Geneset	Geneset_Size	Genes	null_AIC	null_AICc	null_BIC	null_df	NA.	linear_AIC	linear_AICc	linear_BIC	linear_df	linear_ICC	non_linear_fixed_AIC	non_linear_fixed_AICc	non_linear_fixed_BIC	non_linear_fixed_df	non_linear_fixed_ICC	non_linear_mixed_AIC	non_linear_mixed_AICc	non_linear_mixed_BIC	non_linear_mixed_df	non_linear_mixed_ICC	p_value_linear	p_value_non_linear_fixed	p_value_non_linear_mixed	adjusted_linear_p_value	adjusted_non_linear_fixed_p_value	adjusted_non_linear_mixed_p_value	best_model	best_model_pvalue	best_model_adj_pvalue	best_model_aicc	best_model_bic	OptimalClusters
Platelet activation - Homo sapiens (human)	124	24	18238.583983392	18238.600696484	18254.4011785697	1437	NA	17960.6315836403	17960.6902019236	17992.2659739957	1434	0.951024949576068	17963.9942127149	17964.0948416457	18006.1733998554	1432	0.944321559746697	17926.9137641993	17927.2508428509	18005.9997400878	1425	0.953027681322278	2.95531738895711e-61	2.05510606890575e-59	1.47375321107496e-64	4.58074195288352e-59	3.18541440680392e-57	2.28431747716619e-62	non_linear_mixed	1.47375321107496e-64	2.28431747716619e-62	17927.2508428509	18005.9997400878	3
Chronic myeloid leukemia - Homo sapiens (human)	76	20	15316.9407283577	15316.9607952473	15332.210958865	1197	NA	15224.3595933686	15224.4300040978	15254.9000543832	1194	0.956373975002609	15219.8632821703	15219.9841889713	15260.5838968565	1192	0.953414735209208	15120.9207611474	15121.3261665528	15197.271913684	1185	NA	3.13729815531542e-21	1.69786699297335e-21	2.35103374781794e-40	4.86281214073889e-19	2.6316938391087e-19	3.64410230911781e-38	non_linear_mixed	2.35103374781794e-40	3.64410230911781e-38	15121.3261665528	15197.271913684	2
Fc gamma R-mediated phagocytosis - Homo sapiens (human)	96	20	13782.9425976342	13782.9626645238	13798.2128281415	1197	NA	13553.8610717262	13553.9314824554	13584.4015327408	1194	0.950426185730236	13557.1212277214	13557.2421345224	13597.8418424076	1192	0.943523407646834	13556.6839689521	13557.0893743575	13633.0351214888	1185	NA	1.10174309486869e-50	6.04291900536222e-49	1.20838547693556e-46	1.70770179704647e-48	9.36652445831144e-47	1.87299748925011e-44	linear	1.10174309486869e-50	1.70770179704647e-48	13553.9314824554	13584.4015327408	2
Yersinia infection - Homo sapiens (human)	136	24	16456.0294794215	16456.0461925134	16471.8466745992	1437	NA	16186.6155759474	16186.6741942307	16218.2499663028	1434	0.944480076764554	16188.578456454	16188.6790853849	16230.7576435946	1432	0.936857588078824	16184.545111354	16184.8821900056	16263.6310872425	1425	0.945426752245859	2.08032942688233e-59	7.02362875102908e-58	4.16459896021855e-56	3.22451061166761e-57	1.08866245640951e-55	6.45512838833876e-54	non_linear_mixed	4.16459896021855e-56	6.45512838833876e-54	16184.8821900056	16263.6310872425	2
Insulin resistance - Homo sapiens (human)	108	23	16998.9843347855	16999.001776646	17014.67385112	1377	NA	16977.9859048851	16978.0470847831	17009.364937554	1374	0.954520058622329	16974.3391553313	16974.4441881541	17016.1778655565	1372	0.954157584169588	16844.7528229077	16845.1047290661	16923.20040458	1365	NA	5.89181941526998e-06	1.77098833695715e-06	9.83757289942565e-32	0.000913232009366848	0.000274503192228359	1.52482379941098e-29	non_linear_mixed	9.83757289942565e-32	1.52482379941098e-29	16845.1047290661	16923.20040458	2
Cushing syndrome - Homo sapiens (human)	155	24	16364.2929500161	16364.3096631081	16380.1101451938	1437	NA	16030.013460994	16030.0720792773	16061.6478513494	1434	0.928337246989686	16031.8055876263	16031.9062165571	16073.9847747669	1432	0.915191694840043	16039.6374071422	16039.9744857939	16118.7233830308	1425	NA	1.89835076891505e-73	7.25100865314076e-72	2.69541740868809e-67	2.94244369181832e-71	1.12390634123682e-69	4.17789698346654e-65	linear	1.89835076891505e-73	2.94244369181832e-71	16030.0720792773	16061.6478513494	2
Growth hormone synthesis, secretion and action - Homo sapiens (human)	119	22	14690.1204085449	14690.138645627	14705.6765695916	1317	NA	14327.5739961902	14327.6379718185	14358.6863182837	1314	NA	14330.2892480387	14330.3990878556	14371.7723441633	1312	NA	14343.6011694932	14343.9692676527	14421.3819747269	1305	NA	1.43721979222115e-79	9.38698364900779e-78	6.52091226847853e-72	2.22769067794278e-77	1.45498246559621e-75	1.01074140161417e-69	linear	1.43721979222115e-79	2.22769067794278e-77	14327.6379718185	14358.6863182837	2
Cell cycle - Homo sapiens (human)	124	35	24959.2419804591	24959.2534308408	24976.1910583302	2097	NA	24921.8789954665	24921.9191292458	24955.7771512088	2094	NA	24894.3355333676	24894.4043999386	24939.5330743573	2092	NA	24640.7776554803	24641.0079817758	24725.5230448359	2085	NA	2.0608051731815e-09	9.73069423691111e-15	5.44947713822209e-66	3.19424801843133e-07	1.50825760672122e-12	8.44668956424423e-64	non_linear_mixed	5.44947713822209e-66	8.44668956424423e-64	24641.0079817758	24725.5230448359	2
Oocyte meiosis - Homo sapiens (human)	129	32	20774.4428247097	20774.4553508057	20791.1230661047	1917	NA	20492.147126759	20492.1910368478	20525.5076095491	1914	0.951077518852922	20473.7031262654	20473.7784794836	20518.1837699855	1912	0.944649804721305	20469.4659521981	20469.7180530384	20552.8671591734	1905	NA	3.39423895790487e-62	4.91283073639792e-65	3.78788953673313e-63	5.26107038475256e-60	7.61488764141678e-63	5.87122878193636e-61	non_linear_mixed	3.78788953673313e-63	5.87122878193636e-61	20469.7180530384	20552.8671591734	2
HIF-1 signaling pathway - Homo sapiens (human)	109	23	16631.2531472073	16631.2705890678	16646.9426635417	1377	NA	16496.5437830584	16496.6049629565	16527.9228157273	1374	0.956587970709887	16499.6433724053	16499.748405228	16541.4820826305	1372	0.953483428381579	16490.7694962231	16491.1214023814	16569.2170778954	1365	0.957460378972313	2.65769768108658e-30	8.13681348388868e-29	6.39731146452613e-29	4.11943140568419e-28	1.26120609000275e-26	9.9158327700155e-27	non_linear_mixed	6.39731146452613e-29	9.9158327700155e-27	16491.1214023814	16569.2170778954	2
Tight junction - Homo sapiens (human)	169	29	20490.7867915653	20490.8006164501	20507.1717127419	1737	NA	20258.8733717516	20258.9218426114	20291.6432141049	1734	0.940778909915342	20253.5342187896	20253.6174076977	20297.2273419273	1732	0.933915103782339	20236.5495665614	20236.8279888352	20318.4741724445	1725	0.942026491986119	2.68980559334239e-51	2.13586964148595e-51	1.71821105661336e-52	4.16919866968071e-49	3.31059794430322e-49	2.66322713775071e-50	non_linear_mixed	1.71821105661336e-52	2.66322713775071e-50	20236.8279888352	20318.4741724445	4
Small cell lung cancer - Homo sapiens (human)	92	25	17252.0703658948	17252.0864086755	17268.0100270561	1497	NA	16868.6043818419	16868.6606444005	16900.4837041644	1494	0.93937524791959	16868.8169994024	16868.9135788793	16911.3227624991	1492	0.920499867305344	16876.2950106557	16876.6184607904	16955.993316462	1485	NA	4.23469157923417e-84	8.43825814650018e-83	4.22258635389337e-78	6.56377194781296e-82	1.30793001270753e-80	6.54500884853472e-76	linear	4.23469157923417e-84	6.56377194781296e-82	16868.6606444005	16900.4837041644	2
Gastric cancer - Homo sapiens (human)	149	23	16054.3297431656	16054.347185026	16070.0192595	1377	NA	15657.2237438495	15657.2849237475	15688.6027765184	1374	NA	15661.0613019917	15661.1663348145	15702.9000122169	1372	NA	15673.2121674546	15673.564073613	15751.6597491269	1365	NA	4.70291922545623e-87	5.85878528026054e-85	3.12039839988669e-79	7.28952479945715e-85	9.08111718440383e-83	4.83661751982437e-77	linear	4.70291922545623e-87	7.28952479945715e-85	15657.2849237475	15688.6027765184	2
Ubiquitin mediated proteolysis - Homo sapiens (human)	140	22	16319.8871694288	16319.9054065108	16335.4433304755	1317	NA	16296.4180325098	16296.4820081381	16327.5303546033	1314	NA	16287.6859610407	16287.7958008576	16329.1690571653	1312	NA	16142.471354558	16142.8394527175	16220.2521597917	1305	NA	1.78456861144413e-06	5.36318378876638e-08	1.66391802597663e-36	0.00027660813477384	8.31293487258789e-06	2.57907294026378e-34	non_linear_mixed	1.66391802597663e-36	2.57907294026378e-34	16142.8394527175	16220.2521597917	3
Breast cancer - Homo sapiens (human)	147	21	15544.8559143082	15544.8750225884	15560.272515308	1257	NA	15096.2360787572	15096.3031178633	15127.0692807569	1254	0.931165988275031	15098.2644405305	15098.3795484441	15139.37537653	1252	0.91310587798769	15059.5761409774	15059.9619930674	15136.6591459766	1245	0.934653960497277	3.25292042477206e-98	1.85943966507188e-96	2.3460170205871e-101	5.04202665839669e-96	2.88213148086141e-94	3.63632638191001e-99	non_linear_mixed	2.3460170205871e-101	3.63632638191001e-99	15059.9619930674	15136.6591459766	5
Wnt signaling pathway - Homo sapiens (human)	166	24	17011.6360953277	17011.6528084196	17027.4532905054	1437	NA	16710.7547753952	16710.8133936785	16742.3891657506	1434	0.927375942080647	16713.7379849022	16713.838613833	16755.9171720427	1432	0.915832588856589	16681.6712150799	16682.0082937316	16760.7571909685	1425	NA	3.22404948669481e-66	2.00645209252219e-64	2.04336538995243e-68	4.99727670437696e-64	3.1100007434094e-62	3.16721635442626e-66	non_linear_mixed	2.04336538995243e-68	3.16721635442626e-66	16682.0082937316	16760.7571909685	2
Autophagy - animal - Homo sapiens (human)	137	32	23805.9251715829	23805.9376976789	23822.6054129779	1917	NA	23401.99432561	23402.0382356988	23435.3548084001	1914	0.93779674633235	23396.6630122908	23396.738365509	23441.1436560109	1912	0.926734838882345	23316.2246563666	23316.4767572069	23399.6258633419	1905	NA	1.5631431824959e-88	2.08944055766792e-88	2.68579508050816e-102	2.42287193286865e-86	3.23863286438528e-86	4.16298237478765e-100	non_linear_mixed	2.68579508050816e-102	4.16298237478765e-100	23316.4767572069	23399.6258633419	2
Lysosome - Homo sapiens (human)	128	22	15972.6964084883	15972.7146455704	15988.252569535	1317	NA	15742.9352613497	15742.9992369781	15774.0475834432	1314	0.930060645223691	15745.8564526261	15745.9662924431	15787.3395487508	1312	0.919689870525566	15703.7562200243	15704.1243181838	15781.537025258	1305	0.933344488144172	7.85459995553257e-51	3.65466610892809e-49	1.42359762872213e-55	1.21746299310755e-48	5.66473246883854e-47	2.2065763245193e-53	non_linear_mixed	1.42359762872213e-55	2.2065763245193e-53	15704.1243181838	15781.537025258	5
FoxO signaling pathway - Homo sapiens (human)	131	30	21999.424522092	21999.4378851209	22015.9111479236	1797	NA	21914.9748340489	21915.0216829056	21947.9480857123	1794	0.959609368285711	21913.9839660213	21914.0643680314	21957.9483015724	1792	0.957311803972282	21735.4720068269	21735.7410651229	21817.9051359852	1785	NA	1.75375004162289e-19	4.82328765847641e-19	1.58277228289408e-54	2.71831256451548e-17	7.47609587063843e-17	2.45329703848583e-52	non_linear_mixed	1.58277228289408e-54	2.45329703848583e-52	21735.7410651229	21817.9051359852	2
Spinocerebellar ataxia - Homo sapiens (human)	143	21	15612.8880190262	15612.9071273065	15628.304620026	1257	NA	15509.3328586228	15509.399897729	15540.1660606225	1254	NA	15501.6384663939	15501.7535743076	15542.7494023935	1252	NA	15426.6102958027	15426.9961478927	15503.6933008019	1245	0.952933079455751	1.36793962158661e-23	1.70621466484172e-24	2.45107274488455e-38	2.12030641345925e-21	2.64463273050467e-22	3.79916275457105e-36	non_linear_mixed	2.45107274488455e-38	3.79916275457105e-36	15426.9961478927	15503.6933008019	3
RNA transport - Homo sapiens (human)	186	27	21543.4622494747	21543.4771009599	21559.6327937594	1617	NA	21350.6799554173	21350.7320322927	21383.0210439867	1614	0.960793164797779	21303.7923946097	21303.8817800845	21346.9138460355	1612	0.956771791564235	21133.0685618251	21133.3678136954	21213.9212832485	1605	0.964525006087872	7.73162405501721e-43	6.47076652671662e-52	1.93982418677152e-85	1.19840172852767e-40	1.00296881164108e-49	3.00672748949585e-83	non_linear_mixed	1.93982418677152e-85	3.00672748949585e-83	21133.3678136954	21213.9212832485	2
p53 signaling pathway - Homo sapiens (human)	73	22	16927.426023939	16927.4442610211	16942.9821849858	1317	NA	16783.0160697583	16783.0800453867	16814.1283918518	1314	0.956016445292811	16770.9490571977	16771.0588970146	16812.4321533223	1312	0.952033437425901	16674.0065957157	16674.3746938752	16751.7874009494	1305	NA	2.14946776148863e-32	4.11754600466134e-34	2.54867246741793e-52	3.33167503030738e-30	6.38219630722508e-32	3.95044232449779e-50	non_linear_mixed	2.54867246741793e-52	3.95044232449779e-50	16674.3746938752	16751.7874009494	2
AMPK signaling pathway - Homo sapiens (human)	120	24	17741.7872782214	17741.8039913133	17757.6044733991	1437	NA	17668.6140537642	17668.6726720476	17700.2484441197	1434	0.933382174042239	17670.8980424734	17670.9986714042	17713.0772296139	1432	0.928731849921232	17647.9322609747	17648.2693396264	17727.0182368633	1425	NA	4.61707591673733e-17	5.46746128594565e-16	1.6531316300259e-19	7.15646767094286e-15	8.47456499321576e-14	2.56235402654015e-17	non_linear_mixed	1.6531316300259e-19	2.56235402654015e-17	17648.2693396264	17727.0182368633	2
Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)	143	21	13958.9851270462	13959.0042353265	13974.4017280461	1257	NA	13634.0693673581	13634.1364064642	13664.9025693577	1254	0.943206802459398	13637.6767818413	13637.791889755	13678.7877178409	1252	0.932393209944431	13645.3792101363	13645.7650622263	13722.4622151355	1245	NA	2.02144108044194e-71	1.84671924314256e-69	5.76108159231826e-65	3.13323367468501e-69	2.86241482687097e-67	8.92967646809331e-63	linear	2.02144108044194e-71	3.13323367468501e-69	13634.1364064642	13664.9025693577	2
Sphingolipid signaling pathway - Homo sapiens (human)	119	27	20031.1527133345	20031.1675648196	20047.3232576192	1617	NA	19865.4407243978	19865.4928012732	19897.7818129671	1614	0.940345892367498	19862.6376943815	19862.7270798564	19905.7591458073	1612	0.934442352164939	19790.1645412236	19790.4637930939	19871.017262647	1605	0.943799615580472	5.43329400536268e-37	1.11061849988188e-36	1.01607501531635e-49	8.42160570831215e-35	1.72145867481691e-34	1.57491627374034e-47	non_linear_mixed	1.01607501531635e-49	1.57491627374034e-47	19790.4637930939	19871.017262647	2
Hepatocellular carcinoma - Homo sapiens (human)	168	30	20493.3141018175	20493.3274648465	20509.8007276492	1797	NA	20005.1394761328	20005.1863249895	20038.1127277961	1794	0.949552439216917	20005.4914631773	20005.5718651873	20049.4557987284	1792	0.940038793175454	20007.6962029423	20007.9652612383	20090.1293321006	1785	NA	8.73172285204412e-107	2.35631219681692e-105	1.98766701040969e-101	1.35341704206684e-104	3.65228390506623e-103	3.08088386613502e-99	linear	8.73172285204412e-107	1.35341704206684e-104	20005.1863249895	20038.1127277961	2
Hippo signaling pathway - Homo sapiens (human)	157	23	14965.9454005159	14965.9628423764	14981.6349168504	1377	NA	14793.0276350323	14793.0888149303	14824.4066677012	1374	0.938826869286072	14791.0299966779	14791.1350295007	14832.8687069031	1372	0.93309279481504	14793.5907805233	14793.9426866816	14872.0383621956	1365	0.939436218414839	1.51068867639894e-38	4.76908731967129e-38	1.8427516189565e-35	2.34156744841835e-36	7.3920853454905e-36	2.85626500938258e-33	non_linear_fixed	4.76908731967129e-38	7.3920853454905e-36	14791.1350295007	14832.8687069031	3
Protein processing in endoplasmic reticulum - Homo sapiens (human)	170	37	26523.7159359854	26523.7267663103	26540.83172341	2217	NA	26267.1954457377	26267.2334032614	26301.4270205869	2214	0.931725699600405	26233.074930217	26233.140059118	26278.717030016	2212	0.928300065937204	26198.896824334	26199.1146101779	26284.475761457	2205	0.933254893348367	1.28105120694702e-56	7.29210043342763e-63	2.48954549675117e-67	1.98562937076789e-54	1.13027556718128e-60	3.85879551996432e-65	non_linear_mixed	2.48954549675117e-67	3.85879551996432e-65	26199.1146101779	26284.475761457	5
Axon guidance - Homo sapiens (human)	182	31	19810.1561262692	19810.1690573037	19826.7411215694	1857	NA	19347.1015895416	19347.1469214359	19380.2715801419	1854	0.951391073049148	19350.8448162118	19350.9226119978	19395.0714703454	1852	0.942813770883307	19358.4734700271	19358.7337737148	19441.3984465277	1845	NA	2.42424314454011e-101	3.35063716534944e-99	3.29812064697037e-94	3.75757687403716e-99	5.19348760629163e-97	5.11208700280407e-92	linear	2.42424314454011e-101	3.75757687403716e-99	19347.1469214359	19380.2715801419	2
NOD-like receptor signaling pathway - Homo sapiens (human)	181	22	15153.5302755322	15153.5485126143	15169.0864365789	1317	NA	14993.8052035052	14993.8691791335	15024.9175255986	1314	0.944478258969416	14991.0173042586	14991.1271440755	15032.5004003832	1312	0.938700031438979	14942.9823273916	14943.3504255511	15020.7631326253	1305	NA	1.06534256154425e-35	2.12258917710747e-35	2.26016730517688e-43	1.65128097039359e-33	3.29001322451657e-33	3.50325932302416e-41	non_linear_mixed	2.26016730517688e-43	3.50325932302416e-41	14943.3504255511	15020.7631326253	4
Apelin signaling pathway - Homo sapiens (human)	137	21	15754.5791312885	15754.5982395688	15769.9957322884	1257	NA	15654.0749060249	15654.141945131	15684.9081080246	1254	0.95909514559661	15654.6881635728	15654.8032714865	15695.7990995724	1252	0.956402880016942	15614.8968773751	15615.2827294651	15691.9798823743	1245	NA	6.20221189726411e-23	4.32058582427762e-22	9.32281288377803e-29	9.61342844075937e-21	6.69690802763031e-20	1.44503599698559e-26	non_linear_mixed	9.32281288377803e-29	1.44503599698559e-26	15615.2827294651	15691.9798823743	3
Estrogen signaling pathway - Homo sapiens (human)	137	26	19442.1046381474	19442.1200623119	19458.1619614481	1557	NA	19183.5691023406	19183.6231912008	19215.683748942	1554	0.901149374820962	19178.0401390787	19178.1329824056	19220.8596678806	1552	0.888415946219409	18997.3741809552	18997.6850617842	19077.6607974589	1545	NA	4.69518655556489e-57	3.74967269914514e-57	9.91023158747914e-93	7.27753916112558e-55	5.81199268367496e-55	1.53608589605927e-90	non_linear_mixed	9.91023158747914e-93	1.53608589605927e-90	18997.6850617842	19077.6607974589	2
Fluid shear stress and atherosclerosis - Homo sapiens (human)	139	25	16321.4224059718	16321.4384487526	16337.3620671331	1497	NA	16132.0299165553	16132.0861791139	16163.9092388779	1494	0.936816608560774	16135.3328973892	16135.4294768661	16177.838660486	1492	0.935072662491978	16075.1035050561	16075.4269551909	16154.8018108625	1485	0.939835765119818	4.17503264808446e-42	1.94908956712911e-40	7.80354394984082e-51	6.47130060453091e-40	3.02108882905012e-38	1.20954931222533e-48	non_linear_mixed	7.80354394984082e-51	1.20954931222533e-48	16075.4269551909	16154.8018108625	2
Tuberculosis - Homo sapiens (human)	179	20	14761.3786455895	14761.3987124791	14776.6488760968	1197	NA	14640.7501125148	14640.8205232441	14671.2905735295	1194	0.92797933704735	14629.956500366	14630.077407167	14670.6771150522	1192	0.920046407776537	14600.0378502851	14600.4432556905	14676.3890028217	1185	0.93096972372376	2.88110580814347e-27	8.91961291876448e-29	3.41266563141087e-33	4.46571400262238e-25	1.38254000240849e-26	5.28963172868685e-31	non_linear_mixed	3.41266563141087e-33	5.28963172868685e-31	14600.4432556905	14676.3890028217	2
Phospholipase D signaling pathway - Homo sapiens (human)	147	30	21382.8159408415	21382.8293038704	21399.3025666731	1797	NA	21126.9570266907	21127.0038755474	21159.930278354	1794	0.952550779583627	21129.994059518	21130.074461528	21173.9583950691	1792	0.947589572555581	21007.1821822885	21007.4512405844	21089.6153114467	1785	NA	1.78107465937804e-56	9.73223262709745e-55	4.524395118316e-78	2.76066572203597e-54	1.5084960572001e-52	7.01281243338981e-76	non_linear_mixed	4.524395118316e-78	7.01281243338981e-76	21007.4512405844	21089.6153114467	5
Pathogenic Escherichia coli infection - Homo sapiens (human)	196	46	34564.5790838064	34564.5877920792	34582.3480416825	2757	NA	34203.4487255987	34203.4792377673	34238.986641351	2754	0.942151413465179	34202.6778058867	34202.7301504887	34250.0616935564	2752	0.934658713096248	34166.5491603311	34166.7240874448	34255.3939497118	2745	NA	2.91195060631008e-79	3.36219173204087e-78	8.13046431820346e-83	4.51352343978063e-77	5.21139718466335e-76	1.26022196932154e-80	non_linear_mixed	8.13046431820346e-83	1.26022196932154e-80	34166.7240874448	34255.3939497118	3
Transcriptional misregulation in cancer - Homo sapiens (human)	191	21	16125.1165165439	16125.1356248242	16140.5331175438	1257	NA	16019.723663077	16019.7907021831	16050.5568650767	1254	0.95190685620527	16009.4262809811	16009.5413888948	16050.5372169807	1252	0.948532178974895	15912.821520917	15913.207373007	15989.9045259162	1245	NA	5.50256912406435e-24	1.95347213580067e-25	9.7892198114245e-44	8.52898214229974e-22	3.02788181049104e-23	1.5173290707708e-41	non_linear_mixed	9.7892198114245e-44	1.5173290707708e-41	15913.207373007	15989.9045259162	5
Hepatitis C - Homo sapiens (human)	157	29	20814.1854635188	20814.1992884036	20830.5703846954	1737	NA	20436.56940738	20436.6178782398	20469.3392497333	1734	0.935879546537533	20438.3422745524	20438.4254634605	20482.03539769	1732	0.924957980764328	20445.780796283	20446.0592185568	20527.7054021661	1725	NA	7.83155473655085e-83	3.33444424245296e-81	1.53426714023699e-76	1.21389098416538e-80	5.16838857580209e-79	2.37811406736734e-74	linear	7.83155473655085e-83	1.21389098416538e-80	20436.6178782398	20469.3392497333	2
ErbB signaling pathway - Homo sapiens (human)	85	21	14168.745315078	14168.7644233582	14184.1619160778	1257	NA	13848.3331120247	13848.4001511309	13879.1663140244	1254	0.935131894109612	13851.7965892526	13851.9116971663	13892.9075252522	1252	0.923257874359931	13858.967526325	13859.3533784151	13936.0505313242	1245	NA	1.90826373654894e-70	1.601413119394e-68	3.6911236239196e-64	2.95780879165086e-68	2.4821903350607e-66	5.72124161707537e-62	linear	1.90826373654894e-70	2.95780879165086e-68	13848.4001511309	13879.1663140244	2
Insulin signaling pathway - Homo sapiens (human)	137	35	24986.0832532035	24986.0947035852	25003.0323310746	2097	NA	24739.183076014	24739.2232097932	24773.0812317562	2094	0.957969995898011	24740.8746403965	24740.9435069675	24786.0721813862	2092	0.954610686536922	24725.9760231816	24726.2063494772	24810.7214125373	2085	0.958732751212343	1.54364027385689e-54	4.19189842945189e-53	1.01257450026822e-53	2.39264242447818e-52	6.49744256565043e-51	1.56949047541574e-51	non_linear_mixed	1.01257450026822e-53	1.56949047541574e-51	24726.2063494772	24810.7214125373	2
Osteoclast differentiation - Homo sapiens (human)	127	20	13144.4199365563	13144.440003446	13159.6901670637	1197	NA	12816.4308142106	12816.5012249398	12846.9712752252	1194	NA	12820.0912233793	12820.2121301803	12860.8118380655	1192	0.945377624358773	12827.0407283973	12827.4461338027	12903.3918809339	1185	NA	4.36801712747726e-72	4.13440327115545e-70	9.22857454572157e-66	6.77042654758975e-70	6.40832507029094e-68	1.43042905458684e-63	linear	4.36801712747726e-72	6.77042654758975e-70	12816.5012249398	12846.9712752252	3
Apoptosis - Homo sapiens (human)	136	37	25773.2244531768	25773.2352835017	25790.3402406014	2217	NA	25451.9899659174	25452.0279234411	25486.2215407666	2214	0.928182777457827	25441.0514434248	25441.1165723257	25486.6935432237	2212	0.917283225138216	25373.7561945811	25373.973980425	25459.3351317041	2205	0.931271230200652	1.26655682107943e-70	8.47353279148034e-72	4.02844543125501e-83	1.96316307267312e-68	1.31339758267945e-69	6.24409041844527e-81	non_linear_mixed	4.02844543125501e-83	6.24409041844527e-81	25373.973980425	25459.3351317041	5
Cellular senescence - Homo sapiens (human)	156	44	31453.5695312449	31453.578635949	31471.2051338333	2637	NA	31328.3988618735	31328.430764646	31363.6700670503	2634	0.959020009191317	31318.6832701052	31318.7380021462	31365.7115436743	2632	0.956722817997295	31075.5515012174	31075.7344280467	31163.7295141595	2625	NA	3.0254037229226e-28	1.63556862719582e-29	1.41473126982145e-78	4.68937577053003e-26	2.53513137215353e-27	2.19283346822325e-76	non_linear_mixed	1.41473126982145e-78	2.19283346822325e-76	31075.7344280467	31163.7295141595	2
Influenza A - Homo sapiens (human)	172	26	18780.1043351149	18780.1197592794	18796.1616584156	1557	NA	18565.4989180716	18565.5530069319	18597.6135646731	1554	0.93698113823341	18555.7318545109	18555.8246978378	18598.5513833128	1552	0.929058937632901	18499.8485362048	18500.1594170338	18580.1351527085	1545	0.940223188681439	1.48540859356468e-47	1.2356295473729e-48	5.99750655992344e-58	2.30238332002526e-45	1.915225798428e-46	9.29613516788133e-56	non_linear_mixed	5.99750655992344e-58	9.29613516788133e-56	18500.1594170338	18580.1351527085	2
Pancreatic cancer - Homo sapiens (human)	76	20	14120.2628308226	14120.2828977122	14135.5330613299	1197	NA	13770.7951603611	13770.8655710904	13801.3356213758	1194	NA	13774.6095593326	13774.7304661336	13815.3301740188	1192	NA	13785.7552658216	13786.160671227	13862.1064183582	1185	NA	9.76636313692586e-77	1.06142803313313e-74	2.24619384554956e-69	1.51378628622351e-74	1.64521345135635e-72	3.48160046060181e-67	linear	9.76636313692586e-77	1.51378628622351e-74	13770.8655710904	13801.3356213758	2
mTOR signaling pathway - Homo sapiens (human)	154	30	22313.9047500422	22313.9181130711	22330.3913758738	1797	NA	22254.3095269033	22254.3563757599	22287.2827785666	1794	0.952596812153845	22243.9408483125	22244.0212503225	22287.9051838635	1792	0.951479749007299	22131.6332107025	22131.9022689985	22214.0663398608	1785	0.956217988834633	3.74136528669359e-14	8.53902541383152e-16	1.65169900280713e-37	5.79911619437506e-12	1.32354893914389e-13	2.56013345435105e-35	non_linear_mixed	1.65169900280713e-37	2.56013345435105e-35	22131.9022689985	22214.0663398608	3
Thyroid hormone signaling pathway - Homo sapiens (human)	121	28	21282.729424353	21282.743744162	21299.0090715702	1677	NA	21071.7405314229	21071.7907406279	21104.2998258572	1674	0.948207559352548	21074.7042756077	21074.7904515503	21118.1166681869	1672	0.943816325182923	20919.6268247896	20919.915286328	21001.0250608755	1665	NA	8.98684395656099e-47	3.93533039283719e-45	2.03162662075229e-75	1.39296081326695e-44	6.09976210889765e-43	3.14902126216604e-73	non_linear_mixed	2.03162662075229e-75	3.14902126216604e-73	20919.915286328	21001.0250608755	3
Hepatitis B - Homo sapiens (human)	162	26	17855.9422189805	17855.9576431451	17871.9995422813	1557	NA	17392.3640943485	17392.4181832088	17424.47874095	1554	NA	17393.8617689161	17393.954612243	17436.681297718	1552	NA	17405.0163754088	17405.3272562378	17485.3029919124	1545	NA	1.86690293968105e-101	8.46510856179981e-100	4.77709065939666e-94	2.89369955650562e-99	1.31209182707897e-97	7.40449052206483e-92	linear	1.86690293968105e-101	2.89369955650562e-99	17392.4181832088	17424.47874095	2
Neurotrophin signaling pathway - Homo sapiens (human)	119	22	15944.5294928576	15944.5477299396	15960.0856539043	1317	NA	15665.2490763773	15665.3130520056	15696.3613984708	1314	0.945918597476278	15668.0050355219	15668.1148753388	15709.4881316465	1312	0.938193403562162	15642.8658952043	15643.2339933638	15720.646700438	1305	NA	1.5248780850495e-61	7.89051206048369e-60	1.88808620376625e-62	2.36356103182672e-59	1.22302936937497e-57	2.92653361583768e-60	non_linear_mixed	1.88808620376625e-62	2.92653361583768e-60	15643.2339933638	15720.646700438	3
Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)	193	30	20599.3841833488	20599.3975463778	20615.8708091805	1797	NA	20077.0368439547	20077.0836928114	20110.010095618	1794	NA	20078.7382160968	20078.8186181069	20122.7025516479	1792	NA	20089.3989245178	20089.6679828138	20171.8320536761	1785	NA	3.42809205832539e-114	1.93273073956264e-112	1.28253214712754e-106	5.31354269040435e-112	2.9957326463221e-110	1.98792482804768e-104	linear	3.42809205832539e-114	5.31354269040435e-112	20077.0836928114	20110.010095618	2
EGF-Ncore	56	20	15005.0414831262	15005.0615500158	15020.3117136335	1197	NA	14988.0847355411	14988.1551462703	15018.6251965557	1194	NA	14972.9588116138	14973.0797184148	15013.6794263	1192	NA	14845.0856230163	14845.4910284217	14921.4367755529	1185	NA	4.12300461269722e-05	5.6678067992439e-08	6.57239685628276e-33	0.0063906571496807	8.78510053882805e-06	1.01872151272383e-30	non_linear_mixed	6.57239685628276e-33	1.01872151272383e-30	14845.4910284217	14921.4367755529	2
Cell cycle	120	34	24304.9808147584	24304.9926025776	24321.8429300189	2037	NA	24268.8488903307	24268.8902085796	24302.5731208517	2034	NA	24241.4377536509	24241.5086546849	24286.4033943456	2032	NA	23996.2475515291	23996.4847056793	24080.5581278317	2025	0.967001745199682	3.76164956804344e-09	1.87305718911044e-14	6.12646476064593e-64	5.83055683046733e-07	2.90323864312118e-12	9.49602037900119e-62	non_linear_mixed	6.12646476064593e-64	9.49602037900119e-62	23996.4847056793	24080.5581278317	2
Regulation of toll-like receptor signaling pathway	145	20	13701.8764294799	13701.8964963695	13717.1466599872	1197	NA	13305.9767603977	13306.0471711269	13336.5172214123	1194	NA	13306.3312686841	13306.4521754851	13347.0518833703	1192	NA	13311.8291227865	13312.2345281919	13388.1802753232	1185	0.952629404496187	8.58363426981575e-87	1.89266427846753e-85	4.00178177004285e-81	1.33046331182144e-84	2.93362963162467e-83	6.20276174356642e-79	linear	8.58363426981575e-87	1.33046331182144e-84	13306.0471711269	13336.5172214123	2
miRNA regulation of DNA damage response	98	21	15828.1742915502	15828.1933998304	15843.59089255	1257	NA	15769.7170277795	15769.7840668856	15800.5502297791	1254	0.960533175847402	15752.9460554576	15753.0611633713	15794.0569914572	1252	0.958161159413777	15634.3355520241	15634.7214041142	15711.4185570233	1245	NA	6.55309553095217e-14	6.74237808398531e-17	6.66000584842162e-40	1.01572980729759e-11	1.04506860301772e-14	1.03230090650535e-37	non_linear_mixed	6.66000584842162e-40	1.03230090650535e-37	15634.7214041142	15711.4185570233	2
Apoptosis Modulation and Signaling	92	23	16604.7182133387	16604.7356551991	16620.4077296731	1377	NA	16439.4327343139	16439.4939142119	16470.8117669828	1374	0.937247897254117	16442.2171576024	16442.3221904251	16484.0558678276	1372	0.93021875398929	16450.5685542752	16450.9204604336	16529.0161359475	1365	NA	6.71652771359472e-37	2.13505414514108e-35	1.02253026763705e-31	1.04106179560718e-34	3.30933392496868e-33	1.58492191483742e-29	linear	6.71652771359472e-37	1.04106179560718e-34	16439.4939142119	16470.8117669828	2
Leptin signaling pathway	76	20	15279.7965541019	15279.8166209916	15295.0667846093	1197	NA	15012.1908982852	15012.2613090145	15042.7313592999	1194	0.947629063698816	15015.5043992324	15015.6253060334	15056.2250139186	1192	0.941091587866331	14988.4483207592	14988.8537261646	15064.7994732959	1185	NA	5.12115613034981e-59	3.35039109629882e-57	2.7959220197754e-60	7.9377920020422e-57	5.19310619926318e-55	4.33367913065187e-58	non_linear_mixed	2.7959220197754e-60	4.33367913065187e-58	14988.8537261646	15064.7994732959	3
Alzheimer,s disease	144	21	13958.6594854263	13958.6785937066	13974.0760864262	1257	NA	13674.4804044462	13674.5474435523	13705.3136064459	1254	0.941421319688401	13677.7652088844	13677.880316798	13718.8761448839	1252	0.93117640970545	13686.4132738353	13686.7991259253	13763.4962788345	1245	NA	1.32793029097826e-62	9.07827117706123e-61	2.88199933271398e-56	2.05829195101631e-60	1.40713203244449e-58	4.46709896570666e-54	linear	1.32793029097826e-62	2.05829195101631e-60	13674.5474435523	13705.3136064459	2
Glioblastoma signaling pathways	83	22	16629.8077157129	16629.825952795	16645.3638767596	1317	NA	16553.3214553217	16553.38543095	16584.4337774152	1314	0.953687642230865	16551.8797329441	16551.989572761	16593.3628290688	1312	0.951199971428744	16429.1411023795	16429.509200539	16506.9219076132	1305	NA	8.98751230334591e-18	1.82987824512481e-17	2.55396772083101e-41	1.39306440701862e-15	2.83631127994346e-15	3.95864996728807e-39	non_linear_mixed	2.55396772083101e-41	3.95864996728807e-39	16429.509200539	16506.9219076132	2
TNF-alpha signaling pathway	93	20	13805.7415192	13805.7615860896	13821.0117497073	1197	NA	13417.6421382514	13417.7125489806	13448.182599266	1194	NA	13417.3487161246	13417.4696229256	13458.0693308108	1192	NA	13427.3698087526	13427.775214158	13503.7209612892	1185	NA	4.19998299913559e-85	6.58649330386696e-84	1.1906198761482e-78	6.50997364866016e-83	1.02090646209938e-81	1.8454608080297e-76	non_linear_fixed	6.58649330386696e-84	1.02090646209938e-81	13417.4696229256	13458.0693308108	2
Brain-derived neurotrophic factor (BDNF) signaling pathway	144	26	18659.4245298701	18659.4399540347	18675.4818531709	1557	NA	18508.4182666812	18508.4723555415	18540.5329132827	1554	0.961383040456167	18510.7212322385	18510.8140755654	18553.5407610405	1552	0.958337645207555	18502.4423159227	18502.7531967518	18582.7289324264	1545	NA	8.11263298875703e-34	1.87024240804002e-32	2.68197593659348e-32	1.25745811325734e-31	2.89887573246203e-30	4.15706270171989e-30	non_linear_mixed	2.68197593659348e-32	4.15706270171989e-30	18502.7531967518	18582.7289324264	2
Apoptosis	87	23	17234.0693980311	17234.0868398916	17249.7589143656	1377	NA	17169.3274211132	17169.3886010112	17200.7064537821	1374	0.9597458033609	17160.1083091538	17160.2133419765	17201.947019379	1372	0.957363467759378	17025.0455957911	17025.3975019494	17103.4931774634	1365	0.964139767925103	2.96051668403854e-15	1.24291195361787e-16	4.68891242582901e-43	4.58880086025973e-13	1.92651352810769e-14	7.26781426003496e-41	non_linear_mixed	4.68891242582901e-43	7.26781426003496e-41	17025.3975019494	17103.4931774634	2
Mesodermal commitment pathway	153	26	19125.3353181829	19125.3507423475	19141.3926414837	1557	NA	18928.7682779489	18928.8223668092	18960.8829245504	1554	0.913283264363762	18928.1249773452	18928.2178206721	18970.9445061472	1552	0.902618222706845	18917.176490042	18917.487370871	18997.4631065456	1545	0.914846515487241	1.17619372501723e-43	8.13869089517619e-43	7.09405722502367e-43	1.82310027377671e-41	1.26149708875231e-40	1.09957886987867e-40	non_linear_mixed	7.09405722502367e-43	1.09957886987867e-40	18917.487370871	18997.4631065456	5
Ectoderm Differentiation	142	33	22967.9659074918	22967.9780532408	22984.7384638629	1977	NA	22383.5888775309	22383.6314522902	22417.1339902731	1974	0.93124277326767	22358.333112097	22358.4061714577	22403.0599290865	1972	0.915883041262662	22170.0664137853	22170.3108129706	22253.9291956406	1965	0.939606717858402	1.22884009294268e-127	1.15762912636777e-131	3.32551011616003e-168	1.90470214406115e-125	1.79432514587004e-129	5.15454068004804e-166	non_linear_mixed	3.32551011616003e-168	5.15454068004804e-166	22170.3108129706	22253.9291956406	2
Vitamin D Receptor Pathway	184	25	18689.8307413157	18689.8467840965	18705.770402477	1497	NA	18611.7583625189	18611.8146250775	18643.6376848415	1494	NA	18611.3790973197	18611.4756767965	18653.8848604164	1492	NA	18503.8510418288	18504.1744919635	18583.5493476351	1485	NA	4.10448049811444e-18	1.42066637994865e-17	2.82502050251024e-38	6.36194477207738e-16	2.20203288892041e-15	4.37878177889087e-36	non_linear_mixed	2.82502050251024e-38	4.37878177889087e-36	18504.1744919635	18583.5493476351	2
NRF2 pathway	143	28	20814.1711815558	20814.1855013649	20830.450828773	1677	NA	20722.8963691659	20722.9465783709	20755.4556636003	1674	0.93778428765137	20712.3784428487	20712.4646187912	20755.7908354279	1672	0.932707094048356	20615.2900744689	20615.5785360074	20696.6883105549	1665	0.942256630985179	5.98936611299842e-21	1.71220548057137e-22	5.99467670560561e-41	9.28351747514755e-19	2.65391849488563e-20	9.29174889368869e-39	non_linear_mixed	5.99467670560561e-41	9.29174889368869e-39	20615.5785360074	20696.6883105549	3
Myometrial relaxation and contraction pathways	155	28	18668.4470258179	18668.461345627	18684.7266730351	1677	NA	18337.9035412639	18337.9537504689	18370.4628356982	1674	0.922976457283628	18338.8103489268	18338.8965248694	18382.222741506	1672	0.909295322345179	18302.9746462743	18303.2631078128	18384.3728823603	1665	NA	1.2225208555812e-72	2.97854247557372e-71	6.40377805050622e-76	1.89490732615086e-70	4.61674083713926e-69	9.92585597828464e-74	non_linear_mixed	6.40377805050622e-76	9.92585597828464e-74	18303.2631078128	18384.3728823603	4
Focal Adhesion	198	28	19795.3337271589	19795.3480469679	19811.613374376	1677	NA	19511.6287493619	19511.6789585669	19544.1880437963	1674	0.922769975365851	19513.610875271	19513.6970512136	19557.0232678502	1672	0.910795732286085	19524.3631551963	19524.6516167347	19605.7613912822	1665	NA	1.68179411429431e-62	6.02449343111988e-61	5.33813576192447e-56	2.60678087715618e-60	9.33796481823581e-59	8.27411043098294e-54	linear	1.68179411429431e-62	2.60678087715618e-60	19511.6789585669	19544.1880437963	2
TGF-beta Signaling Pathway	132	22	14508.5533200602	14508.5715571422	14524.1094811069	1317	NA	14216.4368406645	14216.5008162928	14247.5491627579	1314	0.895984974076538	14215.0270009594	14215.1368407764	14256.5100970841	1312	0.874921907945929	14210.2193231115	14210.587421271	14288.0001283452	1305	NA	2.54338206794774e-64	1.74781701634832e-63	9.48113258278742e-62	3.942242205319e-62	2.7091163753399e-61	1.46957555033205e-59	non_linear_mixed	9.48113258278742e-62	1.46957555033205e-59	14210.587421271	14288.0001283452	2
Angiopoietin Like Protein 8 Regulatory Pathway	131	23	16213.0529931022	16213.0704349626	16228.7425094366	1377	NA	15991.0355436657	15991.0967235638	16022.4145763347	1374	0.919595828218132	15993.7575214095	15993.8625542322	16035.5962316347	1372	0.909465609912451	15978.1627024428	15978.5146086011	16056.610284115	1365	NA	3.71070431994826e-49	1.5142675076963e-47	1.90943625698142e-48	5.75159169591981e-47	2.34711463692927e-45	2.9596261983212e-46	non_linear_mixed	1.90943625698142e-48	2.9596261983212e-46	15978.5146086011	16056.610284115	3
mRNA Processing	127	20	14008.3000378107	14008.3201047003	14023.570268318	1197	NA	13892.1528497827	13892.223260512	13922.6933107974	1194	0.945414956835261	13881.2786820385	13881.3995888395	13921.9992967247	1192	0.940883207884496	13865.1724616929	13865.5778670983	13941.5236142296	1185	NA	2.66053981638397e-26	7.6853787635791e-28	1.84531486615285e-29	4.12383671539515e-24	1.19123370835476e-25	2.86023804253692e-27	non_linear_mixed	1.84531486615285e-29	2.86023804253692e-27	13865.5778670983	13941.5236142296	2
Ras signaling	184	27	17678.7566922187	17678.7715437039	17694.9272365034	1617	NA	17207.3467681271	17207.3988450025	17239.6878566965	1614	0.945827676150729	17211.0883102056	17211.1776956805	17254.2097616314	1612	0.93541767900827	17221.9780888878	17222.2773407582	17302.8308103112	1605	NA	3.75011694514079e-103	5.27062392010083e-101	2.72105157475147e-95	5.81268126496822e-101	8.16946707615628e-99	4.21762994086478e-93	linear	3.75011694514079e-103	5.81268126496822e-101	17207.3988450025	17239.6878566965	2
Epithelial to mesenchymal transition in colorectal cancer	161	27	20203.9519803066	20203.9668317918	20220.1225245913	1617	NA	19997.7094625646	19997.76153944	20030.050551134	1614	0.952312665231444	19994.6345305248	19994.7239159996	20037.7559819506	1612	0.947568762703923	19898.5495956474	19898.8488475177	19979.4023170708	1605	0.955803071408285	9.53918046616853e-46	2.08054177347018e-45	3.08168332646924e-63	1.47857297225612e-43	3.22483974887879e-43	4.77660915602733e-61	non_linear_mixed	3.08168332646924e-63	4.77660915602733e-61	19898.8488475177	19979.4023170708	5
Breast cancer pathway	154	23	16905.6851256239	16905.7025674843	16921.3746419583	1377	NA	16416.544277571	16416.6054574691	16447.9233102399	1374	0.932854782626526	16419.4147099854	16419.5197428081	16461.2534202106	1372	0.915118708019922	16373.7549585209	16374.1068646792	16452.2025401932	1365	NA	5.39150327884529e-107	5.09644754345286e-105	2.69105302122119e-111	8.3568300822102e-105	7.89949369235193e-103	4.17113218289284e-109	non_linear_mixed	2.69105302122119e-111	4.17113218289284e-109	16374.1068646792	16452.2025401932	5
Pancreatic adenocarcinoma pathway	89	20	14156.6481258812	14156.6681927708	14171.9183563885	1197	NA	13808.4095706776	13808.4799814068	13838.9500316922	1194	NA	13812.3681204074	13812.4890272084	13853.0887350936	1192	NA	13823.7881292194	13824.1935346248	13900.139281756	1185	NA	1.80253588344192e-76	2.09693704344281e-74	5.00341739274669e-69	2.79393061933498e-74	3.25025241733636e-72	7.75529695875736e-67	linear	1.80253588344192e-76	2.79393061933498e-74	13808.4799814068	13838.9500316922	2
EGF-EGFR signaling pathway	162	29	19003.4490165836	19003.4628414684	19019.8339377602	1737	NA	18838.1349147322	18838.183385592	18870.9047570855	1734	0.905487785843775	18842.045450594	18842.1286395022	18885.7385737317	1732	0.899435302974406	18822.0804915471	18822.3589138209	18904.0050974302	1725	NA	6.6216361080645e-37	3.66113701408176e-35	2.53855236058064e-37	1.02635359675e-34	5.67476237182672e-33	3.93475615889999e-35	non_linear_mixed	2.53855236058064e-37	3.93475615889999e-35	18822.3589138209	18904.0050974302	3
Genes related to primary cilium development (based on CRISPR)	103	20	11927.5959787109	11927.6160456005	11942.8662092182	1197	NA	11873.0806295065	11873.1510402357	11903.6210905211	1194	0.927369721742343	11857.916923368	11858.037830169	11898.6375380542	1192	0.925479481378066	11700.2082938035	11700.6136992089	11776.5594463401	1185	0.938075213690803	4.56182209609967e-13	9.79478045840113e-16	7.02633631361249e-47	7.07082424895449e-11	1.51819097105218e-13	1.08908212860994e-44	non_linear_mixed	7.02633631361249e-47	1.08908212860994e-44	11700.6136992089	11776.5594463401	2
Small cell lung cancer	96	26	17891.6652754932	17891.6806996577	17907.7225987939	1557	NA	17496.2994277778	17496.3535166381	17528.4140743793	1554	0.939004452465882	17494.5913765323	17494.6842198592	17537.4109053343	1552	0.926418421118244	17501.3374493287	17501.6483301577	17581.6240658324	1545	NA	1.12021620801379e-86	8.8623995506653e-86	3.48981861463136e-81	1.73633512242137e-84	1.37367193035312e-83	5.40921885267861e-79	non_linear_fixed	8.8623995506653e-86	1.37367193035312e-83	17494.6842198592	17537.4109053343	2
Gastrin signaling pathway	114	22	15768.4522857558	15768.4705228379	15784.0084468026	1317	NA	15648.7926309398	15648.8566065682	15679.9049530333	1314	0.964657452576127	15650.7533467635	15650.8631865804	15692.2364428881	1312	0.9621081569245	15641.8287057086	15642.1968038681	15719.6095109423	1305	NA	4.6591471562944e-27	7.32469756306583e-26	4.23689153381778e-26	7.22167809225632e-25	1.1353281222752e-23	6.56718187741756e-24	non_linear_mixed	4.23689153381778e-26	6.56718187741756e-24	15642.1968038681	15719.6095109423	2
Hepatitis B infection	152	22	15310.9228222652	15310.9410593473	15326.478983312	1317	NA	14912.4610905162	14912.5250661445	14943.5734126097	1314	NA	14915.3923631805	14915.5022029975	14956.8754593052	1312	NA	14927.0708601659	14927.4389583255	15004.8516653997	1305	NA	2.39166013849354e-87	1.90652507392622e-85	8.22204796999495e-80	3.70707321466498e-85	2.95511386458564e-83	1.27441743534922e-77	linear	2.39166013849354e-87	3.70707321466498e-85	14912.5250661445	14943.5734126097	2
Ciliopathies	183	26	16719.733387953	16719.7488121175	16735.7907112537	1557	NA	16505.9691943544	16506.0232832146	16538.0838409558	1554	0.911419876264174	16491.9484884039	16492.0413317308	16534.7680172059	1552	0.898626093199929	16436.9532262946	16437.2641071236	16517.2398427982	1545	NA	2.25783966224213e-47	2.29207050971986e-49	1.76862027142088e-58	3.49965147647531e-45	3.55270929006578e-47	2.74136142070236e-56	non_linear_mixed	1.76862027142088e-58	2.74136142070236e-56	16437.2641071236	16517.2398427982	5
EGFR Tyrosine Kinase Inhibitor Resistance	84	21	15518.2035035187	15518.222611799	15533.6201045186	1257	NA	15330.4218558433	15330.4888949494	15361.2550578429	1254	0.957008142529705	15333.0623716969	15333.1774796106	15374.1733076965	1252	0.953051498526218	15329.1133691484	15329.4992212384	15406.1963741476	1245	NA	9.3040128678527e-42	3.10915955505457e-40	6.41532900538306e-39	1.44212199451717e-39	4.81919731033458e-38	9.94375995834374e-37	non_linear_mixed	6.41532900538306e-39	9.94375995834374e-37	15329.4992212384	15406.1963741476	5
Insulin Signaling	160	30	22294.5978941063	22294.6112571352	22311.0845199379	1797	NA	22209.2998537958	22209.3467026525	22242.2731054591	1794	0.94945036341428	22202.6737021717	22202.7541041818	22246.6380377228	1792	0.947978090630293	22066.9824198336	22067.2514781296	22149.4155489919	1785	NA	1.15274785331505e-19	2.07680951437812e-20	6.29819101257469e-47	1.78675917263832e-17	3.21905474728609e-18	9.76219606949076e-45	non_linear_mixed	6.29819101257469e-47	9.76219606949076e-45	22067.2514781296	22149.4155489919	2
DNA Repair Pathways Full Network	119	20	11986.8801069611	11986.9001738507	12002.1503374684	1197	NA	11941.4613571112	11941.5317678405	11972.0018181259	1194	0.925327826218292	11925.7418436635	11925.8627504645	11966.4624583497	1192	0.920059992325974	11925.3413927379	11925.7467981433	12001.6925452746	1185	NA	3.98358178073576e-11	5.93852891105254e-14	3.58544710370299e-13	6.17455176014042e-09	9.20471981213144e-12	5.55744301073964e-11	non_linear_mixed	3.58544710370299e-13	5.55744301073964e-11	11925.7467981433	12001.6925452746	4
Regulation of Actin Cytoskeleton	151	25	19314.9521786646	19314.9682214453	19330.8918398258	1497	NA	19208.7815486749	19208.8378112335	19240.6608709974	1494	0.926874881595573	19212.7631399394	19212.8597194162	19255.2689030361	1492	0.920047439734318	19188.7745422334	19189.0979923682	19268.4728480398	1485	0.929721362813073	3.74246770386157e-24	1.41177303398766e-22	5.21835127615141e-26	5.80082494098544e-22	2.18824820268087e-20	8.08844447803469e-24	non_linear_mixed	5.21835127615141e-26	8.08844447803469e-24	19189.0979923682	19268.4728480398	2
Calcium Regulation in the Cardiac Cell	151	22	13508.3629238265	13508.3811609086	13523.9190848733	1317	NA	13358.8571554958	13358.9211311241	13389.9694775893	1314	0.910428181086345	13360.7258603625	13360.8357001795	13402.2089564872	1312	0.900657151604016	13362.7917073918	13363.1598055513	13440.5725126255	1305	0.911531607932727	1.70974405519127e-33	3.15566909626565e-32	5.84215369368664e-30	2.65010328554647e-31	4.89128709921176e-30	9.05533822521428e-28	linear	1.70974405519127e-33	2.65010328554647e-31	13358.9211311241	13389.9694775893	2
ErbB signaling pathway	92	23	17271.9328489644	17271.9502908248	17287.6223652988	1377	NA	17199.5731231049	17199.6343030029	17230.9521557738	1374	0.956225390824245	17198.4864885433	17198.5915213661	17240.3251987685	1372	0.953959425317256	17069.5319770178	17069.8838831762	17147.9795586901	1365	NA	6.89966759145115e-17	1.59331180254917e-16	1.11473513624181e-41	1.06944847667493e-14	2.46963329395121e-14	1.7278394611748e-39	non_linear_mixed	1.11473513624181e-41	1.7278394611748e-39	17069.8838831762	17147.9795586901	2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	159	22	14385.3705993227	14385.3888364048	14400.9267603695	1317	NA	14251.1498441292	14251.2138197575	14282.2621662226	1314	0.936850581137677	14227.5091704708	14227.6190102878	14268.9922665955	1312	0.936587788697147	14124.142447762	14124.5105459215	14201.9232529957	1305	NA	3.38735603728517e-30	2.08611054994661e-34	5.89537088687445e-54	5.25040185779201e-28	3.23347135241724e-32	9.1378248746554e-52	non_linear_mixed	5.89537088687445e-54	9.1378248746554e-52	14124.5105459215	14201.9232529957	4
DNA damage response	68	20	15131.3921930668	15131.4122599564	15146.6624235741	1197	NA	15075.8007413296	15075.8711520589	15106.3412023443	1194	0.960445789759667	15059.9491096409	15060.0700164419	15100.6697243271	1192	0.958044127834169	14947.7493658466	14948.154771252	15024.1005183832	1185	NA	2.68641728393706e-13	4.18655011557272e-16	8.59814095296862e-38	4.16394679010245e-11	6.48915267913771e-14	1.33271184771014e-35	non_linear_mixed	8.59814095296862e-38	1.33271184771014e-35	14948.154771252	15024.1005183832	2
DNA damage response (only ATM dependent)	110	21	15981.375857028	15981.3949653083	15996.7924580279	1257	NA	15911.0904593478	15911.157498454	15941.9236613475	1254	0.954418610411693	15911.6864700316	15911.8015779452	15952.7974060311	1252	0.949802057963347	15804.5665775069	15804.9524295969	15881.6495825061	1245	0.958948964488218	1.92124266964357e-16	9.74616114551579e-16	2.22002328923212e-36	2.97792613794753e-14	1.51065497755495e-13	3.44103609830978e-34	non_linear_mixed	2.22002328923212e-36	3.44103609830978e-34	15804.9524295969	15881.6495825061	3
Separation of Sister Chromatids	130	38	23571.9010339996	23571.9115788151	23589.0968261655	2277	NA	23510.3746142799	23510.4115698453	23544.7661986116	2274	0.954075388471354	23437.7802621751	23437.8436703654	23483.6357079507	2272	0.951826003170515	23329.8611250341	23330.0731391684	23415.8400858634	2265	NA	1.44475941737905e-14	2.37951885844565e-29	6.124621625918e-50	2.23937709693752e-12	3.68825423059076e-27	9.4931635201729e-48	non_linear_mixed	6.124621625918e-50	9.4931635201729e-48	23330.0731391684	23415.8400858634	2
Transcriptional regulation by RUNX1	195	20	15559.0574008843	15559.0774677739	15574.3276313916	1197	NA	15473.0485165743	15473.1189273035	15503.5889775889	1194	0.947681232854928	15471.9969336494	15472.1178404504	15512.7175483356	1192	0.946053344838186	15413.256598556	15413.6620039614	15489.6077510927	1185	NA	8.11007857694172e-20	2.19949332248523e-19	5.24349900843026e-30	1.25706217942597e-17	3.40921464985211e-17	8.1274234630669e-28	non_linear_mixed	5.24349900843026e-30	8.1274234630669e-28	15413.6620039614	15489.6077510927	3
Loss of Nlp from mitotic centrosomes	70	20	11520.8685850734	11520.888651963	11536.1388155807	1197	NA	11465.8167187049	11465.8871294342	11496.3571797196	1194	0.858702715451726	11424.5806355919	11424.7015423929	11465.3012502781	1192	0.844523010542688	11392.5211841018	11392.9265895072	11468.8723366384	1185	NA	3.50341565667628e-13	2.49235122885977e-21	1.89276023009921e-26	5.43029426784823e-11	3.86314440473265e-19	2.93377835665378e-24	non_linear_mixed	1.89276023009921e-26	2.93377835665378e-24	11392.9265895072	11468.8723366384	4
Centrosome maturation	82	20	11520.8685850734	11520.888651963	11536.1388155807	1197	NA	11465.8167187051	11465.8871294344	11496.3571797198	1194	0.85870438820402	11424.5807359887	11424.7016427897	11465.3013506749	1192	0.844112748273555	11392.5211841653	11392.9265895707	11468.8723367019	1185	NA	3.50341565702435e-13	2.49247287836671e-21	1.89276028629955e-26	5.43029426838774e-11	3.86333296146839e-19	2.93377844376431e-24	non_linear_mixed	1.89276028629955e-26	2.93377844376431e-24	11392.9265895707	11468.8723367019	4
RHO GTPases Activate Formins	123	38	27956.6030149408	27956.6135597562	27973.7988071066	2277	NA	27564.4722166313	27564.5091721967	27598.863800963	2274	0.943961485810575	27562.7012094215	27562.7646176117	27608.5566551971	2272	0.933897001206787	27490.7070270403	27490.9190411746	27576.6859878695	2265	NA	5.62387049633023e-86	4.27850008642173e-85	3.13000787335322e-97	8.71699926931186e-84	6.63167513395369e-83	4.85151220369749e-95	non_linear_mixed	3.13000787335322e-97	4.85151220369749e-95	27490.9190411746	27576.6859878695	2
Cellular response to heat stress	97	21	15157.6676919091	15157.6868001894	15173.084292909	1257	NA	14922.0810572993	14922.1480964055	14952.914259299	1254	0.926856061056859	14910.9287937943	14911.0439017079	14952.0397297938	1252	0.920396078259078	14914.2102718705	14914.5961239605	14991.2932768697	1245	NA	4.31908749974995e-52	1.96778537570435e-53	3.09543350172549e-50	6.69458562461243e-50	3.05006733234175e-51	4.79792192767451e-48	non_linear_fixed	1.96778537570435e-53	3.05006733234175e-51	14911.0439017079	14952.0397297938	4
COPI-dependent Golgi-to-ER retrograde traffic	82	24	16911.416456753	16911.4331698449	16927.2336519307	1437	NA	16799.580549653	16799.6391679363	16831.2149400084	1434	NA	16780.6455808822	16780.746209813	16822.8247680228	1432	NA	16704.2786869527	16704.6157656044	16783.3646628412	1425	NA	2.25671415717935e-25	1.22688188204184e-28	1.15645316720654e-42	3.49790694362799e-23	1.90166691716485e-26	1.79250240917014e-40	non_linear_mixed	1.15645316720654e-42	1.79250240917014e-40	16704.6157656044	16783.3646628412	5
Golgi-to-ER retrograde transport	116	25	17565.6894238234	17565.7054666041	17581.6290849846	1497	NA	17449.0019779516	17449.0582405102	17480.8813002742	1494	0.952983046196038	17429.3151508841	17429.411730361	17471.8209139809	1492	NA	17349.8673903955	17350.1908405303	17429.5656962018	1485	0.956191362385347	2.03515411552477e-26	7.89072044579806e-30	1.8061641079416e-44	3.15448887906339e-24	1.2230616690987e-27	2.79955436730948e-42	non_linear_mixed	1.8061641079416e-44	2.79955436730948e-42	17350.1908405303	17429.5656962018	5
EPO signaling	186	31	20909.6993101655	20909.7122412	20926.2843054656	1857	NA	20676.8007492321	20676.8460811264	20709.9707398324	1854	0.943864307928153	20675.0889639428	20675.1667597288	20719.3156180764	1852	0.937780754654726	20591.258074571	20591.5183782587	20674.1830510716	1845	NA	1.64698664956103e-51	7.87743155712304e-51	5.51090713494045e-66	2.55282930681959e-49	1.22100189135407e-48	8.5419060591577e-64	non_linear_mixed	5.51090713494045e-66	8.5419060591577e-64	20591.5183782587	20674.1830510716	4
Cellular Senescence	186	24	18705.6594599544	18705.6761730463	18721.4766551321	1437	NA	18688.3289924595	18688.3876107428	18719.9633828149	1434	0.958572793095174	18674.9188787246	18675.0195076554	18717.0980658652	1432	0.957800424527519	18589.8915841358	18590.2286627874	18668.9775600243	1425	NA	3.44586658293304e-05	1.05858548806707e-07	6.67172196678042e-24	0.00534109320354621	1.64080750650396e-05	1.03411690485097e-21	non_linear_mixed	6.67172196678042e-24	1.03411690485097e-21	18590.2286627874	18668.9775600243	5
BCR	129	24	17524.7647954946	17524.7815085865	17540.5819906723	1437	NA	17306.4312894749	17306.4899077582	17338.0656798303	1434	0.95974246621902	17308.8566075819	17308.9572365127	17351.0357947224	1432	0.956021063375392	17302.5844803756	17302.9215590273	17381.6704562641	1425	0.960325805067298	2.32224694042987e-48	8.05622321185121e-47	8.55885763934425e-46	3.5994827576663e-46	1.24871459783694e-44	1.32662293409836e-43	non_linear_mixed	8.55885763934425e-46	1.32662293409836e-43	17302.9215590273	17381.6704562641	4
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	133	26	14104.9723603792	14104.9877845437	14121.0296836799	1557	NA	14011.2340525752	14011.2881414355	14043.3486991767	1554	0.912800519209123	13913.2280228144	13913.3208661413	13956.0475516164	1552	0.904258869390906	13885.9996397507	13886.3105205798	13966.2862562544	1545	0.915980315961196	1.76914476262061e-21	1.20291929394966e-41	3.98745394305476e-45	2.74217438206194e-19	1.86452490562197e-39	6.18055361173487e-43	non_linear_mixed	3.98745394305476e-45	6.18055361173487e-43	13886.3105205798	13966.2862562544	2
IL-7 signaling	185	31	20909.6993101655	20909.7122412	20926.2843054656	1857	NA	20676.8007493002	20676.8460811945	20709.9707399005	1854	0.943863593500584	20675.0889680682	20675.1667638542	20719.3156222018	1852	0.937753785380221	20591.2580810693	20591.5183847569	20674.1830575699	1845	0.947146170575111	1.64698670541354e-51	7.87744760836728e-51	5.51092452078705e-66	2.55282939339098e-49	1.22100437929693e-48	8.54193300721993e-64	non_linear_mixed	5.51092452078705e-66	8.54193300721993e-64	20591.5183847569	20674.1830575699	4
ER to Golgi Anterograde Transport	136	20	13932.74676256	13932.7668294496	13948.0169930673	1197	NA	13841.8150466876	13841.8854574169	13872.3555077023	1194	0.925413261998103	13825.6911759416	13825.8120827426	13866.4117906278	1192	0.918530929397131	13770.196723588	13770.6021289934	13846.5478761247	1185	0.930447906696438	7.09792502724865e-21	1.31883817678989e-23	1.92519452447883e-33	1.10017837922354e-18	2.04419917402433e-21	2.98405151294218e-31	non_linear_mixed	1.92519452447883e-33	2.98405151294218e-31	13770.6021289934	13846.5478761247	2
Urea cycle and metabolism of arginine, proline, glutamate, aspartate and asparagine	105	21	17203.4363138882	17203.4554221684	17218.852914888	1257	NA	16689.1003336889	16689.1673727951	16719.9335356886	1254	NA	16693.0552698405	16693.1703777542	16734.1662058401	1252	NA	16677.0223519337	16677.4082040237	16754.1053569328	1245	NA	1.86806408866377e-112	3.18049228251932e-110	4.03809123780061e-110	2.89549933742885e-110	4.92976303790494e-108	6.25904141859095e-108	non_linear_mixed	4.03809123780061e-110	6.25904141859095e-108	16677.4082040237	16754.1053569328	2
Pyrimidine metabolism	135	23	15720.7106990311	15720.7281408915	15736.4002153655	1377	NA	15638.7813168201	15638.8424967182	15670.160349489	1374	NA	15607.4213444218	15607.5263772445	15649.260054647	1372	NA	15518.1430658392	15518.4949719975	15596.5906475114	1365	NA	6.09876405437401e-19	6.30649645097959e-25	1.02930555309648e-41	9.45308428427971e-17	9.77506949901836e-23	1.59542360729954e-39	non_linear_mixed	1.02930555309648e-41	1.59542360729954e-39	15518.4949719975	15596.5906475114	2
TGF_beta_Receptor	173	33	23675.9669036756	23675.9790494246	23692.7394600467	1977	NA	23196.5070421325	23196.5496168917	23230.0521548746	1974	0.932559378388037	23193.3166310819	23193.3896904426	23238.0434480714	1972	0.920062040003442	23059.5471287642	23059.7915279495	23143.4099106195	1965	0.938194217184378	6.755213116361e-105	3.08050130381573e-104	2.45142415871113e-129	1.04705803303595e-102	4.77477702091438e-102	3.79970744600225e-127	non_linear_mixed	2.45142415871113e-129	3.79970744600225e-127	23059.7915279495	23143.4099106195	3
Anchoring of the basal body to the plasma membrane	97	26	14746.8158418285	14746.831265993	14762.8731651292	1557	NA	14685.2127816355	14685.2668704958	14717.327428237	1554	0.873578952542647	14637.5053001353	14637.5981434622	14680.3248289373	1552	0.863073407300508	14593.183785785	14593.494666614	14673.4704022886	1545	0.879326488611739	1.39120969651404e-14	4.39294435875203e-24	1.30565192355804e-31	2.15637502959676e-12	6.80906375606565e-22	2.02376048151497e-29	non_linear_mixed	1.30565192355804e-31	2.02376048151497e-29	14593.494666614	14673.4704022886	2
Signaling by NOTCH	189	26	16942.0070418999	16942.0224660644	16958.0643652006	1557	NA	16737.6297747858	16737.6838636461	16769.7444213873	1554	0.934450532927608	16727.5178950373	16727.6107383642	16770.3374238393	1552	0.928705621004423	16695.4824228793	16695.7933037083	16775.769039383	1545	0.937131109854621	2.41349382774063e-45	1.62257095695274e-46	7.06740823972776e-51	3.74091543299797e-43	2.51498498327674e-44	1.0954482771578e-48	non_linear_mixed	7.06740823972776e-51	1.0954482771578e-48	16695.7933037083	16775.769039383	2
SUMO E3 ligases SUMOylate target proteins	177	28	21979.0379080913	21979.0522279004	21995.3175553085	1677	NA	21889.7270397567	21889.7772489617	21922.2863341911	1674	0.949923581448847	21878.613509856	21878.6996857985	21922.0259024352	1672	0.94828904652906	21781.6606022156	21781.9490637541	21863.0588383015	1665	0.953534535579947	1.58309201243749e-20	3.33278651210877e-22	1.22955286175642e-40	2.45379261927811e-18	5.1658190937686e-20	1.90580693572245e-38	non_linear_mixed	1.22955286175642e-40	1.90580693572245e-38	21781.9490637541	21863.0588383015	5
Neurotransmitter receptors and postsynaptic signal transmission	185	21	16139.2905297077	16139.309637988	16154.7071307075	1257	NA	16067.632098437	16067.6991375431	16098.4653004367	1254	0.955948507696568	16060.750264024	16060.8653719376	16101.8612000235	1252	0.953019436423343	15946.0864954671	15946.4723475572	16023.1695004663	1245	NA	9.75457675215939e-17	1.36108718069101e-17	9.01618553839598e-40	1.51195939658471e-14	2.10968513007107e-15	1.39750875845138e-37	non_linear_mixed	9.01618553839598e-40	1.39750875845138e-37	15946.4723475572	16023.1695004663	2
mRNA Splicing	185	24	17225.2397642703	17225.2564773622	17241.056959448	1437	NA	17095.677241288	17095.7358595714	17127.3116316434	1434	0.940324260640653	17081.43407062	17081.5346995509	17123.6132577606	1432	0.936478213892402	17049.5604357908	17049.8975144425	17128.6464116794	1425	NA	3.4209834315113e-29	2.06651468802354e-31	3.7983588257606e-36	5.30252431884251e-27	3.20309776643649e-29	5.88745617992894e-34	non_linear_mixed	3.7983588257606e-36	5.88745617992894e-34	17049.8975144425	17128.6464116794	2
Intra-Golgi and retrograde Golgi-to-ER traffic	186	35	24490.935291718	24490.9467420996	24507.8843695891	2097	NA	24330.8511886446	24330.8913224239	24364.7493443869	2094	0.947320150968568	24309.8245352202	24309.8934017912	24355.0220762099	2092	0.942907247263056	24207.2910200734	24207.521346369	24292.0364094291	2085	NA	8.91232542837787e-36	2.26137415317356e-39	1.16429427786938e-58	1.38141044139857e-33	3.50512993741902e-37	1.80465613069754e-56	non_linear_mixed	1.16429427786938e-58	1.80465613069754e-56	24207.521346369	24292.0364094291	5
Cilium Assembly	178	36	21683.9310637748	21683.9421955002	21700.9646542768	2157	NA	21500.1357213905	21500.174736718	21534.2029023946	2154	0.928098617425433	21458.7830343947	21458.8499800014	21504.2059424001	2152	0.920614273153569	21328.5391822895	21328.7630628866	21413.7071347997	2145	0.933909153368671	6.75800178538749e-41	8.42585232163739e-49	8.68453100261086e-74	1.04749027673506e-38	1.3060071098538e-46	1.34610230540468e-71	non_linear_mixed	8.68453100261086e-74	1.34610230540468e-71	21328.7630628866	21413.7071347997	3
VEGF	188	32	21373.2568304729	21373.2693565689	21389.9370718679	1917	NA	21146.5090992989	21146.5530093877	21179.869582089	1914	0.947538257108737	21143.4813783657	21143.5567315839	21187.9620220858	1912	0.942082975585138	21048.2565927489	21048.5086935892	21131.6577997242	1905	0.950855621886675	3.52134999984144e-50	8.5776901383162e-50	2.27986810530303e-67	5.45809249975423e-48	1.32954197143901e-47	3.53379556321969e-65	non_linear_mixed	2.27986810530303e-67	3.53379556321969e-65	21048.5086935892	21131.6577997242	3
Glycerophospholipid metabolism	136	20	16595.7906256763	16595.8106925659	16611.0608561836	1197	NA	16209.3046450418	16209.3750557711	16239.8451060565	1194	0.957591248518735	16213.2995121924	16213.4204189934	16254.0201268786	1192	0.948516578341343	16191.269666905	16191.6750723104	16267.6208194416	1185	NA	9.39088782706282e-85	1.23173258723948e-82	3.41657514469755e-84	1.45558761319474e-82	1.90918551022119e-80	5.29569147428121e-82	non_linear_mixed	3.41657514469755e-84	5.29569147428121e-82	16191.6750723104	16267.6208194416	3
Transport to the Golgi and subsequent modification	167	26	18163.2345644831	18163.2499886477	18179.2918877839	1557	NA	18007.7400166921	18007.7941055524	18039.8546632936	1554	0.917603063486725	18000.4479800144	18000.5408233413	18043.2675088163	1552	0.907707826277635	17943.997100716	17944.307981545	18024.2837172196	1545	0.922119492306223	8.72143984351007e-35	1.85554761362632e-35	3.51198175278475e-45	1.35182317574406e-32	2.8760988011208e-33	5.44357171681637e-43	non_linear_mixed	3.51198175278475e-45	5.44357171681637e-43	17944.307981545	18024.2837172196	2
Factors involved in megakaryocyte development and platelet production	145	36	23063.9666095855	23063.9777413109	23081.0002000875	2157	NA	22939.0202982945	22939.059313622	22973.0874792986	2154	0.961011265048965	22914.6649367599	22914.7318823666	22960.0878447653	2152	0.958395204770999	22752.6373812707	22752.8612618677	22837.8053337808	2145	NA	3.38170632121902e-28	1.39438697251745e-32	1.738907063767e-64	5.24164479788948e-26	2.16129980740205e-30	2.69530594883885e-62	non_linear_mixed	1.738907063767e-64	2.69530594883885e-62	22752.8612618677	22837.8053337808	3
Recruitment of mitotic centrosome proteins and complexes	82	20	11520.8685850734	11520.888651963	11536.1388155807	1197	NA	11465.8167187051	11465.8871294344	11496.3571797198	1194	0.85870438820402	11424.5807359887	11424.7016427897	11465.3013506749	1192	0.844112748273555	11392.5211841653	11392.9265895707	11468.8723367019	1185	NA	3.50341565702435e-13	2.49247287836671e-21	1.89276028629955e-26	5.43029426838774e-11	3.86333296146839e-19	2.93377844376431e-24	non_linear_mixed	1.89276028629955e-26	2.93377844376431e-24	11392.9265895707	11468.8723367019	4
Clathrin-mediated endocytosis	142	23	16996.8423559784	16996.8597978389	17012.5318723129	1377	NA	16589.5225949305	16589.5837748285	16620.9016275994	1374	0.958685624607791	16593.238600332	16593.3436331547	16635.0773105572	1372	0.951001100561586	16595.7169261581	16596.0688323165	16674.1645078304	1365	0.959236927780389	2.88326369785182e-89	3.46678877406833e-87	1.79360946758182e-83	4.46905873167032e-87	5.3735225998059e-85	2.78009467475182e-81	linear	2.88326369785182e-89	4.46905873167032e-87	16589.5837748285	16620.9016275994	2
Loss of proteins required for interphase microtubule organization from the centrosome	70	20	11520.8685850734	11520.888651963	11536.1388155807	1197	NA	11465.8167187049	11465.8871294342	11496.3571797196	1194	0.858702715451726	11424.5806355919	11424.7015423929	11465.3012502781	1192	0.844523010542688	11392.5211841018	11392.9265895072	11468.8723366384	1185	NA	3.50341565667628e-13	2.49235122885977e-21	1.89276023009921e-26	5.43029426784823e-11	3.86314440473265e-19	2.93377835665378e-24	non_linear_mixed	1.89276023009921e-26	2.93377835665378e-24	11392.9265895072	11468.8723366384	4
HIV Infection	192	24	16011.7758772277	16011.7925903196	16027.5930724054	1437	NA	15923.5923538431	15923.6509721265	15955.2267441986	1434	0.937200320084829	15905.6930973734	15905.7937263042	15947.8722845139	1432	0.933216151797501	15855.5335955388	15855.8706741905	15934.6195714274	1425	0.940363635553659	2.76550943888731e-20	2.1187989703641e-23	3.8048261360542e-32	4.28653963027533e-18	3.28413840406436e-21	5.89748051088401e-30	non_linear_mixed	3.8048261360542e-32	5.89748051088401e-30	15855.8706741905	15934.6195714274	2
Interferon Signaling	162	21	13785.6402649253	13785.6593732055	13801.0568659251	1257	NA	13542.183612008	13542.2506511141	13573.0168140076	1254	0.949304836226912	13537.0197767495	13537.1348846632	13578.1307127491	1252	0.941270162103658	13536.666815781	13537.052667871	13613.7498207801	1245	NA	8.57717559457968e-54	7.76454020886643e-54	2.17232267743427e-51	1.32946221715985e-51	1.2035037323743e-51	3.36710015002312e-49	non_linear_mixed	2.17232267743427e-51	3.36710015002312e-49	13537.052667871	13613.7498207801	3
G2/M Transition	138	38	23917.2606135199	23917.2711583354	23934.4564056858	2277	NA	23866.7896987043	23866.8266542697	23901.181283036	2274	0.946251223420883	23802.2209763107	23802.2843845009	23848.0764220863	2272	0.943666692331198	23755.2811002992	23755.4931144334	23841.2600611284	2265	0.94799827540375	3.33307530051726e-12	2.68383369134967e-25	2.52223324696623e-33	5.16626671580175e-10	4.15994222159199e-23	3.90946153279766e-31	non_linear_mixed	2.52223324696623e-33	3.90946153279766e-31	23755.4931144334	23841.2600611284	2
Mitotic G2-G2/M phases	140	39	24512.5030236518	24512.5132976244	24529.7767422769	2337	NA	24459.5382073153	24459.5742124589	24494.0856445654	2334	0.945644466126163	24390.0733808176	24390.1351568793	24436.1366304844	2332	0.943055031048226	24342.7842385014	24342.9907789489	24429.1528316267	2325	0.947395348621204	9.78083301861893e-13	7.25881427579216e-27	6.43864314955927e-35	1.51602911788593e-10	1.12511621274778e-24	9.97989688181687e-33	non_linear_mixed	6.43864314955927e-35	9.97989688181687e-33	24342.9907789489	24429.1528316267	2
Mitotic Prophase	147	21	13989.5237378594	13989.5428461397	14004.9403388593	1257	NA	13759.3604951973	13759.4275343035	13790.193697197	1254	NA	13729.5543623554	13729.6694702691	13770.665298355	1252	NA	13719.9795308516	13720.3653829417	13797.0625358508	1245	NA	6.42949812024948e-51	2.84120497481368e-56	1.06332971907525e-55	9.9657220863867e-49	4.4038677109612e-54	1.64816106456663e-53	non_linear_mixed	1.06332971907525e-55	1.64816106456663e-53	13720.3653829417	13797.0625358508	4
Protein folding	98	21	13095.1369127308	13095.156021011	13110.5535137306	1257	NA	12950.5931614219	12950.660200528	12981.4263634216	1254	0.912658565497191	12950.7755307265	12950.8906386401	12991.886466726	1252	0.901679071770055	12907.5380615095	12907.9239135995	12984.6210665087	1245	NA	2.01125816174091e-32	1.57358924449067e-31	1.30600389440242e-38	3.11745015069841e-30	2.43906332896054e-29	2.02430603632376e-36	non_linear_mixed	1.30600389440242e-38	2.02430603632376e-36	12907.9239135995	12984.6210665087	2
Recruitment of NuMA to mitotic centrosomes	81	20	11520.8685850734	11520.888651963	11536.1388155807	1197	NA	11465.8167187053	11465.8871294346	11496.35717972	1194	0.858704475999133	11424.5806354645	11424.7015422655	11465.3012501507	1192	0.844528044799569	11392.5211846031	11392.9265900085	11468.8723371398	1185	0.865303427924135	3.50341565729089e-13	2.49235107450759e-21	1.89276067383191e-26	5.43029426880088e-11	3.86314416548677e-19	2.93377904443946e-24	non_linear_mixed	1.89276067383191e-26	2.93377904443946e-24	11392.9265900085	11468.8723371398	4
AndrogenReceptor	142	29	22696.3387856398	22696.3526105246	22712.7237068165	1737	NA	22398.3190302506	22398.3675011104	22431.0888726039	1734	0.928392411409755	22394.3219334374	22394.4051223456	22438.0150565751	1732	0.922745525607558	22309.7207818369	22309.9992041107	22391.64538772	1725	0.93307896410285	1.34202748970463e-65	2.61009459206322e-65	2.13277998055888e-80	2.08014260904217e-63	4.045646617698e-63	3.30580896986626e-78	non_linear_mixed	2.13277998055888e-80	3.30580896986626e-78	22309.9992041107	22391.64538772	4
Rab regulation of trafficking	116	20	14752.7116198706	14752.7316867603	14767.981850378	1197	NA	14719.5321213313	14719.6025320606	14750.072582346	1194	NA	14721.0436428488	14721.1645496498	14761.764257535	1192	NA	14697.5117484582	14697.9171538637	14773.8629009949	1185	NA	1.59014963531663e-08	6.87565082049122e-08	5.86374376156897e-12	2.46473193474078e-06	1.06572587717614e-05	9.0888028304319e-10	non_linear_mixed	5.86374376156897e-12	9.0888028304319e-10	14697.9171538637	14773.8629009949	2
ErbB1 downstream signaling	106	22	17014.730547209	17014.7487842911	17030.2867082557	1317	NA	16910.6531854185	16910.7171610468	16941.765507512	1314	0.941548284030712	16914.2751526433	16914.3849924602	16955.7582487679	1312	0.936195179909773	16915.8207673673	16916.1888655268	16993.601572601	1305	NA	1.05605518638163e-23	3.28288963154625e-22	1.62285698958856e-20	1.63688553889153e-21	5.08847892889669e-20	2.51542833386227e-18	linear	1.05605518638163e-23	1.63688553889153e-21	16910.7171610468	16941.765507512	2
p73 transcription factor network	79	26	20170.9338082717	20170.9492324363	20186.9911315725	1557	NA	20061.9763466955	20062.0304355557	20094.0909932969	1554	0.957373946774634	20048.0741468395	20048.1669901664	20090.8936756415	1552	0.954328019243457	19905.118693171	19905.429574	19985.4053096747	1545	NA	9.40248836572907e-25	5.88259074217104e-27	6.43964388445944e-55	1.45738569668801e-22	9.11801565036511e-25	9.98144802091213e-53	non_linear_mixed	6.43964388445944e-55	9.98144802091213e-53	19905.429574	19985.4053096747	5
Nuclear Envelope (NE) Reassembly	78	20	12696.1210824781	12696.1411493677	12711.3913129854	1197	NA	12674.7849979913	12674.8554087205	12705.3254590059	1194	0.873118060921361	12614.1336149164	12614.2545217174	12654.8542296026	1192	0.864216322254326	12553.6815026333	12554.0869080387	12630.03265517	1185	NA	5.00550529332438e-06	2.56845629219997e-18	2.55047307741526e-29	0.000775853320465279	3.98110725290995e-16	3.95323326999365e-27	non_linear_mixed	2.55047307741526e-29	3.95323326999365e-27	12554.0869080387	12630.03265517	5
Mitotic Anaphase	195	56	34982.2744821196	34982.2816334903	35000.6335708785	3357	NA	34901.3411874089	34901.366239601	34938.0593649267	3354	0.939676953193277	34765.5403949991	34765.5833672462	34814.4979650228	3352	0.936542416937941	34600.2408293419	34600.3843700118	34692.0362731363	3345	NA	9.9797642970998e-19	5.35976945688506e-47	1.99602795453026e-79	1.54686346605047e-16	8.30764265817185e-45	3.0938433295219e-77	non_linear_mixed	1.99602795453026e-79	3.0938433295219e-77	34600.3843700118	34692.0362731363	2
Mitotic Metaphase and Anaphase	196	57	35552.0652408493	35552.0722666104	35570.4774283395	3417	NA	35469.7618995437	35469.7865113222	35506.5862745241	3414	0.939893780616421	35331.8056366413	35331.8478530001	35380.9048032817	3412	0.936758626590331	35162.5326671999	35162.6736777757	35254.5936046508	3405	0.943646257386453	5.06919463303455e-19	9.40921981783534e-48	5.14444239803818e-81	7.85725168120355e-17	1.45842907176448e-45	7.97388571695918e-79	non_linear_mixed	5.14444239803818e-81	7.97388571695918e-79	35162.6736777757	35254.5936046508	2
PDGFR-beta signaling pathway	127	24	18276.1769718681	18276.19368496	18291.9941670458	1437	NA	18128.3786550629	18128.4372733462	18160.0130454183	1434	NA	18131.4960951429	18131.5967240737	18173.6752822835	1432	NA	18135.6035675853	18135.940646237	18214.6895434739	1425	0.916251614490011	3.99330470355705e-33	1.34537580328825e-31	6.13306356647708e-29	6.18962229051342e-31	2.08533249509678e-29	9.50624852803948e-27	linear	3.99330470355705e-33	6.18962229051342e-31	18128.4372733462	18160.0130454183	2
Regulation of PLK1 Activity at G2/M Transition	88	28	17078.6375949672	17078.6519147763	17094.9172421844	1677	NA	17052.9563366017	17053.0065458067	17085.5156310361	1674	0.94621058351729	17006.6170082617	17006.7031842043	17050.0294008409	1672	0.944170220961442	16983.0198024664	16983.3082640048	17064.4180385523	1665	0.947854408961336	6.10878293024954e-07	3.16916486481956e-16	7.36535398950701e-20	9.46861354188678e-05	4.91220554047031e-14	1.14162986837359e-17	non_linear_mixed	7.36535398950701e-20	1.14162986837359e-17	16983.3082640048	17064.4180385523	2
Direct p53 effectors	142	29	22888.7491535919	22888.7629784767	22905.1340747685	1737	NA	22721.1033375095	22721.1518083692	22753.8731798627	1734	0.946694557163494	22697.3903189694	22697.4735078775	22741.0834421071	1732	0.942197588800117	22562.2884880372	22562.566910311	22644.2130939204	1725	0.951213846763989	2.07750529888958e-37	1.45449989862057e-41	1.12149384608021e-67	3.22013321327885e-35	2.25447484286188e-39	1.73831546142432e-65	non_linear_mixed	1.12149384608021e-67	1.73831546142432e-65	22562.566910311	22644.2130939204	4
CD4 T cell receptor signaling	132	21	16454.4153196524	16454.4344279327	16469.8319206522	1257	NA	16259.6024003505	16259.6694394566	16290.4356023502	1254	0.949901982425943	16255.8798240839	16255.9949319976	16296.9907600835	1252	0.943506284438841	16227.6202532815	16228.0061053715	16304.7032582807	1245	NA	2.81521305186505e-43	4.23559029738422e-43	9.33966211737918e-47	4.36358023039083e-41	6.56516496094554e-41	1.44764762819377e-44	non_linear_mixed	9.33966211737918e-47	1.44764762819377e-44	16228.0061053715	16304.7032582807	5
Cellular response to starvation	145	22	18462.9730044181	18462.9912415002	18478.5291654649	1317	NA	18364.9649038215	18365.0288794498	18396.0772259149	1314	0.922205682857078	18341.6566013761	18341.7664411931	18383.1396975008	1312	0.914743039950791	18331.476941421	18331.8450395805	18409.2577466547	1305	0.923968879538737	2.13559320190195e-22	1.25079474653932e-26	4.33704839000636e-27	3.31016946294803e-20	1.93873185713594e-24	6.72242500450985e-25	non_linear_mixed	4.33704839000636e-27	6.72242500450985e-25	18331.8450395805	18409.2577466547	5
Programmed Cell Death	142	30	20735.5010840108	20735.5144470397	20751.9877098424	1797	NA	20393.4070743523	20393.453923209	20426.3803260156	1794	0.949290662287101	20382.3563302158	20382.4367322258	20426.3206657668	1792	0.941338633755124	20369.1800160906	20369.4490743865	20451.6131452488	1785	NA	3.85812994116688e-75	2.58606793316231e-76	4.23494680324335e-76	5.98010140880867e-73	4.00840529640159e-74	6.5641675450272e-74	non_linear_mixed	4.23494680324335e-76	6.5641675450272e-74	20369.4490743865	20451.6131452488	2
Metabolism of water-soluble vitamins and cofactors	111	21	14840.6056355215	14840.6247438017	14856.0222365213	1257	NA	14772.0939193982	14772.1609585044	14802.9271213979	1254	0.943567968345158	14768.1617161934	14768.2768241071	14809.272652193	1252	0.942335810506322	14676.2019037503	14676.5877558403	14753.2849087495	1245	0.948575526024095	4.61056625463414e-16	2.58399945462493e-16	8.00174527011778e-34	7.14637769468291e-14	4.00519915466864e-14	1.24027051686826e-31	non_linear_mixed	8.00174527011778e-34	1.24027051686826e-31	14676.5877558403	14753.2849087495	3
RHOA GTPase cycle	149	29	19603.338287528	19603.3521124128	19619.7232087046	1737	NA	19453.8734768951	19453.9219477549	19486.6433192484	1734	0.898950948414295	19457.2940934399	19457.3772823481	19500.9872165776	1732	0.888835000129624	19450.3222383324	19450.6006606062	19532.2468442155	1725	0.901420154418034	1.74489169189132e-33	6.89360485025547e-32	1.74636923665957e-31	2.70458212243154e-31	1.0685087517896e-29	2.70687231682234e-29	non_linear_mixed	1.74636923665957e-31	2.70687231682234e-29	19450.6006606062	19532.2468442155	2
Metabolism of vitamins and cofactors	180	31	21654.246125899	21654.2590569335	21670.8311211991	1857	NA	21537.9152058968	21537.960537791	21571.085196497	1854	0.935126595262322	21537.9818011255	21538.0595969115	21582.2084552591	1852	0.933232574240695	21437.3319797626	21437.5922834502	21520.2569562632	1845	0.939527714927066	2.42881279571845e-26	1.47593511400049e-25	1.0700150973882e-44	3.76465983336359e-24	2.28769942670076e-23	1.65852340095171e-42	non_linear_mixed	1.0700150973882e-44	1.65852340095171e-42	21437.5922834502	21520.2569562632	3
RAC1 GTPase cycle	185	34	25409.9851954131	25409.9969832323	25426.8473106736	2037	NA	25266.0550094445	25266.0963276934	25299.7792399656	2034	NA	25270.0203243892	25270.0912254231	25314.9859650839	2032	NA	25236.3768747903	25236.6140289405	25320.6874510929	2025	NA	2.72788834199053e-32	1.35832508166829e-30	1.01602659513656e-35	4.22822693008532e-30	2.10540387658585e-28	1.57484122246167e-33	non_linear_mixed	1.01602659513656e-35	1.57484122246167e-33	25236.6140289405	25320.6874510929	2
RAC2 GTPase cycle	85	20	15161.559111165	15161.5791780546	15176.8293416723	1197	NA	15065.9178782501	15065.9882889794	15096.4583392648	1194	NA	15066.5537922951	15066.6746990962	15107.2744069814	1192	NA	15061.1840412184	15061.5894466238	15137.5351937551	1185	NA	6.89561818820421e-22	4.64909181930641e-21	8.26788624117348e-21	1.06882081917165e-19	7.20609231992494e-19	1.28152236738189e-18	non_linear_mixed	8.26788624117348e-21	1.28152236738189e-18	15061.5894466238	15137.5351937551	5
Regulation of TP53 Activity	163	30	21746.080836689	21746.094199718	21762.5674625207	1797	NA	21704.3423518683	21704.3892007249	21737.3156035316	1794	NA	21688.3603746502	21688.4407766602	21732.3247102012	1792	NA	21480.9489160756	21481.2179743716	21563.3820452339	1785	0.965317121439747	2.42059128404572e-10	3.05267433676522e-13	8.95626301152563e-55	3.75191649027087e-08	4.73164522198609e-11	1.38822076678647e-52	non_linear_mixed	8.95626301152563e-55	1.38822076678647e-52	21481.2179743716	21563.3820452339	4
RAC3 GTPase cycle	94	22	16536.3161455496	16536.3343826317	16551.8723065963	1317	NA	16413.9848051973	16414.0487808256	16445.0971272908	1314	NA	16414.1946210813	16414.3044608982	16455.6777172059	1312	NA	16400.2302678943	16400.5983660538	16478.011073128	1305	NA	1.2378140599919e-27	8.43874875384815e-27	5.04505020281978e-28	1.91861179298745e-25	1.30800605684646e-24	7.81982781437066e-26	non_linear_mixed	5.04505020281978e-28	7.81982781437066e-26	16400.5983660538	16478.011073128	2
SUMOylation	182	30	23432.9718621444	23432.9852251733	23449.458487976	1797	NA	23336.5709136057	23336.6177624624	23369.544165269	1794	0.950342856965338	23325.4271930607	23325.5075950707	23369.3915286117	1792	0.948674773791382	23223.090457278	23223.3595155739	23305.5235864362	1785	NA	4.73357515767182e-22	1.03910367915449e-23	3.10994726601846e-43	7.33704149439132e-20	1.61061070268946e-21	4.82041826232861e-41	non_linear_mixed	3.10994726601846e-43	4.82041826232861e-41	23223.3595155739	23305.5235864362	3
CDC42 GTPase cycle	160	31	21991.1035134471	21991.1164444816	22007.6885087472	1857	NA	21880.8931044574	21880.9384363516	21914.0630950576	1854	0.943157349397329	21884.385015413	21884.462811199	21928.6116695466	1852	0.938671266492852	21796.6223205161	21796.8826242038	21879.5472970167	1845	NA	5.05222810635041e-25	1.55432755754726e-23	4.90119634890573e-40	7.83095356484313e-23	2.40920771419825e-21	7.59685434080388e-38	non_linear_mixed	4.90119634890573e-40	7.59685434080388e-38	21796.8826242038	21879.5472970167	2
mRNA Splicing - Major Pathway	177	21	15204.4374818538	15204.4565901341	15219.8540828537	1257	NA	15097.3303203521	15097.3973594583	15128.1635223518	1254	0.94041747163032	15082.3740235035	15082.4891314172	15123.4849595031	1252	0.93631648899985	15056.4674920024	15056.8533440925	15133.5504970016	1245	0.942548668995776	2.35270277209347e-24	8.68170233431986e-27	1.88720364822593e-30	3.64668929674488e-22	1.34566386181958e-24	2.92516565475019e-28	non_linear_mixed	1.88720364822593e-30	2.92516565475019e-28	15056.8533440925	15133.5504970016	2
Apoptosis	127	28	19383.956824727	19383.971144536	19400.2364719441	1677	NA	19043.0263620982	19043.0765713032	19075.5856565326	1674	0.951367404295453	19038.8594446358	19038.9456205784	19082.271837215	1672	0.943490726991275	19032.0267454906	19032.315207029	19113.4249815765	1665	0.95206208309905	6.89151918094736e-75	1.39825875034273e-74	4.68456728649391e-73	1.06818547304684e-72	2.16730106303123e-72	7.26107929406556e-71	non_linear_mixed	4.68456728649391e-73	7.26107929406556e-71	19032.315207029	19113.4249815765	4
tRNA processing	103	22	15831.8062968984	15831.8245339804	15847.3624579451	1317	NA	15820.4380677811	15820.5020434095	15851.5503898746	1314	NA	15789.8130835248	15789.9229233417	15831.2961796494	1312	NA	15615.8465845293	15616.2146826888	15693.627389763	1305	NA	0.000593593969779679	5.41209659216878e-10	1.69081547248593e-44	0.0920070653158502	8.38874971786161e-08	2.6207639823532e-42	non_linear_mixed	1.69081547248593e-44	2.6207639823532e-42	15616.2146826888	15693.627389763	4
Protein localization	165	26	16942.2793429072	16942.2947670717	16958.3366662079	1557	NA	16591.5690346719	16591.6231235322	16623.6836812734	1554	0.927755924138272	16586.8172209136	16586.9100642405	16629.6367497156	1552	0.913132963457429	16589.8051231559	16590.1160039849	16670.0917396595	1545	NA	5.25594799497835e-77	8.19503904840011e-77	3.59446892780365e-73	8.14671939221644e-75	1.27023105250202e-74	5.57142683809565e-71	non_linear_fixed	8.19503904840011e-77	1.27023105250202e-74	16586.9100642405	16629.6367497156	2
Death Receptor Signalling	134	23	16742.9254217298	16742.9428635903	16758.6149380643	1377	NA	16655.7110868283	16655.7722667264	16687.0901194973	1374	0.951374172536248	16645.1423806558	16645.2474134785	16686.981090881	1372	0.947703136029944	16544.3423058121	16544.6942119705	16622.7898874844	1365	0.955808254535439	4.46716621245413e-20	1.20471808735124e-21	6.9118662426632e-41	6.9241076293039e-18	1.86731303539442e-19	1.0713392676128e-38	non_linear_mixed	6.9118662426632e-41	1.0713392676128e-38	16544.6942119705	16622.7898874844	5
AURKA Activation by TPX2	73	23	13203.3168389615	13203.334280822	13219.006355296	1377	NA	13141.7179175631	13141.7790974612	13173.096950232	1374	0.857885898170907	13078.3115131438	13078.4165459665	13120.150223369	1372	0.845826791524298	13016.7737213162	13017.1256274746	13095.2213029885	1365	0.86677670496579	1.3940501776456e-14	2.06027648572208e-27	2.15992501132127e-38	2.16077777535069e-12	3.19342855286922e-25	3.34788376754796e-36	non_linear_mixed	2.15992501132127e-38	3.34788376754796e-36	13017.1256274746	13095.2213029885	2