.4515449046633	2
Hepatitis B - Homo sapiens (human)	162	63	1029.53312011506	1029.54903523442	1045.49668578528	1509	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	405.9765619098	406.995429834329	549.648652941766	1485	NA	NA	NA	2.36150970091015e-126	NA	NA	2.10410514351095e-123	non_linear_mixed	2.36150970091015e-126	2.10410514351095e-123	406.995429834329	549.648652941766	2
Measles - Homo sapiens (human)	139	54	625.064368161202	625.082944012595	640.565481791939	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	62.0348003305834	63.2272293526654	201.544823007213	1269	0.991518319493716	NA	NA	1.16596218880178e-113	NA	NA	1.03887231022238e-110	non_linear_mixed	1.16596218880178e-113	1.03887231022238e-110	63.2272293526654	201.544823007213	3
Neurotrophin signaling pathway - Homo sapiens (human)	119	40	336.318426386622	336.343530989133	350.919226240008	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-36.4870556172183	-34.8647380206518	94.9201430632525	933	NA	NA	NA	3.97064995830507e-74	NA	NA	3.53784911284982e-71	non_linear_mixed	3.97064995830507e-74	3.53784911284982e-71	-34.8647380206518	94.9201430632525	2
Fosphenytoin (Antiarrhythmic) Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2411877303288	67.5863204736916	176.933412535681	453	NA	NA	NA	1.04432023867343e-45	NA	NA	9.30489332658028e-43	non_linear_mixed	1.04432023867343e-45	9.30489332658028e-43	67.5863204736916	176.933412535681	3
Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)	193	73	1104.09692479744	1104.11065477456	1120.50246461193	1749	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	263.736220944914	264.613251107327	411.386079275315	1725	NA	NA	NA	4.24410879841899e-172	NA	NA	3.78150093939132e-169	non_linear_mixed	4.24410879841899e-172	3.78150093939132e-169	264.613251107327	411.386079275315	2
Progesterone-mediated oocyte maturation - Homo sapiens (human)	100	40	1022.54177996473	1022.56688456724	1037.14257981812	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	687.060421873195	688.682739469762	818.467620553666	933	NA	NA	NA	1.82934707314393e-66	NA	NA	1.62994824217124e-63	non_linear_mixed	1.82934707314393e-66	1.62994824217124e-63	688.682739469762	818.467620553666	2
Disopyramide Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2411877303288	67.5863204736916	176.933412535681	453	NA	NA	NA	1.04432023867343e-45	NA	NA	9.30489332658028e-43	non_linear_mixed	1.04432023867343e-45	9.30489332658028e-43	67.5863204736916	176.933412535681	3
Procainamide (Antiarrhythmic) Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2411877303288	67.5863204736916	176.933412535681	453	NA	NA	NA	1.04432023867343e-45	NA	NA	9.30489332658028e-43	non_linear_mixed	1.04432023867343e-45	9.30489332658028e-43	67.5863204736916	176.933412535681	3
Phenytoin (Antiarrhythmic) Action Pathway	82	27	428.860324060825	428.89759114157	442.281996149882	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	128.586141657274	131.024851334694	249.381190458786	621	NA	NA	NA	2.81859078547792e-59	NA	NA	2.51136438986083e-56	non_linear_mixed	2.81859078547792e-59	2.51136438986083e-56	131.024851334694	249.381190458786	2
Bopindolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Timolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Carteolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Mercaptopurine Action Pathway	47	22	419.204164250381	419.249965777098	432.011453101499	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	175.445351063378	178.469351063378	290.710950723447	501	0.977824608716572	NA	NA	7.61985620177123e-48	NA	NA	6.78929187577816e-45	non_linear_mixed	7.61985620177123e-48	6.78929187577816e-45	178.469351063378	290.710950723447	2
Azathioprine Action Pathway	47	22	419.204164250381	419.249965777098	432.011453101499	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	175.445351063378	178.469351063378	290.710950723447	501	0.977824608716572	NA	NA	7.61985620177123e-48	NA	NA	6.78929187577816e-45	non_linear_mixed	7.61985620177123e-48	6.78929187577816e-45	178.469351063378	290.710950723447	2
Bevantolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Practolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Dobutamine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Isoprenaline Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Arbutamine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Amiodarone Action Pathway	61	20	297.347049624256	297.397469792324	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2413233586775	67.5864561020403	176.93354816403	453	0.994142972863783	NA	NA	1.04438555999711e-45	NA	NA	9.30547533957422e-43	non_linear_mixed	1.04438555999711e-45	9.30547533957422e-43	67.5864561020403	176.93354816403	3
Levobunolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Metipranolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Mexiletine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2411877303288	67.5863204736916	176.933412535681	453	NA	NA	NA	1.04432023867343e-45	NA	NA	9.30489332658028e-43	non_linear_mixed	1.04432023867343e-45	9.30489332658028e-43	67.5863204736916	176.933412535681	3
Lidocaine (Antiarrhythmic) Action Pathway	63	20	297.347049624256	297.397469792324	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2463685619551	67.5915013053179	176.938593367307	453	0.994152737878887	NA	NA	1.04681833390752e-45	NA	NA	9.32715135511602e-43	non_linear_mixed	1.04681833390752e-45	9.32715135511602e-43	67.5915013053179	176.938593367307	3
Quinidine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2411877303288	67.5863204736916	176.933412535681	453	NA	NA	NA	1.04432023867343e-45	NA	NA	9.30489332658028e-43	non_linear_mixed	1.04432023867343e-45	9.30489332658028e-43	67.5863204736916	176.933412535681	3
Sotalol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Epinephrine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Betaxolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Atenolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Alprenolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Acebutolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Thioguanine Action Pathway	47	22	419.204164250381	419.249965777098	432.011453101499	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	175.445351063378	178.469351063378	290.710950723447	501	0.977824608716572	NA	NA	7.61985620177123e-48	NA	NA	6.78929187577816e-45	non_linear_mixed	7.61985620177123e-48	6.78929187577816e-45	178.469351063378	290.710950723447	2
Muscle/Heart Contraction	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Diltiazem Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Propranolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Pindolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Penbutolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Oxprenolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Metoprolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Esmolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Bisoprolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Bupranolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Nebivolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Amlodipine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Verapamil Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Nitrendipine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Nisoldipine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Nimodipine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Ibutilide Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Tocainide Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2411877303288	67.5863204736916	176.933412535681	453	NA	NA	NA	1.04432023867343e-45	NA	NA	9.30489332658028e-43	non_linear_mixed	1.04432023867343e-45	9.30489332658028e-43	67.5863204736916	176.933412535681	3
Flecainide Action Pathway	61	20	297.347049624256	297.397469792324	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2463685619551	67.5915013053179	176.938593367307	453	0.994152737878887	NA	NA	1.04681833390752e-45	NA	NA	9.32715135511602e-43	non_linear_mixed	1.04681833390752e-45	9.32715135511602e-43	67.5915013053179	176.938593367307	3
Isradipine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Nifedipine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Felodipine Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Nadolol Action Pathway	61	20	297.347049624256	297.397469792323	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2412512885737	67.5863840319366	176.933476093926	453	0.994146405139492	NA	NA	1.04435084908635e-45	NA	NA	9.30516606535934e-43	non_linear_mixed	1.04435084908635e-45	9.30516606535934e-43	67.5863840319366	176.933476093926	3
Carvedilol Action Pathway	62	20	297.347049624256	297.397469792324	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.248278201063	67.5934109444259	176.940503006415	453	0.99411645733197	NA	NA	1.04774062987849e-45	NA	NA	9.33536901221737e-43	non_linear_mixed	1.04774062987849e-45	9.33536901221737e-43	67.5934109444259	176.940503006415	3
Labetalol Action Pathway	62	20	297.347049624256	297.397469792324	309.868407935962	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.248278201063	67.5934109444259	176.940503006415	453	0.99411645733197	NA	NA	1.04774062987849e-45	NA	NA	9.33536901221737e-43	non_linear_mixed	1.04774062987849e-45	9.33536901221737e-43	67.5934109444259	176.940503006415	3
EGF-Core	105	49	993.04219207362	993.06266988932	1008.251814459	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	400.171040138988	401.48811330972	537.05764160737	1149	0.982001902334198	NA	NA	6.51194549033687e-120	NA	NA	5.80214343189015e-117	non_linear_mixed	6.51194549033687e-120	5.80214343189015e-117	401.48811330972	537.05764160737	2
NHR	49	23	320.76787085611	320.811666476548	333.708514994941	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	40.8495447898845	43.7350409730906	157.315342039366	525	0.965131155828023	NA	NA	3.84004217675583e-55	NA	NA	3.42147757948945e-52	non_linear_mixed	3.84004217675583e-55	3.42147757948945e-52	43.7350409730906	157.315342039366	2
TGF-Ncore	45	25	355.296765362546	355.337033818922	368.487554328195	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	109.371453658104	112.014810301461	228.08855434894	573	0.988607717261696	NA	NA	2.79629971516509e-48	NA	NA	2.49150304621209e-45	non_linear_mixed	2.79629971516509e-48	2.49150304621209e-45	112.014810301461	228.08855434894	2
JAK-STAT-Core	104	32	192.058752846093	192.090166458658	205.990122045536	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-56.2215708113206	-54.1783275680773	69.1607519836666	741	NA	NA	NA	9.39828347115929e-49	NA	NA	8.37387057280293e-46	non_linear_mixed	9.39828347115929e-49	8.37387057280293e-46	-54.1783275680773	69.1607519836666	2
Folate Metabolism	69	26	358.013551395094	358.052261072514	371.322002500202	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	177.421898143493	179.958810895171	297.197958089468	597	0.986124057097592	NA	NA	2.77102821790193e-35	NA	NA	2.46898614215062e-32	non_linear_mixed	2.77102821790193e-35	2.46898614215062e-32	179.958810895171	297.197958089468	3
Cell cycle	120	62	1941.02371826794	1941.03989077467	1956.93928291411	1485	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1304.39546310927	1305.43107954763	1447.63554492489	1461	0.970468200790056	NA	NA	4.2317720926119e-129	NA	NA	3.7705089345172e-126	non_linear_mixed	4.2317720926119e-129	3.7705089345172e-126	1305.43107954763	1447.63554492489	2
Proteasome Degradation	64	49	912.476378394035	912.496856209735	927.686000779411	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	91.3459102384342	92.6629834091659	228.232511706816	1149	NA	NA	NA	5.00350155394492e-168	NA	NA	4.45811988456493e-165	non_linear_mixed	5.00350155394492e-168	4.45811988456493e-165	92.6629834091659	228.232511706816	2
Translation Factors	50	31	645.293569235672	645.326001668105	659.129692340171	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	233.23447561031	235.346207453885	357.759583550803	717	NA	NA	NA	3.15561186335267e-82	NA	NA	2.81165017024723e-79	non_linear_mixed	3.15561186335267e-82	2.81165017024723e-79	235.346207453885	357.759583550803	2
Electron Transport Chain (OXPHOS system in mitochondria)	103	35	-238.051832345679	-238.023124211708	-223.851626670167	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-557.334058944459	-555.471989978942	-429.53220786485	813	0.996468279455192	NA	NA	3.75715043632628e-63	NA	NA	3.34762103876672e-60	non_linear_mixed	3.75715043632628e-63	3.34762103876672e-60	-555.471989978942	-429.53220786485	2
Androgen receptor signaling pathway	89	40	525.370704678096	525.395809280606	539.971504531481	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	99.6864846424974	101.308802239064	231.093683322968	933	0.99218887592972	NA	NA	4.7778461317328e-85	NA	NA	4.25706090337392e-82	non_linear_mixed	4.7778461317328e-85	4.25706090337392e-82	101.308802239064	231.093683322968	2
AMP-activated protein kinase (AMPK) signaling	68	24	534.608915934697	534.650873976655	547.677238916785	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	332.286859851677	335.045983939268	449.901766690466	549	0.980204915910315	NA	NA	1.42512339556903e-39	NA	NA	1.269784945452e-36	non_linear_mixed	1.42512339556903e-39	1.269784945452e-36	335.045983939268	449.901766690466	3
Regulation of toll-like receptor signaling pathway	145	44	242.937271187152	242.960084875364	257.82400157995	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-119.633212248065	-118.162395127442	14.3473612871227	1029	0.989582308359727	NA	NA	5.06202549223839e-72	NA	NA	4.5102647135844e-69	non_linear_mixed	5.06202549223839e-72	4.5102647135844e-69	-118.162395127442	14.3473612871227	2
Selenium Micronutrient Network	86	28	451.830398988162	451.866327131875	465.361174009732	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	155.231035701357	157.578861788314	277.008010895482	645	NA	NA	NA	1.57631244891933e-58	NA	NA	1.40449439198712e-55	non_linear_mixed	1.57631244891933e-58	1.40449439198712e-55	157.578861788314	277.008010895482	3
miRNA regulation of DNA damage response	98	38	1018.30975139679	1018.33618311485	1032.75667136701	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	679.598871235666	681.309278475485	809.621150967673	885	NA	NA	NA	3.98895956906191e-67	NA	NA	3.55416297603416e-64	non_linear_mixed	3.98895956906191e-67	3.55416297603416e-64	681.309278475485	809.621150967673	3
Vitamin B12 metabolism	51	23	494.279595882212	494.32339150265	507.220240021043	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	194.917132533765	197.802628716971	311.382929783247	525	0.976307570722723	NA	NA	4.32078678005942e-59	NA	NA	3.84982102103294e-56	non_linear_mixed	4.32078678005942e-59	3.84982102103294e-56	197.802628716971	311.382929783247	2
Energy Metabolism	47	22	375.950006688012	375.995808214729	388.757295539131	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	142.613443704388	145.637443704388	257.879043364457	501	NA	NA	NA	9.38916293861162e-46	NA	NA	8.36574417830295e-43	non_linear_mixed	9.38916293861162e-46	8.36574417830295e-43	145.637443704388	257.879043364457	2
MicroRNAs in cardiomyocyte hypertrophy	104	31	606.794245408536	606.826677840969	620.630368513036	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	299.86652279297	301.978254636545	424.391630733464	717	NA	NA	NA	1.24479413794422e-60	NA	NA	1.1091115769083e-57	non_linear_mixed	1.24479413794422e-60	1.1091115769083e-57	301.978254636545	424.391630733464	2
Apoptosis Modulation and Signaling	92	37	586.897458481032	586.924607802299	601.264373710009	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	224.331343472871	226.089483007755	353.63358053366	861	NA	NA	NA	5.07250342605604e-72	NA	NA	4.51960055261593e-69	non_linear_mixed	5.07250342605604e-72	4.51960055261593e-69	226.089483007755	353.63358053366	2
Integrin-mediated Cell Adhesion	101	39	407.157333178091	407.183084251053	421.682179607524	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1.76223611504889	3.42743435293436	132.485853979944	909	0.993518615822957	NA	NA	7.52947832171763e-81	NA	NA	6.70876518465041e-78	non_linear_mixed	7.52947832171763e-81	6.70876518465041e-78	3.42743435293436	132.485853979944	2
IL-1 signaling pathway	55	22	262.225122771362	262.270924298079	275.03241162248	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	79.083363784903	82.107363784903	194.348963444972	501	0.98553719916964	NA	NA	8.73758838920087e-36	NA	NA	7.78519125477798e-33	non_linear_mixed	8.73758838920087e-36	7.78519125477798e-33	82.107363784903	194.348963444972	2
Sterol regulatory element-binding proteins (SREBP) signaling	68	20	280.751923459967	280.802343628035	293.273281771673	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	101.495802214645	104.840934958008	214.188027019998	453	0.98774688290457	NA	NA	5.06899303733233e-35	NA	NA	4.5164727962631e-32	non_linear_mixed	5.06899303733233e-35	4.5164727962631e-32	104.840934958008	214.188027019998	2
Integrated breast cancer pathway	67	31	370.668854619882	370.701287052314	384.504977724381	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	129.429674803079	131.541406646655	253.954782743573	717	NA	NA	NA	2.44312968897075e-47	NA	NA	2.17682855287294e-44	non_linear_mixed	2.44312968897075e-47	2.17682855287294e-44	131.541406646655	253.954782743573	2
RANKL-RANK signaling pathway	55	20	324.424356267071	324.474776435138	336.945714578777	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	104.971796801072	108.316929544435	217.664021606424	453	0.980802593316691	NA	NA	5.59256326651584e-43	NA	NA	4.98297387046561e-40	non_linear_mixed	5.59256326651584e-43	4.98297387046561e-40	108.316929544435	217.664021606424	3
Thyroid stimulating hormone (TSH) signaling pathway	66	30	413.843585494146	413.877105047219	427.581339130177	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	100.978177184696	103.163148282962	224.617959908969	693	0.989507222188561	NA	NA	7.6654567533975e-62	NA	NA	6.82992196727717e-59	non_linear_mixed	7.6654567533975e-62	6.82992196727717e-59	103.163148282962	224.617959908969	2
Leptin signaling pathway	76	39	481.414009564701	481.439760637662	495.938855994134	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	101.573140090243	103.238338328129	232.296757955138	909	NA	NA	NA	1.4124288470181e-75	NA	NA	1.25847410269313e-72	non_linear_mixed	1.4124288470181e-75	1.25847410269313e-72	103.238338328129	232.296757955138	2
Prolactin Signaling Pathway	76	32	403.000205331053	403.031618943619	416.931574530496	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	86.519396137748	88.5626393809912	211.901718932735	741	NA	NA	NA	1.40220364555297e-62	NA	NA	1.2493634481877e-59	non_linear_mixed	1.40220364555297e-62	1.2493634481877e-59	88.5626393809912	211.901718932735	3
Alzheimer,s disease	144	36	313.07993801774	313.107844994485	327.364656324153	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-21.7684203451868	-19.9598079049954	106.794044412523	837	NA	NA	NA	2.46547901817188e-66	NA	NA	2.19674180519114e-63	non_linear_mixed	2.46547901817188e-66	2.19674180519114e-63	-19.9598079049954	106.794044412523	2
Neural Crest Differentiation	101	31	529.307900182971	529.340332615403	543.14402328747	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	197.14293246623	199.254664309805	321.668040406723	717	0.988996024490568	NA	NA	8.73323819544071e-66	NA	NA	7.78131523213767e-63	non_linear_mixed	8.73323819544071e-66	7.78131523213767e-63	199.254664309805	321.668040406723	5
Arrhythmogenic Right Ventricular Cardiomyopathy	74	33	162.754031201015	162.784488053806	176.777715376458	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-103.928137416259	-101.949079824636	22.28502016273	765	NA	NA	NA	1.83231094186592e-52	NA	NA	1.63258904920253e-49	non_linear_mixed	1.83231094186592e-52	1.63258904920253e-49	-101.949079824636	22.28502016273	2
Glioblastoma signaling pathways	83	34	790.890663763653	790.920220413899	805.003906828545	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	445.636139379772	447.55492110566	572.655326963803	789	NA	NA	NA	1.81825705909314e-68	NA	NA	1.62006703965199e-65	non_linear_mixed	1.81825705909314e-68	1.62006703965199e-65	447.55492110566	572.655326963803	2
Pathogenic Escherichia coli infection	56	32	581.1144985112	581.145912123765	595.045867710643	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	200.917234145947	202.96047738919	326.299556940934	741	NA	NA	NA	1.19270994353496e-75	NA	NA	1.06270455968965e-72	non_linear_mixed	1.19270994353496e-75	1.06270455968965e-72	202.96047738919	326.299556940934	2
B Cell Receptor Signaling Pathway	98	34	244.250919454121	244.280476104368	258.364162519014	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-98.0208771008876	-96.1020953749992	28.9983104831433	789	NA	NA	NA	7.43307914032509e-68	NA	NA	6.62287351402966e-65	non_linear_mixed	7.43307914032509e-68	6.62287351402966e-65	-96.1020953749992	28.9983104831433	2
TNF-alpha signaling pathway	93	34	577.829988247272	577.859544897518	591.943231312164	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	225.754562391013	227.673344116901	352.773749975043	789	0.98406484450323	NA	NA	7.24821895089962e-70	NA	NA	6.45816308525156e-67	non_linear_mixed	7.24821895089962e-70	6.45816308525156e-67	227.673344116901	352.773749975043	2
AGE-RAGE pathway	66	28	278.642024855604	278.677952999317	292.172799877174	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	61.5399488796842	63.8877749666407	183.316924073809	645	NA	NA	NA	1.64505815770828e-42	NA	NA	1.46574681851808e-39	non_linear_mixed	1.64505815770828e-42	1.46574681851808e-39	63.8877749666407	183.316924073809	3
Allograft Rejection	93	29	565.56725851066	565.601940591585	579.203307491663	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	190.045079897062	192.308552950954	312.769520726092	669	NA	NA	NA	1.09528926951653e-74	NA	NA	9.75902739139228e-72	non_linear_mixed	1.09528926951653e-74	9.75902739139228e-72	192.308552950954	312.769520726092	2
Corticotropin-releasing hormone signaling pathway	92	31	319.117094409453	319.149526841886	332.953217513952	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	25.6565289187244	27.7682607622998	150.181636859218	717	0.989576745603905	NA	NA	6.85139961178452e-58	NA	NA	6.10459705410001e-55	non_linear_mixed	6.85139961178452e-58	6.10459705410001e-55	27.7682607622998	150.181636859218	4
Parkin-Ubiquitin Proteasomal System pathway	73	46	1014.75693421197	1014.77875239378	1029.77701989248	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	370.447751405602	371.852955866569	505.628522530203	1077	0.989081237532744	NA	NA	1.02746980330131e-130	NA	NA	9.15475594741467e-128	non_linear_mixed	1.02746980330131e-130	9.15475594741467e-128	371.852955866569	505.628522530203	2
Adipogenesis	131	46	810.278016531756	810.299834713574	825.298102212267	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	244.360083619854	245.765288080821	379.540854744454	1077	0.985840292991097	NA	NA	2.89692469524594e-114	NA	NA	2.58115990346414e-111	non_linear_mixed	2.89692469524594e-114	2.58115990346414e-111	245.765288080821	379.540854744454	4
Histone Modifications	65	20	103.260104704724	103.310524872791	115.781463016429	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-43.0899810343158	-39.744848290953	69.6022437710365	453	0.994900521407221	NA	NA	1.29094602079942e-28	NA	NA	1.15023290453228e-25	non_linear_mixed	1.29094602079942e-28	1.15023290453228e-25	-39.744848290953	69.6022437710365	3
Parkinson,s disease pathway	71	22	120.476640485349	120.522442012066	133.283929336468	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-74.3903403614363	-71.3663403614363	40.8752592986328	501	NA	NA	NA	4.26114613082244e-38	NA	NA	3.7966812025628e-35	non_linear_mixed	4.26114613082244e-38	3.7966812025628e-35	-71.3663403614363	40.8752592986328	2
Oncostatin M Signaling Pathway	65	28	411.323437736894	411.359365880606	424.854212758463	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	197.259391197647	199.607217284603	319.036366391772	645	NA	NA	NA	6.62622641204306e-42	NA	NA	5.90396773313037e-39	non_linear_mixed	6.62622641204306e-42	5.90396773313037e-39	199.607217284603	319.036366391772	2
Brain-derived neurotrophic factor (BDNF) signaling pathway	144	54	713.010157277081	713.028733128475	728.511270907818	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	158.22609083882	159.418519860902	297.73611351545	1269	0.987376540413986	NA	NA	6.20136995203851e-112	NA	NA	5.52542062726632e-109	non_linear_mixed	6.20136995203851e-112	5.52542062726632e-109	159.418519860902	297.73611351545	4
Spinal Cord Injury	117	42	850.106286036679	850.13019041915	864.853456382573	1005	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	431.793814316128	433.336671458986	564.518347429174	981	0.98986881572526	NA	NA	1.60467711024878e-83	NA	NA	1.42976730523166e-80	non_linear_mixed	1.60467711024878e-83	1.42976730523166e-80	433.336671458986	564.518347429174	2
Alpha 6 Beta 4 signaling pathway	33	24	472.716890947255	472.758848989213	485.785213929343	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	237.727174663194	240.486298750785	355.342081501983	549	NA	NA	NA	4.37952253369997e-46	NA	NA	3.90215457752668e-43	non_linear_mixed	4.37952253369997e-46	3.90215457752668e-43	240.486298750785	355.342081501983	2
Retinoblastoma gene in cancer	90	45	1715.50959115613	1715.53189598884	1730.46374011648	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1263.1526510822	1264.58991343962	1397.7399917254	1053	0.952222726505469	NA	NA	1.40575480734864e-90	NA	NA	1.25252753334764e-87	non_linear_mixed	1.40575480734864e-90	1.25252753334764e-87	1264.58991343962	1397.7399917254	2
Apoptosis	87	35	506.483890861601	506.512598995572	520.684096537113	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	148.140500395823	150.00256936134	275.942351475432	813	0.984507967648193	NA	NA	3.7414440289817e-71	NA	NA	3.33362662982269e-68	non_linear_mixed	3.7414440289817e-71	3.33362662982269e-68	150.00256936134	275.942351475432	2
Primary focal segmental glomerulosclerosis (FSGS)	73	30	273.148662399048	273.182181952121	286.886416035079	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	66.8502373644185	69.0352084626844	190.490020088691	693	NA	NA	NA	2.31762540147943e-40	NA	NA	2.06500423271818e-37	non_linear_mixed	2.31762540147943e-40	2.06500423271818e-37	69.0352084626844	190.490020088691	2
Aryl Hydrocarbon Receptor Netpath	46	20	379.371652762715	379.422072930783	391.893011074421	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	187.399800794884	190.744933538247	300.092025600236	453	0.988474485017673	NA	NA	1.59007588903199e-37	NA	NA	1.4167576171275e-34	non_linear_mixed	1.59007588903199e-37	1.4167576171275e-34	190.744933538247	300.092025600236	3
Complement system	93	38	415.366501276379	415.39293299444	429.813421246602	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	149.713123858757	151.423531098576	279.735403590764	885	0.990431704094654	NA	NA	2.95705951924974e-52	NA	NA	2.63474003165152e-49	non_linear_mixed	2.95705951924974e-52	2.63474003165152e-49	151.423531098576	279.735403590764	4
Bladder cancer	40	21	364.839215335792	364.887215335792	377.506944140006	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	190.680465959924	193.856936548159	304.690025197851	477	0.980966443129404	NA	NA	5.06378011949494e-34	NA	NA	4.51182808646999e-31	non_linear_mixed	5.06378011949494e-34	4.51182808646999e-31	193.856936548159	304.690025197851	2
Endoderm differentiation	71	27	480.581772609377	480.619039690122	494.003444698434	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	79.4386244925336	81.877334169953	200.233673294045	621	NA	NA	NA	5.69192432963814e-80	NA	NA	5.07150457770758e-77	non_linear_mixed	5.69192432963814e-80	5.07150457770758e-77	81.877334169953	200.233673294045	2
Mesodermal commitment pathway	153	62	1093.32344791032	1093.33962041705	1109.23901255649	1485	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	304.903303705947	305.938920144303	448.143385521559	1461	0.988094845377916	NA	NA	4.16298046105167e-161	NA	NA	3.70921559079704e-158	non_linear_mixed	4.16298046105167e-161	3.70921559079704e-158	305.938920144303	448.143385521559	2
Ectoderm Differentiation	142	52	572.094047326527	572.113339931028	587.481939973315	1245	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-56.58806437763	-55.3487201153349	81.9029694434631	1221	NA	NA	NA	1.97880202345898e-127	NA	NA	1.76311260290195e-124	non_linear_mixed	1.97880202345898e-127	1.76311260290195e-124	-55.3487201153349	81.9029694434631	3
Apoptosis-related network due to altered Notch3 in ovarian cancer	53	23	665.053732110274	665.097527730712	677.994376249106	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	365.74541913576	368.630915318966	482.211216385241	525	0.987380383169121	NA	NA	4.43181044814713e-59	NA	NA	3.94874310929909e-56	non_linear_mixed	4.43181044814713e-59	3.94874310929909e-56	368.630915318966	482.211216385241	2
Vitamin D Receptor Pathway	184	58	934.256331388729	934.273622455011	949.971821911412	1389	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	293.357316353112	294.465820751939	434.79673105726	1365	NA	NA	NA	5.35498071026225e-130	NA	NA	4.77128781284366e-127	non_linear_mixed	5.35498071026225e-130	4.77128781284366e-127	294.465820751939	434.79673105726	3
Glucocorticoid Receptor Pathway	71	25	675.13755846108	675.177826917456	688.328347426729	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	246.349175939349	248.992532582705	365.066276630184	573	0.989559151143844	NA	NA	1.08702522857174e-85	NA	NA	9.68539478657422e-83	non_linear_mixed	1.08702522857174e-85	9.68539478657422e-83	248.992532582705	365.066276630184	2
NRF2 pathway	143	49	889.80559067868	889.82606849438	905.015213064056	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	335.688169183225	337.005242353957	472.574770651607	1149	NA	NA	NA	8.55026464578809e-112	NA	NA	7.61828579939719e-109	non_linear_mixed	8.55026464578809e-112	7.61828579939719e-109	337.005242353957	472.574770651607	2
Myometrial relaxation and contraction pathways	155	55	771.663677633379	771.681914715446	787.21983868012	1317	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	171.519736079918	172.690014717689	311.525185500589	1293	0.992230583882387	NA	NA	1.94169347379695e-121	NA	NA	1.73004888515308e-118	non_linear_mixed	1.94169347379695e-121	1.73004888515308e-118	172.690014717689	311.525185500589	2
Kit receptor signaling pathway	59	23	377.842955979913	377.886751600351	390.783600118745	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	166.932866434717	169.818362617923	283.398663684199	525	NA	NA	NA	2.81042916515024e-41	NA	NA	2.50409238614886e-38	non_linear_mixed	2.81042916515024e-41	2.50409238614886e-38	169.818362617923	283.398663684199	2
Focal Adhesion	198	84	990.902669524557	990.914597953981	1007.72928141213	2013	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	65.6122277703735	66.3727911506552	217.051734758537	1989	0.993021264457228	NA	NA	4.17595298457782e-190	NA	NA	3.72077410925883e-187	non_linear_mixed	4.17595298457782e-190	3.72077410925883e-187	66.3727911506552	217.051734758537	2
Fas ligand pathway and stress induction of heat shock proteins	43	21	281.868390398009	281.916390398009	294.536119202223	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	154.954221874588	158.130692462823	268.963781112515	477	0.991692148562263	NA	NA	6.82408174621129e-25	NA	NA	6.08025683587426e-22	non_linear_mixed	6.82408174621129e-25	6.08025683587426e-22	158.130692462823	268.963781112515	2
Copper homeostasis	54	22	586.48691949705	586.532721023768	599.294208348169	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	464.033035967219	467.057035967219	579.298635627288	501	0.976534365332288	NA	NA	4.79484263486188e-24	NA	NA	4.27220478766194e-21	non_linear_mixed	4.79484263486188e-24	4.27220478766194e-21	467.057035967219	579.298635627288	2
RAC1-PAK1-p38-MMP2 Pathway	68	28	633.298525026652	633.334453170364	646.829300048221	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	319.138426629871	321.486252716828	440.915401823996	645	0.986932140830973	NA	NA	4.17262078789769e-62	NA	NA	3.71780512201684e-59	non_linear_mixed	4.17262078789769e-62	3.71780512201684e-59	321.486252716828	440.915401823996	2
G Protein Signaling Pathways	91	40	498.6564210787	498.68152568121	513.257220932086	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-3.24830136708187	-1.62598377051535	128.158897313389	933	0.987858879856459	NA	NA	6.88726637586591e-101	NA	NA	6.13655434089653e-98	non_linear_mixed	6.88726637586591e-101	6.13655434089653e-98	-1.62598377051535	128.158897313389	2
MECP2 and Associated Rett Syndrome	73	26	635.581794418556	635.620504095975	648.890245523664	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	305.07395591598	307.610868667657	424.850015861954	597	NA	NA	NA	1.90661236546722e-65	NA	NA	1.6987916176313e-62	non_linear_mixed	1.90661236546722e-65	1.6987916176313e-62	307.610868667657	424.850015861954	2
Lung fibrosis	64	22	464.958184785809	465.003986312527	477.765473636928	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	246.367510120577	249.391510120577	361.633109780646	501	NA	NA	NA	8.30750570801371e-43	NA	NA	7.40198758584022e-40	non_linear_mixed	8.30750570801371e-43	7.40198758584022e-40	249.391510120577	361.633109780646	2
Wnt Signaling Pathway	51	24	303.164476367167	303.206434409125	316.232799349254	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	112.221132569373	114.980256656965	229.836039408162	549	NA	NA	NA	2.5375905547534e-37	NA	NA	2.26099318428528e-34	non_linear_mixed	2.5375905547534e-37	2.26099318428528e-34	114.980256656965	229.836039408162	2
Pathways affected in adenoid cystic carcinoma	63	28	325.869321350305	325.905249494018	339.400096371875	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	47.403823784986	49.7516498719425	169.180798979111	645	0.983821892597867	NA	NA	7.56377165037292e-55	NA	NA	6.73932054048227e-52	non_linear_mixed	7.56377165037292e-55	6.73932054048227e-52	49.7516498719425	169.180798979111	2
TGF-beta Signaling Pathway	132	58	1254.11268353947	1254.12997460575	1269.82817406215	1389	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	560.81320511199	561.921709510817	702.252619816137	1365	NA	NA	NA	5.00444289188868e-141	NA	NA	4.45895861667281e-138	non_linear_mixed	5.00444289188868e-141	4.45895861667281e-138	561.921709510817	702.252619816137	2
Association Between Physico-Chemical Features and Toxicity Associated Pathways	65	24	414.199512516951	414.241470558909	427.267835499039	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	174.619762777138	177.37888686473	292.234669615927	549	0.990218730131556	NA	NA	5.2602119898971e-47	NA	NA	4.68684888299832e-44	non_linear_mixed	5.2602119898971e-47	4.68684888299832e-44	177.37888686473	292.234669615927	2
Novel intracellular components of RIG-I-like receptor (RLR) pathway	60	24	175.741016017578	175.782974059536	188.809338999665	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-72.6466642030077	-69.8875401154164	44.9682426357814	549	0.990972571253139	NA	NA	8.94241136593181e-49	NA	NA	7.96768852704524e-46	non_linear_mixed	8.94241136593181e-49	7.96768852704524e-46	-69.8875401154164	44.9682426357814	2
ATM Signaling Network in Development and Disease	46	26	474.107662158192	474.146371835611	487.4161132633	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	245.648456393834	248.185369145512	365.424516339808	597	0.98450932934182	NA	NA	8.88842785535131e-45	NA	NA	7.91958921911802e-42	non_linear_mixed	8.88842785535131e-45	7.91958921911802e-42	248.185369145512	365.424516339808	3
IL-4 signaling pathway	54	24	329.215861793883	329.257819835841	342.28418477597	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	90.3231927230303	93.0823168106216	207.938099561819	549	NA	NA	NA	7.22534115784802e-47	NA	NA	6.43777897164259e-44	non_linear_mixed	7.22534115784802e-47	6.43777897164259e-44	93.0823168106216	207.938099561819	2
Angiopoietin Like Protein 8 Regulatory Pathway	131	48	558.221078270703	558.241984194048	573.36884279447	1149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	103.337492028572	104.682687758109	239.66737274248	1125	0.986005458724205	NA	NA	4.19970433396777e-91	NA	NA	3.74193656156528e-88	non_linear_mixed	4.19970433396777e-91	3.74193656156528e-88	104.682687758109	239.66737274248	2
Amino Acid metabolism	91	28	495.182396424471	495.218324568184	508.713171446041	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	183.724072925202	186.071899012159	305.501048119327	645	0.992403280843622	NA	NA	1.48432103204706e-61	NA	NA	1.32253003955393e-58	non_linear_mixed	1.48432103204706e-61	1.32253003955393e-58	186.071899012159	305.501048119327	2
Chemokine signaling pathway	165	57	219.44090277771	219.458498085628	235.104218072258	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-400.123988378499	-398.995630169544	-259.154150727572	1341	0.991595804378947	NA	NA	1.62770783198565e-125	NA	NA	1.45028767829921e-122	non_linear_mixed	1.62770783198565e-125	1.45028767829921e-122	-398.995630169544	-259.154150727572	2
ESC Pluripotency Pathways	116	39	599.146704396564	599.172455469526	613.671550825997	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	187.603996598058	189.269194835944	318.327614462953	909	NA	NA	NA	4.03528738298092e-82	NA	NA	3.595441058236e-79	non_linear_mixed	4.03528738298092e-82	3.595441058236e-79	189.269194835944	318.327614462953	2
Wnt signaling pathway and pluripotency	101	46	425.392431587151	425.414249768969	440.412517267662	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	55.9593198617642	57.3645243227307	191.140090986364	1077	0.990400037646368	NA	NA	1.96297443267331e-73	NA	NA	1.74901021951192e-70	non_linear_mixed	1.96297443267331e-73	1.74901021951192e-70	57.3645243227307	191.140090986364	4
Pathways in clear cell renal cell carcinoma	86	20	501.225558240465	501.275978408532	513.746916552171	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	340.839286849317	344.18441959268	453.531511654669	453	0.980332805188205	NA	NA	2.46881621243891e-31	NA	NA	2.19971524528307e-28	non_linear_mixed	2.46881621243891e-31	2.19971524528307e-28	344.18441959268	453.531511654669	3
Pyrimidine metabolism	84	36	1005.50506596362	1005.53297294036	1019.78978427003	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	595.098855539028	596.907467979219	723.661320296737	837	0.975565513281415	NA	NA	6.93243999777149e-82	NA	NA	6.1768040380144e-79	non_linear_mixed	6.93243999777149e-82	6.1768040380144e-79	596.907467979219	723.661320296737	2
Eukaryotic Transcription Initiation	41	22	360.829162514183	360.8749640409	373.636451365302	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	97.070770517258	100.094770517258	212.336370177327	501	NA	NA	NA	7.13834017126814e-52	NA	NA	6.36026109259991e-49	non_linear_mixed	7.13834017126814e-52	6.36026109259991e-49	100.094770517258	212.336370177327	2
Exercise-induced Circadian Regulation	48	22	331.013756361181	331.059557887899	343.8210452123	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	127.506297170398	130.530297170398	242.771896830467	501	0.992723523362492	NA	NA	8.2950921281256e-40	NA	NA	7.39092708615991e-37	non_linear_mixed	8.2950921281256e-40	7.39092708615991e-37	130.530297170398	242.771896830467	2
mRNA Processing	127	74	1499.6667791788	1499.68032319686	1516.11313594945	1773	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	514.140661529091	515.005650087444	662.157872464998	1749	0.982937648283494	NA	NA	6.71477090850156e-203	NA	NA	5.98286087947489e-200	non_linear_mixed	6.71477090850156e-203	5.98286087947489e-200	515.005650087444	662.157872464998	2
Splicing factor NOVA regulated synaptic proteins	42	21	538.503049812967	538.551049812967	551.170778617181	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	294.197192128508	297.373662716743	408.206751366435	477	NA	NA	NA	5.91617771486381e-48	NA	NA	5.27131434394366e-45	non_linear_mixed	5.91617771486381e-48	5.27131434394366e-45	297.373662716743	408.206751366435	2
Endometrial cancer	63	24	329.687588022396	329.729546064354	342.755911004483	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	142.236410694112	144.995534781703	259.851317532901	549	NA	NA	NA	1.2389158691551e-36	NA	NA	1.1038740394172e-33	non_linear_mixed	1.2389158691551e-36	1.1038740394172e-33	144.995534781703	259.851317532901	5
Chromosomal and microsatellite instability in colorectal cancer	73	28	438.087640540806	438.123568684518	451.618415562375	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	195.234120501799	197.581946588755	317.011095695924	645	0.984984921111945	NA	NA	1.15821972845723e-47	NA	NA	1.03197377805539e-44	non_linear_mixed	1.15821972845723e-47	1.03197377805539e-44	197.581946588755	317.011095695924	2
Ebola Virus Pathway on Host	130	58	980.801278432914	980.818569499197	996.516768955597	1389	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	183.587540440378	184.696044839205	325.026955144526	1365	0.992407295411594	NA	NA	5.75096881378176e-163	NA	NA	5.12411321307955e-160	non_linear_mixed	5.75096881378176e-163	5.12411321307955e-160	184.696044839205	325.026955144526	2
Ras signaling	184	62	726.193997919815	726.210170426553	742.109562565994	1485	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	41.2530086215893	42.2886250599455	184.493090437201	1461	NA	NA	NA	2.88640788107221e-139	NA	NA	2.57178942203534e-136	non_linear_mixed	2.88640788107221e-139	2.57178942203534e-136	42.2886250599455	184.493090437201	2
Epithelial to mesenchymal transition in colorectal cancer	161	61	701.376608478285	701.393046834449	717.243391561848	1461	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	28.8083178963518	29.8612426874382	171.609365648426	1437	NA	NA	NA	1.16399757749853e-136	NA	NA	1.03712184155119e-133	non_linear_mixed	1.16399757749853e-136	1.03712184155119e-133	29.8612426874382	171.609365648426	2
Non-small cell lung cancer	72	35	463.101594761421	463.130302895393	477.301800436933	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	147.058629102443	148.920698067961	274.860480182052	813	NA	NA	NA	1.72257643008761e-62	NA	NA	1.53481559920806e-59	non_linear_mixed	1.72257643008761e-62	1.53481559920806e-59	148.920698067961	274.860480182052	4
LncRNA involvement in canonical Wnt signaling and colorectal cancer	97	35	360.974326116067	361.003034250038	375.174531791579	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	81.6176833596832	83.4797523252004	209.419534439292	813	NA	NA	NA	4.99076359649089e-55	NA	NA	4.44677036447338e-52	non_linear_mixed	4.99076359649089e-55	4.44677036447338e-52	83.4797523252004	209.419534439292	2
Breast cancer pathway	154	58	708.224206759664	708.241497825947	723.939697282347	1389	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	185.28802912041	186.396533519237	326.727443824558	1365	NA	NA	NA	2.8168554692251e-105	NA	NA	2.50981822307957e-102	non_linear_mixed	2.8168554692251e-105	2.50981822307957e-102	186.396533519237	326.727443824558	3
Pancreatic adenocarcinoma pathway	89	36	464.288911172358	464.316818149103	478.573629478771	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	155.697636220984	157.506248661176	284.260100978694	837	NA	NA	NA	5.70253871485915e-61	NA	NA	5.0809619949395e-58	non_linear_mixed	5.70253871485915e-61	5.0809619949395e-58	157.506248661176	284.260100978694	2
Wnt signaling	114	43	342.76787435161	342.791220655112	357.585636189734	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-34.4041989182012	-32.8982228225837	98.9556576249195	1005	0.989003562144079	NA	NA	5.00889219786682e-75	NA	NA	4.46292294829933e-72	non_linear_mixed	5.00889219786682e-75	4.46292294829933e-72	-32.8982228225837	98.9556576249195	3
Genotoxicity pathway	64	21	489.590944814804	489.638944814804	502.258673619018	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	274.743720902281	277.920191490516	388.753280140208	477	0.97713237940889	NA	NA	4.62743639879309e-42	NA	NA	4.12304583132464e-39	non_linear_mixed	4.62743639879309e-42	4.12304583132464e-39	277.920191490516	388.753280140208	3
Acute viral myocarditis	78	34	309.915947600207	309.945504250453	324.029190665099	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-14.2646687337393	-12.3458870078509	112.754518850292	789	0.99242407659718	NA	NA	3.75076035411426e-64	NA	NA	3.3419274755158e-61	non_linear_mixed	3.75076035411426e-64	3.3419274755158e-61	-12.3458870078509	112.754518850292	2
Rett syndrome causing genes	48	20	109.739297608204	109.789717776271	122.26065591991	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-53.9005025061535	-50.5553697627906	58.7917222991988	453	NA	NA	NA	5.74427607951221e-32	NA	NA	5.11814998684538e-29	non_linear_mixed	5.74427607951221e-32	5.11814998684538e-29	-50.5553697627906	58.7917222991988	3
Thermogenesis	108	46	491.127739851245	491.149558033063	506.147825531756	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	47.2455743043684	48.6507787653349	182.426345428968	1077	0.99115435759638	NA	NA	8.07081483695025e-89	NA	NA	7.19109601972267e-86	non_linear_mixed	8.07081483695025e-89	7.19109601972267e-86	48.6507787653349	182.426345428968	2
ncRNAs involved in Wnt signaling in hepatocellular carcinoma	90	32	278.225049248945	278.25646286151	292.156418448388	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.0170862784713108	2.06032952171456	125.399409073458	741	0.989706654200996	NA	NA	8.52934583119805e-55	NA	NA	7.59964713559746e-52	non_linear_mixed	8.52934583119805e-55	7.59964713559746e-52	2.06032952171456	125.399409073458	2
Non-genomic actions of 1,25 dihydroxyvitamin D3	68	25	54.0214692273621	54.061737683738	67.2122581930106	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-152.979900734775	-150.336544091418	-34.2628000439387	573	NA	NA	NA	1.68064764775365e-40	NA	NA	1.4974570541485e-37	non_linear_mixed	1.68064764775365e-40	1.4974570541485e-37	-150.336544091418	-34.2628000439387	3
EGF-EGFR signaling pathway	162	65	1094.72224549609	1094.73766966062	1110.77956879682	1557	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	319.063402597687	320.0503477674	463.579312304264	1533	0.98629067695628	NA	NA	2.07595686058929e-158	NA	NA	1.84967756278506e-155	non_linear_mixed	2.07595686058929e-158	1.84967756278506e-155	320.0503477674	463.579312304264	2
Nonalcoholic fatty liver disease	155	54	595.113423173115	595.131999024508	610.614536803852	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-48.6581500481622	-47.4657210260801	90.8518726284678	1269	NA	NA	NA	1.332936100108e-130	NA	NA	1.18764606519622e-127	non_linear_mixed	1.332936100108e-130	1.18764606519622e-127	-47.4657210260801	90.8518726284678	4
G1 to S cell cycle control	64	32	1087.8880840764	1087.91949768896	1101.81945327584	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	802.966478451606	805.009721694849	928.348801246593	741	0.95715513944958	NA	NA	3.71333491733812e-56	NA	NA	3.30858141134826e-53	non_linear_mixed	3.71333491733812e-56	3.30858141134826e-53	805.009721694849	928.348801246593	2
DNA Replication	42	28	1235.82904352968	1235.86497167339	1249.35981855125	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	944.443449185319	946.791275272275	1066.22042437944	645	0.934399593161458	NA	NA	1.80890344097209e-57	NA	NA	1.61173296590614e-54	non_linear_mixed	1.80890344097209e-57	1.61173296590614e-54	946.791275272275	1066.22042437944	2
Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms	46	24	339.062691461688	339.104649503646	352.131014443775	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	28.2885153356414	31.0476394232326	145.90342217443	549	NA	NA	NA	2.04663701811396e-61	NA	NA	1.82355358313954e-58	non_linear_mixed	2.04663701811396e-61	1.82355358313954e-58	31.0476394232326	145.90342217443	2
Envelope proteins and their potential roles in EDMD physiopathology	46	22	348.713107487893	348.758909014611	361.520396339012	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	111.530500861166	114.554500861166	226.796100521235	501	0.982970288178009	NA	NA	1.59164420702025e-46	NA	NA	1.41815498845504e-43	non_linear_mixed	1.59164420702025e-46	1.41815498845504e-43	114.554500861166	226.796100521235	2
Genes related to primary cilium development (based on CRISPR)	103	27	133.240570577574	133.277837658319	146.662242666631	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-51.6152095076628	-49.1764998302434	69.1798392938486	621	0.979277974893442	NA	NA	4.01940739715758e-36	NA	NA	3.5812919908674e-33	non_linear_mixed	4.01940739715758e-36	3.5812919908674e-33	-49.1764998302434	69.1798392938486	2
Regulatory circuits of the STAT3 signaling pathway	78	30	267.172547502669	267.206067055742	280.910301138699	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-40.6596109014219	-38.474639803156	82.9801718228508	693	NA	NA	NA	8.14306259127198e-61	NA	NA	7.25546876882334e-58	non_linear_mixed	8.14306259127198e-61	7.25546876882334e-58	-38.474639803156	82.9801718228508	2
Pathways Regulating Hippo Signaling	98	43	762.318167965979	762.341514269481	777.135929804104	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	245.429582153282	246.9355582489	378.789438696403	1005	NA	NA	NA	5.15578760368315e-104	NA	NA	4.59380675488169e-101	non_linear_mixed	5.15578760368315e-104	4.59380675488169e-101	246.9355582489	378.789438696403	2
Hippo-Merlin Signaling Dysregulation	120	51	929.799650005766	929.819322136914	945.129288394983	1221	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	280.474766926948	281.738980973771	418.4415124299	1197	NA	NA	NA	9.05748197502441e-132	NA	NA	8.07021643974675e-129	non_linear_mixed	9.05748197502441e-132	8.07021643974675e-129	281.738980973771	418.4415124299	5
Fragile X Syndrome	119	46	770.288981389033	770.310799570851	785.309067069544	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	185.476640978988	186.881845439955	320.657412103588	1077	NA	NA	NA	3.18714023045267e-118	NA	NA	2.83974194533333e-115	non_linear_mixed	3.18714023045267e-118	2.83974194533333e-115	186.881845439955	320.657412103588	2
Translation inhibitors in chronically activated PDGFRA cells	46	20	422.190734324017	422.241154492084	434.712092635723	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	214.256843831401	217.601976574763	326.949068636753	453	0.989768566490332	NA	NA	1.09716989281756e-40	NA	NA	9.77578374500448e-38	non_linear_mixed	1.09716989281756e-40	9.77578374500448e-38	217.601976574763	326.949068636753	2
Cytosolic DNA-sensing pathway	73	27	352.493094855237	352.530361935982	365.914766944294	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	51.3460956326821	53.7848053101015	172.141144434194	621	0.983793077161039	NA	NA	1.87235139915574e-59	NA	NA	1.66826509664777e-56	non_linear_mixed	1.87235139915574e-59	1.66826509664777e-56	53.7848053101015	172.141144434194	2
Joubert Syndrome	72	21	153.169111200457	153.217111200457	165.836840004671	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-22.354454878534	-19.1779842902987	91.655104359393	477	NA	NA	NA	2.73578753163336e-34	NA	NA	2.43758669068532e-31	non_linear_mixed	2.73578753163336e-34	2.43758669068532e-31	-19.1779842902987	91.655104359393	2
22q11.2 copy number variation syndrome	149	48	650.007470715428	650.028376638773	665.155235239195	1149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	192.604485646682	193.949681376219	328.93436636059	1125	NA	NA	NA	1.25867552840874e-91	NA	NA	1.12147989581219e-88	non_linear_mixed	1.25867552840874e-91	1.12147989581219e-88	193.949681376219	328.93436636059	2
Small cell lung cancer	96	45	873.698434676249	873.720739508962	888.652583636603	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	409.987197758819	411.424460116234	544.574538402012	1053	NA	NA	NA	6.15334753453149e-93	NA	NA	5.48263265326756e-90	non_linear_mixed	6.15334753453149e-93	5.48263265326756e-90	411.424460116234	544.574538402012	3
Gastrin signaling pathway	114	47	756.003554791697	756.024907104864	771.088159087871	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	283.630476769969	285.005022224515	419.391915435535	1101	NA	NA	NA	9.72933469562153e-95	NA	NA	8.66883721379878e-92	non_linear_mixed	9.72933469562153e-95	8.66883721379878e-92	285.005022224515	419.391915435535	5
Hepatitis B infection	152	58	705.314246768303	705.331537834585	721.029737290986	1389	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	117.132672009191	118.241176408018	258.572086713339	1365	NA	NA	NA	6.2670991891465e-119	NA	NA	5.58398537752953e-116	non_linear_mixed	6.2670991891465e-119	5.58398537752953e-116	118.241176408018	258.572086713339	2
Male infertility	145	48	787.645253243681	787.666159167026	802.793017767449	1149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	300.658442392154	302.003638121692	436.988323106062	1125	NA	NA	NA	8.84184887445796e-98	NA	NA	7.87808734714204e-95	non_linear_mixed	8.84184887445796e-98	7.87808734714204e-95	302.003638121692	436.988323106062	2
Head and Neck Squamous Cell Carcinoma	74	34	538.820395434579	538.849952084825	552.933638499471	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	200.404646770428	202.323428496317	327.423834354459	789	NA	NA	NA	4.58478633892413e-67	NA	NA	4.0850446279814e-64	non_linear_mixed	4.58478633892413e-67	4.0850446279814e-64	202.323428496317	327.423834354459	2
Melanoma	68	28	346.306719647034	346.342647790746	359.837494668603	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	136.192473083458	138.540299170414	257.969448277583	645	0.983820169561397	NA	NA	4.04578588526243e-41	NA	NA	3.60479522376882e-38	non_linear_mixed	4.04578588526243e-41	3.60479522376882e-38	138.540299170414	257.969448277583	2
Endochondral Ossification	63	25	327.479531603711	327.519800060087	340.670320569359	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	97.2049398424485	99.8482964858052	215.922040533285	573	0.986309764070407	NA	NA	3.85163873784039e-45	NA	NA	3.43181011541578e-42	non_linear_mixed	3.85163873784039e-45	3.43181011541578e-42	99.8482964858052	215.922040533285	4
Thyroid hormones production and their peripheral downstream signaling effects	74	26	414.955416962589	414.994126640008	428.263868067697	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	135.395928162578	137.932840914256	255.171988108552	597	NA	NA	NA	4.54004044990033e-55	NA	NA	4.0451760408612e-52	non_linear_mixed	4.54004044990033e-55	4.0451760408612e-52	137.932840914256	255.171988108552	2
Netrin-UNC5B signaling pathway	52	21	371.906434135385	371.954434135385	384.574162939599	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	203.969086311648	207.145556899883	317.978645549575	477	0.985381324481947	NA	NA	8.3385438890478e-33	NA	NA	7.42964260514159e-30	non_linear_mixed	8.3385438890478e-33	7.42964260514159e-30	207.145556899883	317.978645549575	3
Nucleotide Excision Repair	43	22	730.588698079341	730.634499606059	743.39598693046	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	510.058769038	513.082769038	625.324368698069	501	0.901438666612097	NA	NA	3.40969039036752e-43	NA	NA	3.03803413781746e-40	non_linear_mixed	3.40969039036752e-43	3.03803413781746e-40	513.082769038	625.324368698069	2
Cytoplasmic Ribosomal Proteins	88	46	-218.614181227747	-218.592363045929	-203.594095547236	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-599.613073677378	-598.207869216412	-464.432302552778	1077	NA	NA	NA	8.15370734509616e-76	NA	NA	7.26495324448068e-73	non_linear_mixed	8.15370734509616e-76	7.26495324448068e-73	-598.207869216412	-464.432302552778	3
Osteoblast differentiation	118	46	466.362621855945	466.384440037763	481.382707536456	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-27.8393509377521	-26.4341464767856	107.341420186848	1077	0.981718658205421	NA	NA	2.77678960923021e-99	NA	NA	2.47411954182412e-96	non_linear_mixed	2.77678960923021e-99	2.47411954182412e-96	-26.4341464767856	107.341420186848	2
Ciliopathies	183	41	407.935525912086	407.960015708004	422.610403603243	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	90.7603267880519	92.3419167462109	222.834226008463	957	0.979902447328542	NA	NA	1.01173441943049e-62	NA	NA	9.01455367712565e-60	non_linear_mixed	1.01173441943049e-62	9.01455367712565e-60	92.3419167462109	222.834226008463	2
EGFR Tyrosine Kinase Inhibitor Resistance	84	37	918.085179274978	918.112328596245	932.452094503955	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	462.905339698848	464.663479233732	592.207576759636	861	NA	NA	NA	3.64493687899661e-91	NA	NA	3.24763875918598e-88	non_linear_mixed	3.64493687899661e-91	3.24763875918598e-88	464.663479233732	592.207576759636	3
Endochondral Ossification with Skeletal Dysplasias	63	25	327.479531603711	327.519800060087	340.670320569359	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	97.2049398424485	99.8482964858052	215.922040533285	573	0.986309764070407	NA	NA	3.85163873784039e-45	NA	NA	3.43181011541578e-42	non_linear_mixed	3.85163873784039e-45	3.43181011541578e-42	99.8482964858052	215.922040533285	4
Insulin Signaling	160	62	858.149732355541	858.16590486228	874.06529700172	1485	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	180.457614380829	181.493230819185	323.697696196441	1461	NA	NA	NA	9.70690889503012e-138	NA	NA	8.64885582547183e-135	non_linear_mixed	9.70690889503012e-138	8.64885582547183e-135	181.493230819185	323.697696196441	2
TGF-beta receptor signaling in skeletal dysplasias	59	23	434.242715709626	434.286511330064	447.183359848457	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	220.289643538733	223.175139721939	336.755440788215	525	0.980370891860703	NA	NA	6.97199714482665e-42	NA	NA	6.21204945604055e-39	non_linear_mixed	6.97199714482665e-42	6.21204945604055e-39	223.175139721939	336.755440788215	4
The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies	54	28	516.285321550221	516.321249693933	529.81609657179	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	187.327409587667	189.675235674624	309.104384781792	645	0.989022880271615	NA	NA	3.95668459813936e-65	NA	NA	3.52540597694217e-62	non_linear_mixed	3.95668459813936e-65	3.52540597694217e-62	189.675235674624	309.104384781792	2
3q29 copy number variation syndrome	86	20	341.448913117034	341.499333285101	353.97027142874	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	83.0555911790755	86.4007239224384	195.747815984428	453	0.985487137175799	NA	NA	8.63474009449246e-51	NA	NA	7.69355342419278e-48	non_linear_mixed	8.63474009449246e-51	7.69355342419278e-48	86.4007239224384	195.747815984428	2
DNA Repair Pathways Full Network	119	57	1455.83755630085	1455.85515160877	1471.5008715954	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	828.228464591888	829.356822800843	969.198302242815	1341	NA	NA	NA	3.32542681232363e-127	NA	NA	2.96295528978036e-124	non_linear_mixed	3.32542681232363e-127	2.96295528978036e-124	829.356822800843	969.198302242815	2
16p11.2 proximal deletion syndrome	79	36	649.28625574751	649.314162724255	663.570974053923	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	268.772722189949	270.58133463014	397.335186947658	837	NA	NA	NA	1.02652107747283e-75	NA	NA	9.14630280028291e-73	non_linear_mixed	1.02652107747283e-75	9.14630280028291e-73	270.58133463014	397.335186947658	2
p53 transcriptional gene network	72	21	481.516316323138	481.564316323138	494.184045127352	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	354.718419633934	357.89489022217	468.727978871861	477	0.985308416998322	NA	NA	7.18052244354496e-25	NA	NA	6.39784549719856e-22	non_linear_mixed	7.18052244354496e-25	6.39784549719856e-22	357.89489022217	468.727978871861	2
Regulation of Actin Cytoskeleton	151	58	850.622323552421	850.639614618703	866.337814075104	1389	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	120.775251303551	121.883755702378	262.214666007699	1365	NA	NA	NA	9.8272536151655e-149	NA	NA	8.75608297111246e-146	non_linear_mixed	9.8272536151655e-149	8.75608297111246e-146	121.883755702378	262.214666007699	2
Calcium Regulation in the Cardiac Cell	151	57	577.553295657791	577.570890965709	593.216610952338	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-34.438173880981	-33.3098156720258	106.531663769946	1341	0.992903147643206	NA	NA	6.33557476314462e-124	NA	NA	5.64499711396185e-121	non_linear_mixed	6.33557476314462e-124	5.64499711396185e-121	-33.3098156720258	106.531663769946	2
TGF-beta Receptor Signaling	55	22	423.310743026063	423.356544552781	436.118031877182	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	217.559072616356	220.583072616356	332.824672276425	501	NA	NA	NA	2.97559719484884e-40	NA	NA	2.65125710061032e-37	non_linear_mixed	2.97559719484884e-40	2.65125710061032e-37	220.583072616356	332.824672276425	5
Interferon type I signaling pathways	54	21	447.061236885281	447.109236885281	459.728965689495	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	234.521005106913	237.697475695148	348.53056434484	477	0.98924627479282	NA	NA	1.33207300052281e-41	NA	NA	1.18687704346583e-38	non_linear_mixed	1.33207300052281e-41	1.18687704346583e-38	237.697475695148	348.53056434484	2
Notch Signaling Pathway Netpath	61	22	425.795202642003	425.84100416872	438.602491493121	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	164.542082312138	167.566082312138	279.807681972207	501	NA	NA	NA	2.28732929421342e-51	NA	NA	2.03801040114416e-48	non_linear_mixed	2.28732929421342e-51	2.03801040114416e-48	167.566082312138	279.807681972207	3
Senescence and Autophagy in Cancer	106	46	724.626532838894	724.648351020713	739.646618519406	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	220.183213852613	221.58841831358	355.363984977213	1077	NA	NA	NA	2.03572060933448e-101	NA	NA	1.81382706291702e-98	non_linear_mixed	2.03572060933448e-101	1.81382706291702e-98	221.58841831358	355.363984977213	3
Oxidative phosphorylation	61	20	-196.438681755919	-196.388261587851	-183.917323444213	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-411.822279270852	-408.477146527489	-299.1300544655	453	NA	NA	NA	3.61849262095344e-42	NA	NA	3.22407692526952e-39	non_linear_mixed	3.61849262095344e-42	3.22407692526952e-39	-408.477146527489	-299.1300544655	3
ErbB signaling pathway	92	38	958.214823413368	958.24125513143	972.661743383591	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	503.776926232594	505.487333472413	633.799205964601	885	0.976561891661665	NA	NA	5.19733312171408e-91	NA	NA	4.63082381144724e-88	non_linear_mixed	5.19733312171408e-91	4.63082381144724e-88	505.487333472413	633.799205964601	2
T-cell receptor (TCR) signaling pathway	92	33	147.446061665696	147.476518518488	161.46974584114	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-170.767843674797	-168.788786083174	-44.5546860958072	765	NA	NA	NA	6.20876825747583e-63	NA	NA	5.53201251741097e-60	non_linear_mixed	6.20876825747583e-63	5.53201251741097e-60	-168.788786083174	-44.5546860958072	2
Metapathway biotransformation Phase I and II	186	50	1215.36845150876	1215.38851839839	1230.63868201609	1197	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	533.866937302138	535.157039691216	671.299011868092	1173	0.990727388578164	NA	NA	1.53046109861699e-138	NA	NA	1.36364083886774e-135	non_linear_mixed	1.53046109861699e-138	1.36364083886774e-135	535.157039691216	671.299011868092	2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	159	53	615.642636419068	615.661563863863	631.087673650768	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	47.1377886004651	48.3532226840664	186.143123685767	1245	NA	NA	NA	8.32178428947232e-115	NA	NA	7.41470980191984e-112	non_linear_mixed	8.32178428947232e-115	7.41470980191984e-112	48.3532226840664	186.143123685767	5
DNA damage response	68	37	912.139163501711	912.166312822978	926.506078730687	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	569.763856067197	571.52199560208	699.066093127985	861	0.969184108566692	NA	NA	7.07867122333597e-68	NA	NA	6.30709605999235e-65	non_linear_mixed	7.07867122333597e-68	6.30709605999235e-65	571.52199560208	699.066093127985	5
DNA damage response (only ATM dependent)	110	48	561.876274617393	561.897180540738	577.02403914116	1149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	81.1630626772674	82.5082584068047	217.492943391175	1125	0.988941921604744	NA	NA	1.78939005178848e-96	NA	NA	1.59434653614354e-93	non_linear_mixed	1.78939005178848e-96	1.59434653614354e-93	82.5082584068047	217.492943391175	2
Toll-like Receptor Signaling Pathway	103	33	-87.1117395584337	-87.0812827056418	-73.0880553829904	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-319.337246641851	-317.358189050228	-193.124089062861	765	0.990885081726637	NA	NA	1.56721889138711e-45	NA	NA	1.39639203222591e-42	non_linear_mixed	1.56721889138711e-45	1.39639203222591e-42	-317.358189050228	-193.124089062861	3
Separation of Sister Chromatids	130	62	2037.32682884683	2037.34300135357	2053.24239349301	1485	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1350.91949819197	1351.95511463033	1494.15958000758	1461	0.972319468157901	NA	NA	1.41731690969222e-139	NA	NA	1.26282936653577e-136	non_linear_mixed	1.41731690969222e-139	1.26282936653577e-136	1351.95511463033	1494.15958000758	2
VEGFA-VEGFR2 Pathway	92	45	434.621885093652	434.644189926366	449.576034054007	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-8.73456381628841	-7.29730145887397	125.852776826905	1053	NA	NA	NA	1.03750044146064e-88	NA	NA	9.24412893341428e-86	non_linear_mixed	1.03750044146064e-88	9.24412893341428e-86	-7.29730145887397	125.852776826905	2
Signaling by VEGF	100	49	502.700818815245	502.721296630945	517.910441200621	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	11.2474264720016	12.5644996427333	148.134027940383	1149	0.990537244482997	NA	NA	1.03801509984637e-98	NA	NA	9.24871453963115e-96	non_linear_mixed	1.03801509984637e-98	9.24871453963115e-96	12.5644996427333	148.134027940383	2
Formation of a pool of free 40S subunits	113	51	-121.003433813536	-120.983761682388	-105.673795424319	1221	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-575.937561367225	-574.673347320403	-437.970815864274	1197	NA	NA	NA	4.09941544793606e-91	NA	NA	3.65257916411103e-88	non_linear_mixed	4.09941544793606e-91	3.65257916411103e-88	-574.673347320403	-437.970815864274	3
Transcriptional regulation by small RNAs	110	44	842.701932575164	842.724746263377	857.588662967962	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	311.445970355112	312.916787475734	445.426543890299	1029	NA	NA	NA	5.15241313939605e-107	NA	NA	4.59080010720188e-104	non_linear_mixed	5.15241313939605e-107	4.59080010720188e-104	312.916787475734	445.426543890299	2
IL6	74	29	724.889564970156	724.924247051081	738.525613951159	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	360.589009575735	362.852482629627	483.313450404764	669	0.985229805718928	NA	NA	2.23167045692461e-72	NA	NA	1.98841837711982e-69	non_linear_mixed	2.23167045692461e-72	1.98841837711982e-69	362.852482629627	483.313450404764	2
Viral Messenger RNA Synthesis	30	20	602.64693843174	602.697358599807	615.168296743446	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	360.228880333721	363.574013077084	472.921105139074	453	0.95625724872245	NA	NA	1.41659267644554e-47	NA	NA	1.26218407471297e-44	non_linear_mixed	1.41659267644554e-47	1.26218407471297e-44	363.574013077084	472.921105139074	2
Formation of the ternary complex, and subsequently, the 43S complex	59	24	193.124485789752	193.16644383171	206.192808771839	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-94.8710072200322	-92.111883132441	22.7438996187569	549	NA	NA	NA	8.82890556440263e-57	NA	NA	7.86655485788274e-54	non_linear_mixed	8.82890556440263e-57	7.86655485788274e-54	-92.111883132441	22.7438996187569	3
Influenza Viral RNA Transcription and Replication	30	20	602.64693843174	602.697358599807	615.168296743446	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	360.228880333721	363.574013077084	472.921105139074	453	0.95625724872245	NA	NA	1.41659267644554e-47	NA	NA	1.26218407471297e-44	non_linear_mixed	1.41659267644554e-47	1.26218407471297e-44	363.574013077084	472.921105139074	2
Transcriptional regulation by RUNX1	195	61	359.734335246635	359.7507736028	375.601118330199	1461	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-221.927734672215	-220.874809881129	-79.126686920141	1437	NA	NA	NA	1.45784039863617e-117	NA	NA	1.29893579518482e-114	non_linear_mixed	1.45784039863617e-117	1.29893579518482e-114	-220.874809881129	-79.126686920141	2
Prolactin	70	27	192.473124968116	192.510392048862	205.894797057173	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-35.1715803330052	-32.7328706555859	85.6234684685062	621	NA	NA	NA	1.29331758515514e-44	NA	NA	1.15234596837323e-41	non_linear_mixed	1.29331758515514e-44	1.15234596837323e-41	-32.7328706555859	85.6234684685062	2
Formation of the beta-catenin:TCF transactivating complex	94	25	44.4467349933557	44.4870034497315	57.6375239590041	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-119.219544283615	-116.576187640258	-0.502443592778747	573	NA	NA	NA	5.67645149748901e-32	NA	NA	5.05771828426271e-29	non_linear_mixed	5.67645149748901e-32	5.05771828426271e-29	-116.576187640258	-0.502443592778747	3
TCF dependent signaling in response to WNT	190	63	556.200564674098	556.216479793462	572.164130344317	1509	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-16.5494858177042	-15.5306178931759	127.122605214262	1485	NA	NA	NA	1.07412842746268e-115	NA	NA	9.57048428869246e-113	non_linear_mixed	1.07412842746268e-115	9.57048428869246e-113	-15.5306178931759	127.122605214262	2
Hedgehog	72	37	577.988812833922	578.015962155189	592.355728062898	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	33.3570348956652	35.1151744305489	162.659271956454	861	NA	NA	NA	8.24449128045787e-110	NA	NA	7.34584173088796e-107	non_linear_mixed	8.24449128045787e-110	7.34584173088796e-107	35.1151744305489	162.659271956454	2
Loss of Nlp from mitotic centrosomes	70	36	956.311309069098	956.339216045842	970.59602737551	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	595.259187301867	597.067799742058	723.821652059576	837	NA	NA	NA	1.03853911826565e-71	NA	NA	9.25338354374692e-69	non_linear_mixed	1.03853911826565e-71	9.25338354374692e-69	597.067799742058	723.821652059576	2
Translation initiation complex formation	66	30	433.434126157083	433.467645710156	447.171879793113	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	32.6803997193335	34.8653708175994	156.320182443606	693	0.994968200948956	NA	NA	6.85009139283172e-80	NA	NA	6.10343143101306e-77	non_linear_mixed	6.85009139283172e-80	6.10343143101306e-77	34.8653708175994	156.320182443606	2
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	67	31	487.074891901712	487.107324334144	500.911015006211	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	80.6790030172053	82.7907348607807	205.204110957699	717	NA	NA	NA	4.67660521336924e-81	NA	NA	4.16685524511199e-78	non_linear_mixed	4.67660521336924e-81	4.16685524511199e-78	82.7907348607807	205.204110957699	2
Centrosome maturation	82	39	1014.67143886084	1014.69718993381	1029.19628529028	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	620.799690525042	622.464888762927	751.523308389937	909	NA	NA	NA	1.80556938961549e-78	NA	NA	1.6087623261474e-75	non_linear_mixed	1.80556938961549e-78	1.6087623261474e-75	622.464888762927	751.523308389937	2
Protein-protein interactions at synapses	88	30	436.776601311181	436.810120864254	450.514354947212	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	86.6919569692666	88.8769280675325	210.331739693539	693	0.982999218442224	NA	NA	1.85702633421226e-69	NA	NA	1.65461046378312e-66	non_linear_mixed	1.85702633421226e-69	1.65461046378312e-66	88.8769280675325	210.331739693539	2
Nonsense-Mediated Decay (NMD)	117	58	56.4469862859726	56.464277352255	72.1624768086557	1389	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-584.40665124049	-583.298146841663	-442.967236536342	1365	NA	NA	NA	5.47391140861127e-130	NA	NA	4.87725506507265e-127	non_linear_mixed	5.47391140861127e-130	4.87725506507265e-127	-583.298146841663	-442.967236536342	2
Signaling by EGFR	48	23	577.136313952419	577.180109572857	590.07695809125	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	295.876957431627	298.762453614833	412.342754681108	525	NA	NA	NA	2.05355476934358e-55	NA	NA	1.82971729948513e-52	non_linear_mixed	2.05355476934358e-55	1.82971729948513e-52	298.762453614833	412.342754681108	2
Gene Silencing by RNA	139	54	972.171271141355	972.189846992748	987.672384772091	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	305.942382856922	307.134811879004	445.452405533552	1269	NA	NA	NA	2.51444079885833e-135	NA	NA	2.24036675178278e-132	non_linear_mixed	2.51444079885833e-135	2.24036675178278e-132	307.134811879004	445.452405533552	2
RHO GTPases Activate Formins	123	59	1866.61735718083	1866.63435434797	1882.38413100359	1413	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1243.21754220802	1244.30687938381	1385.11850661287	1389	NA	NA	NA	2.54750095349122e-126	NA	NA	2.26982334956067e-123	non_linear_mixed	2.54750095349122e-126	2.26982334956067e-123	1244.30687938381	1385.11850661287	2
Cellular response to heat stress	97	52	1263.99025128619	1264.00954389069	1279.37814393297	1245	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	640.898883393609	642.138227655904	779.389917214702	1221	NA	NA	NA	2.95736069537852e-126	NA	NA	2.63500837958226e-123	non_linear_mixed	2.95736069537852e-126	2.63500837958226e-123	642.138227655904	779.389917214702	2
Interleukin-1 family signaling	68	25	161.662430354116	161.702698810492	174.853219319764	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-8.84933728036259	-6.20598063700594	109.867763410473	573	0.995024878675665	NA	NA	2.61886144196927e-33	NA	NA	2.33340554479462e-30	non_linear_mixed	2.61886144196927e-33	2.33340554479462e-30	-6.20598063700594	109.867763410473	2
Mitochondrial translation initiation	88	44	576.445208082782	576.468021770995	591.331938475581	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-56.4524850475227	-54.9816679269001	77.5280884876649	1029	0.959696734583813	NA	NA	2.57382801282989e-128	NA	NA	2.29328075943144e-125	non_linear_mixed	2.57382801282989e-128	2.29328075943144e-125	-54.9816679269001	77.5280884876649	2
GTP hydrolysis and joining of the 60S ribosomal subunit	124	61	406.390493130343	406.406931486507	422.257276213906	1461	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-346.480943959468	-345.428019168382	-203.679896207394	1437	0.996409818414785	NA	NA	1.35440315440508e-153	NA	NA	1.20677321057492e-150	non_linear_mixed	1.35440315440508e-153	1.20677321057492e-150	-345.428019168382	-203.679896207394	2
DNA Double Strand Break Response	78	32	320.658286137731	320.689699750296	334.589655337174	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	14.5135373940466	16.5567806372898	139.895860189034	741	NA	NA	NA	1.79734120229702e-60	NA	NA	1.60143101124664e-57	non_linear_mixed	1.79734120229702e-60	1.60143101124664e-57	16.5567806372898	139.895860189034	2
Cap-dependent Translation Initiation	131	66	512.861353283744	512.876543157162	528.964479000868	1581	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-210.725493925385	-209.753771560347	-65.7973624712772	1557	NA	NA	NA	2.05741221626854e-147	NA	NA	1.83315428469527e-144	non_linear_mixed	2.05741221626854e-147	1.83315428469527e-144	-209.753771560347	-65.7973624712772	2
Eukaryotic Translation Initiation	131	66	512.861353283744	512.876543157162	528.964479000868	1581	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-210.725493925385	-209.753771560347	-65.7973624712772	1557	NA	NA	NA	2.05741221626854e-147	NA	NA	1.83315428469527e-144	non_linear_mixed	2.05741221626854e-147	1.83315428469527e-144	-209.753771560347	-65.7973624712772	2
Platelet degranulation 	131	55	1041.5209869125	1041.53922399457	1057.07714795924	1317	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	308.339802788223	309.510081425994	448.345252208894	1293	NA	NA	NA	1.9445467658655e-149	NA	NA	1.73259116838616e-146	non_linear_mixed	1.9445467658655e-149	1.73259116838616e-146	309.510081425994	448.345252208894	2
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	20	696.007492218254	696.057912386322	708.52885052996	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	491.044383535051	494.389516278413	603.736608340403	453	NA	NA	NA	4.26643757607186e-40	NA	NA	3.80139588028003e-37	non_linear_mixed	4.26643757607186e-40	3.80139588028003e-37	494.389516278413	603.736608340403	2
DNA Damage Bypass	47	27	809.024583930629	809.061851011374	822.446256019686	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	532.576852288035	535.015561965454	653.371901089547	621	NA	NA	NA	1.93849727278928e-54	NA	NA	1.72720107005525e-51	non_linear_mixed	1.93849727278928e-54	1.72720107005525e-51	535.015561965454	653.371901089547	2
TP53 Regulates Transcription of Cell Cycle Genes	51	21	595.10041168643	595.14841168643	607.768140490644	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	411.589052707889	414.765523296124	525.598611945816	477	NA	NA	NA	7.3908658717766e-36	NA	NA	6.58526149175295e-33	non_linear_mixed	7.3908658717766e-36	6.58526149175295e-33	414.765523296124	525.598611945816	2
Signaling by ERBB2	50	22	691.061066898806	691.106868425523	703.868355749924	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	401.192565483154	404.216565483154	516.458165143223	501	0.986903929014485	NA	NA	3.67771987461105e-57	NA	NA	3.27684840827844e-54	non_linear_mixed	3.67771987461105e-57	3.27684840827844e-54	404.216565483154	516.458165143223	2
B-WICH complex positively regulates rRNA expression	93	27	204.90383446486	204.941101545606	218.325506553917	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-53.9913584145278	-51.5526487371085	66.8036903869836	621	NA	NA	NA	6.83965114382083e-51	NA	NA	6.09412916914436e-48	non_linear_mixed	6.83965114382083e-51	6.09412916914436e-48	-51.5526487371085	66.8036903869836	2
TLR JNK	62	36	568.56536082452	568.593267801264	582.850079130932	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	17.3139525791923	19.1225650193837	145.876417336902	837	NA	NA	NA	3.40103590319299e-111	NA	NA	3.03032298974496e-108	non_linear_mixed	3.40103590319299e-111	3.03032298974496e-108	19.1225650193837	145.876417336902	2
COPI-dependent Golgi-to-ER retrograde traffic	82	29	717.283661733464	717.318343814389	730.919710714468	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	481.594153528012	483.857626581904	604.318594357041	669	0.977552733365558	NA	NA	3.17087318291943e-46	NA	NA	2.82524800598121e-43	non_linear_mixed	3.17087318291943e-46	2.82524800598121e-43	483.857626581904	604.318594357041	2
Oxidative Stress Induced Senescence	124	40	183.48783371931	183.512938321821	198.088633572696	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-91.8351796878987	-90.2128620913322	39.5720189925721	933	0.995400941229001	NA	NA	3.27501780176948e-54	NA	NA	2.9180408613766e-51	non_linear_mixed	3.27501780176948e-54	2.9180408613766e-51	-90.2128620913322	39.5720189925721	2
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	79	21	25.8871550058149	25.9351550058149	38.554883810029	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-116.773988621825	-113.59751803359	-2.76442938389795	477	NA	NA	NA	6.62903534385335e-28	NA	NA	5.90647049137334e-25	non_linear_mixed	6.62903534385335e-28	5.90647049137334e-25	-113.59751803359	-2.76442938389795	2
Positive epigenetic regulation of rRNA expression	108	35	275.56722530153	275.595933435502	289.767430977042	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-76.6316968101447	-74.7696278446274	51.170154269464	813	0.99389745572109	NA	NA	6.8372450022502e-70	NA	NA	6.09198529700493e-67	non_linear_mixed	6.8372450022502e-70	6.09198529700493e-67	-74.7696278446274	51.170154269464	2
Regulation of APC/C activators between G1/S and early anaphase	37	22	801.541253169434	801.587054696152	814.348542020553	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	590.12927942722	593.15327942722	705.394879087289	501	0.967131377273735	NA	NA	2.23339082896551e-41	NA	NA	1.98995122860827e-38	non_linear_mixed	2.23339082896551e-41	1.98995122860827e-38	593.15327942722	705.394879087289	2
KitReceptor	70	32	557.716692689437	557.748106302003	571.64806188888	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	274.372835743452	276.416078986695	399.755158538439	741	NA	NA	NA	7.75923014905139e-56	NA	NA	6.91347406280479e-53	non_linear_mixed	7.75923014905139e-56	6.91347406280479e-53	276.416078986695	399.755158538439	2
Phase I - Functionalization of compounds	101	25	489.117144678806	489.157413135182	502.307933644454	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	216.884379981319	219.527736624675	335.601480672155	573	NA	NA	NA	1.38253160727758e-53	NA	NA	1.23183566208432e-50	non_linear_mixed	1.38253160727758e-53	1.23183566208432e-50	219.527736624675	335.601480672155	2
Golgi-to-ER retrograde transport	116	44	860.683698114479	860.706511802692	875.570428507278	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	474.541332841108	476.012149961731	608.521906376296	1029	NA	NA	NA	7.09781926633477e-77	NA	NA	6.32415696630428e-74	non_linear_mixed	7.09781926633477e-77	6.32415696630428e-74	476.012149961731	608.521906376296	2
Antiviral mechanism by IFN-stimulated genes	37	22	409.177835102225	409.223636628943	421.985123953344	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	138.80918334759	141.83318334759	254.074783007659	501	0.991145160723236	NA	NA	3.29425255333083e-53	NA	NA	2.93517902501777e-50	non_linear_mixed	3.29425255333083e-53	2.93517902501777e-50	141.83318334759	254.074783007659	3
Dual Incision in GG-NER	41	24	748.928762577539	748.970720619497	761.997085559627	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	517.102615733987	519.861739821578	634.717522572776	549	0.964499558102986	NA	NA	1.88403293701155e-45	NA	NA	1.67867334687729e-42	non_linear_mixed	1.88403293701155e-45	1.67867334687729e-42	519.861739821578	634.717522572776	2
NoRC negatively regulates rRNA expression	80	21	64.0917179872142	64.1397179872142	76.7594467914283	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-82.4687989194406	-79.2923283312053	31.5407603184863	477	NA	NA	NA	1.17577659351824e-28	NA	NA	1.04761694482475e-25	non_linear_mixed	1.17577659351824e-28	1.04761694482475e-25	-79.2923283312053	31.5407603184863	2
Negative epigenetic regulation of rRNA expression	88	24	80.7513356182536	80.7932936602116	93.8196586003412	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-89.2295131944959	-86.4703891069046	28.3853936442932	549	0.993744748638563	NA	NA	3.32578771362326e-33	NA	NA	2.96327685283832e-30	non_linear_mixed	3.32578771362326e-33	2.96327685283832e-30	-86.4703891069046	28.3853936442932	2
Signaling by NTRK1 (TRKA)	114	51	975.314393861475	975.334065992623	990.644032250692	1221	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	354.154318382998	355.418532429821	492.12106388595	1197	NA	NA	NA	7.52581243558673e-126	NA	NA	6.70549888010778e-123	non_linear_mixed	7.52581243558673e-126	6.70549888010778e-123	355.418532429821	492.12106388595	5
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	33	20	758.894595729193	758.94501589726	771.415954040899	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	562.343798671594	565.688931414957	675.036023476946	453	0.951705630444612	NA	NA	1.97972585229477e-38	NA	NA	1.76393573439464e-35	non_linear_mixed	1.97972585229477e-38	1.76393573439464e-35	565.688931414957	675.036023476946	2
Inositol phosphate metabolism	41	20	80.963275474377	81.0136956424442	93.4846337860828	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-71.5778840568823	-68.2327513135195	41.11434074847	453	NA	NA	NA	8.21626029099223e-30	NA	NA	7.32068791927408e-27	non_linear_mixed	8.21626029099223e-30	7.32068791927408e-27	-68.2327513135195	41.11434074847	2
EPO signaling	186	75	1048.65659097913	1048.66995400808	1065.14321681078	1797	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	296.036027113863	296.889300251561	444.415659598738	1773	0.985515701390457	NA	NA	1.53014117811105e-153	NA	NA	1.36335578969694e-150	non_linear_mixed	1.53014117811105e-153	1.36335578969694e-150	296.889300251561	444.415659598738	2
Processing of DNA double-strand break ends	98	45	1172.25484020484	1172.27714503755	1187.2089891652	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	666.777517957452	668.214780314866	801.364858600645	1053	0.977128391463095	NA	NA	1.23904474144025e-101	NA	NA	1.10398886462326e-98	non_linear_mixed	1.23904474144025e-101	1.10398886462326e-98	668.214780314866	801.364858600645	2
Constitutive Signaling by Aberrant PI3K in Cancer	79	28	775.807300459538	775.84322860325	789.338075481107	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	418.586431418992	420.934257505949	540.363406613117	645	NA	NA	NA	6.36274394150819e-71	NA	NA	5.6692048518838e-68	non_linear_mixed	6.36274394150819e-71	5.6692048518838e-68	420.934257505949	540.363406613117	2
Transcriptional regulation by RUNX2	73	32	678.300805133799	678.332218746364	692.232174333242	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	343.441539648807	345.48478289205	468.823862443794	741	NA	NA	NA	2.45283431120249e-66	NA	NA	2.18547537128142e-63	non_linear_mixed	2.45283431120249e-66	2.18547537128142e-63	345.48478289205	468.823862443794	2
Epigenetic regulation of gene expression	139	46	517.156833416058	517.178651597876	532.176919096569	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	4.85125597825817	6.25646043922471	140.032027102858	1077	0.991877517515429	NA	NA	4.66346939493869e-103	NA	NA	4.15515123089038e-100	non_linear_mixed	4.66346939493869e-103	4.15515123089038e-100	6.25646043922471	140.032027102858	2
Cellular Senescence	186	70	1212.28438468431	1212.29870449338	1228.5640319015	1677	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	558.202732795454	559.117987032742	704.719557750181	1653	0.989910566943204	NA	NA	9.04628064104906e-133	NA	NA	8.06023605117471e-130	non_linear_mixed	9.04628064104906e-133	8.06023605117471e-130	559.117987032742	704.719557750181	2
Glycosaminoglycan metabolism	119	40	631.44862784051	631.473732443021	646.049427693896	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	177.753438750564	179.375756347131	309.160637431035	933	NA	NA	NA	7.4134399416972e-91	NA	NA	6.60537498805221e-88	non_linear_mixed	7.4134399416972e-91	6.60537498805221e-88	179.375756347131	309.160637431035	2
Signaling by the B Cell Receptor (BCR)	126	27	200.140876818073	200.178143898818	213.56254890713	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-44.1380686187774	-41.699358941358	76.656980182734	621	NA	NA	NA	5.99029872603076e-48	NA	NA	5.33735616489341e-45	non_linear_mixed	5.99029872603076e-48	5.33735616489341e-45	-41.699358941358	76.656980182734	2
Signaling by NTRKs	127	55	1057.49277474319	1057.51101182526	1073.04893578993	1317	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	392.224134872538	393.394413510309	532.229584293209	1293	0.987191618955122	NA	NA	4.00449796588426e-135	NA	NA	3.56800768760288e-132	non_linear_mixed	4.00449796588426e-135	3.56800768760288e-132	393.394413510309	532.229584293209	5
Signaling by ERBB4	58	27	712.887013881167	712.924280961912	726.308685970224	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	358.858778577751	361.29748825517	479.653827379262	621	NA	NA	NA	2.87954722340233e-70	NA	NA	2.56567657605148e-67	non_linear_mixed	2.87954722340233e-70	2.56567657605148e-67	361.29748825517	479.653827379262	2
G alpha (12/13) signalling events	80	21	254.646774607417	254.694774607417	267.314503411631	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	3.47710118272448	6.65357177095978	117.486660420651	477	0.986343304965699	NA	NA	2.4641400029169e-49	NA	NA	2.19554874259896e-46	non_linear_mixed	2.4641400029169e-49	2.19554874259896e-46	6.65357177095978	117.486660420651	2
PI3K/AKT Signaling in Cancer	106	33	836.894021200106	836.924478052898	850.917705375549	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	422.524591506699	424.503649098322	548.737749085688	765	NA	NA	NA	1.05008137427051e-82	NA	NA	9.3562250447502e-80	non_linear_mixed	1.05008137427051e-82	9.3562250447502e-80	424.503649098322	548.737749085688	2
IGF1R signaling cascade	53	20	310.514625151445	310.565045319512	323.035983463151	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	71.4738165001515	74.8189492435144	184.166041305504	453	0.988501910095748	NA	NA	6.74742509754619e-47	NA	NA	6.01195576191365e-44	non_linear_mixed	6.74742509754619e-47	6.01195576191365e-44	74.8189492435144	184.166041305504	3
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	53	20	310.514625151445	310.565045319512	323.035983463151	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	71.4738165001515	74.8189492435144	184.166041305504	453	0.988501910095748	NA	NA	6.74742509754619e-47	NA	NA	6.01195576191365e-44	non_linear_mixed	6.74742509754619e-47	6.01195576191365e-44	74.8189492435144	184.166041305504	3
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	20	602.64693843174	602.697358599807	615.168296743446	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	360.25065956086	363.595792304223	472.942884366212	453	0.956073574158802	NA	NA	1.43093085213282e-47	NA	NA	1.27495938925034e-44	non_linear_mixed	1.43093085213282e-47	1.27495938925034e-44	363.595792304223	472.942884366212	2
Formation of Incision Complex in GG-NER	43	24	368.749527880766	368.791485922724	381.817850862854	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	94.340175050329	97.0992991379203	211.955081889118	549	0.985067206742496	NA	NA	5.01397662160463e-54	NA	NA	4.46745316984972e-51	non_linear_mixed	5.01397662160463e-54	4.46745316984972e-51	97.0992991379203	211.955081889118	2
Presynaptic phase of homologous DNA pairing and strand exchange	39	21	633.865660904316	633.913660904316	646.53338970853	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	409.642317345821	412.818787934057	523.651876583748	477	0.934990740095981	NA	NA	6.24371354167972e-44	NA	NA	5.56314876563663e-41	non_linear_mixed	6.24371354167972e-44	5.56314876563663e-41	412.818787934057	523.651876583748	2
BCR	129	52	536.160887404274	536.180180008775	551.548780051062	1245	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-68.8420780282748	-67.6027337659798	69.6489557928182	1221	NA	NA	NA	1.85620020521062e-122	NA	NA	1.65387438284266e-119	non_linear_mixed	1.85620020521062e-122	1.65387438284266e-119	-67.6027337659798	69.6489557928182	2
IL-1 JNK	62	38	574.993442841154	575.019874559216	589.440362811377	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-2.57121652847729	-0.860809288658281	127.45106320353	885	NA	NA	NA	1.05284655706128e-116	NA	NA	9.38086282341599e-114	non_linear_mixed	1.05284655706128e-116	9.38086282341599e-114	-0.860809288658281	127.45106320353	2
Post-translational protein phosphorylation	107	40	1193.77079777759	1193.7959023801	1208.37159763098	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	561.745987476829	563.368305073396	693.1531861573	933	NA	NA	NA	3.92657562364528e-128	NA	NA	3.49857888066794e-125	non_linear_mixed	3.92657562364528e-128	3.49857888066794e-125	563.368305073396	693.1531861573	3
Mitochondrial biogenesis	53	21	431.78028221222	431.82828221222	444.448011016434	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	184.125546542831	187.302017131067	298.135105780758	477	NA	NA	NA	1.25564869024623e-48	NA	NA	1.11878298300939e-45	non_linear_mixed	1.25564869024623e-48	1.11878298300939e-45	187.302017131067	298.135105780758	2
HDR through Homologous Recombination (HRR)	68	34	1065.08851008388	1065.11806673413	1079.20175314878	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	704.243574217037	706.162355942926	831.262761801068	789	NA	NA	NA	1.14552556285987e-71	NA	NA	1.02066327650814e-68	non_linear_mixed	1.14552556285987e-71	1.02066327650814e-68	706.162355942926	831.262761801068	2
Global Genome Nucleotide Excision Repair (GG-NER)	70	40	1044.7011284152	1044.72623301771	1059.30192826858	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	591.87315010814	593.495467704706	723.280348788611	933	0.97130886844971	NA	NA	1.12228071515058e-90	NA	NA	9.99952117199163e-88	non_linear_mixed	1.12228071515058e-90	9.99952117199163e-88	593.495467704706	723.280348788611	2
IL-1 NFkB	64	38	513.401491841846	513.427923559908	527.848411812069	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-71.7339486310583	-70.0235413912393	58.2883311009487	885	NA	NA	NA	2.72691428585593e-118	NA	NA	2.42968062869764e-115	non_linear_mixed	2.72691428585593e-118	2.42968062869764e-115	-70.0235413912393	58.2883311009487	2
ATM pathway	34	20	374.002184011401	374.052604179468	386.523542323107	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	148.561574777447	151.90670752081	261.2537995828	453	0.972054970595271	NA	NA	3.56668002014878e-44	NA	NA	3.17791189795256e-41	non_linear_mixed	3.56668002014878e-44	3.17791189795256e-41	151.90670752081	261.2537995828	3
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	91	38	659.485532589774	659.511964307836	673.932452559997	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	262.331304212032	264.041711451851	392.353583944039	885	NA	NA	NA	3.79335536424992e-79	NA	NA	3.37987962954668e-76	non_linear_mixed	3.79335536424992e-79	3.37987962954668e-76	264.041711451851	392.353583944039	3
IL-1 p38	66	41	590.747227415811	590.771717211729	605.422105106967	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-21.773670908416	-20.192080950257	110.300228311995	957	0.990313981097131	NA	NA	4.90501952377726e-124	NA	NA	4.37037239568554e-121	non_linear_mixed	4.90501952377726e-124	4.37037239568554e-121	-20.192080950257	110.300228311995	2
Transcriptional regulation by RUNX3	49	20	477.228195714138	477.278615882205	489.749554025843	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	236.170777998692	239.515910742055	348.863002804045	453	0.990057170895606	NA	NA	2.65726432312349e-47	NA	NA	2.36762251190303e-44	non_linear_mixed	2.65726432312349e-47	2.36762251190303e-44	239.515910742055	348.863002804045	2
Nuclear Events (kinase and transcription factor activation)	61	28	644.1216889318	644.157617075513	657.65246395337	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	508.852981766473	511.20080785343	630.629956960598	645	0.841415794486527	NA	NA	1.73786312718888e-26	NA	NA	1.54843604632529e-23	non_linear_mixed	1.73786312718888e-26	1.54843604632529e-23	511.20080785343	630.629956960598	3
Iron uptake and transport	57	22	512.981222472443	513.027023999161	525.788511323562	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	186.639349454624	189.663349454624	301.904949114694	501	0.993996774215513	NA	NA	1.35616960011789e-64	NA	NA	1.20834711370504e-61	non_linear_mixed	1.35616960011789e-64	1.20834711370504e-61	189.663349454624	301.904949114694	2
Eukaryotic Translation Termination	103	47	-143.206941155553	-143.185588842386	-128.122336859379	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-531.387672730378	-530.013127275833	-395.626234064812	1101	NA	NA	NA	2.6963078522192e-77	NA	NA	2.40241029632731e-74	non_linear_mixed	2.6963078522192e-77	2.40241029632731e-74	-530.013127275833	-395.626234064812	2
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	133	61	1678.45112702923	1678.46756538539	1694.31791011279	1461	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1009.57316704687	1010.62609183796	1152.37421479895	1437	NA	NA	NA	6.96366843428574e-136	NA	NA	6.2046285749486e-133	non_linear_mixed	6.96366843428574e-136	6.2046285749486e-133	1010.62609183796	1152.37421479895	2
UCH proteinases	102	52	835.42186474308	835.441157347581	850.809757389868	1245	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	32.7136498706349	33.9529941329299	171.204683691728	1221	NA	NA	NA	3.95831911150429e-164	NA	NA	3.52686232835033e-161	non_linear_mixed	3.95831911150429e-164	3.52686232835033e-161	33.9529941329299	171.204683691728	2
Signaling by MET	46	20	286.162601414509	286.213021582576	298.683959726215	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	68.1314377524715	71.4765704958343	180.823662557824	453	0.995197445946884	NA	NA	1.07401617324485e-42	NA	NA	9.56948410361163e-40	non_linear_mixed	1.07401617324485e-42	9.56948410361163e-40	71.4765704958343	180.823662557824	2
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	38	20	114.804711046035	114.855131214102	127.326069357741	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-43.5025283458689	-40.1573956025061	69.1896964594833	453	NA	NA	NA	6.25963045597486e-31	NA	NA	5.5773307362736e-28	non_linear_mixed	6.25963045597486e-31	5.5773307362736e-28	-40.1573956025061	69.1896964594833	2
Signaling by TGF-beta Receptor Complex	68	32	298.044643471395	298.076057083961	311.976012670838	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-44.0151733565457	-41.9719301133025	81.3671494384414	741	0.994081309115873	NA	NA	8.21519739728795e-68	NA	NA	7.31974088098356e-65	non_linear_mixed	8.21519739728795e-68	7.31974088098356e-65	-41.9719301133025	81.3671494384414	3
Toll Like Receptor 2 (TLR2) Cascade	91	38	659.485532589774	659.511964307836	673.932452559997	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	262.331304212032	264.041711451851	392.353583944039	885	NA	NA	NA	3.79335536424992e-79	NA	NA	3.37987962954668e-76	non_linear_mixed	3.79335536424992e-79	3.37987962954668e-76	264.041711451851	392.353583944039	3
Post-translational modification: synthesis of GPI-anchored proteins	94	23	332.97346989554	333.017265515978	345.914114034371	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	124.237823606462	127.123319789668	240.703620855943	525	0.985770753248725	NA	NA	7.60311778302931e-41	NA	NA	6.77437794467912e-38	non_linear_mixed	7.60311778302931e-41	6.77437794467912e-38	127.123319789668	240.703620855943	2
Complex I biogenesis	57	22	-27.7072172523033	-27.6614157255858	-14.8999284011845	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-263.446878059138	-260.422878059138	-148.181278399069	501	0.990515850549837	NA	NA	3.09832166413752e-46	NA	NA	2.76060460274653e-43	non_linear_mixed	3.09832166413752e-46	2.76060460274653e-43	-260.422878059138	-148.181278399069	2
Respiratory electron transport	89	32	-105.136995040112	-105.105581427546	-91.2056258406689	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-458.217553788448	-456.174310545205	-332.835230993461	741	0.99256480541006	NA	NA	4.50706607069753e-70	NA	NA	4.0157958689915e-67	non_linear_mixed	4.50706607069753e-70	4.0157958689915e-67	-456.174310545205	-332.835230993461	2
Homology Directed Repair	139	63	1705.81525653367	1705.83117165304	1721.77882220389	1509	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1014.1291554252	1015.14802334973	1157.80124645717	1485	NA	NA	NA	1.09475359660789e-140	NA	NA	9.75425454577632e-138	non_linear_mixed	1.09475359660789e-140	9.75425454577632e-138	1015.14802334973	1157.80124645717	2
Integration of energy metabolism	91	39	537.985296947299	538.011048020261	552.510143376732	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	101.898331240208	103.563529478094	232.621949105103	909	0.992448142388037	NA	NA	3.33913220349857e-87	NA	NA	2.97516679331723e-84	non_linear_mixed	3.33913220349857e-87	2.97516679331723e-84	103.563529478094	232.621949105103	2
Formation of TC-NER Pre-Incision Complex	55	27	110.492521272569	110.529788353314	123.914193361626	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-177.130746567915	-174.692036890496	-56.335697766404	621	NA	NA	NA	1.05068503178599e-56	NA	NA	9.36160363321314e-54	non_linear_mixed	1.05068503178599e-56	9.36160363321314e-54	-174.692036890496	-56.335697766404	2
IL4-mediated signaling events	65	20	112.536890214403	112.58731038247	125.058248526109	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-99.5384784307293	-96.1933456873664	13.153746374623	453	0.989394875208598	NA	NA	1.64820337483755e-41	NA	NA	1.46854920698026e-38	non_linear_mixed	1.64820337483755e-41	1.46854920698026e-38	-96.1933456873664	13.153746374623	2
C-MYB transcription factor network	85	33	855.448444570904	855.478901423696	869.472128746347	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	422.470594537396	424.449652129019	548.683752116386	765	0.989865789214598	NA	NA	1.47272122544832e-86	NA	NA	1.31219461187446e-83	non_linear_mixed	1.47272122544832e-86	1.31219461187446e-83	424.449652129019	548.683752116386	2
COPI-mediated anterograde transport	83	31	419.664055146571	419.696487579003	433.50017825107	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	78.5846796891414	80.6964115327168	203.109787629635	717	NA	NA	NA	1.30484760645861e-67	NA	NA	1.16261921735463e-64	non_linear_mixed	1.30484760645861e-67	1.16261921735463e-64	80.6964115327168	203.109787629635	2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	113	39	-116.589972592162	-116.564221519201	-102.065126162729	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-448.763564670642	-447.098366432756	-318.039946805747	909	NA	NA	NA	8.69781819237446e-66	NA	NA	7.74975600940564e-63	non_linear_mixed	8.69781819237446e-66	7.74975600940564e-63	-447.098366432756	-318.039946805747	2
Cellular response to chemical stress	99	36	421.578427550587	421.606334527331	435.863145856999	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	25.0264603713192	26.8350728115106	153.588925129029	837	NA	NA	NA	5.05086249531359e-79	NA	NA	4.50031848332441e-76	non_linear_mixed	5.05086249531359e-79	4.50031848332441e-76	26.8350728115106	153.588925129029	2
RHOD GTPase cycle	51	25	600.303929616672	600.344198073048	613.494718582321	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	327.225984003232	329.869340646589	445.943084694068	573	NA	NA	NA	9.32513322732495e-54	NA	NA	8.30869370554653e-51	non_linear_mixed	9.32513322732495e-54	8.30869370554653e-51	329.869340646589	445.943084694068	2
B cell receptor signaling	134	54	697.304734117068	697.323309968461	712.805847747804	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-51.329839206107	-50.1374101840249	88.180183470523	1269	0.993211852665051	NA	NA	1.06290864544791e-152	NA	NA	9.47051603094089e-150	non_linear_mixed	1.06290864544791e-152	9.47051603094089e-150	-50.1374101840249	88.180183470523	2
Pre-NOTCH Transcription and Translation	95	24	98.1402925478361	98.1822505897942	111.208615529924	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-50.1578993747877	-47.3987752871965	67.4570074640013	549	NA	NA	NA	5.43241961422339e-29	NA	NA	4.84028587627304e-26	non_linear_mixed	5.43241961422339e-29	4.84028587627304e-26	-47.3987752871965	67.4570074640013	2
SUMOylation of DNA damage response and repair proteins	78	36	955.230300060023	955.258207036767	969.515018366435	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	488.95751315256	490.766125592751	617.519977910269	837	NA	NA	NA	1.80566037914247e-93	NA	NA	1.60884339781594e-90	non_linear_mixed	1.80566037914247e-93	1.60884339781594e-90	490.766125592751	617.519977910269	3
Signaling by TGFB family members	96	40	433.804732941856	433.829837544367	448.405532795242	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-0.259102172472637	1.36321542409388	131.148096507998	933	0.993801168137939	NA	NA	8.77060663731909e-87	NA	NA	7.81461051385131e-84	non_linear_mixed	8.77060663731909e-87	7.81461051385131e-84	1.36321542409388	131.148096507998	2
Reproduction	105	21	69.6314101063074	69.6794101063074	82.2991389105215	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-48.5796392900318	-45.4031687017966	65.4299199478951	477	NA	NA	NA	3.04280214660303e-23	NA	NA	2.7111367126233e-20	non_linear_mixed	3.04280214660303e-23	2.7111367126233e-20	-45.4031687017966	65.4299199478951	2
Pre-NOTCH Expression and Processing	107	28	107.873960838107	107.90988898182	121.404735859676	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-79.9693051915724	-77.6214791046159	41.8076700025526	645	0.994328164624076	NA	NA	1.03699501574182e-36	NA	NA	9.23962559025963e-34	non_linear_mixed	1.03699501574182e-36	9.23962559025963e-34	-77.6214791046159	41.8076700025526	2
Signaling by NOTCH1	74	27	376.140149632853	376.177416713598	389.561821721909	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	102.729832002371	105.16854167979	223.524880803882	621	NA	NA	NA	7.98714430339074e-54	NA	NA	7.11654557432115e-51	non_linear_mixed	7.98714430339074e-54	7.11654557432115e-51	105.16854167979	223.524880803882	4
IL-7 signaling	185	76	977.537387322882	977.550574136069	994.063748834785	1821	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	238.300010681196	239.14188150525	387.037264288322	1797	NA	NA	NA	1.02454220230125e-150	NA	NA	9.12867102250415e-148	non_linear_mixed	1.02454220230125e-150	9.12867102250415e-148	239.14188150525	387.037264288322	2
IL3	51	21	199.555066598584	199.603066598584	212.222795402798	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-13.0970213068325	-9.92055071859725	100.912537931094	477	NA	NA	NA	1.26552997567319e-41	NA	NA	1.12758720832481e-38	non_linear_mixed	1.26552997567319e-41	1.12758720832481e-38	-9.92055071859725	100.912537931094	2
IL1	54	21	248.412554890899	248.460554890899	261.080283695113	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	68.2706748481734	71.4471454364087	182.2802340861	477	0.987907182008446	NA	NA	3.39616182764064e-35	NA	NA	3.02598018842781e-32	non_linear_mixed	3.39616182764064e-35	3.02598018842781e-32	71.4471454364087	182.2802340861	2
Dual incision in TC-NER	67	34	887.0131436932	887.042700343446	901.126386758092	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	510.015382679568	511.934164405456	637.034570263598	789	0.974277206718045	NA	NA	5.44056187214494e-75	NA	NA	4.84754062808114e-72	non_linear_mixed	5.44056187214494e-75	4.84754062808114e-72	511.934164405456	637.034570263598	2
Metabolism of nucleotides	102	37	829.829271352362	829.856420673629	844.196186581339	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	391.000541294568	392.758680829452	520.302778355357	861	0.980531049406405	NA	NA	9.01846396079845e-88	NA	NA	8.03545138907142e-85	non_linear_mixed	9.01846396079845e-88	8.03545138907142e-85	392.758680829452	520.302778355357	2
Gap-filling DNA repair synthesis and ligation in TC-NER	66	33	880.711123943298	880.74158079609	894.734808118741	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	515.116736534308	517.095794125931	641.329894113298	765	NA	NA	NA	1.209400484748e-72	NA	NA	1.07757583191047e-69	non_linear_mixed	1.209400484748e-72	1.07757583191047e-69	517.095794125931	641.329894113298	2
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	79	40	949.98483047304	950.009935075551	964.585630326426	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	502.081865628062	503.704183224628	633.489064308533	933	0.976513162180268	NA	NA	1.18179032280004e-89	NA	NA	1.05297517761483e-86	non_linear_mixed	1.18179032280004e-89	1.05297517761483e-86	503.704183224628	633.489064308533	2
Nucleotide Excision Repair	97	51	1190.83074724148	1190.85041937263	1206.1603856307	1221	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	591.615769227678	592.8799832745	729.582514730629	1197	NA	NA	NA	3.04139149359991e-121	NA	NA	2.70987982079752e-118	non_linear_mixed	3.04139149359991e-121	2.70987982079752e-118	592.8799832745	729.582514730629	2
Regulation of mRNA stability by proteins that bind AU-rich elements	39	26	618.972004222394	619.010713899813	632.280455327502	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	328.727367096645	331.264279848322	448.503427042619	597	NA	NA	NA	3.08449435630133e-57	NA	NA	2.74828447146448e-54	non_linear_mixed	3.08449435630133e-57	2.74828447146448e-54	331.264279848322	448.503427042619	2
Interleukin-1 signaling	50	20	163.195427615545	163.245847783613	175.716785927251	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	30.1099641588231	33.4550969021859	142.802188964175	453	NA	NA	NA	4.54510970538979e-26	NA	NA	4.0496927475023e-23	non_linear_mixed	4.54510970538979e-26	4.0496927475023e-23	33.4550969021859	142.802188964175	2
Amyloid fiber formation	93	27	186.838927521765	186.87619460251	200.260599610822	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-66.7026245528016	-64.2639148753822	54.0924242487098	621	NA	NA	NA	8.20497190816233e-50	NA	NA	7.31062997017264e-47	non_linear_mixed	8.20497190816233e-50	7.31062997017264e-47	-64.2639148753822	54.0924242487098	2
COPII-mediated vesicle transport	68	26	753.309111767226	753.347821444645	766.617562872334	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	337.647627963363	340.184540715041	457.423687909338	597	0.984078464620386	NA	NA	5.6745061906358e-83	NA	NA	5.0559850158565e-80	non_linear_mixed	5.6745061906358e-83	5.0559850158565e-80	340.184540715041	457.423687909338	2
ER to Golgi Anterograde Transport	136	49	1039.84275917404	1039.86323698974	1055.05238155941	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	317.908449320851	319.225522491582	454.795050789232	1149	NA	NA	NA	4.59145022794054e-147	NA	NA	4.09098215309503e-144	non_linear_mixed	4.59145022794054e-147	4.09098215309503e-144	319.225522491582	454.795050789232	2
Vpr-mediated nuclear import of PICs	34	23	659.936256934364	659.980052554802	672.876901073195	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	381.836203670379	384.721699853586	498.302000919861	525	0.961494037950201	NA	NA	8.96969539007995e-55	NA	NA	7.99199859256124e-52	non_linear_mixed	8.96969539007995e-55	7.99199859256124e-52	384.721699853586	498.302000919861	3
Signaling by BRAF and RAF fusions	61	26	485.19930123433	485.238010911749	498.507752339438	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	167.714854471551	170.251767223228	287.490914417525	597	0.986883924934513	NA	NA	8.74852552934743e-63	NA	NA	7.79493624664856e-60	non_linear_mixed	8.74852552934743e-63	7.79493624664856e-60	170.251767223228	287.490914417525	2
Glycine, serine, alanine and threonine metabolism	78	33	821.569226013373	821.599682866165	835.592910188816	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	350.792587968958	352.771645560581	477.005745547947	765	0.981486999203463	NA	NA	2.08990087148538e-94	NA	NA	1.86210167649347e-91	non_linear_mixed	2.08990087148538e-94	1.86210167649347e-91	352.771645560581	477.005745547947	2
Methionine and cysteine metabolism	78	28	585.29817238498	585.334100528693	598.82894740655	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	255.727731958493	258.075558045449	377.504707152618	645	NA	NA	NA	2.96507559972515e-65	NA	NA	2.64188235935511e-62	non_linear_mixed	2.96507559972515e-65	2.64188235935511e-62	258.075558045449	377.504707152618	3
Tyrosine metabolism	108	31	438.563505132403	438.595937564835	452.399628236902	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	26.3831510600492	28.4948829036246	150.908259000543	717	0.995412682335677	NA	NA	2.9785542490955e-82	NA	NA	2.65389183594409e-79	non_linear_mixed	2.9785542490955e-82	2.65389183594409e-79	28.4948829036246	150.908259000543	4
Urea cycle and metabolism of arginine, proline, glutamate, aspartate and asparagine	105	45	973.346826918744	973.369131751458	988.300975879099	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	401.252929500836	402.69019185825	535.840270144029	1053	NA	NA	NA	1.47401682725949e-115	NA	NA	1.31334899308821e-112	non_linear_mixed	1.47401682725949e-115	1.31334899308821e-112	402.69019185825	535.840270144029	2
Valine, leucine and isoleucine degradation	49	21	415.221675978295	415.269675978295	427.889404782509	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	132.80526665451	135.981737242745	246.814825892437	477	NA	NA	NA	1.19648257258001e-55	NA	NA	1.06606597216879e-52	non_linear_mixed	1.19648257258001e-55	1.06606597216879e-52	135.981737242745	246.814825892437	2
Aminosugars metabolism	51	25	572.32646395449	572.366732410866	585.517252920138	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	278.179490349837	280.822846993194	396.896591040673	573	0.983135336563922	NA	NA	4.9689209034452e-58	NA	NA	4.42730852496967e-55	non_linear_mixed	4.9689209034452e-58	4.42730852496967e-55	280.822846993194	396.896591040673	2
Glycolysis and Gluconeogenesis	66	31	719.964724824823	719.997157257255	733.800847929322	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	329.82351245724	331.935244300815	454.348620397733	717	0.987219162677715	NA	NA	1.06262058303447e-77	NA	NA	9.46794939483712e-75	non_linear_mixed	1.06262058303447e-77	9.46794939483712e-75	331.935244300815	454.348620397733	2
Androgen and estrogen biosynthesis and metabolism	87	27	671.748052559905	671.78531964065	685.169724648962	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	268.060761646823	270.499471324242	388.855810448334	621	0.991868126773683	NA	NA	1.69693337203089e-80	NA	NA	1.51196763447952e-77	non_linear_mixed	1.69693337203089e-80	1.51196763447952e-77	270.499471324242	388.855810448334	2
Arachidonic acid metabolism	98	34	905.316377748145	905.345934398392	919.429620813038	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	487.672290903498	489.591072629386	614.691478487529	789	NA	NA	NA	2.20649955216352e-83	NA	NA	1.9659911009777e-80	non_linear_mixed	2.20649955216352e-83	1.9659911009777e-80	489.591072629386	614.691478487529	2
Bile acid biosynthesis	53	21	332.16641367053	332.21441367053	344.834142474744	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	96.5379645856883	99.7144351739236	210.547523823615	477	0.993579000342902	NA	NA	3.26149787006304e-46	NA	NA	2.90599460222617e-43	non_linear_mixed	3.26149787006304e-46	2.90599460222617e-43	99.7144351739236	210.547523823615	2
De novo fatty acid biosynthesis	43	20	543.202877333052	543.25329750112	555.724235644758	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	322.960960916291	326.306093659654	435.653185721643	453	NA	NA	NA	3.89197818885236e-43	NA	NA	3.46775256626745e-40	non_linear_mixed	3.89197818885236e-43	3.46775256626745e-40	326.306093659654	435.653185721643	2
Leukotriene metabolism	102	42	1058.04075640573	1058.0646607882	1072.78792675162	1005	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	490.598917810024	492.141774952881	623.32345092307	981	NA	NA	NA	1.38940632546517e-114	NA	NA	1.23796103598947e-111	non_linear_mixed	1.38940632546517e-114	1.23796103598947e-111	492.141774952881	623.32345092307	3
Phosphatidylinositol phosphate metabolism	93	44	747.497508664497	747.52032235271	762.384239057296	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	254.306490485671	255.777307606294	388.287064020859	1029	NA	NA	NA	4.51011250169264e-99	NA	NA	4.01851023900814e-96	non_linear_mixed	4.51011250169264e-99	4.01851023900814e-96	255.777307606294	388.287064020859	3
Pyrimidine metabolism	135	60	1591.98747058833	1592.00418368025	1607.80466576604	1437	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	877.466386219332	878.537207749077	1019.82114281872	1413	NA	NA	NA	1.68118261969335e-145	NA	NA	1.49793371414677e-142	non_linear_mixed	1.68118261969335e-145	1.49793371414677e-142	878.537207749077	1019.82114281872	2
Vitamin B3 (nicotinate and nicotinamide) metabolism	47	20	553.544101846391	553.594522014459	566.065460158097	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	305.254959826135	308.600092569497	417.947184631487	453	0.967645847366712	NA	NA	9.35997786531571e-49	NA	NA	8.3397402779963e-46	non_linear_mixed	9.35997786531571e-49	8.3397402779963e-46	308.600092569497	417.947184631487	2
Vitamin E metabolism	43	23	661.469655947431	661.513451567869	674.410300086263	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	372.272969492024	375.158465675231	488.738766741506	525	0.977772382795183	NA	NA	5.03514985958421e-57	NA	NA	4.48631852488953e-54	non_linear_mixed	5.03514985958421e-57	4.48631852488953e-54	375.158465675231	488.738766741506	3
Transcriptional Regulation by MECP2	64	26	502.84816516304	502.886874840459	516.156616268148	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	245.75497652977	248.291889281448	365.531036475745	597	0.976134099939743	NA	NA	1.57905071322522e-50	NA	NA	1.40693418548367e-47	non_linear_mixed	1.57905071322522e-50	1.40693418548367e-47	248.291889281448	365.531036475745	2
Oncogenic MAPK signaling	69	32	607.051792381816	607.083205994382	620.983161581259	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	201.08390253681	203.127145780053	326.466225331797	741	NA	NA	NA	5.73308411768174e-81	NA	NA	5.10817794885443e-78	non_linear_mixed	5.73308411768174e-81	5.10817794885443e-78	203.127145780053	326.466225331797	2
SUMOylation of transcription cofactors	47	20	397.883375889974	397.933796058041	410.40473420168	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	158.333888671949	161.679021415312	271.026113477301	453	NA	NA	NA	5.33427808234275e-47	NA	NA	4.75284177136739e-44	non_linear_mixed	5.33427808234275e-47	4.75284177136739e-44	161.679021415312	271.026113477301	2
Response of EIF2AK4 (GCN2) to amino acid deficiency	111	50	171.344421576455	171.364488466087	186.614652083783	1197	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-273.346456147719	-272.05635375864	-135.914381581764	1173	NA	NA	NA	5.48431735780073e-89	NA	NA	4.88652676580045e-86	non_linear_mixed	5.48431735780073e-89	4.88652676580045e-86	-272.05635375864	-135.914381581764	2
Integrin	124	51	550.090272655414	550.109944786562	565.419911044631	1221	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-51.2319262368002	-49.9677121899774	86.7348192661512	1197	0.994339723648281	NA	NA	1.09894122709639e-121	NA	NA	9.79156633342883e-119	non_linear_mixed	1.09894122709639e-121	9.79156633342883e-119	-49.9677121899774	86.7348192661512	2
TGF_beta_Receptor	173	78	1193.41236247044	1193.42521043618	1210.01665044155	1869	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	365.754270737159	366.574227353211	515.192862477172	1845	NA	NA	NA	2.07721006369755e-169	NA	NA	1.85079416675452e-166	non_linear_mixed	2.07721006369755e-169	1.85079416675452e-166	366.574227353211	515.192862477172	2
Ribosomal scanning and start codon recognition	66	30	447.64021850912	447.673738062193	461.377972145151	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	40.1368012910544	42.3217723893203	163.776584015327	693	NA	NA	NA	2.76064449681353e-81	NA	NA	2.45973424666085e-78	non_linear_mixed	2.76064449681353e-81	2.45973424666085e-78	42.3217723893203	163.776584015327	2
Fibroblast growth factor-1	74	32	201.861845312286	201.893258924852	215.793214511729	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-89.1807578717161	-87.1375146284729	36.201564923271	741	NA	NA	NA	2.12370695387412e-57	NA	NA	1.89222289590184e-54	non_linear_mixed	2.12370695387412e-57	1.89222289590184e-54	-87.1375146284729	36.201564923271	2
DNA Double-Strand Break Repair	168	77	1968.48386546192	1968.49688064631	1985.04944321853	1845	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1124.44193632072	1125.27270555148	1273.53213613016	1821	NA	NA	NA	7.04901629709102e-173	NA	NA	6.2806735207081e-170	non_linear_mixed	7.04901629709102e-173	6.2806735207081e-170	1125.27270555148	1273.53213613016	2
Anchoring of the basal body to the plasma membrane	97	45	1025.48231005548	1025.5046148882	1040.43645901584	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	584.90532072169	586.342583079104	719.492661364883	1053	0.985382676747864	NA	NA	3.91340596067988e-88	NA	NA	3.48684471096578e-85	non_linear_mixed	3.91340596067988e-88	3.48684471096578e-85	586.342583079104	719.492661364883	2
O-linked glycosylation	115	26	682.226105362323	682.264815039743	695.534556467432	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	377.333760727605	379.870673479283	497.10982067358	597	0.974115309916644	NA	NA	3.23417249291284e-60	NA	NA	2.88164769118534e-57	non_linear_mixed	3.23417249291284e-60	2.88164769118534e-57	379.870673479283	497.10982067358	2
G2/M DNA damage checkpoint	95	43	1041.44733528161	1041.47068158511	1056.26509711973	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	567.591111172337	569.097087267955	700.950967715458	1005	NA	NA	NA	4.78150435452252e-95	NA	NA	4.26032037987957e-92	non_linear_mixed	4.78150435452252e-95	4.26032037987957e-92	569.097087267955	700.950967715458	2
ATR signaling pathway	37	26	1079.91842239114	1079.95713206856	1093.22687349625	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	798.081607867439	800.618520619117	917.857667813414	597	0.933201604963641	NA	NA	1.56830385505915e-55	NA	NA	1.3973587348577e-52	non_linear_mixed	1.56830385505915e-55	1.3973587348577e-52	800.618520619117	917.857667813414	2
Purine nucleotides nucleosides metabolism	107	38	835.934549005069	835.96098072313	850.381468975292	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	367.171156954767	368.881564194586	497.193436686774	885	0.98381062495283	NA	NA	5.48018780024203e-94	NA	NA	4.88284733001565e-91	non_linear_mixed	5.48018780024203e-94	4.88284733001565e-91	368.881564194586	497.193436686774	2
SUMOylation of chromatin organization proteins	72	32	878.633323947286	878.664737559852	892.564693146729	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	502.093942620721	504.137185863964	627.476265415708	741	NA	NA	NA	6.76160380407679e-75	NA	NA	6.02458898943242e-72	non_linear_mixed	6.76160380407679e-75	6.02458898943242e-72	504.137185863964	627.476265415708	3
Signaling by NOTCH	189	63	745.281605594214	745.297520713577	761.245171264432	1509	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	203.644059519057	204.662927443585	347.316150551023	1485	0.992684191829805	NA	NA	3.48529556012386e-109	NA	NA	3.10539834407036e-106	non_linear_mixed	3.48529556012386e-109	3.10539834407036e-106	204.662927443585	347.316150551023	2
SUMOylation of RNA binding proteins	48	26	683.836056285706	683.874765963125	697.144507390814	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	373.762892842022	376.2998055937	493.538952787997	597	0.977411833708606	NA	NA	2.84429881718974e-61	NA	NA	2.53427024611606e-58	non_linear_mixed	2.84429881718974e-61	2.53427024611606e-58	376.2998055937	493.538952787997	3
Ion channel transport	165	49	478.877039569921	478.897517385621	494.086661955297	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-35.4667480116963	-34.1496748409646	101.419853456685	1149	0.994634568386152	NA	NA	1.75145951403165e-103	NA	NA	1.5605504270022e-100	non_linear_mixed	1.75145951403165e-103	1.5605504270022e-100	-34.1496748409646	101.419853456685	2
SUMOylation of DNA replication proteins	39	25	718.053654054013	718.093922510389	731.244443019661	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	390.572658893593	393.216015536949	509.289759584429	573	0.971189834590415	NA	NA	7.93214329786458e-65	NA	NA	7.06753967839734e-62	non_linear_mixed	7.93214329786458e-65	7.06753967839734e-62	393.216015536949	509.289759584429	3
Homologous DNA Pairing and Strand Exchange	42	22	695.475940068432	695.52174159515	708.283228919551	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	465.190026757291	468.214026757291	580.45562641736	501	0.927433756619409	NA	NA	3.83159826625526e-45	NA	NA	3.41395405523343e-42	non_linear_mixed	3.83159826625526e-45	3.41395405523343e-42	468.214026757291	580.45562641736	2
G2/M Checkpoints	119	56	1840.67079068472	1840.68870113248	1856.28100724797	1341	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1229.58896877787	1230.73790494808	1370.08091784711	1317	NA	NA	NA	9.83433854629678e-124	NA	NA	8.76239564475043e-121	non_linear_mixed	9.83433854629678e-124	8.76239564475043e-121	1230.73790494808	1370.08091784711	2
Retrograde transport at the Trans-Golgi-Network	49	21	267.623249908528	267.671249908528	280.290978712742	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	71.4567420716984	74.6332126599337	185.466301309625	477	0.986522439823305	NA	NA	2.35833652986374e-38	NA	NA	2.10127784810859e-35	non_linear_mixed	2.35833652986374e-38	2.10127784810859e-35	74.6332126599337	185.466301309625	2
SUMOylation of ubiquitinylation proteins	39	25	679.129353195064	679.16962165144	692.320142160712	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	381.66678244785	384.310139091207	500.383883138686	573	NA	NA	NA	1.05215076637883e-58	NA	NA	9.37466332843535e-56	non_linear_mixed	1.05215076637883e-58	9.37466332843535e-56	384.310139091207	500.383883138686	2
Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	96	47	1660.71347273282	1660.73482504599	1675.798077029	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1162.61510029415	1163.9896457487	1298.37653895972	1101	NA	NA	NA	4.28083240458247e-100	NA	NA	3.81422167248298e-97	non_linear_mixed	4.28083240458247e-100	3.81422167248298e-97	1163.9896457487	1298.37653895972	2
SUMOylation of SUMOylation proteins	35	23	641.953866893792	641.99766251423	654.894511032623	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	494.506723141289	497.392219324495	610.97252039077	525	0.853318078965791	NA	NA	7.92998199507181e-29	NA	NA	7.06561395760899e-26	non_linear_mixed	7.92998199507181e-29	7.06561395760899e-26	497.392219324495	610.97252039077	2
JAK STAT MolecularVariation 1	98	37	-19.1285762237193	-19.1014269024523	-4.76166099474274	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-274.141385982009	-272.383246447126	-144.839148921221	861	0.970377293399165	NA	NA	4.14654299087061e-50	NA	NA	3.69456980486572e-47	non_linear_mixed	4.14654299087061e-50	3.69456980486572e-47	-272.383246447126	-144.839148921221	2
SUMO E3 ligases SUMOylate target proteins	177	74	1553.30168289797	1553.31522691602	1569.74803966862	1773	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	672.567878376703	673.432866935055	820.58508931261	1749	0.986267999937622	NA	NA	1.18228776940573e-180	NA	NA	1.05341840254051e-177	non_linear_mixed	1.18228776940573e-180	1.05341840254051e-177	673.432866935055	820.58508931261	2
Neurotransmitter receptors and postsynaptic signal transmission	185	62	837.517709307072	837.53388181381	853.433273953251	1485	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	185.923338736507	186.958955174863	329.163420552119	1461	0.988322402997118	NA	NA	3.01766825096622e-132	NA	NA	2.6887424116109e-129	non_linear_mixed	3.01766825096622e-132	2.6887424116109e-129	186.958955174863	329.163420552119	2
Amplification of signal from the kinetochores	96	47	1660.71347273282	1660.73482504599	1675.798077029	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1162.61510029415	1163.9896457487	1298.37653895972	1101	NA	NA	NA	4.28083240458247e-100	NA	NA	3.81422167248298e-97	non_linear_mixed	4.28083240458247e-100	3.81422167248298e-97	1163.9896457487	1298.37653895972	2
mRNA Splicing - Minor Pathway	52	30	614.849693236555	614.883212789628	628.587446872586	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	195.45191462799	197.636885726256	319.091697352263	693	NA	NA	NA	9.56692873960347e-84	NA	NA	8.52413350698669e-81	non_linear_mixed	9.56692873960347e-84	8.52413350698669e-81	197.636885726256	319.091697352263	2
mRNA Splicing	185	110	2119.07261265493	2119.08171735903	2136.70821524335	2637	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	586.428887175712	587.007753944472	745.149310471502	2613	NA	NA	NA	1.11772471058665e-319	NA	NA	9.95892717132707e-317	non_linear_mixed	1.11772471058665e-319	9.95892717132707e-317	587.007753944472	745.149310471502	2
Intra-Golgi and retrograde Golgi-to-ER traffic	186	71	1217.59017931708	1217.60429696413	1233.91238043924	1701	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	530.943919350739	531.846067322099	677.843729450249	1677	NA	NA	NA	1.26221619260923e-139	NA	NA	1.12463462761482e-136	non_linear_mixed	1.26221619260923e-139	1.12463462761482e-136	531.846067322099	677.843729450249	2
HDACs deacetylate histones	94	23	240.194426480153	240.238222100591	253.135070618984	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-5.00713052325384	-2.12163434004773	111.458666726228	525	NA	NA	NA	3.9088821890123e-48	NA	NA	3.48281403040996e-45	non_linear_mixed	3.9088821890123e-48	3.48281403040996e-45	-2.12163434004773	111.458666726228	3
JAK STAT MolecularVariation 2	50	23	67.5886416451824	67.6324372656204	80.5292857840137	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-120.393390436675	-117.507894253469	-3.92759318719311	525	0.97656644924895	NA	NA	9.73706957563721e-37	NA	NA	8.67572899189275e-34	non_linear_mixed	9.73706957563721e-37	8.67572899189275e-34	-117.507894253469	-3.92759318719311	2
MHC class II antigen presentation	60	23	114.237063575646	114.280859196084	127.177707714477	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-20.3862864516875	-17.5007902684813	96.0795107977941	525	0.995377204888796	NA	NA	2.30942956873616e-26	NA	NA	2.05770174574392e-23	non_linear_mixed	2.30942956873616e-26	2.05770174574392e-23	-17.5007902684813	96.0795107977941	2
Nonhomologous End-Joining (NHEJ)	69	27	320.811764365605	320.849031446351	334.233436454662	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	54.15240959496	56.5911192723794	174.947458396471	621	NA	NA	NA	1.85186412566516e-52	NA	NA	1.65001093596766e-49	non_linear_mixed	1.85186412566516e-52	1.65001093596766e-49	56.5911192723794	174.947458396471	2
NCAM signaling for neurite out-growth	59	23	130.348122536128	130.391918156566	143.288766674959	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-76.5593960012187	-73.6738998180126	39.9064012482628	525	0.991893309303707	NA	NA	1.75433496767065e-40	NA	NA	1.56311245619455e-37	non_linear_mixed	1.75433496767065e-40	1.56311245619455e-37	-73.6738998180126	39.9064012482628	3
Wnt	69	27	150.097505384851	150.134772465596	163.519177473907	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-67.2911809635421	-64.8524712861227	53.5038678379693	621	NA	NA	NA	1.44233100285861e-42	NA	NA	1.28511692354702e-39	non_linear_mixed	1.44233100285861e-42	1.28511692354702e-39	-64.8524712861227	53.5038678379693	4
Cyclin D associated events in G1	44	22	336.644282331357	336.690083858075	349.451571182476	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	153.852409338509	156.876409338509	269.118008998578	501	0.992431574243079	NA	NA	1.02376265063289e-35	NA	NA	9.12172521713907e-33	non_linear_mixed	1.02376265063289e-35	9.12172521713907e-33	156.876409338509	269.118008998578	3
G1 Phase	44	22	336.644282331357	336.690083858075	349.451571182476	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	153.852409338509	156.876409338509	269.118008998578	501	0.992431574243079	NA	NA	1.02376265063289e-35	NA	NA	9.12172521713907e-33	non_linear_mixed	1.02376265063289e-35	9.12172521713907e-33	156.876409338509	269.118008998578	3
Regulation of HSF1-mediated heat shock response	81	46	1208.50609437859	1208.52791256041	1223.5261800591	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	654.036540731569	655.441745192536	789.217311856169	1077	NA	NA	NA	7.21603277178896e-112	NA	NA	6.42948519966397e-109	non_linear_mixed	7.21603277178896e-112	6.42948519966397e-109	655.441745192536	789.217311856169	3
Golgi Associated Vesicle Biogenesis	56	25	380.348173859678	380.388442316054	393.538962825326	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	126.319564231844	128.9629208752	245.03666492268	573	NA	NA	NA	6.54590507258856e-50	NA	NA	5.83240141967641e-47	non_linear_mixed	6.54590507258856e-50	5.83240141967641e-47	128.9629208752	245.03666492268	2
Selenocysteine synthesis	103	45	-223.666843016991	-223.644538184277	-208.712694056636	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-623.264572375853	-621.827310018439	-488.67723173266	1053	0.997816874955664	NA	NA	1.18700645455973e-79	NA	NA	1.05762275101272e-76	non_linear_mixed	1.18700645455973e-79	1.05762275101272e-76	-621.827310018439	-488.67723173266	3
Interferon gamma signaling	96	36	701.392987572829	701.420894549573	715.677705879241	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	245.097152362476	246.905764802668	373.659617120186	837	0.987910824831773	NA	NA	2.13744386047021e-91	NA	NA	1.90446247967896e-88	non_linear_mixed	2.13744386047021e-91	1.90446247967896e-88	246.905764802668	373.659617120186	2
Cilium Assembly	178	60	1166.69976066129	1166.71647375322	1182.516955839	1437	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	602.608084947815	603.67890647756	744.962841547206	1413	0.985870000685196	NA	NA	6.98746164517907e-114	NA	NA	6.22582832585455e-111	non_linear_mixed	6.98746164517907e-114	6.22582832585455e-111	603.67890647756	744.962841547206	2
C-type lectin receptors (CLRs)	84	25	647.813708423125	647.853976879501	661.004497388773	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	355.14140328854	357.784759931897	473.858503979376	573	NA	NA	NA	9.90775304235189e-58	NA	NA	8.82780796073554e-55	non_linear_mixed	9.90775304235189e-58	8.82780796073554e-55	357.784759931897	473.858503979376	2
trans-Golgi Network Vesicle Budding	72	32	446.554919828558	446.586333441123	460.486289028001	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	97.8562554909999	99.8994987342431	223.238578285987	741	NA	NA	NA	3.57442362150039e-69	NA	NA	3.18481144675685e-66	non_linear_mixed	3.57442362150039e-69	3.18481144675685e-66	99.8994987342431	223.238578285987	2
PKMTs methylate histone lysines	73	21	66.7911885116332	66.8391885116332	79.4589173158473	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-81.2081009545412	-78.0316303663059	32.8014582833858	477	0.989215686275961	NA	NA	6.20441519562509e-29	NA	NA	5.52813393930196e-26	non_linear_mixed	6.20441519562509e-29	5.52813393930196e-26	-78.0316303663059	32.8014582833858	2
IL2	76	35	722.098256886299	722.12696502027	736.298462561811	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	333.513423477449	335.375492442967	461.315274557058	813	0.982118175681645	NA	NA	2.22547432780724e-77	NA	NA	1.98289762607625e-74	non_linear_mixed	2.22547432780724e-77	1.98289762607625e-74	335.375492442967	461.315274557058	4
Posttranslational regulation of adherens junction stability and dissassembly	53	27	525.167870639147	525.205137719892	538.589542728203	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	180.535942882414	182.974652559833	301.330991683925	621	NA	NA	NA	2.43961617528818e-68	NA	NA	2.17369801218177e-65	non_linear_mixed	2.43961617528818e-68	2.17369801218177e-65	182.974652559833	301.330991683925	2
Mitotic G1 phase and G1/S transition	104	53	1919.20876622731	1919.22769367211	1934.65380345901	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1373.36104670471	1374.57648078831	1512.36638179001	1245	NA	NA	NA	4.59074533101249e-110	NA	NA	4.09035408993213e-107	non_linear_mixed	4.59074533101249e-110	4.09035408993213e-107	1374.57648078831	1512.36638179001	2
Deadenylation-dependent mRNA decay	56	31	692.449662758539	692.482095190972	706.285785863039	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	299.522838904841	301.634570748416	424.047946845335	717	NA	NA	NA	2.82893746318368e-78	NA	NA	2.52058327969666e-75	non_linear_mixed	2.82893746318368e-78	2.52058327969666e-75	301.634570748416	424.047946845335	2
HIV Transcription Initiation	47	24	331.149676505684	331.191634547642	344.217999487771	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	62.0918712112949	64.8509952988861	179.706778050084	549	NA	NA	NA	6.06491411629029e-53	NA	NA	5.40383847761465e-50	non_linear_mixed	6.06491411629029e-53	5.40383847761465e-50	64.8509952988861	179.706778050084	2
RNA Polymerase II Transcription Initiation	47	24	331.149676505684	331.191634547642	344.217999487771	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	62.0918712112949	64.8509952988861	179.706778050084	549	NA	NA	NA	6.06491411629029e-53	NA	NA	5.40383847761465e-50	non_linear_mixed	6.06491411629029e-53	5.40383847761465e-50	64.8509952988861	179.706778050084	2
tRNA processing in the nucleus	58	34	829.9985151928	830.028071843046	844.111758257692	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	373.728659492691	375.647441218579	500.747847076722	789	NA	NA	NA	2.16416811982228e-91	NA	NA	1.92827379476165e-88	non_linear_mixed	2.16416811982228e-91	1.92827379476165e-88	375.647441218579	500.747847076722	2
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	100	41	1008.58511706669	1008.60960686261	1023.25999475785	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	499.658661437418	501.240251395577	631.732560657829	957	NA	NA	NA	2.36420385801546e-102	NA	NA	2.10650563749178e-99	non_linear_mixed	2.36420385801546e-102	2.10650563749178e-99	501.240251395577	631.732560657829	3
Negative regulation of the PI3K/AKT network	107	42	1018.07404478903	1018.0979491715	1032.82121513493	1005	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	499.40674490303	500.949602045887	632.131278016075	981	0.979754965967155	NA	NA	2.19288683900823e-104	NA	NA	1.95386217355634e-101	non_linear_mixed	2.19288683900823e-104	1.95386217355634e-101	500.949602045887	632.131278016075	5
Nuclear Envelope Breakdown	53	33	1116.4698000172	1116.50025686999	1130.49348419264	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	767.209234845324	769.188292436947	893.422392424314	765	NA	NA	NA	2.74105050276029e-69	NA	NA	2.44227599795942e-66	non_linear_mixed	2.74105050276029e-69	2.44227599795942e-66	769.188292436947	893.422392424314	2
Activation of the pre-replicative complex	33	20	929.173625230399	929.224045398466	941.694983542105	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	718.553087323166	721.898220066529	831.245312128518	453	0.886421929733738	NA	NA	3.20883008844192e-41	NA	NA	2.85906760880175e-38	non_linear_mixed	3.20883008844192e-41	2.85906760880175e-38	721.898220066529	831.245312128518	2
RNA Polymerase II Pre-transcription Events	85	33	316.051726008793	316.082182861584	330.075410184236	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-45.9821148427695	-44.0030572511464	80.23104273622	765	NA	NA	NA	6.52586931420381e-72	NA	NA	5.8145495589556e-69	non_linear_mixed	6.52586931420381e-72	5.8145495589556e-69	-44.0030572511464	80.23104273622	2
DroToll-like	65	40	577.542715220874	577.567819823384	592.14351507426	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-7.93113852372943	-6.30882092716291	123.476060156741	933	NA	NA	NA	2.31595679504577e-118	NA	NA	2.06351750438578e-115	non_linear_mixed	2.31595679504577e-118	2.06351750438578e-115	-6.30882092716291	123.476060156741	2
E3 ubiquitin ligases ubiquitinate target proteins	59	22	96.6546175824225	96.70041910914	109.461906433541	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-122.68180755901	-119.65780755901	-7.41620789894117	501	NA	NA	NA	5.89889858091991e-43	NA	NA	5.25591863559964e-40	non_linear_mixed	5.89889858091991e-43	5.25591863559964e-40	-119.65780755901	-7.41620789894117	2
Chaperonin-mediated protein folding	93	38	771.726080833807	771.752512551869	786.17300080403	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	303.421015367344	305.131422607163	433.443295099351	885	NA	NA	NA	6.82492521186177e-94	NA	NA	6.08100836376884e-91	non_linear_mixed	6.82492521186177e-94	6.08100836376884e-91	305.131422607163	433.443295099351	2
Cell junction organization	89	31	494.469869951399	494.502302383832	508.305993055899	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	198.510149428732	200.621881272307	323.035257369225	717	0.989647591924978	NA	NA	2.12675575248503e-58	NA	NA	1.89493937546416e-55	non_linear_mixed	2.12675575248503e-58	1.89493937546416e-55	200.621881272307	323.035257369225	2
G1/S Transition	76	44	1698.89451657806	1698.91733026627	1713.78124697085	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1238.41680791419	1239.88762503481	1372.39738144938	1029	0.961763496399427	NA	NA	2.89136442340525e-92	NA	NA	2.57620570125407e-89	non_linear_mixed	2.89136442340525e-92	2.57620570125407e-89	1239.88762503481	1372.39738144938	2
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	77	31	248.131520025275	248.163952457707	261.967643129774	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-40.2999288368193	-38.1881969932439	84.2251791036742	717	0.992395147131584	NA	NA	7.2010501071101e-57	NA	NA	6.4161356454351e-54	non_linear_mixed	7.2010501071101e-57	6.4161356454351e-54	-38.1881969932439	84.2251791036742	2
RNA Polymerase II Transcription Initiation And Promoter Clearance	47	24	331.149676505684	331.191634547642	344.217999487771	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	62.0918712112949	64.8509952988861	179.706778050084	549	NA	NA	NA	6.06491411629029e-53	NA	NA	5.40383847761465e-50	non_linear_mixed	6.06491411629029e-53	5.40383847761465e-50	64.8509952988861	179.706778050084	2
G alpha (s) signalling events	143	32	150.284211200135	150.3156248127	164.215580399578	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-205.909220328049	-203.865977084806	-80.5268975330618	741	0.988248694100238	NA	NA	1.03438993678537e-70	NA	NA	9.21641433675763e-68	non_linear_mixed	1.03438993678537e-70	9.21641433675763e-68	-203.865977084806	-80.5268975330618	4
RNA Polymerase II HIV Promoter Escape	47	24	331.149676505684	331.191634547642	344.217999487771	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	62.0918712112949	64.8509952988861	179.706778050084	549	NA	NA	NA	6.06491411629029e-53	NA	NA	5.40383847761465e-50	non_linear_mixed	6.06491411629029e-53	5.40383847761465e-50	64.8509952988861	179.706778050084	2
Sphingolipid metabolism	87	30	237.63770743239	237.671226985462	251.37546106842	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-32.0759155382295	-29.8909444399636	91.5638671860432	693	NA	NA	NA	4.46910993234855e-53	NA	NA	3.98197694972256e-50	non_linear_mixed	4.46910993234855e-53	3.98197694972256e-50	-29.8909444399636	91.5638671860432	2
RNA Polymerase II Transcription Termination	67	39	795.847834181634	795.873585254596	810.372680611067	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	266.121701837641	267.786900075527	396.845319702536	909	0.980659346147315	NA	NA	1.0755251808348e-106	NA	NA	9.58292936123803e-104	non_linear_mixed	1.0755251808348e-106	9.58292936123803e-104	267.786900075527	396.845319702536	2
ABC-family proteins mediated transport	58	20	346.999179348878	347.049599516945	359.520537660584	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	155.476776448728	158.821909192091	268.16900125408	453	NA	NA	NA	1.9504702363253e-37	NA	NA	1.73786898056584e-34	non_linear_mixed	1.9504702363253e-37	1.73786898056584e-34	158.821909192091	268.16900125408	2
Fatty acid metabolism	176	57	851.267140890023	851.284736197941	866.930456184571	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	227.888536196878	229.016894405833	368.858373847805	1341	NA	NA	NA	2.57376949996524e-126	NA	NA	2.29322862446903e-123	non_linear_mixed	2.57376949996524e-126	2.29322862446903e-123	229.016894405833	368.858373847805	2
Switching of origins to a post-replicative state	47	24	903.713967552896	903.755925594854	916.782290534984	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	649.078207829991	651.837331917582	766.69311466878	549	0.971916868068269	NA	NA	4.93918254535964e-50	NA	NA	4.40081164791544e-47	non_linear_mixed	4.93918254535964e-50	4.40081164791544e-47	651.837331917582	766.69311466878	2
Response to elevated platelet cytosolic Ca2+	136	58	1063.75696167085	1063.77425273713	1079.47245219353	1389	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	299.365629505688	300.474133904515	440.805044209836	1365	NA	NA	NA	4.99216293353391e-156	NA	NA	4.44801717377871e-153	non_linear_mixed	4.99216293353391e-156	4.44801717377871e-153	300.474133904515	440.805044209836	2
Keratinization	129	21	118.002593531373	118.050593531373	130.670322335587	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	14.7813447233027	17.957815311538	128.79090396123	477	0.989771719243876	NA	NA	1.96405426832707e-20	NA	NA	1.74997235307942e-17	non_linear_mixed	1.96405426832707e-20	1.74997235307942e-17	17.957815311538	128.79090396123	5
VEGF	188	76	1040.36053584651	1040.37372265969	1056.88689735841	1821	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	303.730940459808	304.572811283861	452.468194066933	1797	NA	NA	NA	3.63908677570701e-150	NA	NA	3.24242631715494e-147	non_linear_mixed	3.63908677570701e-150	3.24242631715494e-147	304.572811283861	452.468194066933	2
ECM proteoglycans	56	28	103.187864893681	103.223793037393	116.71863991525	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-172.096440001447	-169.748613914491	-50.319464807322	645	NA	NA	NA	3.33465482282299e-54	NA	NA	2.97117744713529e-51	non_linear_mixed	3.33465482282299e-54	2.97117744713529e-51	-169.748613914491	-50.319464807322	3
Lysine metabolism	60	29	650.599311319996	650.633993400921	664.235360300999	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	292.335247164076	294.598720217969	415.059687993106	669	NA	NA	NA	3.8845153354663e-71	NA	NA	3.46110316390047e-68	non_linear_mixed	3.8845153354663e-71	3.46110316390047e-68	294.598720217969	415.059687993106	3
Cell-Cell communication	124	49	831.641090003412	831.661567819112	846.850712388788	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	229.138441135257	230.455514305988	366.025042603638	1149	0.988495842887166	NA	NA	6.21287418751897e-122	NA	NA	5.5356709010794e-119	non_linear_mixed	6.21287418751897e-122	5.5356709010794e-119	230.455514305988	366.025042603638	2
IL4	63	26	225.447111383858	225.485821061277	238.755562488966	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-14.926726324758	-12.3898135730802	104.849333621217	597	NA	NA	NA	3.64455799837309e-47	NA	NA	3.24730117655042e-44	non_linear_mixed	3.64455799837309e-47	3.24730117655042e-44	-12.3898135730802	104.849333621217	2
Toll Like Receptor 9 (TLR9) Cascade	80	36	577.819586718784	577.847493695528	592.104305025196	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	178.485006295185	180.293618735376	307.047471052894	837	0.993170839364906	NA	NA	1.34523696365713e-79	NA	NA	1.1986061346185e-76	non_linear_mixed	1.34523696365713e-79	1.1986061346185e-76	180.293618735376	307.047471052894	3
Signaling by ROBO receptors	65	30	110.826441985133	110.859961538206	124.564195621164	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-159.574918523172	-157.389947424906	-35.9351357988992	693	0.996311990051659	NA	NA	3.24445528057355e-53	NA	NA	2.89080965499103e-50	non_linear_mixed	3.24445528057355e-53	2.89080965499103e-50	-157.389947424906	-35.9351357988992	2
Cytoprotection by HMOX1	65	24	195.398457438184	195.440415480142	208.466780420272	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-70.8543266139847	-68.0952025263935	46.7605802248044	549	NA	NA	NA	2.23748333030728e-52	NA	NA	1.99359764730379e-49	non_linear_mixed	2.23748333030728e-52	1.99359764730379e-49	-68.0952025263935	46.7605802248044	2
superpathway of purine nucleotide salvage	59	21	231.396742353875	231.444742353875	244.064471158089	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	48.3805316164199	51.5570022046552	162.390090854347	477	NA	NA	NA	9.24874533446644e-36	NA	NA	8.24063209300959e-33	non_linear_mixed	9.24874533446644e-36	8.24063209300959e-33	51.5570022046552	162.390090854347	2
Formation of RNA Pol II elongation complex 	62	21	62.7579981574721	62.8059981574721	75.4257269616863	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-165.108256572436	-161.931785984201	-51.0986973345095	477	NA	NA	NA	1.16789756524568e-44	NA	NA	1.0405967306339e-41	non_linear_mixed	1.16789756524568e-44	1.0405967306339e-41	-161.931785984201	-51.0986973345095	2
RNA Polymerase II Transcription Elongation	62	21	62.7579981574721	62.8059981574721	75.4257269616863	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-165.108256572436	-161.931785984201	-51.0986973345095	477	NA	NA	NA	1.16789756524568e-44	NA	NA	1.0405967306339e-41	non_linear_mixed	1.16789756524568e-44	1.0405967306339e-41	-161.931785984201	-51.0986973345095	2
Synthesis of DNA	76	42	1730.55359697565	1730.57750135812	1745.30076732154	1005	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1240.08340736098	1241.62626450383	1372.80794047402	981	0.95048622790573	NA	NA	1.66349684704052e-98	NA	NA	1.4821756907131e-95	non_linear_mixed	1.66349684704052e-98	1.4821756907131e-95	1241.62626450383	1372.80794047402	2
S Phase	104	54	2021.88978724796	2021.90836309936	2037.3909008787	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1401.83368682156	1403.02611584364	1541.34370949819	1269	0.959041642715808	NA	NA	1.28355596645029e-125	NA	NA	1.14364836610721e-122	non_linear_mixed	1.28355596645029e-125	1.14364836610721e-122	1403.02611584364	1541.34370949819	2
Notch	78	45	764.823145060474	764.845449893188	779.777294020829	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	82.9914842177221	84.4287465751365	217.578824860915	1053	NA	NA	NA	1.30402918480853e-138	NA	NA	1.1618900036644e-135	non_linear_mixed	1.30402918480853e-138	1.1618900036644e-135	84.4287465751365	217.578824860915	2
Selenoamino acid metabolism	128	57	322.60392109684	322.621516404758	338.267236391387	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-261.834121917925	-260.70576370897	-120.864284266997	1341	NA	NA	NA	3.81822507424468e-118	NA	NA	3.40203854115201e-115	non_linear_mixed	3.81822507424468e-118	3.40203854115201e-115	-260.70576370897	-120.864284266997	2
Glycerophospholipid metabolism	136	45	767.20248706738	767.224791900093	782.156636027735	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	213.884811042711	215.322073400125	348.472151685904	1053	NA	NA	NA	1.25693951270128e-111	NA	NA	1.11993310581684e-108	non_linear_mixed	1.25693951270128e-111	1.11993310581684e-108	215.322073400125	348.472151685904	2
MyD88 cascade initiated on plasma membrane	77	34	583.312883516612	583.342440166859	597.426126581505	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	207.512317541761	209.431099267649	334.531505125792	789	NA	NA	NA	9.59845724089193e-75	NA	NA	8.55222540163471e-72	non_linear_mixed	9.59845724089193e-75	8.55222540163471e-72	209.431099267649	334.531505125792	3
Toll Like Receptor 10 (TLR10) Cascade	77	34	583.312883516612	583.342440166859	597.426126581505	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	207.512317541761	209.431099267649	334.531505125792	789	NA	NA	NA	9.59845724089193e-75	NA	NA	8.55222540163471e-72	non_linear_mixed	9.59845724089193e-75	8.55222540163471e-72	209.431099267649	334.531505125792	3
TRIF(TICAM1)-mediated TLR4 signaling 	89	40	584.918866013538	584.943970616048	599.519665866924	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	112.927101310019	114.549418906585	244.33429999049	933	0.993082188995723	NA	NA	1.16787489924055e-94	NA	NA	1.04057653522333e-91	non_linear_mixed	1.16787489924055e-94	1.04057653522333e-91	114.549418906585	244.33429999049	3
MyD88-independent TLR4 cascade 	90	40	584.918866013538	584.943970616048	599.519665866924	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	112.927101310019	114.549418906585	244.33429999049	933	0.993082188995723	NA	NA	1.16787489924055e-94	NA	NA	1.04057653522333e-91	non_linear_mixed	1.16787489924055e-94	1.04057653522333e-91	114.549418906585	244.33429999049	3
Toll Like Receptor 4 (TLR4) Cascade	112	46	725.46101687751	725.482835059328	740.481102558021	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	233.739117399592	235.144321860558	368.919888524192	1077	0.992877827944991	NA	NA	9.1257003240172e-99	NA	NA	8.13099898869933e-96	non_linear_mixed	9.1257003240172e-99	8.13099898869933e-96	235.144321860558	368.919888524192	2
Glycosphingolipid metabolism	69	28	606.818867810134	606.854795953847	620.349642831703	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	271.344202364305	273.692028451261	393.12117755843	645	NA	NA	NA	1.83512850305508e-66	NA	NA	1.63509949622207e-63	non_linear_mixed	1.83512850305508e-66	1.63509949622207e-63	273.692028451261	393.12117755843	2
Formation of HIV-1 elongation complex containing HIV-1 Tat	47	20	72.6094988820678	72.659919050135	85.1308571937736	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-138.17445896375	-134.829326220387	-25.4822341583973	453	NA	NA	NA	2.97751002368248e-41	NA	NA	2.65296143110109e-38	non_linear_mixed	2.97751002368248e-41	2.65296143110109e-38	-134.829326220387	-25.4822341583973	2
Tat-mediated elongation of the HIV-1 transcript	47	20	72.6094988820678	72.659919050135	85.1308571937736	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-138.17445896375	-134.829326220387	-25.4822341583973	453	NA	NA	NA	2.97751002368248e-41	NA	NA	2.65296143110109e-38	non_linear_mixed	2.97751002368248e-41	2.65296143110109e-38	-134.829326220387	-25.4822341583973	2
Putative anti-Inflammatory metabolites formation from EPA	41	21	614.428808710527	614.476808710527	627.096537514741	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	383.069221144444	386.245691732679	497.078780382371	477	NA	NA	NA	2.33609017370711e-45	NA	NA	2.08145634477303e-42	non_linear_mixed	2.33609017370711e-45	2.08145634477303e-42	386.245691732679	497.078780382371	2
HIV Transcription Elongation	47	20	72.6094988820678	72.659919050135	85.1308571937736	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-138.17445896375	-134.829326220387	-25.4822341583973	453	NA	NA	NA	2.97751002368248e-41	NA	NA	2.65296143110109e-38	non_linear_mixed	2.97751002368248e-41	2.65296143110109e-38	-134.829326220387	-25.4822341583973	2
IL5	48	21	232.609091489199	232.657091489199	245.276820293413	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	37.240243765888	40.4167143541233	151.249803003815	477	0.991107560123248	NA	NA	3.39095146108428e-38	NA	NA	3.02133775182609e-35	non_linear_mixed	3.39095146108428e-38	3.02133775182609e-35	40.4167143541233	151.249803003815	2
Toll Like Receptor 3 (TLR3) Cascade	87	40	584.918866013538	584.943970616048	599.519665866924	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	112.927101310019	114.549418906585	244.33429999049	933	0.993082188995723	NA	NA	1.16787489924055e-94	NA	NA	1.04057653522333e-91	non_linear_mixed	1.16787489924055e-94	1.04057653522333e-91	114.549418906585	244.33429999049	3
Toll Like Receptor 5 (TLR5) Cascade	77	34	583.312883516612	583.342440166859	597.426126581505	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	207.512317541761	209.431099267649	334.531505125792	789	NA	NA	NA	9.59845724089193e-75	NA	NA	8.55222540163471e-72	non_linear_mixed	9.59845724089193e-75	8.55222540163471e-72	209.431099267649	334.531505125792	3
Toll Like Receptor 7/8 (TLR7/8) Cascade	79	35	581.527322182493	581.556030316465	595.727527858005	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	231.532218877639	233.394287843156	359.334069957248	813	NA	NA	NA	1.93728109508822e-69	NA	NA	1.7261174557236e-66	non_linear_mixed	1.93728109508822e-69	1.7261174557236e-66	233.394287843156	359.334069957248	4
Transport to the Golgi and subsequent modification	167	61	1210.32526984811	1210.34170820427	1226.19205293167	1461	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	334.333869316832	335.386794107919	477.134917068906	1437	NA	NA	NA	1.19707239347782e-179	NA	NA	1.06659150258874e-176	non_linear_mixed	1.19707239347782e-179	1.06659150258874e-176	335.386794107919	477.134917068906	2
Factors involved in megakaryocyte development and platelet production	145	43	837.040763003004	837.064109306506	851.858524841128	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	492.066188734563	493.57216483018	625.426045277684	1005	0.984563311659526	NA	NA	2.07520866789894e-68	NA	NA	1.84901092309796e-65	non_linear_mixed	2.07520866789894e-68	1.84901092309796e-65	493.57216483018	625.426045277684	2
Antigen processing-Cross presentation	40	20	409.928254743993	409.97867491206	422.449613055699	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	120.321989198006	123.667121941369	233.014214003358	453	NA	NA	NA	4.15753911047329e-57	NA	NA	3.7043673474317e-54	non_linear_mixed	4.15753911047329e-57	3.7043673474317e-54	123.667121941369	233.014214003358	2
Formation of HIV elongation complex in the absence of HIV Tat	49	20	72.6094988820678	72.659919050135	85.1308571937736	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-138.17445896375	-134.829326220387	-25.4822341583973	453	NA	NA	NA	2.97751002368248e-41	NA	NA	2.65296143110109e-38	non_linear_mixed	2.97751002368248e-41	2.65296143110109e-38	-134.829326220387	-25.4822341583973	2
Extra-nuclear estrogen signaling	73	30	725.451786138058	725.48530569113	739.189539774088	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	373.334304761126	375.519275859391	496.974087485398	693	NA	NA	NA	7.10556454321534e-70	NA	NA	6.33105800800487e-67	non_linear_mixed	7.10556454321534e-70	6.33105800800487e-67	375.519275859391	496.974087485398	2
RNA polymerase II transcribes snRNA genes	77	30	243.498634074124	243.532153627197	257.236387710154	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-107.172165933367	-104.987194835101	16.4676167909055	693	NA	NA	NA	1.40775818953772e-69	NA	NA	1.25431254687811e-66	non_linear_mixed	1.40775818953772e-69	1.25431254687811e-66	-104.987194835101	16.4676167909055	2
Nuclear Receptor transcription pathway	53	24	302.359268831751	302.401226873709	315.427591813839	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	39.427034884583	42.1861589721743	157.041941723372	549	NA	NA	NA	1.04810566188651e-51	NA	NA	9.3386214474088e-49	non_linear_mixed	1.04810566188651e-51	9.3386214474088e-49	42.1861589721743	157.041941723372	2
Transcription of the HIV genome	74	33	319.131276562006	319.161733414797	333.154960737449	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-38.8350311242483	-36.8559735326253	87.3781264547412	765	NA	NA	NA	4.47207716289539e-71	NA	NA	3.98462075213979e-68	non_linear_mixed	4.47207716289539e-71	3.98462075213979e-68	-36.8559735326253	87.3781264547412	2
TGF-beta super family signaling pathway canonical	115	54	852.052564120951	852.071139972344	867.553677751687	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	97.5354601912745	98.7278892133565	237.045482867904	1269	NA	NA	NA	6.08383371517209e-154	NA	NA	5.42069584021833e-151	non_linear_mixed	6.08383371517209e-154	5.42069584021833e-151	98.7278892133565	237.045482867904	2
Phase II - Conjugation of compounds	111	36	597.575327622892	597.603234599636	611.860045929304	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	111.328655684847	113.137268125038	239.891120442556	837	NA	NA	NA	1.26088087522022e-97	NA	NA	1.12344485982121e-94	non_linear_mixed	1.26088087522022e-97	1.12344485982121e-94	113.137268125038	239.891120442556	3
Recruitment of mitotic centrosome proteins and complexes	82	39	1014.67143886084	1014.69718993381	1029.19628529028	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	620.799690525042	622.464888762927	751.523308389937	909	NA	NA	NA	1.80556938961549e-78	NA	NA	1.6087623261474e-75	non_linear_mixed	1.80556938961549e-78	1.6087623261474e-75	622.464888762927	751.523308389937	2
Rev-mediated nuclear export of HIV RNA	34	23	668.541348444908	668.585144065346	681.481992583739	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	382.04179217166	384.927288354866	498.507589421142	525	NA	NA	NA	1.77648982360513e-56	NA	NA	1.58285243283217e-53	non_linear_mixed	1.77648982360513e-56	1.58285243283217e-53	384.927288354866	498.507589421142	2
Cargo recognition for clathrin-mediated endocytosis	105	43	717.955576708218	717.97892301172	732.773338546343	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	214.852040051089	216.358016146707	348.21189659421	1005	0.993164718876067	NA	NA	3.87339561350733e-101	NA	NA	3.45119549163503e-98	non_linear_mixed	3.87339561350733e-101	3.45119549163503e-98	216.358016146707	348.21189659421	2
Clathrin-mediated endocytosis	142	57	904.003126664698	904.020721972616	919.666441959246	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	206.736554643818	207.864912852773	347.706392294745	1341	NA	NA	NA	7.3002785355475e-142	NA	NA	6.50454817517282e-139	non_linear_mixed	7.3002785355475e-142	6.50454817517282e-139	207.864912852773	347.706392294745	3
Loss of proteins required for interphase microtubule organization from the centrosome	70	36	956.311309069098	956.339216045842	970.59602737551	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	595.259187301867	597.067799742058	723.821652059576	837	NA	NA	NA	1.03853911826565e-71	NA	NA	9.25338354374692e-69	non_linear_mixed	1.03853911826565e-71	9.25338354374692e-69	597.067799742058	723.821652059576	2
Late Phase of HIV Life Cycle	141	63	1140.41677909047	1140.43269420983	1156.38034476068	1509	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	333.751507504882	334.77037542941	477.423598536848	1485	NA	NA	NA	5.75921746215619e-165	NA	NA	5.13146275878116e-162	non_linear_mixed	5.75921746215619e-165	5.13146275878116e-162	334.77037542941	477.423598536848	2
HIV Life Cycle	151	68	1246.52006767492	1246.53480968966	1262.71275228149	1629	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	420.309651052272	421.252294443793	566.043812511421	1605	NA	NA	NA	4.206811474448e-169	NA	NA	3.74826902373316e-166	non_linear_mixed	4.206811474448e-169	3.74826902373316e-166	421.252294443793	566.043812511421	2
Interactions of Vpr with host cellular proteins	37	24	670.959992028261	671.00195007022	684.028315010349	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	379.104885802033	381.864009889624	496.719792640822	549	NA	NA	NA	1.45219683271081e-57	NA	NA	1.29390737794533e-54	non_linear_mixed	1.45219683271081e-57	1.29390737794533e-54	381.864009889624	496.719792640822	3
Interactions of Rev with host cellular proteins	38	25	696.557210205508	696.597478661884	709.747999171156	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	383.406452679022	386.049809322378	502.123553369858	573	0.97512066234637	NA	NA	6.70392708165913e-62	NA	NA	5.97319902975829e-59	non_linear_mixed	6.70392708165913e-62	5.97319902975829e-59	386.049809322378	502.123553369858	2
L1CAM interactions	102	38	259.47128261514	259.497714333202	273.918202585363	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-70.4026375995526	-68.6922303597336	59.6196421324544	885	NA	NA	NA	2.57011705982666e-65	NA	NA	2.28997430030555e-62	non_linear_mixed	2.57011705982666e-65	2.28997430030555e-62	-68.6922303597336	59.6196421324544	2
Host Interactions of HIV factors	89	47	1043.19888865363	1043.2202409668	1058.2834929498	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	483.853441951906	485.227987406451	619.614880617472	1101	0.988717925640542	NA	NA	6.88474741359973e-113	NA	NA	6.13430994551736e-110	non_linear_mixed	6.88474741359973e-113	6.13430994551736e-110	485.227987406451	619.614880617472	5
HIV Infection	192	85	1516.18264156516	1516.19442938441	1533.04475682567	2037	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	474.595643679908	475.347134733586	626.354681024541	2013	NA	NA	NA	8.04316410772175e-215	NA	NA	7.16645921998008e-212	non_linear_mixed	8.04316410772175e-215	7.16645921998008e-212	475.347134733586	626.354681024541	2
Interferon Signaling	162	69	1231.54475982295	1231.55928766798	1247.78124082778	1653	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	379.191911343904	380.120658272651	525.320240387425	1629	0.989992770793866	NA	NA	1.22359205204984e-174	NA	NA	1.0902205183764e-171	non_linear_mixed	1.22359205204984e-174	1.0902205183764e-171	380.120658272651	525.320240387425	2
G2/M Transition	138	70	1809.62769090409	1809.64201071316	1825.90733812129	1677	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1095.45766485611	1096.3729190934	1241.97448981084	1653	0.983282580576873	NA	NA	1.99366525464745e-145	NA	NA	1.77635574189088e-142	non_linear_mixed	1.99366525464745e-145	1.77635574189088e-142	1096.3729190934	1241.97448981084	2
Mitotic G2-G2/M phases	140	71	1816.55874503459	1816.57286268164	1832.88094615675	1701	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1095.20282934961	1096.10497732097	1242.10263944912	1677	NA	NA	NA	6.08087390929129e-147	NA	NA	5.41805865317854e-144	non_linear_mixed	6.08087390929129e-147	5.41805865317854e-144	1096.10497732097	1242.10263944912	2
Fcgamma receptor (FCGR) dependent phagocytosis	155	29	198.065353513423	198.100035594348	211.701402494426	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-131.535339597255	-129.271866543363	-8.81089876822551	669	NA	NA	NA	2.9231231711566e-65	NA	NA	2.60450274550053e-62	non_linear_mixed	2.9231231711566e-65	2.60450274550053e-62	-129.271866543363	-8.81089876822551	2
DDX58/IFIH1-mediated induction of interferon-alpha/beta	61	23	190.874306213764	190.918101834202	203.814950352595	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-24.4719194104582	-21.5864232272521	91.9938778390234	525	NA	NA	NA	3.68103981594517e-42	NA	NA	3.27980647600715e-39	non_linear_mixed	3.68103981594517e-42	3.27980647600715e-39	-21.5864232272521	91.9938778390234	2
Signaling by FGFR2	74	33	494.27350373493	494.303960587722	508.297187910373	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	89.0850512536375	91.0641088452606	215.298208832627	765	NA	NA	NA	8.30748114157258e-81	NA	NA	7.40196569714117e-78	non_linear_mixed	8.30748114157258e-81	7.40196569714117e-78	91.0641088452606	215.298208832627	2
TLR p38	63	38	587.756898668398	587.78333038646	602.203818638621	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	15.8516763559404	17.5620835957594	145.873956087947	885	NA	NA	NA	1.61444689355159e-115	NA	NA	1.43847218215446e-112	non_linear_mixed	1.61444689355159e-115	1.43847218215446e-112	17.5620835957594	145.873956087947	2
Signaling by Hedgehog	79	27	104.61996275193	104.657229832675	118.041634840987	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-111.32417759828	-108.885467920861	9.47087120323116	621	0.995446085948655	NA	NA	2.79821499840797e-42	NA	NA	2.4932095635815e-39	non_linear_mixed	2.79821499840797e-42	2.4932095635815e-39	-108.885467920861	9.47087120323116	2
Condensation of Prophase Chromosomes	78	20	346.313081631662	346.36350179973	358.834439943368	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	221.573931689883	224.919064433246	334.266156495235	453	NA	NA	NA	1.76738826355336e-24	NA	NA	1.57474294282604e-21	non_linear_mixed	1.76738826355336e-24	1.57474294282604e-21	224.919064433246	334.266156495235	2
TNF	67	39	580.805577546338	580.831328619299	595.330423975771	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-4.97671279742463	-3.31151455953916	125.74690506747	909	0.988720435384963	NA	NA	1.99559405530025e-118	NA	NA	1.77807430327252e-115	non_linear_mixed	1.99559405530025e-118	1.77807430327252e-115	-3.31151455953916	125.74690506747	2
Ion homeostasis	44	22	144.703535294106	144.749336820824	157.510824145225	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-3.28620316668849	-0.262203166688494	111.979396493381	501	NA	NA	NA	6.23081184889491e-29	NA	NA	5.55165335736536e-26	non_linear_mixed	6.23081184889491e-29	5.55165335736536e-26	-0.262203166688494	111.979396493381	2
Mitotic Prophase	147	63	1557.93811971512	1557.95403483448	1573.90168538534	1509	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	913.21729002782	914.236157952349	1056.88938105979	1485	0.982669756128502	NA	NA	8.41806675508366e-131	NA	NA	7.50049747877954e-128	non_linear_mixed	8.41806675508366e-131	7.50049747877954e-128	914.236157952349	1056.88938105979	2
SRP-dependent cotranslational protein targeting to membrane	123	52	36.3089462565614	36.328238861063	51.6968389033495	1245	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-496.950507161298	-495.711162899003	-358.459473340205	1221	NA	NA	NA	1.96514281051062e-107	NA	NA	1.75094224416497e-104	non_linear_mixed	1.96514281051062e-107	1.75094224416497e-104	-495.711162899003	-358.459473340205	2
Potential therapeutics for SARS	80	41	467.216825428824	467.241315224743	481.891703119981	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	72.2089817955882	73.7905717537472	204.282881015999	957	NA	NA	NA	1.05226089404691e-78	NA	NA	9.37564456595795e-76	non_linear_mixed	1.05226089404691e-78	9.37564456595795e-76	73.7905717537472	204.282881015999	2
SARS-CoV Infections	111	49	578.729601617595	578.750079433295	593.939224002971	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	93.2356880455959	94.5527612163276	230.122289513977	1149	NA	NA	NA	1.80893785438764e-97	NA	NA	1.61176362825939e-94	non_linear_mixed	1.80893785438764e-97	1.61176362825939e-94	94.5527612163276	230.122289513977	2
Sensory processing of sound	58	20	278.026454475097	278.076874643164	290.547812786802	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	49.7041583920516	53.0492911354144	162.396383197404	453	0.989504098839656	NA	NA	9.46686990164503e-45	NA	NA	8.43498108236572e-42	non_linear_mixed	9.46686990164503e-45	8.43498108236572e-42	53.0492911354144	162.396383197404	3
Regulation of actin dynamics for phagocytic cup formation	138	23	119.77612799292	119.819923613358	132.716772131751	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-124.810068980242	-121.924572797036	-8.34427173076068	525	0.995584979263358	NA	NA	5.19651806107733e-48	NA	NA	4.6300975924199e-45	non_linear_mixed	5.19651806107733e-48	4.6300975924199e-45	-121.924572797036	-8.34427173076068	2
Negative regulation of MAPK pathway	44	20	448.126644245207	448.177064413274	460.648002556913	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	168.621467851111	171.966600594474	281.313692656464	453	NA	NA	NA	4.65657336106492e-55	NA	NA	4.14900686470884e-52	non_linear_mixed	4.65657336106492e-55	4.14900686470884e-52	171.966600594474	281.313692656464	2
Protein folding	98	40	786.307696222355	786.332800824866	800.908496075741	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	326.303538295251	327.925855891818	457.710736975722	933	NA	NA	NA	3.62660332053374e-92	NA	NA	3.23130355859556e-89	non_linear_mixed	3.62660332053374e-92	3.23130355859556e-89	327.925855891818	457.710736975722	2
EPH-Ephrin signaling	74	29	445.354771140612	445.389453221537	458.990820121615	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	98.215931084274	100.479404138166	220.940371913303	669	0.992134117520412	NA	NA	7.46785568096326e-69	NA	NA	6.65385941173827e-66	non_linear_mixed	7.46785568096326e-69	6.65385941173827e-66	100.479404138166	220.940371913303	3
TP53 Regulates Metabolic Genes	76	24	418.121644840218	418.163602882176	431.189967822305	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	220.087776915077	222.846901002668	337.702683753866	549	0.993647328982549	NA	NA	1.00737336097913e-38	NA	NA	8.975696646324e-36	non_linear_mixed	1.00737336097913e-38	8.975696646324e-36	222.846901002668	337.702683753866	2
Recruitment of NuMA to mitotic centrosomes	81	40	1028.80916468483	1028.83426928734	1043.40996453821	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	625.657994950342	627.280312546909	757.065193630813	933	NA	NA	NA	2.18995191378381e-80	NA	NA	1.95124715518137e-77	non_linear_mixed	2.18995191378381e-80	1.95124715518137e-77	627.280312546909	757.065193630813	2
Signaling by FGFR	88	38	604.496078774597	604.522510492658	618.94299874482	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	157.294674826274	159.005082066093	287.316954558281	885	0.992808904938089	NA	NA	1.65252312034553e-89	NA	NA	1.47239810022787e-86	non_linear_mixed	1.65252312034553e-89	1.47239810022787e-86	159.005082066093	287.316954558281	2
Interleukin-17 signaling	65	29	522.138168848271	522.172850929196	535.774217829275	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	175.485040919009	177.748513972901	298.209481748039	669	0.99324733584254	NA	NA	9.39338759713787e-69	NA	NA	8.36950834904984e-66	non_linear_mixed	9.39338759713787e-69	8.36950834904984e-66	177.748513972901	298.209481748039	3
RAB GEFs exchange GTP for GDP on RABs	90	32	175.374366464815	175.405780077381	189.305735664258	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-120.97963649822	-118.936393254977	4.40268629676717	741	0.991444355521677	NA	NA	1.76823413009355e-58	NA	NA	1.57549660991335e-55	non_linear_mixed	1.76823413009355e-58	1.57549660991335e-55	-118.936393254977	4.40268629676717	2
Intrinsic Pathway for Apoptosis	52	21	369.612809081895	369.660809081895	382.280537886109	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	163.339361095582	166.515831683817	277.348920333509	477	NA	NA	NA	2.34423780102894e-40	NA	NA	2.08871588071679e-37	non_linear_mixed	2.34423780102894e-40	2.08871588071679e-37	166.515831683817	277.348920333509	2
AndrogenReceptor	142	73	1149.34548353562	1149.35921351274	1165.75102335011	1749	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	252.978483000818	253.855513163231	400.628341331219	1725	NA	NA	NA	5.72254523730029e-184	NA	NA	5.09878780643456e-181	non_linear_mixed	5.72254523730029e-184	5.09878780643456e-181	253.855513163231	400.628341331219	2
HCMV Early Events	109	35	783.494078434213	783.522786568185	797.694284109725	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	375.817646186075	377.679715151592	503.619497265684	813	NA	NA	NA	2.54241630739098e-81	NA	NA	2.26529292988536e-78	non_linear_mixed	2.54241630739098e-81	2.26529292988536e-78	377.679715151592	503.619497265684	3
Fc epsilon receptor (FCERI) signaling	150	25	219.914715647295	219.95498410367	233.105504612943	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-31.6712173159845	-29.0278606726279	87.0458833748515	573	NA	NA	NA	2.03175319488695e-49	NA	NA	1.81029209664428e-46	non_linear_mixed	2.03175319488695e-49	1.81029209664428e-46	-29.0278606726279	87.0458833748515	2
Signaling by Insulin receptor	78	31	389.584770380295	389.617202812727	403.420893484794	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	32.8972714580046	35.00900330158	157.422379398498	717	0.99195070792422	NA	NA	8.18850537923628e-71	NA	NA	7.29595829289952e-68	non_linear_mixed	8.18850537923628e-71	7.29595829289952e-68	35.00900330158	157.422379398498	2
Nuclear Pore Complex (NPC) Disassembly	36	24	738.930446494866	738.972404536824	751.998769476954	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	466.329304054655	469.088428142246	583.944210893444	549	NA	NA	NA	1.16449834502908e-53	NA	NA	1.03756802542091e-50	non_linear_mixed	1.16449834502908e-53	1.03756802542091e-50	469.088428142246	583.944210893444	2
Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding	33	22	493.0913061644	493.137107691118	505.898595015519	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	219.658656444041	222.682656444041	334.92425610411	501	NA	NA	NA	7.90445464242669e-54	NA	NA	7.04286908640218e-51	non_linear_mixed	7.90445464242669e-54	7.04286908640218e-51	222.682656444041	334.92425610411	2
Wnt Canonical	120	57	598.107178981545	598.124774289463	613.770494276093	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-168.366554666397	-167.238196457442	-27.3967170154699	1341	0.994471725857827	NA	NA	1.81259213492584e-156	NA	NA	1.61501959221892e-153	non_linear_mixed	1.81259213492584e-156	1.61501959221892e-153	-167.238196457442	-27.3967170154699	4
MyD88 dependent cascade initiated on endosome	78	35	581.527322182493	581.556030316465	595.727527858005	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	231.532218877639	233.394287843156	359.334069957248	813	NA	NA	NA	1.93728109508822e-69	NA	NA	1.7261174557236e-66	non_linear_mixed	1.93728109508822e-69	1.7261174557236e-66	233.394287843156	359.334069957248	4
Caspase Cascade in Apoptosis	57	26	489.93147317057	489.970182847989	503.239924275678	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	316.227949874185	318.764862625863	436.00400982016	597	NA	NA	NA	6.21759960549041e-34	NA	NA	5.53988124849196e-31	non_linear_mixed	6.21759960549041e-34	5.53988124849196e-31	318.764862625863	436.00400982016	3
Regulation of nuclear beta catenin signaling and target gene transcription	81	35	313.153575018198	313.182283152169	327.35378069371	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-29.9529057298002	-28.090836764283	97.8489453498084	813	0.992957604188824	NA	NA	5.01269106718977e-68	NA	NA	4.46630774086609e-65	non_linear_mixed	5.01269106718977e-68	4.46630774086609e-65	-28.090836764283	97.8489453498084	2
EML4 and NUDC in mitotic spindle formation	100	48	1675.58307873832	1675.60398466167	1690.73084326209	1149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1169.02133105414	1170.36652678368	1305.35121176805	1125	0.960027826064991	NA	NA	7.3607654823604e-102	NA	NA	6.55844204478311e-99	non_linear_mixed	7.3607654823604e-102	6.55844204478311e-99	1170.36652678368	1305.35121176805	2
Mitotic Prometaphase	192	93	2869.31369815298	2869.3244701458	2886.44565812348	2229	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1875.21232481476	1875.89835022311	2029.39996454929	2205	NA	NA	NA	1.01003009469875e-204	NA	NA	8.9993681437659e-202	non_linear_mixed	1.01003009469875e-204	8.9993681437659e-202	1875.89835022311	2029.39996454929	2
SHP2 signaling	59	26	351.350499199184	351.389208876603	364.658950304292	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	86.3945078963413	88.9314206480191	206.170567842316	597	NA	NA	NA	4.09009890625372e-52	NA	NA	3.64427812547206e-49	non_linear_mixed	4.09009890625372e-52	3.64427812547206e-49	88.9314206480191	206.170567842316	2
Rab regulation of trafficking	116	40	159.734394342348	159.759498944858	174.335194195733	957	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-210.538665967355	-208.916348370788	-79.131467286884	933	0.992250935690601	NA	NA	1.31849079206454e-73	NA	NA	1.1747752957295e-70	non_linear_mixed	1.31849079206454e-73	1.1747752957295e-70	-208.916348370788	-79.131467286884	2
mTOR signaling pathway	64	29	857.339869246981	857.374551327906	870.975918227984	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	497.982646899472	500.246119953364	620.707087728501	669	0.982737999660391	NA	NA	2.31596337698378e-71	NA	NA	2.06352336889255e-68	non_linear_mixed	2.31596337698378e-71	2.06352336889255e-68	500.246119953364	620.707087728501	2
Insulin Pathway	46	22	547.551133048895	547.596934575612	560.358421900014	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	284.652752123983	287.676752123983	399.918351784052	501	0.972171125882423	NA	NA	1.06473014779131e-51	NA	NA	9.48674561682053e-49	non_linear_mixed	1.06473014779131e-51	9.48674561682053e-49	287.676752123983	399.918351784052	2
Signaling events mediated by HDAC Class II	38	22	210.609618352559	210.655419879277	223.416907203678	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-24.934118627376	-21.910118627376	90.3314810326931	501	0.995454343405703	NA	NA	3.39153098328286e-46	NA	NA	3.02185410610503e-43	non_linear_mixed	3.39153098328286e-46	3.02185410610503e-43	-21.910118627376	90.3314810326931	4
Signaling mediated by p38-alpha and p38-beta	35	21	393.309660187108	393.357660187108	405.977388991322	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	185.245545268604	188.422015856839	299.255104506531	477	NA	NA	NA	1.03372674620592e-40	NA	NA	9.21050530869474e-38	non_linear_mixed	1.03372674620592e-40	9.21050530869474e-38	188.422015856839	299.255104506531	2
Glucocorticoid receptor regulatory network	80	25	408.649771289556	408.690039745932	421.840560255204	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	143.485901995619	146.129258638976	262.203002686455	573	NA	NA	NA	3.71316610190555e-52	NA	NA	3.30843099679785e-49	non_linear_mixed	3.71316610190555e-52	3.30843099679785e-49	146.129258638976	262.203002686455	2
Neurotrophic factor-mediated Trk receptor signaling	63	26	353.682164453276	353.720874130695	366.990615558384	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	96.6278644752192	99.164777226897	216.403924421194	597	NA	NA	NA	1.60781439265356e-50	NA	NA	1.43256262385433e-47	non_linear_mixed	1.60781439265356e-50	1.43256262385433e-47	99.164777226897	216.403924421194	3
Aurora B signaling	41	25	815.662830857522	815.703099313898	828.853619823171	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	603.088101812043	605.7314584554	721.805202502879	573	NA	NA	NA	1.31118607300569e-41	NA	NA	1.16826679104807e-38	non_linear_mixed	1.31118607300569e-41	1.16826679104807e-38	605.7314584554	721.805202502879	2
LPA receptor mediated events	63	25	173.533133995874	173.573402452249	186.723922961522	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-18.6073887755863	-15.9640321322297	100.10971191525	573	0.984832501325519	NA	NA	1.47271226117233e-37	NA	NA	1.31218662470455e-34	non_linear_mixed	1.47271226117233e-37	1.31218662470455e-34	-15.9640321322297	100.10971191525	2
ErbB1 downstream signaling	106	43	777.858649861648	777.88199616515	792.676411699773	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	218.229518746313	219.73549484193	351.589375289434	1005	NA	NA	NA	6.00495879862406e-113	NA	NA	5.35041828957403e-110	non_linear_mixed	6.00495879862406e-113	5.35041828957403e-110	219.73549484193	351.589375289434	2
Validated nuclear estrogen receptor alpha network	64	25	357.874778183943	357.915046640319	371.065567149591	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	92.5042224324659	95.1475790758225	211.221323123302	573	NA	NA	NA	3.37282310942629e-52	NA	NA	3.00518539049882e-49	non_linear_mixed	3.37282310942629e-52	3.00518539049882e-49	95.1475790758225	211.221323123302	2
Validated targets of C-MYC transcriptional repression	74	29	666.508298293631	666.542980374556	680.144347274634	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	321.866668029461	324.130141083353	444.59110885849	669	0.989917201125683	NA	NA	2.42846614104596e-68	NA	NA	2.16376333167195e-65	non_linear_mixed	2.42846614104596e-68	2.16376333167195e-65	324.130141083353	444.59110885849	2
CDC42 signaling events	71	29	600.047334370091	600.082016451016	613.683383351094	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	152.979426338634	155.242899392526	275.703867167663	669	NA	NA	NA	1.76138054176473e-89	NA	NA	1.56939006271238e-86	non_linear_mixed	1.76138054176473e-89	1.56939006271238e-86	155.242899392526	275.703867167663	2
Insulin receptor signalling cascade	54	21	338.23343697989	338.28143697989	350.901165784104	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	98.1221516444418	101.298622232677	212.131710882369	477	0.986562607208413	NA	NA	4.11469927449872e-47	NA	NA	3.66619705357836e-44	non_linear_mixed	4.11469927449872e-47	3.66619705357836e-44	101.298622232677	212.131710882369	3
Downstream signaling in naïve CD8+ T cells	68	22	157.330460537426	157.376262064144	170.137749388545	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-53.3026232354952	-50.2786232354952	61.9629764245739	501	NA	NA	NA	3.19045217748719e-41	NA	NA	2.84269289014108e-38	non_linear_mixed	3.19045217748719e-41	2.84269289014108e-38	-50.2786232354952	61.9629764245739	2
Fanconi anemia pathway	46	23	684.14007056152	684.183866181958	697.080714700352	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	446.875203507473	449.760699690679	563.341000756954	525	NA	NA	NA	1.53232488733247e-46	NA	NA	1.36530147461323e-43	non_linear_mixed	1.53232488733247e-46	1.36530147461323e-43	449.760699690679	563.341000756954	2
Coregulation of Androgen receptor activity	61	32	478.535475130346	478.566888742912	492.466844329789	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	134.211827156023	136.255070399266	259.59414995101	741	0.987848788756728	NA	NA	2.82183266352758e-68	NA	NA	2.51425290320307e-65	non_linear_mixed	2.82183266352758e-68	2.51425290320307e-65	136.255070399266	259.59414995101	2
Regulation of Telomerase	68	29	509.373032789714	509.407714870639	523.009081770718	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	183.009778249179	185.273251303071	305.734219078208	669	NA	NA	NA	1.34258686103696e-64	NA	NA	1.19624489318393e-61	non_linear_mixed	1.34258686103696e-64	1.19624489318393e-61	185.273251303071	305.734219078208	2
Signaling events mediated by focal adhesion kinase	62	22	202.06506999999	202.110871526708	214.872358851109	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-9.76151624620175	-6.73751624620175	105.504083413867	501	NA	NA	NA	1.84713638485034e-41	NA	NA	1.64579851890166e-38	non_linear_mixed	1.84713638485034e-41	1.64579851890166e-38	-6.73751624620175	105.504083413867	2
BCR signaling pathway	68	23	64.0929614178227	64.1367570382607	77.033605556654	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-98.9953514520256	-96.1098552688195	17.470445797456	525	NA	NA	NA	7.35619445991769e-32	NA	NA	6.55436926378666e-29	non_linear_mixed	7.35619445991769e-32	6.55436926378666e-29	-96.1098552688195	17.470445797456	2
Beta1 integrin cell surface interactions	66	27	440.499603059119	440.536870139864	453.921275148176	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	208.367077567761	210.80578724518	329.162126369272	621	NA	NA	NA	1.63586340125751e-45	NA	NA	1.45755429052044e-42	non_linear_mixed	1.63586340125751e-45	1.45755429052044e-42	210.80578724518	329.162126369272	2
Thromboxane A2 receptor signaling	56	20	55.1510028728785	55.2014230409457	67.6723611845843	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-86.2005398558513	-82.8554071124885	26.491684949501	453	NA	NA	NA	1.18380891406651e-27	NA	NA	1.05477374243326e-24	non_linear_mixed	1.18380891406651e-27	1.05477374243326e-24	-82.8554071124885	26.491684949501	2
AP-1 transcription factor network	70	29	719.59860894389	719.633291024815	733.234657924893	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	459.53969775779	461.803170811682	582.264138586819	669	NA	NA	NA	3.98374492028769e-51	NA	NA	3.54951672397633e-48	non_linear_mixed	3.98374492028769e-51	3.54951672397633e-48	461.803170811682	582.264138586819	2
PLK1 signaling events	44	28	904.761398032887	904.7973261766	918.292173054457	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	662.180118343289	664.527944430245	783.957093537414	645	0.973140855033424	NA	NA	1.3136097343305e-47	NA	NA	1.17042627328848e-44	non_linear_mixed	1.3136097343305e-47	1.17042627328848e-44	664.527944430245	783.957093537414	2
Transport of bile salts and organic acids, metal ions and amine compounds	84	27	246.882937937389	246.920205018135	260.304610026446	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	15.1564595566214	17.5951692340407	135.951508358133	621	0.986434227964035	NA	NA	1.97261508606962e-45	NA	NA	1.75760004168803e-42	non_linear_mixed	1.97261508606962e-45	1.75760004168803e-42	17.5951692340407	135.951508358133	2
p75(NTR)-mediated signaling	70	24	238.803690118517	238.845648160475	251.872013100605	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	36.2670383153355	39.0261624029268	153.881945154125	549	0.993025634911228	NA	NA	1.29214751699771e-39	NA	NA	1.15130343764496e-36	non_linear_mixed	1.29214751699771e-39	1.15130343764496e-36	39.0261624029268	153.881945154125	2
Integrin-linked kinase signaling	45	26	502.751391855495	502.790101532915	516.059842960604	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	241.21695621537	243.753868967048	360.993016161345	597	0.983132929713473	NA	NA	2.00703872935875e-51	NA	NA	1.78827150785864e-48	non_linear_mixed	2.00703872935875e-51	1.78827150785864e-48	243.753868967048	360.993016161345	2
HIF-1-alpha transcription factor network	66	24	598.734449387198	598.776407429156	611.802772369286	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	326.856712388536	329.615836476127	444.471619227325	549	NA	NA	NA	1.63118854460279e-53	NA	NA	1.45338899324108e-50	non_linear_mixed	1.63118854460279e-53	1.45338899324108e-50	329.615836476127	444.471619227325	3
Regulation of Androgen receptor activity	51	22	144.023505330817	144.069306857534	156.830794181935	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-85.6142939007098	-82.5902939007098	29.6513057593592	501	0.991191010062532	NA	NA	5.16491073603141e-45	NA	NA	4.60193546580399e-42	non_linear_mixed	5.16491073603141e-45	4.60193546580399e-42	-82.5902939007098	29.6513057593592	2
Plasma membrane estrogen receptor signaling	42	21	165.375696668295	165.423696668295	178.043425472509	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-45.2163385213208	-42.0398679330855	68.7932207166062	477	0.990823664746854	NA	NA	3.25097662778792e-41	NA	NA	2.89662017535904e-38	non_linear_mixed	3.25097662778792e-41	2.89662017535904e-38	-42.0398679330855	68.7932207166062	2
p73 transcription factor network	79	33	816.965610443436	816.996067296228	830.989294618879	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	502.945787982534	504.924845574157	629.158945561523	765	0.977302265714614	NA	NA	4.45686487557375e-62	NA	NA	3.97106660413621e-59	non_linear_mixed	4.45686487557375e-62	3.97106660413621e-59	504.924845574157	629.158945561523	2
ATF-2 transcription factor network	60	24	654.03447849634	654.076436538298	667.102801478428	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	433.043791921102	435.802916008693	550.658698759891	549	0.977157185483206	NA	NA	2.75922736286122e-43	NA	NA	2.45847158030935e-40	non_linear_mixed	2.75922736286122e-43	2.45847158030935e-40	435.802916008693	550.658698759891	2
FOXM1 transcription factor network	42	25	953.961306089266	954.001574545642	967.152095054915	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	714.434319122384	717.077675765741	833.15141981322	573	NA	NA	NA	5.39002109825212e-47	NA	NA	4.80250879854264e-44	non_linear_mixed	5.39002109825212e-47	4.80250879854264e-44	717.077675765741	833.15141981322	2
RNA Polymerase II Promoter Escape	46	23	316.96321974954	317.007015369978	329.903863888372	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	59.8636622645199	62.749158447726	176.329459514001	525	0.983725264393028	NA	NA	1.57438930121428e-50	NA	NA	1.40278086738193e-47	non_linear_mixed	1.57438930121428e-50	1.40278086738193e-47	62.749158447726	176.329459514001	2
Nuclear Envelope (NE) Reassembly	78	41	1319.94964288778	1319.9741326837	1334.62452057894	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	839.025931810938	840.607521769097	971.099831031348	957	0.974559360021387	NA	NA	1.61766979128713e-96	NA	NA	1.44134378403683e-93	non_linear_mixed	1.61766979128713e-96	1.44134378403683e-93	840.607521769097	971.099831031348	2
Mitotic Anaphase	195	95	3111.52830325836	3111.53884807382	3128.7240954242	2277	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	2025.15184549456	2025.82324869172	2179.91397498717	2253	NA	NA	NA	2.35296576423627e-224	NA	NA	2.09649249593451e-221	non_linear_mixed	2.35296576423627e-224	2.09649249593451e-221	2025.82324869172	2179.91397498717	2
Mitotic Metaphase and Anaphase	196	96	3141.38702199206	3141.39745677467	3158.61422805751	2301	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	2038.77965486633	2039.44397824067	2193.82450945536	2277	0.974983132345282	NA	NA	8.2199110095137e-228	NA	NA	7.32394070947671e-225	non_linear_mixed	8.2199110095137e-228	7.32394070947671e-225	2039.44397824067	2193.82450945536	2
Role of Calcineurin-dependent NFAT signaling in lymphocytes	56	24	313.652386233613	313.694344275571	326.7207092157	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	98.9419848388261	101.701108926417	216.556891677615	549	0.992345919709038	NA	NA	4.92701626008217e-42	NA	NA	4.38997148773322e-39	non_linear_mixed	4.92701626008217e-42	4.38997148773322e-39	101.701108926417	216.556891677615	2
a6b1 and a6b4 Integrin signaling	45	26	588.480865954161	588.51957563158	601.789317059269	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	301.464886858531	304.001799610209	421.240946804505	597	0.987459902138321	NA	NA	1.3955524766205e-56	NA	NA	1.24343725666886e-53	non_linear_mixed	1.3955524766205e-56	1.24343725666886e-53	304.001799610209	421.240946804505	3
PDGFR-beta signaling pathway	127	47	688.758033301329	688.779385614497	703.842637597503	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	79.1036462974386	80.478191751984	214.865084963005	1101	0.99137050281393	NA	NA	1.96057434783721e-123	NA	NA	1.74687174392296e-120	non_linear_mixed	1.96057434783721e-123	1.74687174392296e-120	80.478191751984	214.865084963005	2
Signaling events mediated by PTP1B	52	20	261.837322714509	261.887742882577	274.358681026215	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	85.1946705386532	88.5398032820161	197.886895344005	453	NA	NA	NA	1.65083131808651e-34	NA	NA	1.47089070441508e-31	non_linear_mixed	1.65083131808651e-34	1.47089070441508e-31	88.5398032820161	197.886895344005	2
Regulation of retinoblastoma protein	64	28	624.437557278614	624.473485422327	637.968332300184	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	336.253148152941	338.600974239897	458.030123347066	645	NA	NA	NA	8.08262952943472e-57	NA	NA	7.20162291072633e-54	non_linear_mixed	8.08262952943472e-57	7.20162291072633e-54	338.600974239897	458.030123347066	2
Apoptotic execution phase	52	27	551.576729794214	551.613996874959	564.99840188327	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	358.055474404	360.494184081419	478.850523205511	621	NA	NA	NA	7.86030042429431e-38	NA	NA	7.00352767804623e-35	non_linear_mixed	7.86030042429431e-38	7.00352767804623e-35	360.494184081419	478.850523205511	2
FOXA2 and FOXA3 transcription factor networks	45	21	249.43992755512	249.48792755512	262.107656359334	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-2.86297077913568	0.313499809099618	111.146588458791	477	0.99176628091153	NA	NA	1.45721001704838e-49	NA	NA	1.29837412519011e-46	non_linear_mixed	1.45721001704838e-49	1.29837412519011e-46	0.313499809099618	111.146588458791	2
Arf6 trafficking events	47	22	280.226754020298	280.272555547015	293.034042871417	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	85.7232739137725	88.7472739137725	200.988873573842	501	NA	NA	NA	5.02768107869187e-38	NA	NA	4.47966384111446e-35	non_linear_mixed	5.02768107869187e-38	4.47966384111446e-35	88.7472739137725	200.988873573842	2
FGF signaling pathway	56	25	314.421956473709	314.462224930085	327.612745439358	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	89.0712366554753	91.714593298832	207.788337346311	573	NA	NA	NA	3.71727739215269e-44	NA	NA	3.31209415640805e-41	non_linear_mixed	3.71727739215269e-44	3.31209415640805e-41	91.714593298832	207.788337346311	3
Signaling events mediated by VEGFR1 and VEGFR2	68	34	608.554867622417	608.584424272663	622.668110687309	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	246.532908788764	248.451690514652	373.552096372794	789	NA	NA	NA	6.56267334969001e-72	NA	NA	5.8473419545738e-69	non_linear_mixed	6.56267334969001e-72	5.8473419545738e-69	248.451690514652	373.552096372794	2
TCR signaling in naïve CD4+ T cells	67	20	174.823999069883	174.87441923795	187.345357381589	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-36.0842726009805	-32.7391398576176	76.6079522043718	453	0.988863883777858	NA	NA	2.81276938107922e-41	NA	NA	2.50617751854159e-38	non_linear_mixed	2.81276938107922e-41	2.50617751854159e-38	-32.7391398576176	76.6079522043718	2
Regulation of PLK1 Activity at G2/M Transition	88	47	1196.98721360782	1197.00856592099	1212.071817904	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	706.884342345374	708.25888779992	842.64578101094	1101	0.987140192987349	NA	NA	1.98397759081238e-98	NA	NA	1.76772403341383e-95	non_linear_mixed	1.98397759081238e-98	1.76772403341383e-95	708.25888779992	842.64578101094	2
Regulation of mitotic cell cycle	44	28	1009.20948095161	1009.24540909532	1022.74025597318	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	728.472155392641	730.819981479597	850.249130586766	645	0.971961498511256	NA	NA	2.62018767111627e-55	NA	NA	2.33458721496459e-52	non_linear_mixed	2.62018767111627e-55	2.33458721496459e-52	730.819981479597	850.249130586766	2
TGF-beta receptor signaling	50	20	238.444043379928	238.494463547995	250.965401691634	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	29.7298154030227	33.0749481463856	142.422040208375	453	0.992199529494987	NA	NA	7.67798783725643e-41	NA	NA	6.84108716299548e-38	non_linear_mixed	7.67798783725643e-41	6.84108716299548e-38	33.0749481463856	142.422040208375	2
Direct p53 effectors	142	53	1282.93301961853	1282.95194706332	1298.37805685023	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	743.035381810038	744.250815893639	882.04071689534	1245	NA	NA	NA	8.05355789955271e-109	NA	NA	7.17572008850146e-106	non_linear_mixed	8.05355789955271e-109	7.17572008850146e-106	744.250815893639	882.04071689534	2
Integrins in angiogenesis	63	28	326.418090178543	326.454018322256	339.948865200113	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	22.0352157873544	24.3830418743109	143.812190981479	645	0.990263079405182	NA	NA	4.10707449053996e-60	NA	NA	3.6594033710711e-57	non_linear_mixed	4.10707449053996e-60	3.6594033710711e-57	24.3830418743109	143.812190981479	2
Syndecan-2-mediated signaling events	41	23	330.73939883897	330.783194459408	343.680042977801	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	103.326194824795	106.211691008001	219.791992074276	525	NA	NA	NA	1.43877311757253e-44	NA	NA	1.28194684775713e-41	non_linear_mixed	1.43877311757253e-44	1.28194684775713e-41	106.211691008001	219.791992074276	2
CD4 T cell receptor signaling-JNK cascade	57	20	-43.8429409181631	-43.7925207500958	-31.3215826064573	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-169.517939340713	-166.172806597351	-56.8257145353612	453	0.972437795232278	NA	NA	1.17380319712455e-24	NA	NA	1.04585864863797e-21	non_linear_mixed	1.17380319712455e-24	1.04585864863797e-21	-166.172806597351	-56.8257145353612	2
Leptin	62	25	422.346975221769	422.387243678144	435.537764187417	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	157.174458125228	159.817814768585	275.891558816064	573	NA	NA	NA	3.69826098449715e-52	NA	NA	3.29515053718696e-49	non_linear_mixed	3.69826098449715e-52	3.29515053718696e-49	159.817814768585	275.891558816064	2
Notch	58	24	417.466847856487	417.508805898445	430.535170838575	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	109.823123686476	112.582247774068	227.438030525266	549	NA	NA	NA	8.89590671232676e-61	NA	NA	7.92625288068314e-58	non_linear_mixed	8.89590671232676e-61	7.92625288068314e-58	112.582247774068	227.438030525266	2
Selective autophagy	59	25	403.685426929917	403.725695386293	416.876215895565	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	109.384118763303	112.02747540666	228.101219454139	573	NA	NA	NA	4.62263811148559e-58	NA	NA	4.11877055733366e-55	non_linear_mixed	4.62263811148559e-58	4.11877055733366e-55	112.02747540666	228.101219454139	2
CD4 T cell receptor signaling-NFkB cascade	99	48	517.809023264354	517.829929187698	532.956787788121	1149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-187.521326737772	-186.176131008235	-51.1914460238648	1125	0.994411633319874	NA	NA	1.45741673522225e-143	NA	NA	1.29855831108302e-140	non_linear_mixed	1.45741673522225e-143	1.29855831108302e-140	-186.176131008235	-51.1914460238648	2
Binding and Uptake of Ligands by Scavenger Receptors	42	20	-227.514123038301	-227.463702870234	-214.992764726595	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-310.904439557436	-307.559306814073	-198.212214752084	453	NA	NA	NA	8.68404956880887e-17	NA	NA	7.7374881658087e-14	non_linear_mixed	8.68404956880887e-17	7.7374881658087e-14	-307.559306814073	-198.212214752084	3
insulin	78	41	818.618942074445	818.643431870364	833.293819765602	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	370.997304679466	372.578894637625	503.071203899876	957	0.989188678120545	NA	NA	1.35185571125479e-89	NA	NA	1.20450343872802e-86	non_linear_mixed	1.35185571125479e-89	1.20450343872802e-86	372.578894637625	503.071203899876	2
Influenza Infection	44	26	718.695411912932	718.734121590352	732.003863018041	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	402.683587084852	405.22049983653	522.459647030827	597	0.97032430398856	NA	NA	1.74797145499865e-62	NA	NA	1.5574425664038e-59	non_linear_mixed	1.74797145499865e-62	1.5574425664038e-59	405.22049983653	522.459647030827	3
Activation of ATR in response to replication stress	37	22	998.390968425426	998.436769952143	1011.19825727654	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	749.842477628549	752.866477628549	865.108077288618	501	NA	NA	NA	8.30056691948113e-49	NA	NA	7.39580512525769e-46	non_linear_mixed	8.30056691948113e-49	7.39580512525769e-46	752.866477628549	865.108077288618	2
Mitotic Spindle Checkpoint	114	55	1898.17098632227	1898.18922340434	1913.72714736902	1317	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1290.32091053987	1291.49118917764	1430.32635996055	1293	NA	NA	NA	4.68922393862963e-123	NA	NA	4.178098529319e-120	non_linear_mixed	4.68922393862963e-123	4.178098529319e-120	1291.49118917764	1430.32635996055	2
purine nucleotides <i>de novo</i> biosynthesis	59	21	377.011515744828	377.059515744828	389.679244549042	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	156.068445948867	159.244916537102	270.078005186794	477	NA	NA	NA	2.82025468483302e-43	NA	NA	2.51284692418622e-40	non_linear_mixed	2.82025468483302e-43	2.51284692418622e-40	159.244916537102	270.078005186794	2
E2F transcription factor network	75	28	883.870006222347	883.90593436606	897.400781243917	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	620.456146357832	622.803972444788	742.233121551957	645	0.965203084399502	NA	NA	8.37847592665546e-52	NA	NA	7.46522205065002e-49	non_linear_mixed	8.37847592665546e-52	7.46522205065002e-49	622.803972444788	742.233121551957	3
Autophagy	113	43	621.310409327214	621.333755630716	636.128171165338	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	161.203186356535	162.709162452152	294.563042899656	1005	0.993920433720604	NA	NA	3.45211241814867e-92	NA	NA	3.07583216457047e-89	non_linear_mixed	3.45211241814867e-92	3.07583216457047e-89	162.709162452152	294.563042899656	2
CD4 T cell receptor signaling	132	60	708.284782662201	708.301495754123	724.101977839911	1437	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-147.163523465945	-146.0927019362	-4.80876686655384	1413	NA	NA	NA	2.70287324363104e-175	NA	NA	2.40826006007525e-172	non_linear_mixed	2.70287324363104e-175	2.40826006007525e-172	-146.0927019362	-4.80876686655384	2
DNA Replication	81	46	1922.30452046347	1922.32633864529	1937.32460614398	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1385.94797914228	1387.35318360325	1521.12875026688	1077	0.948444828458936	NA	NA	4.4275842997359e-108	NA	NA	3.94497761106469e-105	non_linear_mixed	4.4275842997359e-108	3.94497761106469e-105	1387.35318360325	1521.12875026688	2
Cellular response to starvation	145	60	291.640863842243	291.657576934165	307.458059019953	1437	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-297.856024776376	-296.785203246631	-155.501268176985	1413	NA	NA	NA	3.32112116696183e-119	NA	NA	2.95911895976299e-116	non_linear_mixed	3.32112116696183e-119	2.95911895976299e-116	-296.785203246631	-155.501268176985	2
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	47	24	331.149676505684	331.191634547642	344.217999487771	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	62.0918712112949	64.8509952988861	179.706778050084	549	NA	NA	NA	6.06491411629029e-53	NA	NA	5.40383847761465e-50	non_linear_mixed	6.06491411629029e-53	5.40383847761465e-50	64.8509952988861	179.706778050084	2
Programmed Cell Death	142	59	1075.8820238775	1075.89902104464	1091.64879770026	1413	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	523.10387668937	524.193213865163	665.004841094219	1389	0.984910361726707	NA	NA	1.6300390503587e-111	NA	NA	1.4523647938696e-108	non_linear_mixed	1.6300390503587e-111	1.4523647938696e-108	524.193213865163	665.004841094219	2
Metabolism of steroids	124	33	733.913223558472	733.943680411263	747.936907733915	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	346.600165702235	348.579223293858	472.813323281225	765	NA	NA	NA	4.07113356878093e-77	NA	NA	3.62738000978381e-74	non_linear_mixed	4.07113356878093e-77	3.62738000978381e-74	348.579223293858	472.813323281225	2
insulin Mam	82	41	818.618942074445	818.643431870363	833.293819765602	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	370.997479302263	372.579069260422	503.071378522674	957	NA	NA	NA	1.35196853100068e-89	NA	NA	1.2046039611216e-86	non_linear_mixed	1.35196853100068e-89	1.2046039611216e-86	372.579069260422	503.071378522674	2
PLC beta mediated events	50	22	267.49365474882	267.539456275537	280.300943599938	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	86.7921002366021	89.8161002366021	202.057699896671	501	0.987783871888811	NA	NA	2.63663891118153e-35	NA	NA	2.34924526986274e-32	non_linear_mixed	2.63663891118153e-35	2.34924526986274e-32	89.8161002366021	202.057699896671	3
G-protein mediated events	55	24	271.788272118175	271.830230160133	284.856595100262	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	79.331312571488	82.0904366590792	196.946219410277	549	0.987835264167742	NA	NA	1.27537798790234e-37	NA	NA	1.13636178722099e-34	non_linear_mixed	1.27537798790234e-37	1.13636178722099e-34	82.0904366590792	196.946219410277	2
Inositol phosphate metabolism	51	23	163.715686767143	163.759482387581	176.656330905974	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-1.55646575393379	1.32903042927231	114.909331495548	525	0.981464492048339	NA	NA	2.76123041948494e-32	NA	NA	2.46025630376108e-29	non_linear_mixed	2.76123041948494e-32	2.46025630376108e-29	1.32903042927231	114.909331495548	2
FCGR3A-mediated phagocytosis	137	25	132.539403374329	132.579671830705	145.730192339978	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-126.753041780247	-124.10968513689	-8.03594108941112	573	0.995162966911945	NA	NA	5.68733452701939e-51	NA	NA	5.06741506357427e-48	non_linear_mixed	5.68733452701939e-51	5.06741506357427e-48	-124.10968513689	-8.03594108941112	2
Leishmania phagocytosis	137	25	132.539403374329	132.579671830705	145.730192339978	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-126.753041780247	-124.10968513689	-8.03594108941112	573	0.995162966911945	NA	NA	5.68733452701939e-51	NA	NA	5.06741506357427e-48	non_linear_mixed	5.68733452701939e-51	5.06741506357427e-48	-124.10968513689	-8.03594108941112	2
Parasite infection	137	25	132.539403374329	132.579671830705	145.730192339978	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-126.753041780247	-124.10968513689	-8.03594108941112	573	0.995162966911945	NA	NA	5.68733452701939e-51	NA	NA	5.06741506357427e-48	non_linear_mixed	5.68733452701939e-51	5.06741506357427e-48	-124.10968513689	-8.03594108941112	2
Transport of inorganic cations/anions and amino acids/oligopeptides	102	26	213.060484347921	213.09919402534	226.368935453029	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	21.6401128270269	24.1770255787047	141.416172773001	597	NA	NA	NA	2.04304568055963e-37	NA	NA	1.82035370137863e-34	non_linear_mixed	2.04304568055963e-37	1.82035370137863e-34	24.1770255787047	141.416172773001	4
L13a-mediated translational silencing of Ceruloplasmin expression	123	60	395.028069695559	395.044782787481	410.845264873269	1437	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-337.208036769162	-336.137215239417	-194.853280169771	1413	0.99628034832745	NA	NA	3.07802065214801e-149	NA	NA	2.74251640106387e-146	non_linear_mixed	3.07802065214801e-149	2.74251640106387e-146	-336.137215239417	-194.853280169771	2
ADORA2B mediated anti-inflammatory cytokines production	132	27	-206.244942917785	-206.207675837039	-192.823270828728	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-406.146331460051	-403.707621782631	-285.351282658539	621	NA	NA	NA	4.3000465057216e-39	NA	NA	3.83134143659794e-36	non_linear_mixed	4.3000465057216e-39	3.83134143659794e-36	-403.707621782631	-285.351282658539	2
Estrogen-dependent gene expression	142	43	438.165648179187	438.188994482689	452.983410017312	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	3.18751865995773	4.69349475557526	136.547375203078	1005	NA	NA	NA	5.66899687111803e-87	NA	NA	5.05107621216617e-84	non_linear_mixed	5.66899687111803e-87	5.05107621216617e-84	4.69349475557526	136.547375203078	2
TP53 Regulates Transcription of DNA Repair Genes	66	28	290.699426092915	290.735354236628	304.230201114485	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1.40797329004232	3.75579937699884	123.184948484167	645	0.987304525162731	NA	NA	4.816905892103e-57	NA	NA	4.29186314986378e-54	non_linear_mixed	4.816905892103e-57	4.29186314986378e-54	3.75579937699884	123.184948484167	2
APC/C-mediated degradation of cell cycle proteins	44	28	1009.20948095161	1009.24540909532	1022.74025597318	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	728.472155392641	730.819981479597	850.249130586766	645	0.971961498511256	NA	NA	2.62018767111627e-55	NA	NA	2.33458721496459e-52	non_linear_mixed	2.62018767111627e-55	2.33458721496459e-52	730.819981479597	850.249130586766	2
FoxO family signaling	50	23	595.88892201838	595.932717638818	608.829566157211	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	329.551302207259	332.436798390465	446.01709945674	525	0.98797484007556	NA	NA	2.15089273069019e-52	NA	NA	1.91644542304496e-49	non_linear_mixed	2.15089273069019e-52	1.91644542304496e-49	332.436798390465	446.01709945674	2
Opioid Signalling	91	39	491.628779812531	491.654530885492	506.153626241964	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	113.521896925867	115.187095163753	244.245514790762	909	0.989561132296954	NA	NA	3.21507350993962e-75	NA	NA	2.8646304973562e-72	non_linear_mixed	3.21507350993962e-75	2.8646304973562e-72	115.187095163753	244.245514790762	2
Endothelins	64	21	186.406778508822	186.454778508822	199.074507313036	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	48.2225303438103	51.3990009320456	162.232089581737	477	0.982656348358905	NA	NA	4.80189537145524e-27	NA	NA	4.27848877596662e-24	non_linear_mixed	4.80189537145524e-27	4.27848877596662e-24	51.3990009320456	162.232089581737	2
Senescence-Associated Secretory Phenotype (SASP)	112	36	686.763260495085	686.791167471829	701.047978801497	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	350.963028895625	352.771641335817	479.525493653335	837	NA	NA	NA	1.57399241030764e-66	NA	NA	1.40242723758411e-63	non_linear_mixed	1.57399241030764e-66	1.40242723758411e-63	352.771641335817	479.525493653335	2
Assembly of collagen fibrils and other multimeric structures	47	20	269.281773741348	269.332193909415	281.803132053054	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	91.2207255761122	94.5658583194751	203.912950381465	453	0.989157479578288	NA	NA	8.69923639829131e-35	NA	NA	7.75101963087755e-32	non_linear_mixed	8.69923639829131e-35	7.75101963087755e-32	94.5658583194751	203.912950381465	3
Collagen formation	91	28	222.241803488786	222.277731632498	235.772578510355	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-25.573543127078	-23.2257170401215	96.2034320670471	645	NA	NA	NA	1.16564883586109e-48	NA	NA	1.03859311275223e-45	non_linear_mixed	1.16564883586109e-48	1.03859311275223e-45	-23.2257170401215	96.2034320670471	2
HCMV Infection	113	37	906.757960431161	906.785109752428	921.124875660137	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	437.590458760316	439.3485982952	566.892695821105	861	NA	NA	NA	4.5160998549951e-94	NA	NA	4.02384497080064e-91	non_linear_mixed	4.5160998549951e-94	4.02384497080064e-91	439.3485982952	566.892695821105	2
Cardiac conduction	105	29	156.628230965715	156.66291304664	170.264279946718	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-105.683812563888	-103.420339509996	17.0406282651414	669	0.994248144379255	NA	NA	1.39831354032177e-51	NA	NA	1.2458973644267e-48	non_linear_mixed	1.39831354032177e-51	1.2458973644267e-48	-103.420339509996	17.0406282651414	2
Muscle contraction	174	52	289.4449118428	289.464204447302	304.832804489588	1245	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-171.920376579055	-170.681032316759	-33.4293427579614	1221	0.993852155788657	NA	NA	1.89088495723613e-92	NA	NA	1.68477849689739e-89	non_linear_mixed	1.89088495723613e-92	1.68477849689739e-89	-170.681032316759	-33.4293427579614	2
DNA Replication Pre-Initiation	37	23	1017.02518207166	1017.0689776921	1029.96582621049	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	784.364638164619	787.250134347825	900.8304354141	525	NA	NA	NA	1.28238045036372e-45	NA	NA	1.14260098127407e-42	non_linear_mixed	1.28238045036372e-45	1.14260098127407e-42	787.250134347825	900.8304354141	2
Plasma lipoprotein assembly, remodeling, and clearance	60	20	147.489314265002	147.53973443307	160.010672576708	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-0.517595198538402	2.82753754482444	112.174629606814	453	0.991063859594989	NA	NA	6.18343548832317e-29	NA	NA	5.50944102009595e-26	non_linear_mixed	6.18343548832317e-29	5.50944102009595e-26	2.82753754482444	112.174629606814	3
Resolution of Abasic Sites (AP sites)	37	22	755.906540620062	755.95234214678	768.713829471181	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	522.418329315955	525.442329315955	637.683928976024	501	0.931877061086682	NA	NA	8.75491048213655e-46	NA	NA	7.80062523958367e-43	non_linear_mixed	8.75491048213655e-46	7.80062523958367e-43	525.442329315955	637.683928976024	2
Base Excision Repair	93	34	954.421065806735	954.450622456981	968.534308871628	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	594.312763170517	596.231544896405	721.331950754548	789	0.964008852751726	NA	NA	1.62327329601135e-71	NA	NA	1.44633650674611e-68	non_linear_mixed	1.62327329601135e-71	1.44633650674611e-68	596.231544896405	721.331950754548	2
Metabolism of water-soluble vitamins and cofactors	111	34	1053.83773292437	1053.86728957461	1067.95097598926	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	630.603896250076	632.522677975964	757.623083834107	789	0.968279731777223	NA	NA	1.53694452823013e-84	NA	NA	1.36941757465304e-81	non_linear_mixed	1.53694452823013e-84	1.36941757465304e-81	632.522677975964	757.623083834107	2
Non-integrin membrane-ECM interactions	42	25	237.851933120158	237.892201576534	251.042722085807	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	42.0649587776686	44.7083154210252	160.782059468505	573	0.991775302883282	NA	NA	2.80320308159024e-38	NA	NA	2.4976539456969e-35	non_linear_mixed	2.80320308159024e-38	2.4976539456969e-35	44.7083154210252	160.782059468505	2
Validated transcriptional targets of TAp63 isoforms	55	22	446.910861102179	446.956662628897	459.718149953298	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	250.528417345178	253.552417345178	365.794017005247	501	NA	NA	NA	2.1374779635977e-38	NA	NA	1.90449286556555e-35	non_linear_mixed	2.1374779635977e-38	1.90449286556555e-35	253.552417345178	365.794017005247	2
Regulation of insulin secretion	67	25	323.064550976725	323.1048194331	336.255339942373	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	8.39082804789086	11.0341846912475	127.107928738727	573	0.990504695573893	NA	NA	3.27799192258619e-62	NA	NA	2.9206908030243e-59	non_linear_mixed	3.27799192258619e-62	2.9206908030243e-59	11.0341846912475	127.107928738727	3
mechanism of gene regulation by peroxisome proliferators via ppara	52	24	372.436775066369	372.478733108327	385.505098048456	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	104.106623266652	106.865747354244	221.721530105442	549	NA	NA	NA	8.51000045029056e-53	NA	NA	7.58241040120888e-50	non_linear_mixed	8.51000045029056e-53	7.58241040120888e-50	106.865747354244	221.721530105442	2
RHOA GTPase cycle	149	62	1195.60018886092	1195.61636136766	1211.5157535071	1485	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	363.365351424442	364.400967862798	506.605433240054	1461	NA	NA	NA	2.23099535445409e-170	NA	NA	1.98781686081859e-167	non_linear_mixed	2.23099535445409e-170	1.98781686081859e-167	364.400967862798	506.605433240054	2
Degradation of beta-catenin by the destruction complex	38	20	110.503745037785	110.554165205852	123.025103349491	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-13.1002890638761	-9.75515632051328	99.5919357414762	453	0.995731949618599	NA	NA	2.90222021850052e-24	NA	NA	2.58587821468396e-21	non_linear_mixed	2.90222021850052e-24	2.58587821468396e-21	-9.75515632051328	99.5919357414762	4
Peptide chain elongation	100	45	-237.73421264118	-237.711907808466	-222.780063680825	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-640.429415936769	-638.992153579354	-505.842075293575	1053	0.997881721515033	NA	NA	2.72043322572568e-80	NA	NA	2.42390600412158e-77	non_linear_mixed	2.72043322572568e-80	2.42390600412158e-77	-638.992153579354	-505.842075293575	3
Eukaryotic Translation Elongation	105	46	-210.428289228504	-210.406471046686	-195.408203547993	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-611.247622654798	-609.842418193831	-476.066851530198	1077	0.997881429264579	NA	NA	6.63964899640479e-80	NA	NA	5.91592725579667e-77	non_linear_mixed	6.63964899640479e-80	5.91592725579667e-77	-609.842418193831	-476.066851530198	3
Regulation of TP53 Activity through Phosphorylation	93	48	1347.12825200564	1347.14915792898	1362.27601652941	1149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	833.163173190158	834.508368919695	969.493053904065	1125	0.975846567248605	NA	NA	2.10101518101373e-103	NA	NA	1.87200452628323e-100	non_linear_mixed	2.10101518101373e-103	1.87200452628323e-100	834.508368919695	969.493053904065	2
RHOB GTPase cycle	70	34	519.287009448702	519.316566098948	533.400252513594	813	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	130.578912825175	132.497694551064	257.598100409206	789	NA	NA	NA	2.09893250840832e-77	NA	NA	1.87014886499182e-74	non_linear_mixed	2.09893250840832e-77	1.87014886499182e-74	132.497694551064	257.598100409206	2
il-2 receptor beta chain in t cell activation	48	20	232.823218873636	232.873639041703	245.344577185342	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	80.6328194489266	83.9779521922894	193.325044254279	453	NA	NA	NA	9.60658985379648e-30	NA	NA	8.55947155973266e-27	non_linear_mixed	9.60658985379648e-30	8.55947155973266e-27	83.9779521922894	193.325044254279	2
PI Metabolism	84	26	158.190873561109	158.229583238528	171.499324666217	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-31.296540893721	-28.7596281420431	88.4795190522536	597	NA	NA	NA	4.91631411114124e-37	NA	NA	4.38043587302684e-34	non_linear_mixed	4.91631411114124e-37	4.38043587302684e-34	-28.7596281420431	88.4795190522536	3
RHOC GTPase cycle	74	38	801.591769888913	801.618201606975	816.038689859136	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	285.081096084782	286.791503324601	415.103375816789	885	NA	NA	NA	6.18261502538283e-104	NA	NA	5.50870998761611e-101	non_linear_mixed	6.18261502538283e-104	5.50870998761611e-101	286.791503324601	415.103375816789	2
hiv-1 nef: negative effector of fas and tnf	53	25	308.9694678157	309.009736272076	322.160256781348	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	133.532296101616	136.175652744973	252.249396792452	573	0.977252251092273	NA	NA	2.84455144577958e-34	NA	NA	2.53449533818961e-31	non_linear_mixed	2.84455144577958e-34	2.53449533818961e-31	136.175652744973	252.249396792452	2
Ca2+ pathway	55	26	88.7567575124411	88.7954671898604	102.065208617549	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-114.373465174339	-111.836552422661	5.40259477163556	597	NA	NA	NA	9.85434334199841e-40	NA	NA	8.78021991772059e-37	non_linear_mixed	9.85434334199841e-40	8.78021991772059e-37	-111.836552422661	5.40259477163556	2
Beta-catenin independent WNT signaling	94	38	54.1683022676705	54.1947339857322	68.6152222378935	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-265.953618103738	-264.243210863919	-135.931338371731	885	NA	NA	NA	2.53144488084382e-63	NA	NA	2.25551738883184e-60	non_linear_mixed	2.53144488084382e-63	2.25551738883184e-60	-264.243210863919	-135.931338371731	2
agrin in postsynaptic differentiation	47	23	372.419242059616	372.463037680054	385.359886198447	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	120.259700262068	123.145196445274	236.725497511549	525	0.989407278351442	NA	NA	1.55735170530202e-49	NA	NA	1.3876003694241e-46	non_linear_mixed	1.55735170530202e-49	1.3876003694241e-46	123.145196445274	236.725497511549	2
Metabolism of vitamins and cofactors	180	55	1621.7343257801	1621.75256286217	1637.29048682684	1317	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	918.050047631797	919.220326269568	1058.05549705247	1293	0.974218640180949	NA	NA	3.24042660520503e-143	NA	NA	2.88722010523768e-140	non_linear_mixed	3.24042660520503e-143	2.88722010523768e-140	919.220326269568	1058.05549705247	3
t cell receptor signaling pathway	56	20	-3.01831767483034	-2.96789750676312	9.50304063687547	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-152.54619702963	-149.201064286268	-39.8539722242781	453	NA	NA	NA	3.14391293643538e-29	NA	NA	2.80122642636392e-26	non_linear_mixed	3.14391293643538e-29	2.80122642636392e-26	-149.201064286268	-39.8539722242781	2
CXCR4-mediated signaling events	86	31	61.4687516682016	61.501184100634	75.3048747727009	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-205.664555768341	-203.552823924765	-81.1394478278474	717	0.991673903069755	NA	NA	1.48536596873169e-52	NA	NA	1.32346107813994e-49	non_linear_mixed	1.48536596873169e-52	1.32346107813994e-49	-203.552823924765	-81.1394478278474	2
Toll-like Receptor Cascades	130	52	722.162225141817	722.181517746318	737.550117788605	1245	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	181.480719726015	182.72006398831	319.971753547108	1221	NA	NA	NA	5.52225200990486e-109	NA	NA	4.92032654082523e-106	non_linear_mixed	5.52225200990486e-109	4.92032654082523e-106	182.72006398831	319.971753547108	4
Glycerophospholipid biosynthesis	130	32	265.403012644142	265.434426256707	279.334381843585	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-58.703601931351	-56.6603586881077	66.6787208636362	741	NA	NA	NA	3.88368492338883e-64	NA	NA	3.46036326673945e-61	non_linear_mixed	3.88368492338883e-64	3.46036326673945e-61	-56.6603586881077	66.6787208636362	2
mapkinase signaling pathway	57	20	165.211158966507	165.261579134575	177.732517278213	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-5.488653202205	-2.14352045884216	107.203571603147	453	0.983127475731	NA	NA	2.40628828877179e-33	NA	NA	2.14400286529567e-30	non_linear_mixed	2.40628828877179e-33	2.14400286529567e-30	-2.14352045884216	107.203571603147	2
RAC1 GTPase cycle	185	65	1243.21288656744	1243.22831073197	1259.27020986818	1557	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	368.497408804571	369.484353974284	513.013318511148	1533	NA	NA	NA	2.23149924753489e-179	NA	NA	1.98826582955359e-176	non_linear_mixed	2.23149924753489e-179	1.98826582955359e-176	369.484353974284	513.013318511148	2
Arginine Proline metabolism	55	23	486.256002954073	486.299798574511	499.196647092904	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	179.702603133845	182.588099317051	296.168400383326	525	NA	NA	NA	1.48378051852665e-60	NA	NA	1.32204844200724e-57	non_linear_mixed	1.48378051852665e-60	1.32204844200724e-57	182.588099317051	296.168400383326	2
Wnt Mammals	120	57	598.107178981545	598.124774289463	613.770494276093	1365	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-168.366554666397	-167.238196457442	-27.3967170154699	1341	0.994471725857827	NA	NA	1.81259213492584e-156	NA	NA	1.61501959221892e-153	non_linear_mixed	1.81259213492584e-156	1.61501959221892e-153	-167.238196457442	-27.3967170154699	4
TCR signaling	73	23	23.1275911941705	23.1713868146084	36.0682353330018	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-207.197055175737	-204.311558992531	-90.7312579262558	525	NA	NA	NA	3.7638209882702e-45	NA	NA	3.35356450054875e-42	non_linear_mixed	3.7638209882702e-45	3.35356450054875e-42	-204.311558992531	-90.7312579262558	2
Nuclear import of Rev protein	36	24	680.441972082746	680.483930124704	693.510295064833	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	383.852643255025	386.611767342616	501.467550093814	549	0.972186249092836	NA	NA	1.5837367714049e-58	NA	NA	1.41110946332176e-55	non_linear_mixed	1.5837367714049e-58	1.41110946332176e-55	386.611767342616	501.467550093814	3
RAC2 GTPase cycle	85	42	760.46068695984	760.484591342311	775.207857305734	1005	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	233.06944019189	234.612297334747	365.793973304936	981	NA	NA	NA	3.30641544215452e-106	NA	NA	2.94601615895968e-103	non_linear_mixed	3.30641544215452e-106	2.94601615895968e-103	234.612297334747	365.793973304936	2
Regulation of TP53 Activity	163	72	1829.17653544975	1829.19045656344	1845.54069529784	1725	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1040.73501518786	1041.62442695256	1188.01245382068	1701	0.978405957393088	NA	NA	4.11987852256385e-161	NA	NA	3.67081176360439e-158	non_linear_mixed	4.11987852256385e-161	3.67081176360439e-158	1041.62442695256	1188.01245382068	2
RAC3 GTPase cycle	94	45	925.979719900145	926.002024732858	940.933868860499	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	343.767904534281	345.205166891695	478.355245177474	1053	NA	NA	NA	1.11812341920584e-117	NA	NA	9.96247966512399e-115	non_linear_mixed	1.11812341920584e-117	9.96247966512399e-115	345.205166891695	478.355245177474	2
Extension of Telomeres	51	24	855.960565043962	856.00252308592	869.02888802605	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	596.50982974476	599.268953832351	714.124736583549	549	0.933489072448857	NA	NA	5.28420551273894e-51	NA	NA	4.7082271118504e-48	non_linear_mixed	5.28420551273894e-51	4.7082271118504e-48	599.268953832351	714.124736583549	3
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	124	47	1272.23050823735	1272.25186055051	1287.31511253352	1125	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	554.273803698036	555.648349152581	690.035242363602	1101	NA	NA	NA	3.16955226402453e-146	NA	NA	2.82407106724586e-143	non_linear_mixed	3.16955226402453e-146	2.82407106724586e-143	555.648349152581	690.035242363602	2
SUMOylation	182	75	1554.59931556718	1554.61267859613	1571.08594139883	1797	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	663.786337269001	664.639610406698	812.165969753876	1773	NA	NA	NA	8.62009305897281e-183	NA	NA	7.68050291554478e-180	non_linear_mixed	8.62009305897281e-183	7.68050291554478e-180	664.639610406698	812.165969753876	2
IL2-mediated signaling events	54	27	399.395913368922	399.433180449667	412.817585457979	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	129.403894565017	131.842604242437	250.198943366529	621	NA	NA	NA	3.92576662603751e-53	NA	NA	3.49785806379942e-50	non_linear_mixed	3.92576662603751e-53	3.49785806379942e-50	131.842604242437	250.198943366529	4
Signaling events mediated by HDAC Class I	56	25	319.592664591243	319.632933047619	332.783453556891	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	19.9878494550759	22.6312060984325	138.704950145912	573	NA	NA	NA	3.85698970543167e-59	NA	NA	3.43657782753962e-56	non_linear_mixed	3.85698970543167e-59	3.43657782753962e-56	22.6312060984325	138.704950145912	2
RHOG GTPase cycle	74	33	660.423736296384	660.454193149176	674.447420471827	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	263.838593530116	265.81765112174	390.051751109106	765	0.988310007786296	NA	NA	4.97183131402645e-79	NA	NA	4.42990170079757e-76	non_linear_mixed	4.97183131402645e-79	4.42990170079757e-76	265.81765112174	390.051751109106	2
Resolution of Sister Chromatid Cohesion	109	53	1847.09451379233	1847.11344123712	1862.53955102403	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1284.07172398951	1285.28715807311	1423.07705907481	1245	NA	NA	NA	1.16977808881868e-113	NA	NA	1.04227227713744e-110	non_linear_mixed	1.16977808881868e-113	1.04227227713744e-110	1285.28715807311	1423.07705907481	2
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	81	32	629.087250238138	629.118663850703	643.018619437581	765	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	224.891031429054	226.934274672298	350.273354224041	741	NA	NA	NA	1.33200952036679e-80	NA	NA	1.18682048264681e-77	non_linear_mixed	1.33200952036679e-80	1.18682048264681e-77	226.934274672298	350.273354224041	2
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	94	24	167.195563157458	167.237521199416	180.263886139545	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-24.1075115234428	-21.3483874358516	93.5073953153462	549	NA	NA	NA	2.15490853348207e-37	NA	NA	1.92002350333252e-34	non_linear_mixed	2.15490853348207e-37	1.92002350333252e-34	-21.3483874358516	93.5073953153462	2
TLR NFkB	69	39	534.050350323829	534.076101396791	548.575196753262	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-61.8894092445111	-60.2242110066256	68.8342086203839	909	0.988616729750422	NA	NA	1.47950929866422e-120	NA	NA	1.31824278510982e-117	non_linear_mixed	1.47950929866422e-120	1.31824278510982e-117	-60.2242110066256	68.8342086203839	2
Telomere Maintenance	104	36	1070.39007441987	1070.41798139662	1084.67479272628	861	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	684.09353493244	685.902147372632	812.65599969015	837	NA	NA	NA	6.59681787089664e-77	NA	NA	5.87776472296891e-74	non_linear_mixed	6.59681787089664e-77	5.87776472296891e-74	685.902147372632	812.65599969015	2
Chromosome Maintenance	133	46	1560.75290926938	1560.7747274512	1575.77299494989	1101	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1033.40450848907	1034.80971295003	1168.58527961367	1077	0.96903109786986	NA	NA	3.37525693871635e-106	NA	NA	3.00735393239627e-103	non_linear_mixed	3.37525693871635e-106	3.00735393239627e-103	1034.80971295003	1168.58527961367	2
CDC42 GTPase cycle	160	50	1055.15358044303	1055.17364733266	1070.42381095035	1197	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	327.349060717084	328.639163106162	464.781135283038	1173	0.986002556914227	NA	NA	2.65117768224923e-148	NA	NA	2.36219931488406e-145	non_linear_mixed	2.65117768224923e-148	2.36219931488406e-145	328.639163106162	464.781135283038	2
Validated targets of C-MYC transcriptional activation	87	41	838.432074625814	838.456564421733	853.106952316971	981	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	387.023836272372	388.605426230531	519.097735492783	957	NA	NA	NA	2.21252747807232e-90	NA	NA	1.97136198296244e-87	non_linear_mixed	2.21252747807232e-90	1.97136198296244e-87	388.605426230531	519.097735492783	2
Regulation of nuclear SMAD2/3 signaling	77	30	554.899199769637	554.932719322709	568.636953405667	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	204.192028775763	206.376999874028	327.831811500035	693	NA	NA	NA	1.38376940913528e-69	NA	NA	1.23293854353953e-66	non_linear_mixed	1.38376940913528e-69	1.23293854353953e-66	206.376999874028	327.831811500035	2
superpathway of inositol phosphate compounds	70	30	68.5364202719849	68.5699398250575	82.2741739080152	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-119.661885476424	-117.476914378159	3.97789724784826	693	NA	NA	NA	8.82675827173844e-37	NA	NA	7.86464162011895e-34	non_linear_mixed	8.82675827173844e-37	7.86464162011895e-34	-117.476914378159	3.97789724784826	2
RHOJ GTPase cycle	56	22	612.013374595479	612.059176122197	624.820663446598	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	312.407680506138	315.431680506138	427.673280166208	501	NA	NA	NA	3.85540160575232e-59	NA	NA	3.43516283072532e-56	non_linear_mixed	3.85540160575232e-59	3.43516283072532e-56	315.431680506138	427.673280166208	2
mRNA Splicing - Major Pathway	177	108	2072.26689316147	2072.2761667318	2089.84744833389	2589	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	555.235022473276	555.824726061419	713.460019025024	2565	NA	NA	NA	2.46069019421342e-316	NA	NA	2.19247496304416e-313	non_linear_mixed	2.46069019421342e-316	2.19247496304416e-313	555.824726061419	713.460019025024	2
Costimulation by the CD28 family	77	24	96.9344929739757	96.9764510159337	110.002815956063	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-88.798696846017	-86.0395727584257	28.8162099927721	549	0.984913181368428	NA	NA	2.70044474828329e-36	NA	NA	2.40609627072041e-33	non_linear_mixed	2.70044474828329e-36	2.40609627072041e-33	-86.0395727584257	28.8162099927721	2
Apoptosis	127	54	995.888412564608	995.906988416002	1011.38952619535	1293	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	506.876036223653	508.068465245735	646.386058900283	1269	NA	NA	NA	3.34719381490992e-98	NA	NA	2.98234968908474e-95	non_linear_mixed	3.34719381490992e-98	2.98234968908474e-95	508.068465245735	646.386058900283	2
RHOQ GTPase cycle	60	24	659.340095387402	659.38205342936	672.40841836949	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	297.211605540399	299.97072962799	414.826512379188	549	NA	NA	NA	6.23997135308105e-72	NA	NA	5.55981447559521e-69	non_linear_mixed	6.23997135308105e-72	5.55981447559521e-69	299.97072962799	414.826512379188	2
Transport of Mature mRNA derived from an Intron-Containing Transcript	75	48	1240.71526517872	1240.73617110207	1255.86302970249	1149	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	574.560747591552	575.90594332109	710.89062830546	1125	NA	NA	NA	2.60672230863953e-135	NA	NA	2.32258957699782e-132	non_linear_mixed	2.60672230863953e-135	2.32258957699782e-132	575.90594332109	710.89062830546	2
rRNA modification in the nucleus and cytosol	57	37	827.846005935335	827.873155256602	842.212921164312	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	278.580410016854	280.338549551738	407.882647077643	861	0.97979219059669	NA	NA	8.85161099312176e-111	NA	NA	7.88678539487149e-108	non_linear_mixed	8.85161099312176e-111	7.88678539487149e-108	280.338549551738	407.882647077643	2
Class B/2 (Secretin family receptors)	91	27	-103.114589769338	-103.077322688593	-89.6929176802817	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-303.555467682443	-301.116758005023	-182.760418880931	621	0.992410517368425	NA	NA	3.36216849862233e-39	NA	NA	2.99569213227249e-36	non_linear_mixed	3.36216849862233e-39	2.99569213227249e-36	-301.116758005023	-182.760418880931	3
MAP kinase activation	65	29	522.138168848271	522.172850929196	535.774217829275	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	175.485040919009	177.748513972901	298.209481748039	669	0.99324733584254	NA	NA	9.39338759713787e-69	NA	NA	8.36950834904984e-66	non_linear_mixed	9.39338759713787e-69	8.36950834904984e-66	177.748513972901	298.209481748039	3
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	77	35	581.527322182494	581.556030316465	595.727527858006	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	231.532178594428	233.394247559945	359.334029674036	813	NA	NA	NA	1.93724422104909e-69	NA	NA	1.72608460095474e-66	non_linear_mixed	1.93724422104909e-69	1.72608460095474e-66	233.394247559945	359.334029674036	4
Glycolysis	72	33	835.409570046287	835.440026899079	849.433254221731	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	468.666905336952	470.645962928575	594.880062915941	765	0.983955448779343	NA	NA	7.0210636003012e-73	NA	NA	6.25576766786837e-70	non_linear_mixed	7.0210636003012e-73	6.25576766786837e-70	470.645962928575	594.880062915941	2
FGF	67	24	214.622110125135	214.664068167093	227.690433107222	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-26.1460776243341	-23.3869535367428	91.468829214455	549	NA	NA	NA	3.03733734752268e-47	NA	NA	2.70626757664271e-44	non_linear_mixed	3.03733734752268e-47	2.70626757664271e-44	-23.3869535367428	91.468829214455	2
Toll Like Receptor TLR1:TLR2 Cascade	91	38	659.485532589774	659.511964307836	673.932452559997	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	262.331304212032	264.041711451851	392.353583944039	885	NA	NA	NA	3.79335536424992e-79	NA	NA	3.37987962954668e-76	non_linear_mixed	3.79335536424992e-79	3.37987962954668e-76	264.041711451851	392.353583944039	3
Regulation of PTEN gene transcription	60	20	235.805072506949	235.855492675016	248.326430818655	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	83.8883013121917	87.2334340555545	196.580526117544	453	NA	NA	NA	1.0852362472643e-29	NA	NA	9.66945496312488e-27	non_linear_mixed	1.0852362472643e-29	9.66945496312488e-27	87.2334340555545	196.580526117544	2
Post NMDA receptor activation events	62	25	339.568529870878	339.608798327254	352.759318836527	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	102.842281412141	105.485638055498	221.559382102977	573	0.989085887383595	NA	NA	1.96494027509917e-46	NA	NA	1.75076178511336e-43	non_linear_mixed	1.96494027509917e-46	1.75076178511336e-43	105.485638055498	221.559382102977	2
Toll Like Receptor TLR6:TLR2 Cascade	91	38	659.485532589774	659.511964307836	673.932452559997	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	262.331304212032	264.041711451851	392.353583944039	885	NA	NA	NA	3.79335536424992e-79	NA	NA	3.37987962954668e-76	non_linear_mixed	3.79335536424992e-79	3.37987962954668e-76	264.041711451851	392.353583944039	3
p53 pathway	59	28	628.208045557213	628.243973700926	641.738820578782	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	353.96170017425	356.309526261206	475.738675368375	645	0.980068577622456	NA	NA	5.40977052353648e-54	NA	NA	4.820105536471e-51	non_linear_mixed	5.40977052353648e-54	4.820105536471e-51	356.309526261206	475.738675368375	2
Activation of NMDA receptors and postsynaptic events	75	30	492.025271706169	492.058791259241	505.763025342199	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	181.017948209864	183.20291930813	304.657730934137	693	NA	NA	NA	1.83441999294372e-61	NA	NA	1.63446821371285e-58	non_linear_mixed	1.83441999294372e-61	1.63446821371285e-58	183.20291930813	304.657730934137	2
RHOF GTPase cycle	42	20	476.395636052071	476.446056220138	488.916994363776	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	286.835318300103	290.180451043466	399.527543105455	453	NA	NA	NA	4.75621869924568e-37	NA	NA	4.2377908610279e-34	non_linear_mixed	4.75621869924568e-37	4.2377908610279e-34	290.180451043466	399.527543105455	2
Integrin cell surface interactions	66	21	321.375505911377	321.423505911377	334.043234715591	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	126.571773461276	129.748244049511	240.581332699203	477	NA	NA	NA	4.3855839025681e-38	NA	NA	3.90755525718817e-35	non_linear_mixed	4.3855839025681e-38	3.90755525718817e-35	129.748244049511	240.581332699203	2
RHOBTB GTPase Cycle	36	23	434.24031280941	434.284108429848	447.180956948242	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	163.402850213871	166.288346397077	279.868647463353	525	NA	NA	NA	2.64812625771667e-53	NA	NA	2.35948049562555e-50	non_linear_mixed	2.64812625771667e-53	2.35948049562555e-50	166.288346397077	279.868647463353	2
PTEN Regulation	93	31	275.855186103375	275.887618535808	289.691309207875	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	25.103576001597	27.2153078451725	149.628683942091	717	0.993901349888553	NA	NA	2.99098160703297e-49	NA	NA	2.66496461186638e-46	non_linear_mixed	2.99098160703297e-49	2.66496461186638e-46	27.2153078451725	149.628683942091	2
RND2 GTPase cycle	43	20	622.011503581095	622.061923749162	634.532861892801	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	370.815949374884	374.161082118247	483.508174180236	453	NA	NA	NA	2.43475775207064e-49	NA	NA	2.16936915709494e-46	non_linear_mixed	2.43475775207064e-49	2.16936915709494e-46	374.161082118247	483.508174180236	2
Mitochondrial protein import	65	29	456.406082300251	456.440764381176	470.042131281254	693	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	68.7715522083683	71.0350252622605	191.495993037398	669	0.982976103076091	NA	NA	3.49476737882032e-77	NA	NA	3.11383773452891e-74	non_linear_mixed	3.49476737882032e-77	3.11383773452891e-74	71.0350252622605	191.495993037398	2
RND3 GTPase cycle	42	22	598.885715084277	598.931516610995	611.693003935396	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	305.172340339307	308.196340339307	420.437939999376	501	NA	NA	NA	6.08690152343043e-58	NA	NA	5.42342925737651e-55	non_linear_mixed	6.08690152343043e-58	5.42342925737651e-55	308.196340339307	420.437939999376	2
mRNA 3,-end processing	58	35	687.120077341697	687.148785475668	701.320283017209	837	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	223.671475089848	225.533544055365	351.473326169456	813	NA	NA	NA	6.97749019395871e-93	NA	NA	6.21694376281721e-90	non_linear_mixed	6.97749019395871e-93	6.21694376281721e-90	225.533544055365	351.473326169456	2
Transport of Mature Transcript to Cytoplasm	84	52	1378.73503311217	1378.75432571667	1394.12292575896	1245	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	711.756574208029	712.995918470324	850.247608029122	1221	NA	NA	NA	1.74852093974696e-135	NA	NA	1.55793215731454e-132	non_linear_mixed	1.74852093974696e-135	1.55793215731454e-132	712.995918470324	850.247608029122	2
Protein ubiquitination	80	31	445.574336235624	445.606768668057	459.410459340124	741	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.2496991018002	66.3614309453756	188.774807042294	717	NA	NA	NA	6.98600635801783e-76	NA	NA	6.22453166499388e-73	non_linear_mixed	6.98600635801783e-76	6.22453166499388e-73	66.3614309453756	188.774807042294	2
Glucose metabolism	92	37	874.816677238	874.843826559267	889.183592466977	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	464.03630874255	465.794448277434	593.338545803339	861	0.985686712689088	NA	NA	5.80121158223814e-82	NA	NA	5.16887951977419e-79	non_linear_mixed	5.80121158223814e-82	5.16887951977419e-79	465.794448277434	593.338545803339	2
RUNX1 regulates transcription of genes involved in differentiation of HSCs	85	26	61.2513776771424	61.2900873545618	74.5598287822507	621	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-115.488000416477	-112.951087664799	4.28805952949739	597	NA	NA	NA	1.58028564766899e-34	NA	NA	1.40803451207307e-31	non_linear_mixed	1.58028564766899e-34	1.40803451207307e-31	-112.951087664799	4.28805952949739	2
Mitochondrial translation elongation	88	44	602.955513025116	602.978326713329	617.842243417915	1053	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-42.2376682097405	-40.766851089118	91.742905325447	1029	0.958874686908236	NA	NA	6.69713833858031e-131	NA	NA	5.96715025967506e-128	non_linear_mixed	6.69713833858031e-131	5.96715025967506e-128	-40.766851089118	91.742905325447	2
The citric acid (TCA) cycle and respiratory electron transport	162	53	270.842379500072	270.861306944867	286.287416731773	1269	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-339.534167125519	-338.318733041918	-200.528832040217	1245	NA	NA	NA	1.38291312045722e-123	NA	NA	1.23217559032738e-120	non_linear_mixed	1.38291312045722e-123	1.23217559032738e-120	-338.318733041918	-200.528832040217	3
Prefoldin mediated transfer of substrate  to CCT/TriC	28	20	460.197408624091	460.247828792158	472.718766935797	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	202.564413780177	205.90954652354	315.256638585529	453	NA	NA	NA	1.22903685338822e-50	NA	NA	1.0950718363689e-47	non_linear_mixed	1.22903685338822e-50	1.0950718363689e-47	205.90954652354	315.256638585529	2
Potassium Channels	103	21	77.6855461284613	77.7335461284613	90.3532749326754	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-108.244638353992	-105.068167765757	5.76492088393496	477	0.990762812456949	NA	NA	2.46970946872733e-36	NA	NA	2.20051113663605e-33	non_linear_mixed	2.46970946872733e-36	2.20051113663605e-33	-105.068167765757	5.76492088393496	2
Cell death signalling via NRAGE, NRIF and NADE	76	25	280.902542548906	280.942811005282	294.093331514555	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	26.8275217582013	29.4708784015579	145.544622449037	573	NA	NA	NA	6.40649543150928e-50	NA	NA	5.70818742947477e-47	non_linear_mixed	6.40649543150928e-50	5.70818742947477e-47	29.4708784015579	145.544622449037	2
Interferon alpha/beta signaling	72	30	622.795917466256	622.829437019328	636.533671102286	717	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	248.719825879537	250.904796977803	372.35960860381	693	NA	NA	NA	2.17412178955374e-74	NA	NA	1.93714251449238e-71	non_linear_mixed	2.17412178955374e-74	1.93714251449238e-71	250.904796977803	372.35960860381	2
Macroautophagy	106	39	623.365063671644	623.390814744605	637.889910101077	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	201.658632255312	203.323830493198	332.382250120207	909	NA	NA	NA	3.18338374975026e-84	NA	NA	2.83639492102748e-81	non_linear_mixed	3.18338374975026e-84	2.83639492102748e-81	203.323830493198	332.382250120207	2
Degradation of the extracellular matrix	103	38	82.8302032983675	82.8566350164292	97.2771232685905	909	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-228.834962164242	-227.124554924423	-98.8126824322352	885	0.994945835850938	NA	NA	1.34692917428759e-61	NA	NA	1.20011389429024e-58	non_linear_mixed	1.34692917428759e-61	1.20011389429024e-58	-227.124554924423	-98.8126824322352	2
Visual phototransduction	103	25	475.7849198443	475.825188300676	488.975708809949	597	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	202.97875154835	205.622108191707	321.695852239186	573	NA	NA	NA	1.05840529698433e-53	NA	NA	9.43039119613034e-51	non_linear_mixed	1.05840529698433e-53	9.43039119613034e-51	205.622108191707	321.695852239186	3
RHO GTPases activate PKNs	96	28	239.01581555232	239.051743696033	252.54659057389	669	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-41.9611047900275	-39.613278703071	79.8158704040976	645	0.995152937948285	NA	NA	2.34295108470427e-55	NA	NA	2.08756941647151e-52	non_linear_mixed	2.34295108470427e-55	2.08756941647151e-52	-39.613278703071	79.8158704040976	2
tRNA processing	103	49	1084.10649990092	1084.12697771662	1099.3161222863	1173	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	407.935646829008	409.25271999974	544.82224829739	1149	NA	NA	NA	2.0296575673525e-137	NA	NA	1.80842489251107e-134	non_linear_mixed	2.0296575673525e-137	1.80842489251107e-134	409.25271999974	544.82224829739	3
rRNA processing	63	39	872.664842460505	872.690593533467	887.189688889938	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	309.654590515807	311.319788753693	440.378208380702	909	NA	NA	NA	1.17686960576708e-113	NA	NA	1.04859081873847e-110	non_linear_mixed	1.17686960576708e-113	1.04859081873847e-110	311.319788753693	440.378208380702	2
Platelet homeostasis	85	24	221.115752612422	221.15771065438	234.18407559451	573	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	31.182591803281	33.9417158908723	148.79749864207	549	0.991545840591439	NA	NA	4.01535308690199e-37	NA	NA	3.57767960042967e-34	non_linear_mixed	4.01535308690199e-37	3.57767960042967e-34	33.9417158908723	148.79749864207	2
Protein localization	165	68	769.934811410344	769.949553425086	786.127496016916	1629	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-67.4532515170954	-66.5106081255742	78.280909942054	1605	NA	NA	NA	1.80847158500876e-171	NA	NA	1.61134818224281e-168	non_linear_mixed	1.80847158500876e-171	1.61134818224281e-168	-66.5106081255742	78.280909942054	3
Signaling by PDGF	54	21	246.585210596128	246.633210596128	259.252939400342	501	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	52.2890932722144	55.4655638604497	166.298652510141	477	NA	NA	NA	5.52516965305643e-38	NA	NA	4.92292616087328e-35	non_linear_mixed	5.52516965305643e-38	4.92292616087328e-35	55.4655638604497	166.298652510141	2
Mitochondrial translation termination	88	43	582.813599047926	582.836945351428	597.63136088605	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-42.1447302402686	-40.6387541446511	91.2151263028521	1005	NA	NA	NA	1.1987536029668e-126	NA	NA	1.06808946024342e-123	non_linear_mixed	1.1987536029668e-126	1.06808946024342e-123	-40.6387541446511	91.2151263028521	2
Mitochondrial translation	94	45	596.753668839092	596.775973671806	611.707817799447	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-56.3956765685154	-54.958414211101	78.1916640746778	1053	NA	NA	NA	1.42098145564438e-132	NA	NA	1.26609447697914e-129	non_linear_mixed	1.42098145564438e-132	1.26609447697914e-129	-54.958414211101	78.1916640746778	2
Alpha6Beta4Integrin	71	39	791.519834833494	791.545585906455	806.044681262927	933	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	342.722993427122	344.388191665008	473.446611292017	909	0.982447494213639	NA	NA	7.70912299536589e-90	NA	NA	6.86882858887101e-87	non_linear_mixed	7.70912299536589e-90	6.86882858887101e-87	344.388191665008	473.446611292017	2
p75 NTR receptor-mediated signalling	96	33	313.24612234202	313.276579194812	327.269806517464	789	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-51.1735841660965	-49.1945265744734	75.039573412893	765	0.994796045200581	NA	NA	2.10925997142669e-72	NA	NA	1.87935063454118e-69	non_linear_mixed	2.10925997142669e-72	1.87935063454118e-69	-49.1945265744734	75.039573412893	2
Death Receptor Signalling	134	43	365.618797350297	365.642143653799	380.436559188421	1029	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-122.21841545502	-120.712439359402	11.1414410881009	1005	0.994647141609955	NA	NA	5.88083619126936e-98	NA	NA	5.239825046421e-95	non_linear_mixed	5.88083619126936e-98	5.239825046421e-95	-120.712439359402	11.1414410881009	2
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	105	50	-153.829737891648	-153.809671002016	-138.55950738432	1197	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-648.969976528973	-647.679874139895	-511.537901963019	1173	0.99792389448009	NA	NA	1.77022878660742e-99	NA	NA	1.57727384886722e-96	non_linear_mixed	1.77022878660742e-99	1.57727384886722e-96	-647.679874139895	-511.537901963019	2
AURKA Activation by TPX2	73	37	966.884556164782	966.911705486049	981.251471393759	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	596.825158183395	598.583297718279	726.127395244184	861	0.984409233127778	NA	NA	1.45896389990424e-73	NA	NA	1.29993683481468e-70	non_linear_mixed	1.45896389990424e-73	1.29993683481468e-70	598.583297718279	726.127395244184	2
Stimuli-sensing channels	94	23	204.991621442626	205.035417063064	217.932265581457	549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-11.5677003476326	-8.68220416442647	104.898096901849	525	0.995146037513396	NA	NA	2.1102183641715e-42	NA	NA	1.88020456247681e-39	non_linear_mixed	2.1102183641715e-42	1.88020456247681e-39	-8.68220416442647	104.898096901849	2
DAP12 interactions	45	20	400.674957583549	400.725377751617	413.196315895255	477	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	129.673351563077	133.01848430644	242.365576368429	453	NA	NA	NA	2.45322762528588e-53	NA	NA	2.18582581412972e-50	non_linear_mixed	2.45322762528588e-53	2.18582581412972e-50	133.01848430644	242.365576368429	2
Recognition of DNA damage by PCNA-containing replication complex	30	22	717.208380100174	717.254181626892	730.015668951293	525	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	505.145108329178	508.169108329178	620.410707989247	501	0.967375037349497	NA	NA	1.65736142584727e-41	NA	NA	1.47670903042991e-38	non_linear_mixed	1.65736142584727e-41	1.47670903042991e-38	508.169108329178	620.410707989247	2
Peroxisomal protein import	64	27	100.55202817062	100.589295251366	113.973700259677	645	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-156.208346901503	-153.769637224084	-35.4132980999916	621	0.995547981752559	NA	NA	1.84284070787492e-50	NA	NA	1.64197107071655e-47	non_linear_mixed	1.84284070787492e-50	1.64197107071655e-47	-153.769637224084	-35.4132980999916	2
HATs acetylate histones	142	45	386.397070978448	386.419375811162	401.351219938803	1077	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-51.2377431559642	-49.8004807985498	83.349597487229	1053	NA	NA	NA	1.59480632568481e-87	NA	NA	1.42097243618517e-84	non_linear_mixed	1.59480632568481e-87	1.42097243618517e-84	-49.8004807985498	83.349597487229	2
rRNA processing in the nucleus and cytosol	57	37	827.846005935335	827.873155256602	842.212921164312	885	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	278.580410016854	280.338549551738	407.882647077643	861	0.97979219059669	NA	NA	8.85161099312176e-111	NA	NA	7.88678539487149e-108	non_linear_mixed	8.85161099312176e-111	7.88678539487149e-108	280.338549551738	407.882647077643	2
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	117	58	56.4469862859726	56.464277352255	72.1624768086557	1389	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	-584.40665124049	-583.298146841663	-442.967236536342	1365	NA	NA	NA	5.47391140861127e-130	NA	NA	4.87725506507265e-127	non_linear_mixed	5.47391140861127e-130	4.87725506507265e-127	-583.298146841663	-442.967236536342	2