Geneset	Geneset_Size	Genes	null_AIC	null_AICc	null_BIC	null_df	NA.	linear_AIC	linear_AICc	linear_BIC	linear_df	linear_ICC	non_linear_fixed_AIC	non_linear_fixed_AICc	non_linear_fixed_BIC	non_linear_fixed_df	non_linear_fixed_ICC	non_linear_mixed_AIC	non_linear_mixed_AICc	non_linear_mixed_BIC	non_linear_mixed_df	non_linear_mixed_ICC	p_value_linear	p_value_non_linear_fixed	p_value_non_linear_mixed	adjusted_linear_p_value	adjusted_non_linear_fixed_p_value	adjusted_non_linear_mixed_p_value	best_model	best_model_pvalue	best_model_adj_pvalue	best_model_aicc	best_model_bic	OptimalClusters
Focal adhesion - Homo sapiens (human)	200	36	21586.1666259083	21586.180547022	21602.5307857564	1725	NA	21396.3783732969	21396.427182129	21429.1066929931	1722	0.955432592348775	21398.2798449238	21398.3636145573	21441.9176045187	1720	0.948186357592234	21391.9482567022	21392.228630534	21473.7690559427	1713	NA	3.4289088995517e-42	8.04345538074586e-41	5.55628335741361e-40	4.01182341247549e-40	9.41084279547266e-39	6.50085152817392e-38	non_linear_mixed	5.55628335741361e-40	6.50085152817392e-38	21392.228630534	21473.7690559427	2
Oxytocin signaling pathway - Homo sapiens (human)	153	28	16018.0639228302	16018.081833278	16033.6741393935	1341	NA	16021.0843689676	16021.1471961927	16052.3048020941	1338	0.935149533799798	16023.3073848143	16023.4152499828	16064.9346289829	1336	0.936100814930319	16027.5228582643	16027.8843040474	16105.5739410805	1329	NA	0.394788322985784	0.446309212557561	0.267498152938787	1	1	1	null	NA	NA	16018.081833278	16033.6741393935	NA
Fc gamma R-mediated phagocytosis - Homo sapiens (human)	95	21	11983.718627656	11983.7425320384	11998.4657980018	1005	NA	11981.2642062201	11981.348122304	12010.7585469118	1002	0.932658357099488	11983.4201400142	11983.5642841583	12022.7459276032	1000	0.934868364671595	11991.0512832996	11991.5351542673	12064.787135029	993	NA	0.0374969527839199	0.0672062382794671	0.162544922383418	1	1	1	linear	0.0374969527839199	1	11981.348122304	12010.7585469118	2
Yersinia infection - Homo sapiens (human)	135	26	15079.1015507995	15079.120843404	15094.4894434463	1245	NA	15074.7797764882	15074.8474638371	15105.5555617817	1242	0.928485545003378	15078.2331511261	15078.3493738864	15119.2675315176	1240	0.930157462718449	15084.2827644849	15084.6723748746	15161.2222277189	1233	NA	0.0160199488777837	0.0540525731324051	0.0929965170106593	1	1	1	linear	0.0160199488777837	1	15074.8474638371	15105.5555617817	2
Serotonergic synapse - Homo sapiens (human)	112	20	11939.3626158373	11939.3877204398	11953.9634156907	957	NA	11936.6932255942	11936.7813683014	11965.8948253009	954	0.92785593250383	11937.2528215103	11937.4042410687	11976.188287786	952	0.924461603379435	11947.1377348471	11947.6462094234	12020.141734114	945	NA	0.0340253193599035	0.0333139252507918	0.18115186194779	1	1	1	linear	0.0340253193599035	1	11936.7813683014	11965.8948253009	2
Adherens junction - Homo sapiens (human)	70	20	11776.3874156545	11776.412520257	11790.9882155079	957	NA	11769.0631683869	11769.1513110942	11798.2647680937	954	0.899303581197642	11771.9398915075	11772.0913110658	11810.8753577832	952	0.902862507937518	11777.8672456642	11778.3757202405	11850.8712449312	945	NA	0.0039853804326046	0.0130031821283598	0.0320870116296825	0.466289510614738	1	1	linear	0.0039853804326046	0.466289510614738	11769.1513110942	11798.2647680937	2
Glutamatergic synapse - Homo sapiens (human)	113	21	12472.3363961023	12472.3603004848	12487.0835664482	1005	NA	12470.4689763689	12470.5528924529	12499.9633170607	1002	0.929202158623704	12471.9253634036	12472.0695075477	12511.2511509926	1000	0.925544662581022	12478.3947202013	12478.878591169	12552.1305719307	993	NA	0.0488326993525194	0.0643921131628613	0.117472951543245	1	1	1	null	NA	NA	12472.3603004848	12487.0835664482	NA
Growth hormone synthesis, secretion and action - Homo sapiens (human)	118	22	12703.173525957	12703.1963396452	12718.0602563498	1053	NA	12709.0593800079	12709.139456271	12738.8328407935	1050	0.934089226619531	12709.3070958408	12709.4446316574	12749.0050435549	1048	0.933804521693195	12712.4958237406	12712.9573622021	12786.9294757046	1041	NA	0.990087430203286	0.56880271598923	0.259536893168931	1	1	1	null	NA	NA	12703.1963396452	12718.0602563498	NA
Tight junction - Homo sapiens (human)	168	36	22008.3553333607	22008.3692544744	22024.7194932088	1725	NA	21860.8566782257	21860.9054870578	21893.5849979219	1722	0.949700579143919	21860.8260716591	21860.9098412926	21904.463831254	1720	0.94359571044204	21850.0726418004	21850.3530156322	21931.8934410409	1713	0.95046043727541	4.6343097573386e-33	3.32705732559328e-32	1.45020888446541e-32	5.42214241608616e-31	3.89265707094413e-30	1.69674439482453e-30	non_linear_mixed	1.45020888446541e-32	1.69674439482453e-30	21850.3530156322	21931.8934410409	4
Chemokine signaling pathway - Homo sapiens (human)	191	23	13631.7985583274	13631.8203765092	13646.8186440079	1101	NA	13606.2493208287	13606.3258932991	13636.2894921897	1098	0.907704135689677	13608.727351057	13608.8588579063	13648.7809128717	1096	0.897932435068205	13613.922271546	13614.3634480166	13689.0226999485	1089	0.908559269299669	6.51281036976211e-07	3.64286917807352e-06	3.49398092586081e-05	7.61998813262167e-05	0.000426215693834602	0.00408795768325715	linear	6.51281036976211e-07	7.61998813262167e-05	13606.3258932991	13636.2894921897	2
Ribosome biogenesis in eukaryotes - Homo sapiens (human)	107	21	14154.6241785889	14154.6480829714	14169.3713489348	1005	NA	14030.7974941551	14030.881410239	14060.2918348469	1002	NA	14030.5058968399	14030.650040984	14069.8316844289	1000	NA	13974.0582176958	13974.5420886636	14047.7940694253	993	NA	5.8941758110844e-28	3.17916919178289e-27	3.71914872545756e-37	6.89618569896875e-26	3.71962795438599e-25	4.35140400878535e-35	non_linear_mixed	3.71914872545756e-37	4.35140400878535e-35	13974.5420886636	14047.7940694253	2
GnRH signaling pathway - Homo sapiens (human)	92	22	12645.7164976654	12645.7393113537	12660.6032280582	1053	NA	12650.517252472	12650.5973287351	12680.2907132576	1050	0.935507208276885	12649.7693354303	12649.906871247	12689.4672831445	1048	0.935533091569991	12651.1954364211	12651.6569748827	12725.6290883851	1041	NA	0.753185351152033	0.311394268644356	0.100760917534191	1	1	1	null	NA	NA	12645.7393113537	12660.6032280582	NA
Ubiquitin mediated proteolysis - Homo sapiens (human)	139	29	17589.0784724034	17589.0957634697	17604.7939629261	1389	NA	17592.1780109471	17592.2386607666	17623.6089919924	1386	NA	17591.5266894068	17591.6308108819	17633.434664134	1384	NA	17582.7916425565	17583.1404797658	17661.3690951699	1377	NA	0.407228034443173	0.18272925981336	0.00252768663363662	1	1	0.295739336135485	non_linear_mixed	0.00252768663363662	0.295739336135485	17583.1404797658	17661.3690951699	4
Phagosome - Homo sapiens (human)	150	28	18065.5847343307	18065.6026447785	18081.194950894	1341	NA	18052.4985198966	18052.5613471217	18083.7189530231	1338	NA	18055.6544862294	18055.7623513979	18097.281730398	1336	NA	18058.2913763887	18058.6528221718	18136.3424592049	1329	NA	0.00026240298793806	0.00128795990498188	0.0017768832830306	0.030701149588753	0.15069130888288	0.207895344114581	linear	0.00026240298793806	0.030701149588753	18052.5613471217	18083.7189530231	2
Autophagy - animal - Homo sapiens (human)	136	39	24528.2330061165	24528.2458540822	24544.8372940876	1869	NA	24463.2874604412	24463.3325006557	24496.4960363834	1866	0.920729359784326	24466.5949504861	24466.6722451721	24510.8730517424	1864	0.917608389189385	24364.1388071406	24364.3974278303	24447.1602469962	1857	0.926605470642751	2.67775092458105e-15	4.6728864380107e-14	9.26547235466925e-34	3.13296858175982e-13	5.46727713247252e-12	1.0840602654963e-31	non_linear_mixed	9.26547235466925e-34	1.0840602654963e-31	24364.3974278303	24447.1602469962	3
Gap junction - Homo sapiens (human)	87	21	12089.865839944	12089.8897443265	12104.6130102899	1005	NA	12090.8215544326	12090.9054705165	12120.3158951243	1002	0.938555797249757	12094.2813723707	12094.4255165149	12133.6071599598	1000	0.937489685781459	12082.7215179672	12083.205388935	12156.4573696967	993	0.940705605155664	0.168582915397545	0.348772576526623	0.00187259675386258	1	1	0.219093820201921	non_linear_mixed	0.00187259675386258	0.219093820201921	12083.205388935	12156.4573696967	2
Circadian entrainment - Homo sapiens (human)	96	21	12453.9193457396	12453.943250122	12468.6665160855	1005	NA	12451.7850717655	12451.8689878494	12481.2794124573	1002	0.931613573953881	12454.137654273	12454.2817984171	12493.463441862	1000	0.928075744335166	12460.2022469394	12460.6861179072	12533.9380986689	993	NA	0.0433166659579992	0.0816625853281594	0.124554263403043	1	1	1	linear	0.0433166659579992	1	12451.8689878494	12481.2794124573	2
RNA transport - Homo sapiens (human)	185	31	20672.1268764042	20672.1430489109	20688.0424410503	1485	NA	20558.8691025189	20558.9258209524	20590.7002318113	1482	0.942972690546699	20560.8983924212	20560.9957555044	20603.3398981443	1480	0.949688397522437	20492.8111109831	20493.1371979396	20572.388934214	1473	NA	1.11502283082392e-25	1.72384143375842e-24	6.74128774689733e-37	1.30457671206399e-23	2.01689447749736e-22	7.88730666386988e-35	non_linear_mixed	6.74128774689733e-37	7.88730666386988e-35	20493.1371979396	20572.388934214	3
Spliceosome - Homo sapiens (human)	150	29	17265.4152015045	17265.4324925708	17281.1306920272	1389	NA	17241.3447594265	17241.405409246	17272.7757404718	1386	0.904074706624786	17244.4472104953	17244.5513319703	17286.3551852224	1384	0.894353369813831	17248.6910378269	17249.0398750362	17327.2684904403	1377	NA	1.33376425904625e-06	9.50455218339607e-06	5.44851148822554e-05	0.000156050418308412	0.00111203260545734	0.00637475844122388	linear	1.33376425904625e-06	0.000156050418308412	17241.405409246	17272.7757404718	2
Axon guidance - Homo sapiens (human)	181	38	22278.5312632276	22278.5444500408	22295.0576247395	1821	NA	22022.9568176402	22023.0030476897	22056.009540664	1818	0.965000820451019	22021.3821175916	22021.4614564346	22065.4524149567	1816	0.958238908545702	22001.3544333112	22001.6199200369	22083.9862408708	1809	0.96574950582502	2.05219888390263e-56	1.14582261142247e-55	2.65841416896016e-57	2.40107269416608e-54	1.34061245536429e-53	3.11034457768339e-55	non_linear_mixed	2.65841416896016e-57	3.11034457768339e-55	22001.6199200369	22083.9862408708	2
NOD-like receptor signaling pathway - Homo sapiens (human)	180	32	18874.4914716522	18874.5071374486	18890.5022823934	1533	NA	18847.2756737424	18847.3306116103	18879.2972952247	1530	0.92501782074255	18846.944641655	18847.038944209	18889.6401369646	1528	0.91820021352149	18851.3525396703	18851.668329144	18931.4065933759	1521	0.925515236662827	2.90016982991639e-07	4.65270629429097e-07	4.41036204224849e-06	3.39319870100218e-05	5.44366636432044e-05	0.000516012358943074	non_linear_fixed	4.65270629429097e-07	5.44366636432044e-05	18847.038944209	18889.6401369646	3
Apelin signaling pathway - Homo sapiens (human)	136	29	17549.8620621245	17549.8793531908	17565.5775526472	1389	NA	17499.7254066316	17499.7860564511	17531.156387677	1386	NA	17499.1264345186	17499.2305559937	17541.0344092458	1384	NA	17499.4874114212	17499.8362486305	17578.0648640347	1377	NA	3.92810414364704e-12	8.56406652288265e-12	4.82277484885171e-11	4.59588184806704e-10	1.00199578317727e-09	5.6426465731565e-09	non_linear_fixed	8.56406652288265e-12	1.00199578317727e-09	17499.2305559937	17541.0344092458	5
Estrogen signaling pathway - Homo sapiens (human)	136	32	20365.240575763	20365.2562415593	20381.2513865041	1533	NA	19987.9276539804	19987.9825918483	20019.9492754627	1530	0.894380488432232	19984.7148613576	19984.8091639116	20027.4103566673	1528	0.912305280647584	19569.4181321167	19569.7339215904	19649.4721858223	1521	0.922820387475185	9.10965662106785e-83	3.26620765940503e-82	9.27690055714321e-168	1.06582982466494e-80	3.82146296150388e-80	1.08539736518576e-165	non_linear_mixed	9.27690055714321e-168	1.08539736518576e-165	19569.7339215904	19649.4721858223	2
C-type lectin receptor signaling pathway - Homo sapiens (human)	103	23	12935.2390484558	12935.2608666376	12950.2591341363	1101	NA	12927.9951657623	12928.0717382327	12958.0353371233	1098	NA	12927.2921728289	12927.4236796782	12967.3457346436	1096	NA	12931.3675750102	12931.8087514808	13006.4680034128	1089	0.920895805620227	0.00413780915236857	0.00301372636182272	0.00577655767114341	0.484123670827123	0.352605984333258	0.675857247523779	non_linear_fixed	0.00301372636182272	0.352605984333258	12927.4236796782	12967.3457346436	3
Tuberculosis - Homo sapiens (human)	178	32	20023.759607789	20023.7752735853	20039.7704185301	1533	NA	19942.1144854366	19942.1694233045	19974.1361069189	1530	0.918930428540216	19946.0610559099	19946.155358464	19988.7565512196	1528	0.916587423023723	19845.3761820875	19845.6919715612	19925.4302357931	1521	NA	7.01908396802411e-19	2.04446065459034e-17	1.05031270607047e-36	8.21232824258821e-17	2.3920189658707e-15	1.22886586610245e-34	non_linear_mixed	1.05031270607047e-36	1.22886586610245e-34	19845.6919715612	19925.4302357931	3
Phospholipase D signaling pathway - Homo sapiens (human)	146	29	17348.3553297908	17348.3726208571	17364.0708203135	1389	NA	17326.0047831232	17326.0654329427	17357.4357641686	1386	NA	17324.138535324	17324.2426567991	17366.0465100512	1384	NA	17322.8169967302	17323.1658339395	17401.3944493437	1377	NA	3.06589800097121e-06	2.15570486108507e-06	1.68362217735745e-06	0.000358710066113632	0.000252217468746953	0.000196983794750821	non_linear_mixed	1.68362217735745e-06	0.000196983794750821	17323.1658339395	17401.3944493437	2
Pathogenic Escherichia coli infection - Homo sapiens (human)	195	53	32741.7560030426	32741.7654518615	32759.2804818159	2541	NA	32711.0762313191	32711.1093412915	32746.1251888658	2538	0.932995613211815	32712.2760587423	32712.332863476	32759.008002138	2536	0.933442510728984	32704.9654010658	32705.1552744836	32792.5877949327	2529	NA	5.37814111439304e-08	1.90102527846058e-07	1.61924557161624e-08	6.29242510383985e-06	2.22419957579888e-05	1.894517318791e-06	non_linear_mixed	1.61924557161624e-08	1.894517318791e-06	32705.1552744836	32792.5877949327	2
Transcriptional misregulation in cancer - Homo sapiens (human)	190	33	18837.6961855969	18837.7113754704	18853.7993113141	1581	NA	18825.5569984521	18825.6102641464	18857.7632498863	1578	0.930101967313431	18817.0899015047	18817.1813300761	18860.0315700837	1576	0.927354617070495	18800.0391709469	18800.3452933958	18880.5547995325	1569	0.931845972004817	0.000411711300405965	1.12021542774252e-05	1.12409119940816e-08	0.0481702221474979	0.00131065205045875	1.31518670330754e-06	non_linear_mixed	1.12409119940816e-08	1.31518670330754e-06	18800.3452933958	18880.5547995325	3
Hepatitis C - Homo sapiens (human)	156	32	18899.189873578	18899.2055393743	18915.2006843191	1533	NA	18895.4621240387	18895.5170619066	18927.4837455209	1530	0.933393871154685	18894.395799817	18894.4901023711	18937.0912951267	1528	0.932335587067671	18892.106540955	18892.4223304287	18972.1605946606	1521	0.934204961876238	0.0210279374134697	0.0112794386452713	0.00191318363166584	1	1	0.223842484904904	non_linear_mixed	0.00191318363166584	0.223842484904904	18892.4223304287	18972.1605946606	3
Insulin signaling pathway - Homo sapiens (human)	136	27	15210.5602783876	15210.578854239	15226.0613920183	1293	NA	15191.1458412436	15191.2110080395	15222.1480685051	1290	0.909572435382524	15189.6455188616	15189.7574069735	15230.9818218769	1288	0.901621391129331	15185.578881559	15185.953881559	15263.0844497127	1281	NA	1.26468795220468e-05	9.737330702341e-06	2.10740753188357e-06	0.00147968490407948	0.0011392676921739	0.000246566681230378	non_linear_mixed	2.10740753188357e-06	0.000246566681230378	15185.953881559	15263.0844497127	2
cGMP-PKG signaling pathway - Homo sapiens (human)	166	30	17744.0708552862	17744.0875683781	17759.8880504639	1437	NA	17719.6787710549	17719.7373893382	17751.3131614103	1434	0.927993246225874	17719.9345845573	17720.0352134881	17762.1137716978	1432	0.920948727970494	17726.291512258	17726.6285909097	17805.3774881465	1425	NA	1.14131677412288e-06	2.23679895688308e-06	3.62755249448364e-05	0.000133534062572377	0.000261705477955321	0.00424423641854586	linear	1.14131677412288e-06	0.000133534062572377	17719.7373893382	17751.3131614103	2
Apoptosis - Homo sapiens (human)	135	36	21427.0713831126	21427.0853042263	21443.4355429607	1725	NA	21228.7527142619	21228.8015230939	21261.481033958	1722	0.916612876364978	21230.6615375642	21230.7453071977	21274.2992971591	1720	0.921733117835686	20965.0796540597	20965.3600278915	21046.9004533002	1713	NA	4.92004478589162e-44	1.20748748727875e-42	2.118563759544e-96	5.75645239949319e-42	1.41276036011613e-40	2.47871959866648e-94	non_linear_mixed	2.118563759544e-96	2.47871959866648e-94	20965.3600278915	21046.9004533002	2
Cellular senescence - Homo sapiens (human)	155	48	27137.9926623671	27138.0030971497	27155.2198684326	2301	NA	27129.7814534364	27129.8180228748	27164.2358655673	2298	0.929617150377797	27130.7270939433	27130.7898390413	27176.6663101178	2296	0.926294770709844	27111.1042926952	27111.314082905	27197.2403230224	2289	0.930946525658337	0.00263131253377803	0.0040227283055612	9.74699463366625e-07	0.307863566452029	0.47065921175066	0.000114039837213895	non_linear_mixed	9.74699463366625e-07	0.000114039837213895	27111.314082905	27197.2403230224	2
Epstein-Barr virus infection - Homo sapiens (human)	200	37	20565.5970502281	20565.6105942462	20582.0434069988	1773	NA	20531.7539623524	20531.8014468069	20564.6466758937	1770	0.940755849170226	20534.7062097372	20534.787703795	20578.5631611257	1768	0.941871798857492	20526.0714729221	20526.3442001948	20608.3032567754	1761	0.941673011871792	1.15031430341797e-08	9.8714582267111e-08	5.1004487295024e-09	1.34586773499903e-06	1.1549606125252e-05	5.96752501351781e-07	non_linear_mixed	5.1004487295024e-09	5.96752501351781e-07	20526.3442001948	20608.3032567754	3
Hepatitis B - Homo sapiens (human)	161	25	14677.4454357143	14677.465502604	14692.7156662217	1197	NA	14682.2449869603	14682.3153976895	14712.7854479749	1194	NA	14685.4592950994	14685.5802019004	14726.1799097856	1192	NA	14693.3787371868	14693.7841425923	14769.7298897235	1185	NA	0.752896683910815	0.851059406132862	0.779896629337778	1	1	1	null	NA	NA	14677.465502604	14692.7156662217	NA
Neurotrophin signaling pathway - Homo sapiens (human)	118	23	13692.9850396465	13693.0068578283	13708.005125327	1101	NA	13682.8978032802	13682.9743757506	13712.9379746412	1098	0.921730635996985	13684.8273592235	13684.9588660728	13724.8809210382	1096	0.915843968454883	13690.3089960706	13690.7501725412	13765.4094244732	1089	NA	0.00108822688651216	0.00275514274175186	0.00860066798358911	0.127322545721923	0.322351700784968	1	linear	0.00108822688651216	0.127322545721923	13682.9743757506	13712.9379746412	2
Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)	192	38	21928.3797570262	21928.3929438394	21944.9061185381	1821	NA	21902.841519842	21902.8877498916	21935.8942428658	1818	0.929577571335731	21904.1692467518	21904.2485855947	21948.2395441168	1816	0.924846232708071	21903.3135405269	21903.5790272526	21985.9453480864	1809	NA	6.54765506897583e-07	2.16192696658029e-06	2.03664448726269e-06	7.66075643070172e-05	0.000252945455089894	0.000238287405009735	linear	6.54765506897583e-07	7.66075643070172e-05	21902.8877498916	21935.8942428658	2
Integrated breast cancer pathway	66	23	14014.5536968673	14014.5755150492	14029.5737825479	1101	NA	14007.0189494844	14007.0955219548	14037.0591208454	1098	0.92026810101021	14000.4646654746	14000.5961723239	14040.5182272893	1096	0.924252687083245	13937.9171435657	13938.3583200363	14013.0175719683	1089	NA	0.00361197256230794	0.000208724471002062	4.17774584439123e-16	0.422600789790029	0.0244207631072413	4.88796263793774e-14	non_linear_mixed	4.17774584439123e-16	4.88796263793774e-14	13938.3583200363	14013.0175719683	2
Alzheimer,s disease	143	27	15065.7448364232	15065.7634122746	15081.245950054	1293	NA	15053.5887200335	15053.6538868294	15084.5909472949	1290	0.895695369799992	15053.4313059988	15053.5431941107	15094.7676090141	1288	0.892382701703329	15030.3451060994	15030.7201060994	15107.8506742531	1281	NA	0.000408413331847536	0.000456397500630868	2.90346533573501e-08	0.0477843598261617	0.0533985075738116	3.39705444280996e-06	non_linear_mixed	2.90346533573501e-08	3.39705444280996e-06	15030.7201060994	15107.8506742531	5
Adipogenesis	130	24	14136.5751186373	14136.5960245607	14151.7228831611	1149	NA	13835.2841249579	13835.3574874033	13865.5796540054	1146	0.951862114378184	13835.7343000111	13835.8602842631	13876.1283387412	1144	0.934850235785595	13831.2144443476	13831.6369795588	13906.9532669664	1137	NA	2.62863324411551e-66	4.67287786023026e-65	3.14464787279458e-63	3.07550089561515e-64	5.4672670964694e-63	3.67923801116966e-61	non_linear_mixed	3.14464787279458e-63	3.67923801116966e-61	13831.6369795588	13906.9532669664	2
Brain-derived neurotrophic factor (BDNF) signaling pathway	143	27	16733.755885981	16733.7744618324	16749.2569996117	1293	NA	16707.1653833043	16707.2305501002	16738.1676105657	1290	0.934688893726162	16710.110233597	16710.2221217089	16751.4465366123	1288	0.939458062927509	16718.8668963458	16719.2418963458	16796.3724644995	1281	0.935114561352119	3.92923766530973e-07	2.80073290645211e-06	0.000109758375506518	4.59720806841239e-05	0.000327685750054897	0.0128417299342626	linear	3.92923766530973e-07	4.59720806841239e-05	16707.2305501002	16738.1676105657	2
Spinal Cord Injury	116	20	11246.0546247123	11246.0797293148	11260.6554245657	957	NA	11242.3242942725	11242.4124369797	11271.5258939793	954	0.929392465081504	11244.9880980872	11245.1395176455	11283.9235643629	952	0.925042357227083	11238.179602848	11238.6880774242	11311.1836021149	945	NA	0.0210031585056985	0.0500767950450214	0.00144657173430525	1	1	0.169248892913714	non_linear_mixed	0.00144657173430525	0.169248892913714	11238.6880774242	11311.1836021149	2
Mesodermal commitment pathway	152	32	19225.6926735831	19225.7083393794	19241.7034843242	1533	NA	19218.4214438376	19218.4763817055	19250.4430653199	1530	0.918340336976327	19213.9139145725	19214.0082171266	19256.6094098822	1528	0.917396252804274	19204.7988113495	19205.1146008232	19284.8528650551	1521	NA	0.00408530261012767	0.000576802810969619	1.07454983712198e-05	0.477980405384937	0.0674859288834454	0.00125722330943271	non_linear_mixed	1.07454983712198e-05	0.00125722330943271	19205.1146008232	19284.8528650551	5
NRF2 pathway	142	25	16512.1788737538	16512.1989406435	16527.4491042612	1197	NA	16481.4171372641	16481.4875479934	16511.9575982788	1194	NA	16475.7008622782	16475.8217690792	16516.4214769644	1192	NA	16334.0577917209	16334.4631971263	16410.4089442575	1185	NA	5.16766086943497e-08	7.25834462840119e-09	1.18986547290103e-36	6.04616321723891e-06	8.4922632152294e-07	1.39214260329421e-34	non_linear_mixed	1.18986547290103e-36	1.39214260329421e-34	16334.4631971263	16410.4089442575	2
Focal Adhesion	197	35	21031.7181625903	21031.7324823993	21047.9978098075	1677	NA	20846.8731835604	20846.9233927654	20879.4324779948	1674	0.955161958770114	20848.7900531965	20848.8762291391	20892.2024457757	1672	0.947826785581538	20842.9400881179	20843.2285496563	20924.3383242038	1665	0.955776035243714	4.00938538972874e-41	9.24359571050081e-40	7.44440976485534e-39	4.69098090598263e-39	1.08150069812859e-37	8.70995942488075e-37	non_linear_mixed	7.44440976485534e-39	8.70995942488075e-37	20843.2285496563	20924.3383242038	2
TGF-beta Signaling Pathway	131	24	13833.6748594561	13833.6957653794	13848.8226239798	1149	NA	13819.2032769713	13819.2766394167	13849.4988060188	1146	0.932014476130667	13822.6282123373	13822.7541965892	13863.0222510673	1144	0.928300290217161	13822.7850663517	13823.207601563	13898.5238889705	1137	NA	0.000135522012179453	0.000793784802016725	0.000487611105423214	0.015856075424996	0.0928728218359568	0.057050499334516	linear	0.000135522012179453	0.015856075424996	13819.2766394167	13849.4988060188	2
Angiopoietin Like Protein 8 Regulatory Pathway	130	25	14059.9846683002	14060.0047351898	14075.2548988075	1197	NA	14062.0396798725	14062.1100906017	14092.5801408871	1194	NA	14060.3577779128	14060.4786847139	14101.0783925991	1192	0.90130670337988	14065.8058723022	14066.2112777076	14142.1570248389	1185	NA	0.267465985410821	0.0865243433438817	0.110368527107653	1	1	1	null	NA	NA	14060.0047351898	14075.2548988075	NA
Chemokine signaling pathway	164	22	13087.9290785414	13087.9518922296	13102.8158089342	1053	NA	13063.3854640934	13063.4655403565	13093.158924879	1050	0.902806205044993	13065.8697113565	13066.0072471732	13105.5676590707	1048	0.89190984831939	13071.3154673211	13071.7770057826	13145.7491192851	1041	0.903697790701254	1.06051558949816e-06	5.78258097035021e-06	5.68478373513163e-05	0.000124080323971284	0.000676561973530974	0.006651196970104	linear	1.06051558949816e-06	0.000124080323971284	13063.4655403565	13093.158924879	2
mRNA Processing	126	32	18544.8403386304	18544.8560044267	18560.8511493715	1533	NA	18499.8235007486	18499.8784386165	18531.8451222309	1530	0.915332902402709	18503.4066881882	18503.5009907422	18546.1021834979	1528	0.916214979371793	18509.7254808133	18510.041270287	18589.7795345189	1521	NA	4.851843255206e-11	7.04841086649722e-10	3.27133335412575e-08	5.67665660859101e-09	8.24664071380175e-08	3.82746002432713e-06	linear	4.851843255206e-11	5.67665660859101e-09	18499.8784386165	18531.8451222309	2
Ebola Virus Pathway on Host	129	28	16804.1952435481	16804.2131539958	16819.8054601113	1341	NA	16802.2546547561	16802.3174819812	16833.4750878826	1338	0.919856723758726	16804.4972190761	16804.6050842447	16846.1244632448	1336	0.917478531019429	16815.0172739371	16815.3787197202	16893.0683567533	1329	NA	0.0472556470327573	0.0842579703364463	0.356238950581391	1	1	1	null	NA	NA	16804.2131539958	16819.8054601113	NA
Ras signaling	183	34	19839.2236474708	19839.2383894855	19855.4163320774	1629	NA	19821.2258137807	19821.2775060884	19853.6111829938	1626	0.924042958061766	19821.5122595687	19821.6009841528	19864.6927518529	1624	0.918098151560114	19824.8831765935	19825.1802062965	19905.8465996264	1617	NA	2.50060049519907e-05	4.1445197487566e-05	0.000135065455604818	0.00292570257938291	0.00484908810604522	0.0158026583057637	linear	2.50060049519907e-05	0.00292570257938291	19821.2775060884	19853.6111829938	2
Breast cancer pathway	153	20	12365.6900033906	12365.7151079931	12380.290803244	957	NA	12359.7250025316	12359.8131452388	12388.9266022383	954	0.908570521809309	12354.9353202259	12355.0867397842	12393.8707865016	952	0.913598069037725	12303.9868368859	12304.4953114622	12376.9908361528	945	NA	0.00750401946378898	0.0009012119321078	3.33349221988597e-13	0.87797027726331	0.105441796056613	3.90018589726659e-11	non_linear_mixed	3.33349221988597e-13	3.90018589726659e-11	12304.4953114622	12376.9908361528	2
EGF-EGFR signaling pathway	161	33	18405.1042834017	18405.1194732752	18421.2074091189	1581	NA	18368.9725777129	18369.0258434072	18401.1788291471	1578	0.886445227021969	18371.436268899	18371.5276974705	18414.377937478	1576	0.881987846760649	18373.1755115474	18373.4816339964	18453.691140133	1569	0.887500832343042	3.76205166765003e-09	2.7049306107444e-08	1.23279098198263e-07	4.40160045115053e-07	3.16476881457094e-06	1.44236544891968e-05	linear	3.76205166765003e-09	4.40160045115053e-07	18369.0258434072	18401.1788291471	2
Fragile X Syndrome	118	20	10900.5331792287	10900.5582838313	10915.1339790821	957	NA	10862.0143063969	10862.1024491042	10891.2159061037	954	0.891510328629747	10865.0761373488	10865.2275569072	10904.0116036245	952	0.896778104690698	10873.3613713849	10873.8698459611	10946.3653706518	945	0.892321401767994	1.17086749273259e-09	1.17134258636618e-08	8.68672116768013e-07	1.36991496649713e-07	1.37047082604843e-06	0.000101634637661857	linear	1.17086749273259e-09	1.36991496649713e-07	10862.1024491042	10891.2159061037	2
Gastrin signaling pathway	113	27	15260.4112019998	15260.4297778512	15275.9123156306	1293	NA	15248.3038665533	15248.3690333493	15279.3060938148	1290	0.924359449452271	15248.6643189165	15248.7762070284	15290.0006219318	1288	0.919987052980287	15252.4888981484	15252.8638981484	15329.9944663021	1281	NA	0.000417988251109432	0.000584895469892418	0.00142250069568244	0.0489046253798036	0.0684327699774129	0.166432581394846	linear	0.000417988251109432	0.0489046253798036	15248.3690333493	15279.3060938148	2
Hepatitis B infection	151	22	13235.3400597938	13235.3628734821	13250.2267901866	1053	NA	13237.0573392793	13237.1374155424	13266.8308000649	1050	0.930895752052207	13238.7137529346	13238.8512887512	13278.4117006488	1048	NA	13245.4171733444	13245.8787118059	13319.8508253084	1041	NA	0.232509384715353	0.249948217531639	0.305659716875143	1	1	1	null	NA	NA	13235.3628734821	13250.2267901866	NA
Ciliopathies	182	27	14969.5795402125	14969.5981160639	14985.0806538433	1293	NA	14824.9091729893	14824.9743397853	14855.9114002508	1290	0.880348982349586	14823.9267095246	14824.0385976365	14865.2630125399	1288	0.904861755893814	14742.319039206	14742.694039206	14819.8246073597	1281	NA	1.8886596509533e-32	8.35246831938363e-32	7.46889983562364e-47	2.20973179161537e-30	9.77238793367884e-30	8.73861280767965e-45	non_linear_mixed	7.46889983562364e-47	8.73861280767965e-45	14742.694039206	14819.8246073597	5
Insulin Signaling	159	33	19424.2698438786	19424.2850337521	19440.3729695958	1581	NA	19168.1595015893	19168.2127672837	19200.3657530236	1578	0.943231778431918	19168.3800784537	19168.4715070251	19211.3217470327	1576	0.927419163844308	19165.2615221068	19165.5676445558	19245.7771506924	1569	0.943913758681299	1.57141908197717e-56	2.135664779104e-55	1.7206680543836e-53	1.83856032591329e-54	2.49872779155168e-53	2.01318162362881e-51	non_linear_mixed	1.7206680543836e-53	2.01318162362881e-51	19165.5676445558	19245.7771506924	3
DNA Repair Pathways Full Network	118	26	12812.8831814805	12812.902474085	12828.2710741273	1245	NA	12752.3671225905	12752.4348099394	12783.142907884	1242	0.948407152826411	12754.6262725292	12754.7424952894	12795.6606529206	1240	0.946814504530818	12759.1630997482	12759.5527101378	12836.1025629822	1233	0.948842004090267	2.37690909380682e-14	2.36147673294428e-13	1.12117952686955e-11	2.78098363975398e-12	2.76292777754481e-11	1.31178004643738e-09	linear	2.37690909380682e-14	2.78098363975398e-12	12752.4348099394	12783.142907884	2
Regulation of Actin Cytoskeleton	150	25	16033.6176953052	16033.6377621949	16048.8879258126	1197	NA	15989.8263157581	15989.8967264873	16020.3667767727	1194	0.929499427307662	15992.6950251099	15992.8159319109	16033.4156397961	1192	0.925519204834008	16003.033026918	16003.4384323234	16079.3841794547	1185	NA	8.84972902720095e-11	8.97002938398708e-10	2.14809887113854e-07	1.03541829618251e-08	1.04949343792649e-07	2.51327567923209e-05	linear	8.84972902720095e-11	1.03541829618251e-08	15989.8967264873	16020.3667767727	2
Calcium Regulation in the Cardiac Cell	150	25	14654.3326162602	14654.3526831498	14669.6028467675	1197	NA	14654.0545135105	14654.1249242398	14684.5949745252	1194	0.934871688994029	14657.624710805	14657.745617606	14698.3453254912	1192	0.933579733680131	14668.3246880926	14668.730093498	14744.6758406292	1185	0.935251456705948	0.0988365907546362	0.24328569191279	0.615265087835593	1	1	1	null	NA	NA	14654.3526831498	14669.6028467675	NA
Senescence and Autophagy in Cancer	105	22	13401.9927062109	13402.0155198991	13416.8794366037	1053	NA	13388.3207230745	13388.4007993376	13418.0941838601	1050	0.9343929132866	13389.8585663114	13389.996102128	13429.5565140255	1048	0.929768635013638	13398.6026031043	13399.0641415659	13473.0362550683	1041	NA	0.000198492491763244	0.000493729348802912	0.00678705291262136	0.0232236215362995	0.0577663338099408	0.794085190776699	linear	0.000198492491763244	0.0232236215362995	13388.4007993376	13418.0941838601	2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	158	27	14691.8031995483	14691.8217753997	14707.3043131791	1293	NA	14585.0971553365	14585.1623221324	14616.0993825979	1290	0.929910542063189	14578.3996853749	14578.5115734868	14619.7359883902	1288	0.933466103447442	14445.9352397032	14446.3102397032	14523.4408078569	1281	NA	2.87018865931297e-24	5.96474591628413e-25	9.69648874690348e-51	3.35812073139617e-22	6.97875272205244e-23	1.13448918338771e-48	non_linear_mixed	9.69648874690348e-51	1.13448918338771e-48	14446.3102397032	14523.4408078569	2
Transcriptional regulation by RUNX1	194	30	19028.8343837506	19028.8510968426	19044.6515789283	1437	NA	19013.1159742651	19013.1745925484	19044.7503646205	1434	0.922509161107404	19004.8418254196	19004.9424543504	19047.0210125601	1432	0.917906772459107	18951.0344733644	18951.3715520161	19030.1204492529	1425	NA	7.46501125509878e-05	2.38914038604148e-06	2.4703470015159e-16	0.00873406316846557	0.000279529425166853	2.8903059917736e-14	non_linear_mixed	2.4703470015159e-16	2.8903059917736e-14	18951.3715520161	19030.1204492529	4
Mitochondrial translation initiation	87	20	10149.1681014238	10149.1932060263	10163.7689012772	957	NA	10075.5714562003	10075.6595989075	10104.773055907	954	0.882574800995453	10077.2428438048	10077.3942633632	10116.1783100805	952	NA	10071.2597063392	10071.7681809155	10144.2637056061	945	NA	3.74586780603921e-17	3.31822589133354e-16	2.35215286859783e-16	4.38266533306587e-15	3.88232429286024e-14	2.75201885625946e-14	non_linear_mixed	2.35215286859783e-16	2.75201885625946e-14	10071.7681809155	10144.2637056061	5
Signaling by NTRK1 (TRKA)	113	22	12644.0053171527	12644.0281308409	12658.8920475455	1053	NA	12594.407161688	12594.4872379511	12624.1806224736	1050	0.889519953166961	12596.7829476127	12596.9204834293	12636.4808953268	1048	0.88690369571032	12536.1027912838	12536.5643297453	12610.5364432478	1041	NA	5.11793661746237e-12	4.55042049001614e-11	2.56059392716328e-22	5.98798584243097e-10	5.32399197331889e-09	2.99589489478104e-20	non_linear_mixed	2.56059392716328e-22	2.99589489478104e-20	12536.5643297453	12610.5364432478	2
Cellular Senescence	185	25	15503.4614256064	15503.481492496	15518.7316561137	1197	NA	15469.2528272376	15469.3232379669	15499.7932882523	1194	NA	15463.8825950376	15464.0035018386	15504.6032097238	1192	0.935970136151955	15431.6274160424	15432.0328214478	15507.978568579	1185	NA	9.62359939959422e-09	1.68990231863378e-09	3.63007666708659e-15	1.12596112975252e-06	1.97718571280152e-07	4.24718970049131e-13	non_linear_mixed	3.63007666708659e-15	4.24718970049131e-13	15432.0328214478	15507.978568579	2
Glycosaminoglycan metabolism	118	25	14245.3354884764	14245.355555366	14260.6057189837	1197	NA	14244.2837828437	14244.3541935729	14274.8242438583	1194	0.915842231165554	14245.3943584097	14245.5152652107	14286.1149730959	1192	0.918516373848748	14218.1503947305	14218.5558001359	14294.5015472671	1185	NA	0.0702678712236654	0.0769205881299136	8.63992539452283e-07	1	1	0.000101087127115917	non_linear_mixed	8.63992539452283e-07	0.000101087127115917	14218.5558001359	14294.5015472671	2
Signaling by NTRKs	126	24	13697.6031761551	13697.6240820785	13712.7509406789	1149	NA	13643.0805051989	13643.1538676443	13673.3760342464	1146	0.893455385248363	13645.2207190894	13645.3467033414	13685.6147578194	1144	0.891698422588352	13577.6375293744	13578.0600645856	13653.3763519932	1137	0.903124374358163	4.54541864792886e-13	3.90793449262347e-12	9.46273431823799e-25	5.31813981807677e-11	4.57228335636946e-10	1.10713991523385e-22	non_linear_mixed	9.46273431823799e-25	1.10713991523385e-22	13578.0600645856	13653.3763519932	2
BCR	128	23	13460.9503344016	13460.9721525835	13475.9704200822	1101	NA	13453.4966446599	13453.5732171303	13483.5368160209	1098	NA	13451.70886575	13451.8403725994	13491.7624275647	1096	NA	13454.2191253932	13454.6603018637	13529.3195537957	1089	NA	0.0037514714427998	0.00173286983537563	0.00216463472333379	0.438922158807577	0.202745770738949	0.253262262630054	non_linear_fixed	0.00173286983537563	0.202745770738949	13451.8403725994	13491.7624275647	3
Nucleotide Excision Repair	96	22	12059.4875446437	12059.5103583319	12074.3742750365	1053	NA	12009.2984131575	12009.3784894206	12039.0718739431	1050	0.938320829708872	12012.9296460302	12013.0671818468	12052.6275937443	1048	0.941110132296712	12019.4890264378	12019.9505648994	12093.9226784018	1041	NA	3.8281064194612e-12	6.2372519047106e-11	4.17315283652691e-09	4.47888451076961e-10	7.2975847285114e-09	4.88258881873648e-07	linear	3.8281064194612e-12	4.47888451076961e-10	12009.3784894206	12039.0718739431	2
TGF_beta_Receptor	172	34	20281.0439288124	20281.0586708272	20297.236613419	1629	NA	20257.0992043603	20257.150896668	20289.4845735735	1626	0.907162961997051	20253.1254267806	20253.2141513647	20296.3059190648	1624	0.911119495075933	20162.5913884525	20162.8884181555	20243.5548114853	1617	0.913847763176537	1.41750262583685e-06	3.91817998008993e-07	1.91414152730228e-24	0.000165847807222911	4.58427057670522e-05	2.23954558694367e-22	non_linear_mixed	1.91414152730228e-24	2.23954558694367e-22	20162.8884181555	20243.5548114853	4
Anchoring of the basal body to the plasma membrane	96	28	14282.3035485331	14282.3214589808	14297.9137650963	1341	NA	14215.7216776052	14215.7845048303	14246.9421107317	1338	0.955566036747774	14213.965197832	14214.0730630005	14255.5924420006	1336	0.951923466620814	14206.4912399388	14206.8526857219	14284.542322755	1329	NA	1.19471858030111e-15	1.86786969129835e-15	6.05960023046691e-16	1.3978207389523e-13	2.18540753881907e-13	7.08973226964629e-14	non_linear_mixed	6.05960023046691e-16	7.08973226964629e-14	14206.8526857219	14284.542322755	2
Signaling by NOTCH	188	31	17572.9423094426	17572.9584819493	17588.8578740887	1485	NA	17564.026697889	17564.0834163224	17595.8578271813	1482	0.91590967247871	17563.9200115761	17564.0173746593	17606.3615172992	1480	0.915215531591116	17548.0765709358	17548.4026578923	17627.6543941667	1473	0.918461686003889	0.00189020334191983	0.0019038411775133	2.20782894468111e-06	0.22115379100462	0.222749417769056	0.00025831598652769	non_linear_mixed	2.20782894468111e-06	0.00025831598652769	17548.4026578923	17627.6543941667	2
Ion channel transport	164	21	13569.3935459644	13569.4174503469	13584.1407163103	1005	NA	13564.4854506225	13564.5693667064	13593.9797913143	1002	NA	13563.0198298997	13563.1639740438	13602.3456174887	1000	NA	13565.2369473312	13565.7208182989	13638.9727990606	993	NA	0.0122333621900301	0.00585427354386003	0.00524747342222458	1	0.684950004631623	0.613954390400276	non_linear_fixed	0.00585427354386003	0.684950004631623	13563.1639740438	13602.3456174887	2
SUMO E3 ligases SUMOylate target proteins	176	37	22904.9060281199	22904.9195721379	22921.3523848905	1773	NA	22881.0242998153	22881.0717842698	22913.9170133566	1770	0.927777534286609	22873.1755060091	22873.2570000669	22917.0324573976	1768	0.923922259366545	22786.2238254699	22786.4965527427	22868.4556093232	1761	NA	1.46141610458259e-06	6.67826653572383e-08	1.72008695945119e-24	0.000170985684236163	7.81357184679688e-06	2.01250174255789e-22	non_linear_mixed	1.72008695945119e-24	2.01250174255789e-22	22786.4965527427	22868.4556093232	2
Neurotransmitter receptors and postsynaptic signal transmission	184	22	13479.430998179	13479.4538118672	13494.3177285718	1053	NA	13478.5945484682	13478.6746247313	13508.3680092538	1050	NA	13481.2042217124	13481.341757529	13520.9021694265	1048	NA	13482.5157114325	13482.9772498941	13556.9493633965	1041	0.922542963873937	0.0772974618011574	0.144172456006299	0.0516347912641571	1	1	1	null	NA	NA	13479.4538118672	13494.3177285718	NA
mRNA Splicing	184	43	24897.0689388292	24897.0805893146	24913.966142209	2061	NA	24809.440424568	24809.4812607371	24843.2348313276	2058	0.909165080303486	24812.4921856144	24812.5622586071	24857.5513946272	2056	0.907663012600375	24817.1420011313	24817.3763761313	24901.6280180304	2049	0.909670123717641	3.63945993451353e-20	7.33020401143292e-19	9.43755106939013e-17	4.25816812338083e-18	8.57633869337652e-17	1.10419347511864e-14	linear	3.63945993451353e-20	4.25816812338083e-18	24809.4812607371	24843.2348313276	2
Intra-Golgi and retrograde Golgi-to-ER traffic	185	45	24031.0988997856	24031.110031511	24048.1324902876	2157	NA	23982.6472269506	23982.6862422781	24016.7144079547	2154	0.928976646030892	23982.8406101324	23982.9075557391	24028.2635181379	2152	0.922600485514568	23969.2742037746	23969.4980843716	24054.4421562848	2145	0.930032924499846	8.98839195074288e-12	2.78224030038763e-11	3.15871097536849e-13	1.05164185823692e-09	3.25522115145353e-09	3.69569184118113e-11	non_linear_mixed	3.15871097536849e-13	3.69569184118113e-11	23969.4980843716	24054.4421562848	2
Cilium Assembly	177	41	21378.8398639561	21378.8520839154	21395.594183189	1965	NA	21176.2445597497	21176.2873950378	21209.7531982154	1962	0.941391785922648	21172.48729284	21172.5607997313	21217.1654774609	1960	0.941397442019804	21018.3416621273	21018.5875637667	21102.1132582915	1953	0.946776219259513	5.85820773981861e-45	8.97854582194686e-45	7.22436998894029e-75	6.85410305558777e-43	1.05048986116778e-42	8.45251288706014e-73	non_linear_mixed	7.22436998894029e-75	8.45251288706014e-73	21018.5875637667	21102.1132582915	2
Negative regulation of the PI3K/AKT network	106	20	12630.4125315712	12630.4376361737	12645.0133314245	957	NA	12539.8327900179	12539.9209327251	12569.0343897246	954	0.92726514861602	12535.0103118001	12535.1617313585	12573.9457780758	952	0.917527782351879	12488.6687927645	12489.1772673408	12561.6727920314	945	NA	8.44865493226857e-21	3.83348360157214e-21	3.53782887564239e-29	9.88492627075423e-19	4.4851758138394e-19	4.13925978450159e-27	non_linear_mixed	3.53782887564239e-29	4.13925978450159e-27	12489.1772673408	12561.6727920314	5
Cytoprotection by HMOX1	64	23	12985.9897483406	12986.0115665225	13001.0098340212	1101	NA	12960.5831714639	12960.6597439343	12990.623342825	1098	0.915031624779847	12963.2271773469	12963.3586841962	13003.2807391616	1096	0.907622815036183	12965.7390856909	12966.1802621615	13040.8395140935	1089	NA	6.97942949141335e-07	4.1948269055612e-06	1.38405694547706e-05	8.16593250495362e-05	0.00049079474795066	0.00161934662620817	linear	6.97942949141335e-07	8.16593250495362e-05	12960.6597439343	12990.623342825	2
Notch	77	23	14064.6326018992	14064.654420081	14079.6526875797	1101	NA	13964.992174355	13965.0687468254	13995.032345716	1098	0.944304636760662	13967.3847649198	13967.5162717691	14007.4383267345	1096	0.952250319167657	13980.4948878199	13980.9360642904	14055.5953162224	1089	0.944374990436691	9.51441265678757e-23	1.56286129093408e-21	1.39645371328874e-17	1.11318628084415e-20	1.82854771039287e-19	1.63385084454783e-15	linear	9.51441265678757e-23	1.11318628084415e-20	13965.0687468254	13995.032345716	2
Toll Like Receptor 4 (TLR4) Cascade	111	21	12165.6467424521	12165.6706468346	12180.393912798	1005	NA	12132.3266719156	12132.4105879996	12161.8210126074	1002	NA	12134.2178961576	12134.3620403017	12173.5436837466	1000	0.920874758041324	12139.5937902176	12140.0776611854	12213.3296419471	993	NA	1.48475224032192e-08	7.68540768485528e-08	1.36750340429586e-06	1.73716012117665e-06	8.99192699128067e-06	0.000159997898302615	linear	1.48475224032192e-08	1.73716012117665e-06	12132.4105879996	12161.8210126074	2
Transport to the Golgi and subsequent modification	166	37	20243.2633174382	20243.2768614563	20259.7096742089	1773	NA	20224.351602487	20224.3990869415	20257.2443160283	1770	0.912454750098781	20228.2147091254	20228.2962031831	20272.0716605138	1768	0.908277363675325	20228.0483014271	20228.3210286998	20310.2800852804	1761	0.913360449903543	1.61108770673161e-05	0.000136354644091882	9.69841907991338e-05	0.00188497261687598	0.0159534933587502	0.0113471503234987	linear	1.61108770673161e-05	0.00188497261687598	20224.3990869415	20257.2443160283	2
Extra-nuclear estrogen signaling	72	20	12462.8993495072	12462.9244541097	12477.5001493606	957	NA	12456.3101396286	12456.3982823358	12485.5117393354	954	0.905613279410456	12453.2650757397	12453.4164952981	12492.2005420154	952	0.905954073738277	12408.5818758829	12409.0903504592	12481.5858751499	945	NA	0.00561467452110621	0.0014633772226951	8.63219377805822e-12	0.656916918969427	0.171215135055327	1.00996667203281e-09	non_linear_mixed	8.63219377805822e-12	1.00996667203281e-09	12409.0903504592	12481.5858751499	3
Phase II - Conjugation of compounds	110	22	10930.9377662199	10930.9605799082	10945.8244966127	1053	NA	10849.2526036164	10849.3326798795	10879.026064402	1050	0.90619686687259	10851.0520365908	10851.1895724074	10890.7499843049	1048	0.920680843771468	10856.7906566406	10857.2521951021	10931.2243086046	1041	NA	6.88149500386374e-19	7.10116052106387e-18	1.28317978786844e-15	8.05134915452058e-17	8.30835780964472e-16	1.50132035180608e-13	linear	6.88149500386374e-19	8.05134915452058e-17	10849.3326798795	10879.026064402	2
Clathrin-mediated endocytosis	141	30	17851.5619404776	17851.5786535695	17867.3791356553	1437	NA	17852.8618829464	17852.9205012297	17884.4962733018	1434	0.942515855381678	17850.9533183174	17851.0539472482	17893.132505458	1432	0.940844755446748	17835.2828447037	17835.6199233554	17914.3688205922	1425	NA	0.195124827006001	0.0597164144805745	6.46267406872486e-05	1	1	0.00756132866040808	non_linear_mixed	6.46267406872486e-05	0.00756132866040808	17835.6199233554	17914.3688205922	2
HIV Infection	191	35	19542.2245167163	19542.2388365254	19558.5041639335	1677	NA	19510.5473076494	19510.5975168544	19543.1066020838	1674	0.943573980718772	19513.9637301434	19514.0499060859	19557.3761227226	1672	0.944948525498965	19515.6050523986	19515.893513937	19597.0032884845	1665	NA	3.30808588415552e-08	3.3443637495103e-07	1.08708783207046e-06	3.87046048446196e-06	3.91290558692705e-05	0.000127189276352244	linear	3.30808588415552e-08	3.87046048446196e-06	19510.5975168544	19543.1066020838	2
Interferon Signaling	161	25	13700.6164308352	13700.6364977249	13715.8866613426	1197	NA	13681.6147548986	13681.6851656279	13712.1552159133	1194	0.933202985025704	13684.8654370091	13684.9863438101	13725.5860516953	1192	0.935469242748848	13686.563204992	13686.9686103974	13762.9143575287	1185	0.934087966417163	1.542804506262e-05	9.9725510287123e-05	0.000150513979736014	0.00180508127232654	0.0116678847035934	0.0176101356291136	linear	1.542804506262e-05	0.00180508127232654	13681.6851656279	13712.1552159133	2
G2/M Transition	137	48	25225.5276004894	25225.538035272	25242.7548065549	2301	NA	25136.433276313	25136.4698457514	25170.8876884439	2298	0.948835103768725	25122.0037317398	25122.0664768378	25167.9429479143	2296	0.946534169359156	25090.0932651495	25090.3030553592	25176.2292954767	2289	0.950157835920406	1.76215567277988e-20	7.37021315647432e-23	6.84865546514971e-28	2.06172213715246e-18	8.62314939307496e-21	8.01292689422516e-26	non_linear_mixed	6.84865546514971e-28	8.01292689422516e-26	25090.3030553592	25176.2292954767	2
Mitotic G2-G2/M phases	139	48	25225.5276004894	25225.538035272	25242.7548065549	2301	NA	25136.433276313	25136.4698457514	25170.8876884439	2298	0.948835103768725	25122.0037317398	25122.0664768378	25167.9429479143	2296	0.946534169359156	25090.0932651495	25090.3030553592	25176.2292954767	2289	0.950157835920406	1.76215567277988e-20	7.37021315647432e-23	6.84865546514971e-28	2.06172213715246e-18	8.62314939307496e-21	8.01292689422516e-26	non_linear_mixed	6.84865546514971e-28	8.01292689422516e-26	25090.3030553592	25176.2292954767	2
AndrogenReceptor	141	44	26683.3158515939	26683.3272367931	26700.2820235283	2109	NA	26585.928183673	26585.9680886612	26619.860527542	2106	0.935405189118792	26582.4330635351	26582.5015371442	26627.6761886937	2104	0.942343017682568	26558.7896098487	26559.0186174823	26643.6204695211	2097	0.937598604508569	2.90381485039782e-22	2.66636579285889e-22	1.12837441871841e-25	3.39746337496545e-20	3.1196479776449e-20	1.32019806990054e-23	non_linear_mixed	1.12837441871841e-25	1.32019806990054e-23	26559.0186174823	26643.6204695211	4
mTOR signaling pathway	63	22	13013.8111137924	13013.8339274806	13028.6978441852	1053	NA	13006.9736864028	13007.0537626659	13036.7471471884	1050	0.902391211768756	13010.6992755996	13010.8368114163	13050.3972233138	1048	0.90363145152235	13020.8697536986	13021.3312921601	13095.3034056626	1041	NA	0.0050016991727761	0.0223529629130171	0.151816494833818	0.585198803214803	1	1	linear	0.0050016991727761	0.585198803214803	13007.0537626659	13036.7471471884	2
ErbB1 downstream signaling	105	29	17769.3500858757	17769.367376942	17785.0655763984	1389	NA	17749.5758629861	17749.6365128056	17781.0068440315	1386	0.926371512165137	17753.5003786038	17753.6045000789	17795.408353331	1384	0.931888725204879	17766.1295713774	17766.4784085867	17844.7070239908	1377	0.926598524937245	1.063395929775e-05	9.54285372882798e-05	0.00718155310259461	0.00124417323783675	0.0111651388627287	0.840241713003569	linear	1.063395929775e-05	0.00124417323783675	17749.6365128056	17781.0068440315	2
PDGFR-beta signaling pathway	126	29	17814.7062848951	17814.7235759614	17830.4217754178	1389	NA	17783.4114267739	17783.4720765934	17814.8424078193	1386	0.928039756440396	17787.3087321433	17787.4128536184	17829.2167068705	1384	0.934396556429393	17799.7099961988	17800.0588334081	17878.2874488123	1377	0.928288397707542	3.98563944404277e-08	4.98494327495426e-07	0.000105382116311795	4.66319814953004e-06	5.83238363169648e-05	0.01232970760848	linear	3.98563944404277e-08	4.66319814953004e-06	17783.4720765934	17814.8424078193	2
Signaling events mediated by VEGFR1 and VEGFR2	67	20	11907.8524376645	11907.877542267	11922.4532375179	957	NA	11905.1988731256	11905.2870158328	11934.4004728323	954	0.926814776062227	11905.8981196262	11906.0495391846	11944.8335859019	952	0.922918700897331	11913.1887983195	11913.6972728957	11986.1927975864	945	NA	0.0342698053824468	0.0354191188307656	0.0969756217403902	1	1	1	linear	0.0342698053824468	1	11905.2870158328	11934.4004728323	2
Direct p53 effectors	141	31	19168.3920869206	19168.4082594273	19184.3076515667	1485	NA	19013.158938111	19013.2156565445	19044.9900674034	1482	0.937018354118733	19015.0781473998	19015.1755104829	19057.5196531229	1480	0.934436321227761	18843.3281943122	18843.6542812687	18922.9060175431	1473	NA	9.9312239087021e-35	1.94596662068507e-33	2.21045132187819e-67	1.16195319731815e-32	2.27678094620153e-31	2.58622804659749e-65	non_linear_mixed	2.21045132187819e-67	2.58622804659749e-65	18843.6542812687	18922.9060175431	3
Programmed Cell Death	141	38	22201.9894239058	22202.002610719	22218.5157854177	1821	NA	22196.4379736155	22196.4842036651	22229.4906966393	1818	0.942954076315723	22198.2548907934	22198.3342296364	22242.3251881585	1816	0.940692362470598	22201.1222803644	22201.3877670901	22283.7540879239	1809	NA	0.00908883829988418	0.0173866009927697	0.0154651387616085	1	1	1	linear	0.00908883829988418	1	22196.4842036651	22229.4906966393	2
Estrogen-dependent gene expression	141	26	16833.1967915803	16833.2160841848	16848.5846842271	1245	NA	16437.7609606394	16437.8286479883	16468.5367459329	1242	0.842465107271144	16417.088338029	16417.2045607893	16458.1227184204	1240	0.884073564479103	15949.1052441269	15949.4948545165	16026.0447073608	1233	0.890574354055214	1.08178974338295e-86	6.98036329608528e-90	1.05085110349687e-186	1.26569399975805e-84	8.16702505641977e-88	1.22949579109134e-184	non_linear_mixed	1.05085110349687e-186	1.22949579109134e-184	15949.4948545165	16026.0447073608	4
Muscle contraction	173	20	12088.1316729497	12088.1567775522	12102.7324728031	957	NA	11913.441744168	11913.5298868753	11942.6433438748	954	0.96816081347766	11915.9291221012	11916.0805416596	11954.8645883769	952	0.961655634110894	11909.8980563947	11910.406530971	11982.9020556616	945	NA	6.25851683719595e-39	1.81134086970197e-37	1.12786640013149e-36	7.32246469951926e-37	2.1192688175513e-35	1.31960368815384e-34	non_linear_mixed	1.12786640013149e-36	1.31960368815384e-34	11910.406530971	11982.9020556616	3
RHOA GTPase cycle	148	41	22289.327066701	22289.3392866603	22306.0813859339	1965	NA	22204.0989987295	22204.1418340176	22237.6076371952	1962	0.913869268126804	22207.0208804573	22207.0943873486	22251.6990650782	1960	0.905259846257599	22190.679612003	22190.9255136424	22274.4512081672	1953	NA	1.19334403707049e-19	2.20124385310506e-18	1.83097833311777e-20	1.39621252337247e-17	2.57545530813292e-16	2.1422446497478e-18	non_linear_mixed	1.83097833311777e-20	2.1422446497478e-18	22190.9255136424	22274.4512081672	2
RHOB GTPase cycle	69	22	11940.1520027664	11940.1748164546	11955.0387331592	1053	NA	11887.1311687852	11887.2112450483	11916.9046295708	1050	0.900969209259307	11889.7566257928	11889.8941616094	11929.454573507	1048	0.895480977507389	11887.7672396361	11888.2287780976	11962.2008916001	1041	NA	9.51505503675252e-13	1.00698627069607e-11	2.00935380847275e-11	1.11326143930004e-10	1.17817393671441e-09	2.35094395591312e-09	linear	9.51505503675252e-13	1.11326143930004e-10	11887.2112450483	11916.9046295708	2
RHOC GTPase cycle	73	23	12596.3283187206	12596.3501369024	12611.3484044011	1101	NA	12555.6657707048	12555.7423431752	12585.7059420658	1098	0.915711600701628	12557.8408547359	12557.9723615852	12597.8944165506	1096	0.910153774178425	12556.9725867849	12557.4137632555	12632.0730151874	1089	0.917098021997861	4.1002053105098e-10	2.82440807062006e-09	5.48121599723593e-09	4.79724021329647e-08	3.30455744262547e-07	6.41302271676604e-07	linear	4.1002053105098e-10	4.79724021329647e-08	12555.7423431752	12585.7059420658	2
Metabolism of vitamins and cofactors	179	31	17414.9483788642	17414.9645513709	17430.8639435104	1485	NA	17400.3160722944	17400.3727907279	17432.1472015867	1482	0.933854709012708	17398.8449135763	17398.9422766594	17441.2864192994	1480	0.928997300842174	17386.6791643443	17387.0052513008	17466.2569875752	1473	NA	0.000125505312678582	8.52059000416179e-05	5.55450045345781e-07	0.0146841215833941	0.00996909030486929	6.49876553054564e-05	non_linear_mixed	5.55450045345781e-07	6.49876553054564e-05	17387.0052513008	17466.2569875752	2
Toll-like Receptor Cascades	129	25	14329.8162813082	14329.8363481979	14345.0865118156	1197	NA	14291.7586655133	14291.8290762425	14322.2991265279	1194	NA	14293.6199807615	14293.7408875625	14334.3405954477	1192	NA	14297.8215485235	14298.2269539289	14374.1727010601	1185	0.927419352708804	1.46724510371256e-09	8.28355732701574e-09	1.19956673747325e-07	1.7166767713437e-07	9.69176207260841e-07	1.4034930828437e-05	linear	1.46724510371256e-09	1.7166767713437e-07	14291.8290762425	14322.2991265279	2
RAC1 GTPase cycle	184	43	26302.8752179181	26302.8868684035	26319.7724212979	2061	NA	26281.1763961541	26281.2172323232	26314.9708029137	2058	0.935666015498381	26284.2943130583	26284.364386051	26329.3535220712	2056	0.935030245634351	26287.7326603561	26287.9670353561	26372.2186772551	2049	0.936123282939765	4.20101945509864e-06	2.80163781362454e-05	9.96908285945468e-05	0.000491519276246541	0.00327791624194072	0.011663826945562	linear	4.20101945509864e-06	0.000491519276246541	26281.2172323232	26314.9708029137	2
RAC3 GTPase cycle	93	22	13882.9868763279	13883.0096900161	13897.8736067207	1053	NA	13871.7099499127	13871.7900261758	13901.4834106983	1050	0.921529077584591	13875.4562109246	13875.5937467413	13915.1541586388	1048	0.923561643341506	13882.8620124956	13883.3235509572	13957.2956644596	1041	0.922194544293504	0.000619847228571451	0.00359594710520827	0.0195599341943076	0.0725221257428597	0.420725811309368	1	linear	0.000619847228571451	0.0725221257428597	13871.7900261758	13901.4834106983	2
SUMOylation	181	40	24636.5814317069	24636.593957803	24653.261673102	1917	NA	24610.2352157076	24610.2791257965	24643.5956984977	1914	0.927926291163779	24602.51282925	24602.5881824682	24646.9934729702	1912	0.923783145162447	24507.7206315919	24507.9727324322	24591.1218385672	1905	NA	4.42397925980992e-07	2.24312576345208e-08	1.48873799100447e-26	5.17605573397761e-05	2.62445714323893e-06	1.74182344947523e-24	non_linear_mixed	1.48873799100447e-26	1.74182344947523e-24	24507.9727324322	24591.1218385672	2
RHOG GTPase cycle	73	20	12128.9817600947	12129.0068646972	12143.5825599481	957	NA	12115.6035451832	12115.6916878905	12144.80514489	954	0.922198359324864	12118.1093758179	12118.2607953763	12157.0448420936	952	0.915769136714841	12122.090349396	12122.5988239723	12195.094348663	945	0.923170047781636	0.000228328413768619	0.00085628241768622	0.00204651667076001	0.0267144244109284	0.100185042869288	0.239442450478921	linear	0.000228328413768619	0.0267144244109284	12115.6916878905	12144.80514489	2
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	80	23	13330.2234063589	13330.2452245407	13345.2434920394	1101	NA	13328.1228354398	13328.1994079102	13358.1630068008	1098	0.927993798869644	13330.3669026992	13330.4984095485	13370.4204645139	1096	0.92473443568453	13331.0602597893	13331.5014362599	13406.1606881918	1089	0.929093761062514	0.0439782976734991	0.0794047656624381	0.0263723807750535	1	1	1	linear	0.0439782976734991	1	13328.1994079102	13358.1630068008	2
CDC42 GTPase cycle	159	37	22180.6532967509	22180.666840769	22197.0996535216	1773	NA	22145.9588694319	22146.0063538864	22178.8515829732	1770	0.940040046580201	22148.1004426902	22148.1819367479	22191.9573940786	1768	0.934379691681588	22148.8842813234	22149.1570085961	22231.1160651767	1761	0.940589134490537	7.59152180814536e-09	4.55219379810156e-08	1.31708832689752e-07	8.88208051553007e-07	5.32606674377882e-06	1.54099334247009e-05	linear	7.59152180814536e-09	8.88208051553007e-07	22146.0063538864	22178.8515829732	2
mRNA Splicing - Major Pathway	176	40	23256.1627276225	23256.1752537185	23272.8429690175	1917	NA	23172.6799588419	23172.7238689308	23206.040441632	1914	0.908889342063435	23176.0094544229	23176.0848076412	23220.4900981431	1912	0.907438183304816	23181.304522893	23181.5566237333	23264.7057298683	1905	NA	2.82909770182729e-19	6.23916663883785e-18	9.31565631901726e-16	3.31004431113793e-17	7.29982496744028e-16	1.08993178932502e-13	linear	2.82909770182729e-19	3.31004431113793e-17	23172.7238689308	23206.040441632	2
Apoptosis	126	33	19346.7831857722	19346.7983756456	19362.8863114893	1581	NA	19347.77664842	19347.8299141143	19379.9828998542	1578	0.937826043218696	19349.9884874566	19350.0799160281	19392.9301560356	1576	0.938544130816172	19352.3656982793	19352.6718207283	19432.8813268649	1569	NA	0.171319072652609	0.236362066517151	0.103589657582296	1	1	1	null	NA	NA	19346.7983756456	19362.8863114893	NA
Mitochondrial translation elongation	87	20	10491.7610397496	10491.7861443521	10506.3618396029	957	NA	10390.5521465057	10390.640289213	10419.7537462125	954	0.897453109107812	10392.4480491006	10392.599468659	10431.3835153763	952	0.911170152366433	10383.2983716504	10383.8068462266	10456.3023709173	945	NA	4.37457433749165e-23	5.72368244247281e-22	1.97589441839643e-22	5.11825197486523e-21	6.69670845769319e-20	2.31179646952383e-20	non_linear_mixed	1.97589441839643e-22	2.31179646952383e-20	10383.8068462266	10456.3023709173	3
Alpha6Beta4Integrin	70	20	12033.1284021341	12033.1535067366	12047.7292019875	957	NA	12036.2725850689	12036.3607277762	12065.4741847757	954	0.907608128534969	12038.89556598	12039.0469855384	12077.8310322557	952	0.904250021488162	12045.0988638021	12045.6073383783	12118.102863069	945	NA	0.414393667019414	0.516403271424995	0.443310300779324	1	1	1	null	NA	NA	12033.1535067366	12047.7292019875	NA
Death Receptor Signalling	133	24	15036.1911381627	15036.2120440861	15051.3389026865	1149	NA	14991.9663688135	14992.0397312589	15022.2618978611	1146	0.943013776627414	14991.7771573518	14991.9031416038	15032.1711960818	1144	0.944923678833181	14998.1365731004	14998.5591083116	15073.8753957192	1137	0.943481648980194	7.15535803610048e-11	1.72288180368213e-10	9.50464181738872e-09	8.37176890223756e-09	2.01577171030809e-08	1.11204309263448e-06	non_linear_fixed	1.72288180368213e-10	2.01577171030809e-08	14991.9031416038	15032.1711960818	2